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The map label for this gene is trxC [H]

Identifier: 114798133

GI number: 114798133

Start: 2534975

End: 2535433

Strand: Reverse

Name: trxC [H]

Synonym: HNE_2426

Alternate gene names: 114798133

Gene position: 2535433-2534975 (Counterclockwise)

Preceding gene: 114800223

Following gene: 114798631

Centisome position: 68.43

GC content: 64.71

Gene sequence:

>459_bases
ATGGCAAGTGAAGACAGGATGATCGTTTGCCTCGCCTGCAATGCGGTGAACCGCGTGCCGGAGGGCAGGGCACTGACGGC
TGCGAAATGCGGGCGCTGTGCAGGGCTTTTGGCAACGCCCCACCCCGCCGAAATCACCAATGACCAGATGCGCGCCCTGG
AAAAGAAAGACACCGGCGCCTTCATTGTTGATCTCTGGGCGCCCTGGTGTGGCCCCTGCCGCATGATGGCGCCCCACTAT
GACGCCGCCGCAGAGCGCCTTCAGGGGGATGTCCGCTTCTATAAAATCAATACCGACCAGCACCCTGATGCTGCCGTTCG
CCTGAATATCCGCGGCGTGCCGACGCTCGTGGCGTGGAAAGGCGGGCGGGAACTCACCCGGCAGTCTGGCGCTCCGGCTG
GCGGCGCGCTCGAACGATGGGTGCGTGGACTGTTCGGTCTCGCGCCGGCGCCCAACTGA

Upstream 100 bases:

>100_bases
TGAGGGCGGGCAAGGCGGAAACATTCTATGAGAATGCCGCCCTCGCCCTTATCAAGACCTACAAGCTGAAAGGCTGAAAG
ACGCGACAGGAGACGCTGAC

Downstream 100 bases:

>100_bases
TCCTCAAGCGGAGTAACCTGAAATGAATCTCGACCGTGCTGTTCTCGCCTTTGCCGGCGTTGTCGTCCTCATCGGCCTGA
CGCTGGGCTATTATGTATCG

Product: putative thioredoxin

Products: NA

Alternate protein names: Trx-2; Protein-disulfide reductase [H]

Number of amino acids: Translated: 152; Mature: 151

Protein sequence:

>152_residues
MASEDRMIVCLACNAVNRVPEGRALTAAKCGRCAGLLATPHPAEITNDQMRALEKKDTGAFIVDLWAPWCGPCRMMAPHY
DAAAERLQGDVRFYKINTDQHPDAAVRLNIRGVPTLVAWKGGRELTRQSGAPAGGALERWVRGLFGLAPAPN

Sequences:

>Translated_152_residues
MASEDRMIVCLACNAVNRVPEGRALTAAKCGRCAGLLATPHPAEITNDQMRALEKKDTGAFIVDLWAPWCGPCRMMAPHY
DAAAERLQGDVRFYKINTDQHPDAAVRLNIRGVPTLVAWKGGRELTRQSGAPAGGALERWVRGLFGLAPAPN
>Mature_151_residues
ASEDRMIVCLACNAVNRVPEGRALTAAKCGRCAGLLATPHPAEITNDQMRALEKKDTGAFIVDLWAPWCGPCRMMAPHYD
AAAERLQGDVRFYKINTDQHPDAAVRLNIRGVPTLVAWKGGRELTRQSGAPAGGALERWVRGLFGLAPAPN

Specific function: Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=139, Percent_Identity=28.7769784172662, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI21361657, Length=110, Percent_Identity=30, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI1788936, Length=135, Percent_Identity=38.5185185185185, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI87082331, Length=97, Percent_Identity=40.2061855670103, Blast_Score=86, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6321648, Length=70, Percent_Identity=44.2857142857143, Blast_Score=77, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319925, Length=103, Percent_Identity=34.9514563106796, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 16450; Mature: 16319

Theoretical pI: Translated: 8.62; Mature: 8.62

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
4.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASEDRMIVCLACNAVNRVPEGRALTAAKCGRCAGLLATPHPAEITNDQMRALEKKDTGA
CCCCCCEEEEEECCHHHCCCCCCEECHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCE
FIVDLWAPWCGPCRMMAPHYDAAAERLQGDVRFYKINTDQHPDAAVRLNIRGVPTLVAWK
EEEEECCCCCCCCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCEEEEEEECCCCEEEEEC
GGRELTRQSGAPAGGALERWVRGLFGLAPAPN
CCHHHHHHCCCCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
ASEDRMIVCLACNAVNRVPEGRALTAAKCGRCAGLLATPHPAEITNDQMRALEKKDTGA
CCCCCEEEEEECCHHHCCCCCCEECHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCE
FIVDLWAPWCGPCRMMAPHYDAAAERLQGDVRFYKINTDQHPDAAVRLNIRGVPTLVAWK
EEEEECCCCCCCCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCEEEEEEECCCCEEEEEC
GGRELTRQSGAPAGGALERWVRGLFGLAPAPN
CCHHHHHHCCCCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]