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The map label for this gene is sdhA [H]

Identifier: 114798098

GI number: 114798098

Start: 3413339

End: 3415126

Strand: Direct

Name: sdhA [H]

Synonym: HNE_3245

Alternate gene names: 114798098

Gene position: 3413339-3415126 (Clockwise)

Preceding gene: 114799518

Following gene: 114799101

Centisome position: 92.13

GC content: 63.81

Gene sequence:

>1788_bases
ATGAGCAGCTATAACTGGATTGATCATACCTACGACGTGGTCGTGGTCGGCGCCGGCGGCTCCGGTCTCCGCGCAGCCCT
TGGCGCCGCGCAGGCGGGCCTGCGCACGGCCTGTATCACCAAGGTCTTCCCCACCCGCTCCCACACCGTGGCAGCTCAGG
GCGGCATCGCCGCCTCGCTCGGCAACATGTCCGACGACAGCTGGCAGTGGCACATGTACGACACCGTCAAGGGCTCCGAC
TGGCTCGGCGACCAGGACGCGATCGAATATCTCGTGCGCAACGCGCCTGACGCGGTTTACGAACTTGAGCATTGGGGCAT
GCCCTTCTCGCGCACCGAGGAAGGCAAGATCTACCAGCGCGCTTTCGGCGGCATGACCCGCAATTTCGGCGAAGGCCCCG
TCCAGCGCACCTGCGCGGCGGCAGACCGGACCGGCCACGCCATGCTGCACACCCTCTATGGCCAGTGCGTGCGCGAAGAG
ACCGAATTCTTCATCGAGTATTTCGCCCTTGATCTGATCATGGATGATGACGGCGTCTGCCGCGGTGTCACCGCCTGGAA
ACTCGACGATGGCACGCTTCACCGCTTCCGCGCCCAGAAAACCATCTTGGCAACCGGCGGCTATGGCCGCGCCTATTTCT
CCTGCACCTCGGCCCACACCTGCACCGGCGATGGCAATGCCATGGTCCTGCGCGCCGGTCTGCCGCTTCAGGACATGGAA
TTCGTCCAGTTCCACCCCACCGGCATCTACGGCTCAGGCTGCCTGATCACCGAAGGCGCCCGCGGCGAAGGCGGCTATCT
GACAAACTCCGAAGGCGAACGCTTCATGGAGCGCTATGCGCCATCCGCCAAAGACCTCGCCTCGCGCGATGTTGTCAGCC
GCGCGATGACCATGGAAATCCGCGACGGCCGCGGCGTCGGGCCGGAGAAAGACCACATCTTCCTCCACCTGAACCACCTC
GCGCCTGAAACCCTGCATGAGCGCCTTCCGGGCATCTCGGAAACCGCCAAGATCTTTGCCGGCGTCGACGTCACCAAGGA
GCCGATCCCGGTTCTGCCGACCGTCCACTACAATATGGGCGGCATCCCGACGAACTTCCACGGCGAAGTCCTCACCAAGA
AGAACGGCGATCCCGACGCGGTTGTCCCCGGCCTGATGGCTGTGGGCGAAGCGGCCTGTGTGTCCGTACACGGCGCAAAC
CGCCTCGGCTCCAACTCGCTGATCGACCTGGTCGTGTTCGGCCGCGCCGCCGGTCTGCGCTGCGGCGCCACCACCGAGGC
AGGCGCCCGCCAGCCCGGACTCGCCAAGACCGCAACCGACAGCCACATCGCCCGCCTCGACAAGATGCGCAACGCCACCG
GCGACCAGCCGGTTGCCAAGCTCCGCCTAGAAATGCAGCGCGCGATGCAGTCCAACTGCGCCGTGTTCCGCACAGGCTCG
GTGCTGAAAGAGGGCGTCGACGCAATCGAGGACGTCTACAAGAAACTGCCGGGCATCGATGTCAAAGATCGCGGCATGGT
CTGGAACACAGATCTCGTTGAAGCGCTCGAATTTGAAAACCTGATCTGCCAGGCGGCCGTGACGGTGAATTCGGCCGCAA
ACCGGGAAGAAAGCCGCGGCGCTCATGCCCGCGAAGATTTCGCCGACCGCAACGACGAGACATGGATGAAACACACCCTC
GCCTGGTGCGACGATGCCGGTAAGGTCTCGCTCGATTACCGCCCGGTTCACGAATACACGCTCTCCAACGAGATCGAGTA
CATCAAGCCAAAAGCGCGGGTATACTGA

Upstream 100 bases:

>100_bases
TGAACACCTTTGCCGCCTATGCGATGTTCATCGCCGTCGCCATGGCCGTGGTTCAGATCTGGACGGCACGCTGAGACACG
CGAAGAAGAGATAAAAGAAT

Downstream 100 bases:

>100_bases
TCACTTGACTATCAAGACCGGCGCGGTGCCCAGATGACCCCCTACAAGACTGTCTGGGTTCGCGCCGGGAAACTGAAGAA
GGAAGAGAAGAAACTCCTCG

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 595; Mature: 594

Protein sequence:

>595_residues
MSSYNWIDHTYDVVVVGAGGSGLRAALGAAQAGLRTACITKVFPTRSHTVAAQGGIAASLGNMSDDSWQWHMYDTVKGSD
WLGDQDAIEYLVRNAPDAVYELEHWGMPFSRTEEGKIYQRAFGGMTRNFGEGPVQRTCAAADRTGHAMLHTLYGQCVREE
TEFFIEYFALDLIMDDDGVCRGVTAWKLDDGTLHRFRAQKTILATGGYGRAYFSCTSAHTCTGDGNAMVLRAGLPLQDME
FVQFHPTGIYGSGCLITEGARGEGGYLTNSEGERFMERYAPSAKDLASRDVVSRAMTMEIRDGRGVGPEKDHIFLHLNHL
APETLHERLPGISETAKIFAGVDVTKEPIPVLPTVHYNMGGIPTNFHGEVLTKKNGDPDAVVPGLMAVGEAACVSVHGAN
RLGSNSLIDLVVFGRAAGLRCGATTEAGARQPGLAKTATDSHIARLDKMRNATGDQPVAKLRLEMQRAMQSNCAVFRTGS
VLKEGVDAIEDVYKKLPGIDVKDRGMVWNTDLVEALEFENLICQAAVTVNSAANREESRGAHAREDFADRNDETWMKHTL
AWCDDAGKVSLDYRPVHEYTLSNEIEYIKPKARVY

Sequences:

>Translated_595_residues
MSSYNWIDHTYDVVVVGAGGSGLRAALGAAQAGLRTACITKVFPTRSHTVAAQGGIAASLGNMSDDSWQWHMYDTVKGSD
WLGDQDAIEYLVRNAPDAVYELEHWGMPFSRTEEGKIYQRAFGGMTRNFGEGPVQRTCAAADRTGHAMLHTLYGQCVREE
TEFFIEYFALDLIMDDDGVCRGVTAWKLDDGTLHRFRAQKTILATGGYGRAYFSCTSAHTCTGDGNAMVLRAGLPLQDME
FVQFHPTGIYGSGCLITEGARGEGGYLTNSEGERFMERYAPSAKDLASRDVVSRAMTMEIRDGRGVGPEKDHIFLHLNHL
APETLHERLPGISETAKIFAGVDVTKEPIPVLPTVHYNMGGIPTNFHGEVLTKKNGDPDAVVPGLMAVGEAACVSVHGAN
RLGSNSLIDLVVFGRAAGLRCGATTEAGARQPGLAKTATDSHIARLDKMRNATGDQPVAKLRLEMQRAMQSNCAVFRTGS
VLKEGVDAIEDVYKKLPGIDVKDRGMVWNTDLVEALEFENLICQAAVTVNSAANREESRGAHAREDFADRNDETWMKHTL
AWCDDAGKVSLDYRPVHEYTLSNEIEYIKPKARVY
>Mature_594_residues
SSYNWIDHTYDVVVVGAGGSGLRAALGAAQAGLRTACITKVFPTRSHTVAAQGGIAASLGNMSDDSWQWHMYDTVKGSDW
LGDQDAIEYLVRNAPDAVYELEHWGMPFSRTEEGKIYQRAFGGMTRNFGEGPVQRTCAAADRTGHAMLHTLYGQCVREET
EFFIEYFALDLIMDDDGVCRGVTAWKLDDGTLHRFRAQKTILATGGYGRAYFSCTSAHTCTGDGNAMVLRAGLPLQDMEF
VQFHPTGIYGSGCLITEGARGEGGYLTNSEGERFMERYAPSAKDLASRDVVSRAMTMEIRDGRGVGPEKDHIFLHLNHLA
PETLHERLPGISETAKIFAGVDVTKEPIPVLPTVHYNMGGIPTNFHGEVLTKKNGDPDAVVPGLMAVGEAACVSVHGANR
LGSNSLIDLVVFGRAAGLRCGATTEAGARQPGLAKTATDSHIARLDKMRNATGDQPVAKLRLEMQRAMQSNCAVFRTGSV
LKEGVDAIEDVYKKLPGIDVKDRGMVWNTDLVEALEFENLICQAAVTVNSAANREESRGAHAREDFADRNDETWMKHTLA
WCDDAGKVSLDYRPVHEYTLSNEIEYIKPKARVY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=614, Percent_Identity=62.5407166123778, Blast_Score=752, Evalue=0.0,
Organism=Escherichia coli, GI1786942, Length=555, Percent_Identity=55.4954954954955, Blast_Score=567, Evalue=1e-163,
Organism=Escherichia coli, GI1790597, Length=580, Percent_Identity=42.2413793103448, Blast_Score=414, Evalue=1e-117,
Organism=Escherichia coli, GI1788928, Length=554, Percent_Identity=30.8664259927798, Blast_Score=197, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17550100, Length=615, Percent_Identity=62.1138211382114, Blast_Score=760, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505833, Length=615, Percent_Identity=59.5121951219512, Blast_Score=714, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322701, Length=597, Percent_Identity=66.499162479062, Blast_Score=796, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322416, Length=599, Percent_Identity=65.7762938230384, Blast_Score=778, Evalue=0.0,
Organism=Drosophila melanogaster, GI17137288, Length=612, Percent_Identity=63.0718954248366, Blast_Score=786, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655642, Length=612, Percent_Identity=63.0718954248366, Blast_Score=786, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655647, Length=612, Percent_Identity=63.0718954248366, Blast_Score=786, Evalue=0.0,
Organism=Drosophila melanogaster, GI24663005, Length=613, Percent_Identity=54.9755301794454, Blast_Score=675, Evalue=0.0,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 64998; Mature: 64867

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSYNWIDHTYDVVVVGAGGSGLRAALGAAQAGLRTACITKVFPTRSHTVAAQGGIAASL
CCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCHHHHHHHHHCCCCCCEEEECCCCEEEC
GNMSDDSWQWHMYDTVKGSDWLGDQDAIEYLVRNAPDAVYELEHWGMPFSRTEEGKIYQR
CCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCHHHHH
AFGGMTRNFGEGPVQRTCAAADRTGHAMLHTLYGQCVREETEFFIEYFALDLIMDDDGVC
HHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCC
RGVTAWKLDDGTLHRFRAQKTILATGGYGRAYFSCTSAHTCTGDGNAMVLRAGLPLQDME
CCEEEEEECCCHHHHHHCCEEEEEECCCCCEEEEECCCCEECCCCCEEEEECCCCCCCCC
FVQFHPTGIYGSGCLITEGARGEGGYLTNSEGERFMERYAPSAKDLASRDVVSRAMTMEI
EEEEECCCEECCCEEEECCCCCCCCEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHEEEE
RDGRGVGPEKDHIFLHLNHLAPETLHERLPGISETAKIFAGVDVTKEPIPVLPTVHYNMG
CCCCCCCCCCCEEEEEECCCCHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCEEECCCC
GIPTNFHGEVLTKKNGDPDAVVPGLMAVGEAACVSVHGANRLGSNSLIDLVVFGRAAGLR
CCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEECCCCCCC
CGATTEAGARQPGLAKTATDSHIARLDKMRNATGDQPVAKLRLEMQRAMQSNCAVFRTGS
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEECCH
VLKEGVDAIEDVYKKLPGIDVKDRGMVWNTDLVEALEFENLICQAAVTVNSAANREESRG
HHHHHHHHHHHHHHHCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHEEECCCCCCHHHCC
AHAREDFADRNDETWMKHTLAWCDDAGKVSLDYRPVHEYTLSNEIEYIKPKARVY
CCCHHHHHCCCCHHHHHHHHHHCCCCCEEEECCCCCHHHHCCCCCEEECCCCCCC
>Mature Secondary Structure 
SSYNWIDHTYDVVVVGAGGSGLRAALGAAQAGLRTACITKVFPTRSHTVAAQGGIAASL
CCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCHHHHHHHHHCCCCCCEEEECCCCEEEC
GNMSDDSWQWHMYDTVKGSDWLGDQDAIEYLVRNAPDAVYELEHWGMPFSRTEEGKIYQR
CCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCHHHHH
AFGGMTRNFGEGPVQRTCAAADRTGHAMLHTLYGQCVREETEFFIEYFALDLIMDDDGVC
HHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCC
RGVTAWKLDDGTLHRFRAQKTILATGGYGRAYFSCTSAHTCTGDGNAMVLRAGLPLQDME
CCEEEEEECCCHHHHHHCCEEEEEECCCCCEEEEECCCCEECCCCCEEEEECCCCCCCCC
FVQFHPTGIYGSGCLITEGARGEGGYLTNSEGERFMERYAPSAKDLASRDVVSRAMTMEI
EEEEECCCEECCCEEEECCCCCCCCEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHEEEE
RDGRGVGPEKDHIFLHLNHLAPETLHERLPGISETAKIFAGVDVTKEPIPVLPTVHYNMG
CCCCCCCCCCCEEEEEECCCCHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCEEECCCC
GIPTNFHGEVLTKKNGDPDAVVPGLMAVGEAACVSVHGANRLGSNSLIDLVVFGRAAGLR
CCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEECCCCCCC
CGATTEAGARQPGLAKTATDSHIARLDKMRNATGDQPVAKLRLEMQRAMQSNCAVFRTGS
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEECCH
VLKEGVDAIEDVYKKLPGIDVKDRGMVWNTDLVEALEFENLICQAAVTVNSAANREESRG
HHHHHHHHHHHHHHHCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHEEECCCCCCHHHCC
AHAREDFADRNDETWMKHTLAWCDDAGKVSLDYRPVHEYTLSNEIEYIKPKARVY
CCCHHHHHCCCCHHHHHHHHHHCCCCCEEEECCCCCHHHHCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA