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The map label for this gene is lolC [H]

Identifier: 114798078

GI number: 114798078

Start: 1806549

End: 1807820

Strand: Direct

Name: lolC [H]

Synonym: HNE_1765

Alternate gene names: 114798078

Gene position: 1806549-1807820 (Clockwise)

Preceding gene: 114799658

Following gene: 114797117

Centisome position: 48.76

GC content: 56.13

Gene sequence:

>1272_bases
ATGCCTTCCGCAACGCCTTTTGGCAAACTGGAGCGAACGCTTGCCTGGAGGTATCTCAGGGCGCGCCGTGAACATGGGGG
CGCCAGCCTTATCGCGGTCATTTCATTCATCGGAATTTTCTTCGCGGTGGCCGCGTTGATTATCACCATGTCGATCATGA
GTGGATTTCGTGCGACCCTGCTCGACGCACTCTTGGGCGGCGAACCCCATATCTCCGCCGCAGTCGATGGCATGCCGCAG
GACGAGGCGGAAGCATTGGCCAAGATAATCTCTGAAACCCCGGATGTTATCAGCGCGTCTCCTTATATCGAGCAGTTCGT
TTTGCTGTCTGCAAATGGTGTGAGAACGGGCGGCGTGGTTCGCGCGGTTCCGCCTGCCGATCTCAAAACCATGCCGATCC
TAAAGGACGGGGGCGAGGCGGCCCTGGCCGCTGGGTTTGGACAAGGCCGAAATGGCGGCAATGTCATCATGATCGGACAA
TACCTCGCAGCAAATCTGGGGCTTCAGCCCGGCGATAGTGTCGAGGTCGTGACATCGCAGATGCGATCTGGTCCCCTAGG
ACAAACGCCGATCAGCAAGTCTTATGTTGTTGGAGACATTTTCCGGACCGGCTCCGCACAGTTGGACAACGTCTATGTAT
TCATGCCGATGAATCAGGCGCAGATATTGTTCCAGTCCAAAGGGCGCTATCAGTTTCTGGATATCCGGGTGAAAAATCCC
GACATGACAGAGGTCGCCATGCAGCGCATCTCTGAAGCGACAGGTTACAGTCTGCTTCTACGAGATTGGAAGACCAAGAA
CCGGACATATCTGGGCGCGCTGAGAACTGAGCGTGTCATGGTGAGATTGCTGGTAACGATCATCATGATGATTGCCACAC
TGAACATCATTGTCGGGGTTGTAATGCTGGTCAAAAACAAGACGCGGGATGTGGCCATCCTGCGGACCATCGGTCTCAGC
CGCGGCGGCGTTCTGCGGGTATTCCTGATGGTAGGAACCGTTCTTGGCTCACTGGGCGCTCTGCTTGGGATGGTTGTGGG
TGTGCTGTTCATTCTCAACATCGGCCCGATCGAGGCTCTGATCAATCTCGCGATTGATGGGGAAGTGTTCCCGGCAGAGC
AGTATGGCCTGGATCATCTGCCAGCTGTGCTTGATTGGGGCGAAGTGGCTAGCACGGGCGCCTACGCGCTGATCATGTCC
ATGGTCGTCTCACTGATCCCGGCAATCTGGGCGTCGTCGCAAGACCCGGTCAAAGCGCTGAGGTTTGAATGA

Upstream 100 bases:

>100_bases
CTGAAGGCAAGGTCGAGGTCAAGAATCGCAAGACGGGCGAGAAGCATGATGTCAAAATCGAAGATATGCTGGCTCAACTG
AAAGGCTCCTGATGAGCGCG

Downstream 100 bases:

>100_bases
TGCAACCCGTACTCGAACTTCTGGGAATTGACCGGACGTATCATACTGCGGCCGGCGCATTGCAGGTGTTGCAGGGCACC
GACCTGCGCGTTTCGCCCGG

Product: LolC/E family lipoprotein releasing system, transmembrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 423; Mature: 422

Protein sequence:

>423_residues
MPSATPFGKLERTLAWRYLRARREHGGASLIAVISFIGIFFAVAALIITMSIMSGFRATLLDALLGGEPHISAAVDGMPQ
DEAEALAKIISETPDVISASPYIEQFVLLSANGVRTGGVVRAVPPADLKTMPILKDGGEAALAAGFGQGRNGGNVIMIGQ
YLAANLGLQPGDSVEVVTSQMRSGPLGQTPISKSYVVGDIFRTGSAQLDNVYVFMPMNQAQILFQSKGRYQFLDIRVKNP
DMTEVAMQRISEATGYSLLLRDWKTKNRTYLGALRTERVMVRLLVTIIMMIATLNIIVGVVMLVKNKTRDVAILRTIGLS
RGGVLRVFLMVGTVLGSLGALLGMVVGVLFILNIGPIEALINLAIDGEVFPAEQYGLDHLPAVLDWGEVASTGAYALIMS
MVVSLIPAIWASSQDPVKALRFE

Sequences:

>Translated_423_residues
MPSATPFGKLERTLAWRYLRARREHGGASLIAVISFIGIFFAVAALIITMSIMSGFRATLLDALLGGEPHISAAVDGMPQ
DEAEALAKIISETPDVISASPYIEQFVLLSANGVRTGGVVRAVPPADLKTMPILKDGGEAALAAGFGQGRNGGNVIMIGQ
YLAANLGLQPGDSVEVVTSQMRSGPLGQTPISKSYVVGDIFRTGSAQLDNVYVFMPMNQAQILFQSKGRYQFLDIRVKNP
DMTEVAMQRISEATGYSLLLRDWKTKNRTYLGALRTERVMVRLLVTIIMMIATLNIIVGVVMLVKNKTRDVAILRTIGLS
RGGVLRVFLMVGTVLGSLGALLGMVVGVLFILNIGPIEALINLAIDGEVFPAEQYGLDHLPAVLDWGEVASTGAYALIMS
MVVSLIPAIWASSQDPVKALRFE
>Mature_422_residues
PSATPFGKLERTLAWRYLRARREHGGASLIAVISFIGIFFAVAALIITMSIMSGFRATLLDALLGGEPHISAAVDGMPQD
EAEALAKIISETPDVISASPYIEQFVLLSANGVRTGGVVRAVPPADLKTMPILKDGGEAALAAGFGQGRNGGNVIMIGQY
LAANLGLQPGDSVEVVTSQMRSGPLGQTPISKSYVVGDIFRTGSAQLDNVYVFMPMNQAQILFQSKGRYQFLDIRVKNPD
MTEVAMQRISEATGYSLLLRDWKTKNRTYLGALRTERVMVRLLVTIIMMIATLNIIVGVVMLVKNKTRDVAILRTIGLSR
GGVLRVFLMVGTVLGSLGALLGMVVGVLFILNIGPIEALINLAIDGEVFPAEQYGLDHLPAVLDWGEVASTGAYALIMSM
VVSLIPAIWASSQDPVKALRFE

Specific function: Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787362, Length=395, Percent_Identity=28.1012658227848, Blast_Score=121, Evalue=7e-29,
Organism=Escherichia coli, GI1787360, Length=417, Percent_Identity=26.8585131894484, Blast_Score=97, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 45392; Mature: 45261

Theoretical pI: Translated: 9.13; Mature: 9.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSATPFGKLERTLAWRYLRARREHGGASLIAVISFIGIFFAVAALIITMSIMSGFRATL
CCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDALLGGEPHISAAVDGMPQDEAEALAKIISETPDVISASPYIEQFVLLSANGVRTGGVV
HHHHHCCCCCCHHHHCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHEECCCCCCCCEE
RAVPPADLKTMPILKDGGEAALAAGFGQGRNGGNVIMIGQYLAANLGLQPGDSVEVVTSQ
EECCCCCCCCCCEECCCCCEEEEECCCCCCCCCCEEEECHHHHHHCCCCCCCHHHHHHHH
MRSGPLGQTPISKSYVVGDIFRTGSAQLDNVYVFMPMNQAQILFQSKGRYQFLDIRVKNP
HHCCCCCCCCCCCCHHHHHHHHCCCCCCCCEEEEEECCCHHHHEECCCCEEEEEEEECCC
DMTEVAMQRISEATGYSLLLRDWKTKNRTYLGALRTERVMVRLLVTIIMMIATLNIIVGV
CHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VMLVKNKTRDVAILRTIGLSRGGVLRVFLMVGTVLGSLGALLGMVVGVLFILNIGPIEAL
HHHHHCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
INLAIDGEVFPAEQYGLDHLPAVLDWGEVASTGAYALIMSMVVSLIPAIWASSQDPVKAL
HHHHCCCCCCCHHHCCCCHHHHHHCHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHH
RFE
CCC
>Mature Secondary Structure 
PSATPFGKLERTLAWRYLRARREHGGASLIAVISFIGIFFAVAALIITMSIMSGFRATL
CCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDALLGGEPHISAAVDGMPQDEAEALAKIISETPDVISASPYIEQFVLLSANGVRTGGVV
HHHHHCCCCCCHHHHCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHEECCCCCCCCEE
RAVPPADLKTMPILKDGGEAALAAGFGQGRNGGNVIMIGQYLAANLGLQPGDSVEVVTSQ
EECCCCCCCCCCEECCCCCEEEEECCCCCCCCCCEEEECHHHHHHCCCCCCCHHHHHHHH
MRSGPLGQTPISKSYVVGDIFRTGSAQLDNVYVFMPMNQAQILFQSKGRYQFLDIRVKNP
HHCCCCCCCCCCCCHHHHHHHHCCCCCCCCEEEEEECCCHHHHEECCCCEEEEEEEECCC
DMTEVAMQRISEATGYSLLLRDWKTKNRTYLGALRTERVMVRLLVTIIMMIATLNIIVGV
CHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VMLVKNKTRDVAILRTIGLSRGGVLRVFLMVGTVLGSLGALLGMVVGVLFILNIGPIEAL
HHHHHCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
INLAIDGEVFPAEQYGLDHLPAVLDWGEVASTGAYALIMSMVVSLIPAIWASSQDPVKAL
HHHHCCCCCCCHHHCCCCHHHHHHCHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHH
RFE
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]