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The map label for this gene is mccA [H]

Identifier: 114797946

GI number: 114797946

Start: 1314026

End: 1315927

Strand: Direct

Name: mccA [H]

Synonym: HNE_1285

Alternate gene names: 114797946

Gene position: 1314026-1315927 (Clockwise)

Preceding gene: 114797387

Following gene: 114800506

Centisome position: 35.47

GC content: 66.3

Gene sequence:

>1902_bases
GTGACCATCACCAAGCTGCTCGTCGCTAACCGGGGCGAGATCGCCGCCCGCATTTTCCGCACCTGCCGCGAACTGGGCAT
CGAGACCGTCGCGGTCTTCTCCGAAGCCGACCGCGCCGCCAAACATGTGCGCGAAGCCGACGAAGCCGTCTGCATCGGCC
CGGCGCCCGCCCCTGAAAGCTATCTGCGCGTTGAGGCGATCCTTGCCGCCGCGAAGGAGACGGGCGCTGACGCCATCCAT
CCGGGCTATGGTTTCCTCTCCGAGAACGCCGCCTTTGCCGAAGCCGTCGTTGCCGCCGGCCTCATCTGGGTTGGCCCGCC
GCCGTCTGCCATCCGCTCCATGGGGCCGAAGGATGAGGCCAAGCGCATTGCAGAGGACGCCGGCGTGCCCGTGCTGCCCG
GCTATCGCGGCGAGGCGCAGGATATCGAGACACTGAAGAAGGCGGCCAAGAAGGTCGGCTATCCGCTGCTCATCAAAGCG
GTCGCCGGGGGCGGCGGCCGCGGCATCCGGCAGGTCTCGAAAGAGGCGGAACTGGAAGCTGAACTCATCAGCGCCGTGCG
CGAAGCCGAGAGCGCCTTTGGCGATGGCCGCGTGATGCTGGAGAAGCTGGTTCTCCAGCCGCGCCATATCGAGGTGCAGG
TGTTTGGCGACGCCCATGGCAACGTCGTTCACCTGTTTGAACGCGATTGCTCGCTGCAACGCCGCCGCCAGAAAGTGCTC
GAAGAAGCGCCTGCGCCCGGTATGCCGGAAGACGTGCGCGCCGCGATGACGGACGCGGCCGTAAAGCTCGCCAAGGCGGT
TGGCTATCAGGGCGCGGGCACAGTGGAATTCATCGTGGACGGATCAAGGCCGCTGGCGGCCGATACGTTCTGGTTCCTCG
AAATGAATACGCGGCTTCAGGTCGAACATCCGGTCACCGAAATGGTCACCGGGCAGGATCTGGTCGAGTGGCAACTCATC
GTCGCGTCGGGCGGCACGCTGCCGCTGGCGCAGGACGAGATTGAACTCAATGGCCACGCCATCGAGGCGCGCATCTGCGC
CGAAGACCCGGCCGAAGGTTTCCGCCCCGGCGCGGGCGTGATCCTGGAGTTTGGCCTGCTGGAAGAGGCCGATGGCGAGA
TCATCCGCTGGGATACCGGCTTTGAAACCGGCGACCGCGTGCCCTCCAACTACGACTCCATGATCGCTAAGCTGATCGTT
TATGGCGACCATCGCGACGAGGCGCTCGAACGGCTCACCGATACGCTGGCGCATACCCAGCTGGCGGGCGTGCCCTCCAA
TGCGGGCTTCCTGCGCCGGTGCGCTCTGTCGGAAGAGTTTCAGACGGGCACGCATCATGTGAACTGGATCGGCGAGAATG
TGGACGCTCTGGCCGCCGTGCCGGAGGAACACCGCGACGCCTCCCTGAACGCCGTGGCGAGCCTGCTGCTGGAAGATCAG
GGCGACCCCTCGCCGTGGGCGATCCGCGACGGGTTCCGCATGAATGCCGCCCCCCGCCGCACGGTTGTGCTGGCGGCGGA
TGGAGACGCGGAGATGGTCGAGGCCGGCATCCCGATGGCCGAGGATGTGCCATTCCCTCTGGTGACGGACATTTCTCCAC
GCCGCTTTGCTGTGACCTGCGGGGGCGATACGTTCCTCGTCACCGTGCCCGAATACAGCGCCGACGCCGAAGCCGCCCTT
GGCGGCGATGCCGTGAAAGCGCCGATGCCCGGCAAAGTGCTGACGATCACGGCAAAGGCGGGCGACACGGTCACGCGCGG
TGACACGCTGGCTGTGCTCGAAGCGATGAAGATGGAACACGCCCTGGCCGCGCCGCGCGACGGCGTGGTGGAGGCCATCC
ATTCCAGCGCCGGCCAGCAGGTTGCCGAGGGCGACCTGCTGGTCTCGCTGGTGGAAGAGTAA

Upstream 100 bases:

>100_bases
GAAATGGTGTCTTTATCGAAGCTCGGATCATGGTATCTGCTGATGATCATCAGTTTCGTCCTGGTTGCCAGCGTGCACCG
GGGCCGGGGAGGCAAGACCA

Downstream 100 bases:

>100_bases
AGCCTAGCTCAGTTCCAGCCCGTTCAGCTCGCCGCTTTCGCGCCAGGCTTTCAGGATGCGGAAATAGGCATTGGGGCCTT
CGCCATAGGAGTTGTTCTGC

Product: methylcrotonoyl-CoA carboxylase subunit alpha

Products: NA

Alternate protein names: Biotin carboxylase; Biotin carboxyl carrier protein; BCCP [H]

Number of amino acids: Translated: 633; Mature: 632

Protein sequence:

>633_residues
MTITKLLVANRGEIAARIFRTCRELGIETVAVFSEADRAAKHVREADEAVCIGPAPAPESYLRVEAILAAAKETGADAIH
PGYGFLSENAAFAEAVVAAGLIWVGPPPSAIRSMGPKDEAKRIAEDAGVPVLPGYRGEAQDIETLKKAAKKVGYPLLIKA
VAGGGGRGIRQVSKEAELEAELISAVREAESAFGDGRVMLEKLVLQPRHIEVQVFGDAHGNVVHLFERDCSLQRRRQKVL
EEAPAPGMPEDVRAAMTDAAVKLAKAVGYQGAGTVEFIVDGSRPLAADTFWFLEMNTRLQVEHPVTEMVTGQDLVEWQLI
VASGGTLPLAQDEIELNGHAIEARICAEDPAEGFRPGAGVILEFGLLEEADGEIIRWDTGFETGDRVPSNYDSMIAKLIV
YGDHRDEALERLTDTLAHTQLAGVPSNAGFLRRCALSEEFQTGTHHVNWIGENVDALAAVPEEHRDASLNAVASLLLEDQ
GDPSPWAIRDGFRMNAAPRRTVVLAADGDAEMVEAGIPMAEDVPFPLVTDISPRRFAVTCGGDTFLVTVPEYSADAEAAL
GGDAVKAPMPGKVLTITAKAGDTVTRGDTLAVLEAMKMEHALAAPRDGVVEAIHSSAGQQVAEGDLLVSLVEE

Sequences:

>Translated_633_residues
MTITKLLVANRGEIAARIFRTCRELGIETVAVFSEADRAAKHVREADEAVCIGPAPAPESYLRVEAILAAAKETGADAIH
PGYGFLSENAAFAEAVVAAGLIWVGPPPSAIRSMGPKDEAKRIAEDAGVPVLPGYRGEAQDIETLKKAAKKVGYPLLIKA
VAGGGGRGIRQVSKEAELEAELISAVREAESAFGDGRVMLEKLVLQPRHIEVQVFGDAHGNVVHLFERDCSLQRRRQKVL
EEAPAPGMPEDVRAAMTDAAVKLAKAVGYQGAGTVEFIVDGSRPLAADTFWFLEMNTRLQVEHPVTEMVTGQDLVEWQLI
VASGGTLPLAQDEIELNGHAIEARICAEDPAEGFRPGAGVILEFGLLEEADGEIIRWDTGFETGDRVPSNYDSMIAKLIV
YGDHRDEALERLTDTLAHTQLAGVPSNAGFLRRCALSEEFQTGTHHVNWIGENVDALAAVPEEHRDASLNAVASLLLEDQ
GDPSPWAIRDGFRMNAAPRRTVVLAADGDAEMVEAGIPMAEDVPFPLVTDISPRRFAVTCGGDTFLVTVPEYSADAEAAL
GGDAVKAPMPGKVLTITAKAGDTVTRGDTLAVLEAMKMEHALAAPRDGVVEAIHSSAGQQVAEGDLLVSLVEE
>Mature_632_residues
TITKLLVANRGEIAARIFRTCRELGIETVAVFSEADRAAKHVREADEAVCIGPAPAPESYLRVEAILAAAKETGADAIHP
GYGFLSENAAFAEAVVAAGLIWVGPPPSAIRSMGPKDEAKRIAEDAGVPVLPGYRGEAQDIETLKKAAKKVGYPLLIKAV
AGGGGRGIRQVSKEAELEAELISAVREAESAFGDGRVMLEKLVLQPRHIEVQVFGDAHGNVVHLFERDCSLQRRRQKVLE
EAPAPGMPEDVRAAMTDAAVKLAKAVGYQGAGTVEFIVDGSRPLAADTFWFLEMNTRLQVEHPVTEMVTGQDLVEWQLIV
ASGGTLPLAQDEIELNGHAIEARICAEDPAEGFRPGAGVILEFGLLEEADGEIIRWDTGFETGDRVPSNYDSMIAKLIVY
GDHRDEALERLTDTLAHTQLAGVPSNAGFLRRCALSEEFQTGTHHVNWIGENVDALAAVPEEHRDASLNAVASLLLEDQG
DPSPWAIRDGFRMNAAPRRTVVLAADGDAEMVEAGIPMAEDVPFPLVTDISPRRFAVTCGGDTFLVTVPEYSADAEAALG
GDAVKAPMPGKVLTITAKAGDTVTRGDTLAVLEAMKMEHALAAPRDGVVEAIHSSAGQQVAEGDLLVSLVEE

Specific function: This protein carries two functions:biotin carboxyl carrier protein and biotin carboxyltransferase [H]

COG id: COG4770

COG function: function code I; Acetyl/propionyl-CoA carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=683, Percent_Identity=44.3631039531479, Blast_Score=532, Evalue=1e-151,
Organism=Homo sapiens, GI65506442, Length=678, Percent_Identity=39.2330383480826, Blast_Score=441, Evalue=1e-123,
Organism=Homo sapiens, GI189095269, Length=678, Percent_Identity=39.2330383480826, Blast_Score=440, Evalue=1e-123,
Organism=Homo sapiens, GI295821183, Length=639, Percent_Identity=39.5931142410016, Blast_Score=423, Evalue=1e-118,
Organism=Homo sapiens, GI106049528, Length=473, Percent_Identity=44.8202959830867, Blast_Score=376, Evalue=1e-104,
Organism=Homo sapiens, GI106049295, Length=473, Percent_Identity=44.8202959830867, Blast_Score=376, Evalue=1e-104,
Organism=Homo sapiens, GI106049292, Length=473, Percent_Identity=44.8202959830867, Blast_Score=376, Evalue=1e-104,
Organism=Homo sapiens, GI38679971, Length=712, Percent_Identity=28.9325842696629, Blast_Score=243, Evalue=5e-64,
Organism=Homo sapiens, GI38679960, Length=712, Percent_Identity=28.9325842696629, Blast_Score=243, Evalue=6e-64,
Organism=Homo sapiens, GI38679974, Length=712, Percent_Identity=28.9325842696629, Blast_Score=242, Evalue=6e-64,
Organism=Homo sapiens, GI38679977, Length=712, Percent_Identity=28.9325842696629, Blast_Score=242, Evalue=7e-64,
Organism=Homo sapiens, GI38679967, Length=712, Percent_Identity=28.9325842696629, Blast_Score=242, Evalue=7e-64,
Organism=Homo sapiens, GI134142062, Length=709, Percent_Identity=29.0550070521862, Blast_Score=231, Evalue=1e-60,
Organism=Escherichia coli, GI1789654, Length=450, Percent_Identity=48.8888888888889, Blast_Score=399, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI71987519, Length=665, Percent_Identity=44.9624060150376, Blast_Score=508, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI17567343, Length=683, Percent_Identity=39.0922401171303, Blast_Score=434, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17562816, Length=472, Percent_Identity=42.3728813559322, Blast_Score=345, Evalue=3e-95,
Organism=Caenorhabditis elegans, GI71997168, Length=692, Percent_Identity=26.4450867052023, Blast_Score=215, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI71997163, Length=515, Percent_Identity=28.9320388349515, Blast_Score=208, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI133931226, Length=681, Percent_Identity=26.5785609397944, Blast_Score=198, Evalue=8e-51,
Organism=Saccharomyces cerevisiae, GI6319685, Length=435, Percent_Identity=44.1379310344828, Blast_Score=377, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6321376, Length=473, Percent_Identity=42.2832980972516, Blast_Score=336, Evalue=5e-93,
Organism=Saccharomyces cerevisiae, GI6319695, Length=476, Percent_Identity=41.3865546218487, Blast_Score=336, Evalue=6e-93,
Organism=Saccharomyces cerevisiae, GI6324343, Length=522, Percent_Identity=30.0766283524904, Blast_Score=225, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6323863, Length=463, Percent_Identity=30.6695464362851, Blast_Score=216, Evalue=8e-57,
Organism=Drosophila melanogaster, GI24651757, Length=674, Percent_Identity=43.026706231454, Blast_Score=514, Evalue=1e-146,
Organism=Drosophila melanogaster, GI24651759, Length=635, Percent_Identity=42.2047244094488, Blast_Score=466, Evalue=1e-131,
Organism=Drosophila melanogaster, GI24652212, Length=491, Percent_Identity=43.1771894093686, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652210, Length=491, Percent_Identity=43.1771894093686, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652214, Length=491, Percent_Identity=43.1771894093686, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI19921944, Length=491, Percent_Identity=43.1771894093686, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652216, Length=491, Percent_Identity=43.1771894093686, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI281363050, Length=491, Percent_Identity=43.1771894093686, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652224, Length=491, Percent_Identity=43.1771894093686, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652222, Length=491, Percent_Identity=43.1771894093686, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652220, Length=491, Percent_Identity=43.1771894093686, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652218, Length=491, Percent_Identity=43.1771894093686, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24586458, Length=698, Percent_Identity=28.2234957020057, Blast_Score=220, Evalue=2e-57,
Organism=Drosophila melanogaster, GI161076409, Length=698, Percent_Identity=28.2234957020057, Blast_Score=220, Evalue=2e-57,
Organism=Drosophila melanogaster, GI161076407, Length=698, Percent_Identity=28.2234957020057, Blast_Score=220, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24586460, Length=698, Percent_Identity=28.2234957020057, Blast_Score=220, Evalue=2e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR001882
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR000089
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054
- InterPro:   IPR011053 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00364 Biotin_lipoyl; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14 [H]

Molecular weight: Translated: 67478; Mature: 67347

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: PS50975 ATP_GRASP ; PS00867 CPSASE_2 ; PS50979 BC ; PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTITKLLVANRGEIAARIFRTCRELGIETVAVFSEADRAAKHVREADEAVCIGPAPAPES
CCCEEEECCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCEEEECCCCCCHH
YLRVEAILAAAKETGADAIHPGYGFLSENAAFAEAVVAAGLIWVGPPPSAIRSMGPKDEA
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEECCCHHHHHCCCCHHHH
KRIAEDAGVPVLPGYRGEAQDIETLKKAAKKVGYPLLIKAVAGGGGRGIRQVSKEAELEA
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHH
ELISAVREAESAFGDGRVMLEKLVLQPRHIEVQVFGDAHGNVVHLFERDCSLQRRRQKVL
HHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEEEHHCHHHHHHHHHHH
EEAPAPGMPEDVRAAMTDAAVKLAKAVGYQGAGTVEFIVDGSRPLAADTFWFLEMNTRLQ
HHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCEEEEEEECCEEE
VEHPVTEMVTGQDLVEWQLIVASGGTLPLAQDEIELNGHAIEARICAEDPAEGFRPGAGV
ECCCHHHHHCCCCCEEEEEEEECCCCCCCCCCCEEECCEEEEEEEECCCCCCCCCCCCCE
ILEFGLLEEADGEIIRWDTGFETGDRVPSNYDSMIAKLIVYGDHRDEALERLTDTLAHTQ
EEEECCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHEECCCHHHHHHHHHHHHHHHH
LAGVPSNAGFLRRCALSEEFQTGTHHVNWIGENVDALAAVPEEHRDASLNAVASLLLEDQ
HCCCCCCCHHHHHHHCCHHHCCCCCEEEEECCCCHHHHCCCHHHCCCHHHHHHHHHHHCC
GDPSPWAIRDGFRMNAAPRRTVVLAADGDAEMVEAGIPMAEDVPFPLVTDISPRRFAVTC
CCCCCEEECCCCCCCCCCCEEEEEEECCCHHHHHCCCCCCCCCCCCEEECCCCCEEEEEE
GGDTFLVTVPEYSADAEAALGGDAVKAPMPGKVLTITAKAGDTVTRGDTLAVLEAMKMEH
CCCEEEEECCCCCCCCCHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHH
ALAAPRDGVVEAIHSSAGQQVAEGDLLVSLVEE
HHCCCCHHHHHHHHHHCCCHHHCCHHHHHECCC
>Mature Secondary Structure 
TITKLLVANRGEIAARIFRTCRELGIETVAVFSEADRAAKHVREADEAVCIGPAPAPES
CCEEEECCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCEEEECCCCCCHH
YLRVEAILAAAKETGADAIHPGYGFLSENAAFAEAVVAAGLIWVGPPPSAIRSMGPKDEA
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEECCCHHHHHCCCCHHHH
KRIAEDAGVPVLPGYRGEAQDIETLKKAAKKVGYPLLIKAVAGGGGRGIRQVSKEAELEA
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHH
ELISAVREAESAFGDGRVMLEKLVLQPRHIEVQVFGDAHGNVVHLFERDCSLQRRRQKVL
HHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEEEHHCHHHHHHHHHHH
EEAPAPGMPEDVRAAMTDAAVKLAKAVGYQGAGTVEFIVDGSRPLAADTFWFLEMNTRLQ
HHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCEEEEEEECCEEE
VEHPVTEMVTGQDLVEWQLIVASGGTLPLAQDEIELNGHAIEARICAEDPAEGFRPGAGV
ECCCHHHHHCCCCCEEEEEEEECCCCCCCCCCCEEECCEEEEEEEECCCCCCCCCCCCCE
ILEFGLLEEADGEIIRWDTGFETGDRVPSNYDSMIAKLIVYGDHRDEALERLTDTLAHTQ
EEEECCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHEECCCHHHHHHHHHHHHHHHH
LAGVPSNAGFLRRCALSEEFQTGTHHVNWIGENVDALAAVPEEHRDASLNAVASLLLEDQ
HCCCCCCCHHHHHHHCCHHHCCCCCEEEEECCCCHHHHCCCHHHCCCHHHHHHHHHHHCC
GDPSPWAIRDGFRMNAAPRRTVVLAADGDAEMVEAGIPMAEDVPFPLVTDISPRRFAVTC
CCCCCEEECCCCCCCCCCCEEEEEEECCCHHHHHCCCCCCCCCCCCEEECCCCCEEEEEE
GGDTFLVTVPEYSADAEAALGGDAVKAPMPGKVLTITAKAGDTVTRGDTLAVLEAMKMEH
CCCEEEEECCCCCCCCCHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHH
ALAAPRDGVVEAIHSSAGQQVAEGDLLVSLVEE
HHCCCCHHHHHHHHHHCCCHHHCCHHHHHECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]