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The map label for this gene is maeB [H]

Identifier: 114797897

GI number: 114797897

Start: 288170

End: 290437

Strand: Reverse

Name: maeB [H]

Synonym: HNE_0296

Alternate gene names: 114797897

Gene position: 290437-288170 (Counterclockwise)

Preceding gene: 114799878

Following gene: 114799242

Centisome position: 7.84

GC content: 61.86

Gene sequence:

>2268_bases
ATGACCACGCAGCGTCCGAGCTTCACCGATCAGGAAGCCCTTGATTTCCACTCCCACCCGACCGCCGGGAAAATCTCCAT
GGTGCCCACAAAGCCCATGGGCACGCAGCGCGACCTGTCGCTGGCCTACAGCCCCGGTGTTGCTATCCCGGTGCTGGCGA
TCGCGGAAAACCCGGACAAGGCGTATGACTATACCTCCAAGGGCAACCTTGTGGCGGTCATCTCCAACGGCACCGCCATC
CTGGGGCTCGGCAATCTGGGGCCGATGGCCTCCAAGCCGGTGATGGAAGGAAAGTCGGTTCTTTTCAAACGCTTCGCGGA
CATCGACAGCTTCGATGTGGAAGTTGACACGACCGATGTCGAAGACTTCATCCGCACCGTGCGCAATATCGGCGCGACCT
GGGGCGGCATCAATCTGGAGGACATCTCCTCCCCTGCCTGCTTCATCATCGAGAGCCGCCTGCGCGACGAACTCGACATT
CCGGTCTTCCATGACGACCAGCATGGCACCGCGATCATCGCCGCTGCCGGCCTGATCAATGCCTGCCACATCACCGGGCG
CCAATTGAAAGACACCAAGGTCGCCATTTCGGGCGCCGGGGCTGCCGGTCTCTCGGTGGCTGGCCTCATCCGCCATCTGG
GCGTGAAGGCAGAGAATATCCTGATCTGCGACACCGCCGGCGTGGTCTATGAAGGCCGCACCGAGAAGATGGACCAGTTC
AAGTCCGCCTTCGCTGTCAAGACGGCCAAGCGCACGCTGACAGAAGCGATGGACGGGGCCGACGTGTTCCTCGGACTTTC
GGTCAAGGGCGCGGTGACCAAAGAGATGGTCAAGTCGATGGCCAAGAACCCGATCATCTTTGCGATGGCAAACCCGGACC
CGGAAATCACCCCCGAAGAGATCAAATCGGTCCGCAGCGATGCGATCATCGCCACGGGCCGGTCTGACTATCCAAACCAG
GTGAACAATGTTCTGGGCTTTCCTTACATCTTCCGCGGCGCGCTCGACGTGCGCGCCCGCGGTATCAATGAGGAAATGAA
GGTTGCCTGCGCCCGCGCGCTGGCCGAACTTGCCCGCGAAGATGTGCCCGATGAAGTGGCCGCCGCCTATCACGGCGCCC
GGCCGAGCTTTGGCCGGGAATATATCATTCCAAGTCCGTTTGACCCGCGCCTGATCAGCTTCGTTCCACCCTTTGTCGCG
CAGGCGGCCATGGATACCGGCGTGGCCCGCAAGCCGATTGCGGATATGGACAACTACCGCCGCTCGCTGATCCGCCGGGC
GGACCCGTCGGCCGCCTTCCTTCAAGGCTTGCAGGCACGGGCCCGCGAGACCCAGCGCCGCATCGTGTTTGCTGAAGGTG
AAGAACCCGCCGTCGTGCGCGCCGCCTACAGCTTCAAGAACCAAGGCCTTGGCCATCCGATCCTGATTGGCCGCGAGGCC
CAGGTGGAGCGCGCGATGGAGCAGATGGGCATTCCGCTCGGCTCGCTCGATATCATCAATGCGCGCCTTTCCGACAAGAA
CCCGGTCTATGTCGACTTCCTGTATGAGCGCCTGCAGCGCCGCGGCTATCTCAAGCGCGACGTTCAGCGCCTGGTGAATC
AGGACAGGAACATCTTCGGCAGCTGTATGCTTAAGAATGGCGACGCGGACGGCATGGTCACGGGCGTCACACGCAATTAC
GACGCCGCCCTGAAAGACGCGATGCTGGTGCTCGACCCGATTGCGGGCCAGGCCCTGATCGGCATGTCGATGGTGATCAA
TCTCGGCAAGACGATCTTCATTGCCGATACCAGCGTACATGAACTGCCCGACGGGCCGACCCTGGCAAACATCGCCCTGG
AAGCGGCCCGCGCGGTGCGCGCCCTTGGCTTCACCCCGCGCGTGGCTTTCCTGTCCTACTCCACCTTCGGCAATCCGATG
GGCGAGCGGGGCGACCGGGTGCGCGAAGCTGTGGCGATCCTTGATCAGCGCACGGACATTGATTTCGAGTATGAAGGCGA
CATCAATGCTGATGTGGCGATGAACCCGAACCACCGGATGGTGTATCCGTTCTCGCGCCTCAGCGGCCCGGCGAACGTGT
TGGTCATGCCGGCGATCCATTCGGCCTCGATTGCGACCAATCTGTTGGAAGCGATGAGCCGGGCAACCGTCATCGGACCG
ATGCTGTTTGGCCTGGAAAAGCCGGTGCAGATTTCTTCACTCGGCGCCACTGTGGGCGACATCGTGGACCTTGCCACGAT
TGCAGCCTACGACACCGACAACGTCTAA

Upstream 100 bases:

>100_bases
ACCTGCGCACCCATTTCACTGTTGGCACGGCCCTCGGCGCGGCCTAGACGGGACGAAGAGCGACATCAATGACAAAAACA
ACCGTCCGAGCGAACCCGAA

Downstream 100 bases:

>100_bases
GGCCTTCCGCCAGAAAGATCACACCCCGGCTGCGTCCAGCGCGGCCGGGGTTTTCTGTCTGGCCATTCGCGCCCATTCCA
GCAGTGAGAGCACCACGGCA

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 755; Mature: 754

Protein sequence:

>755_residues
MTTQRPSFTDQEALDFHSHPTAGKISMVPTKPMGTQRDLSLAYSPGVAIPVLAIAENPDKAYDYTSKGNLVAVISNGTAI
LGLGNLGPMASKPVMEGKSVLFKRFADIDSFDVEVDTTDVEDFIRTVRNIGATWGGINLEDISSPACFIIESRLRDELDI
PVFHDDQHGTAIIAAAGLINACHITGRQLKDTKVAISGAGAAGLSVAGLIRHLGVKAENILICDTAGVVYEGRTEKMDQF
KSAFAVKTAKRTLTEAMDGADVFLGLSVKGAVTKEMVKSMAKNPIIFAMANPDPEITPEEIKSVRSDAIIATGRSDYPNQ
VNNVLGFPYIFRGALDVRARGINEEMKVACARALAELAREDVPDEVAAAYHGARPSFGREYIIPSPFDPRLISFVPPFVA
QAAMDTGVARKPIADMDNYRRSLIRRADPSAAFLQGLQARARETQRRIVFAEGEEPAVVRAAYSFKNQGLGHPILIGREA
QVERAMEQMGIPLGSLDIINARLSDKNPVYVDFLYERLQRRGYLKRDVQRLVNQDRNIFGSCMLKNGDADGMVTGVTRNY
DAALKDAMLVLDPIAGQALIGMSMVINLGKTIFIADTSVHELPDGPTLANIALEAARAVRALGFTPRVAFLSYSTFGNPM
GERGDRVREAVAILDQRTDIDFEYEGDINADVAMNPNHRMVYPFSRLSGPANVLVMPAIHSASIATNLLEAMSRATVIGP
MLFGLEKPVQISSLGATVGDIVDLATIAAYDTDNV

Sequences:

>Translated_755_residues
MTTQRPSFTDQEALDFHSHPTAGKISMVPTKPMGTQRDLSLAYSPGVAIPVLAIAENPDKAYDYTSKGNLVAVISNGTAI
LGLGNLGPMASKPVMEGKSVLFKRFADIDSFDVEVDTTDVEDFIRTVRNIGATWGGINLEDISSPACFIIESRLRDELDI
PVFHDDQHGTAIIAAAGLINACHITGRQLKDTKVAISGAGAAGLSVAGLIRHLGVKAENILICDTAGVVYEGRTEKMDQF
KSAFAVKTAKRTLTEAMDGADVFLGLSVKGAVTKEMVKSMAKNPIIFAMANPDPEITPEEIKSVRSDAIIATGRSDYPNQ
VNNVLGFPYIFRGALDVRARGINEEMKVACARALAELAREDVPDEVAAAYHGARPSFGREYIIPSPFDPRLISFVPPFVA
QAAMDTGVARKPIADMDNYRRSLIRRADPSAAFLQGLQARARETQRRIVFAEGEEPAVVRAAYSFKNQGLGHPILIGREA
QVERAMEQMGIPLGSLDIINARLSDKNPVYVDFLYERLQRRGYLKRDVQRLVNQDRNIFGSCMLKNGDADGMVTGVTRNY
DAALKDAMLVLDPIAGQALIGMSMVINLGKTIFIADTSVHELPDGPTLANIALEAARAVRALGFTPRVAFLSYSTFGNPM
GERGDRVREAVAILDQRTDIDFEYEGDINADVAMNPNHRMVYPFSRLSGPANVLVMPAIHSASIATNLLEAMSRATVIGP
MLFGLEKPVQISSLGATVGDIVDLATIAAYDTDNV
>Mature_754_residues
TTQRPSFTDQEALDFHSHPTAGKISMVPTKPMGTQRDLSLAYSPGVAIPVLAIAENPDKAYDYTSKGNLVAVISNGTAIL
GLGNLGPMASKPVMEGKSVLFKRFADIDSFDVEVDTTDVEDFIRTVRNIGATWGGINLEDISSPACFIIESRLRDELDIP
VFHDDQHGTAIIAAAGLINACHITGRQLKDTKVAISGAGAAGLSVAGLIRHLGVKAENILICDTAGVVYEGRTEKMDQFK
SAFAVKTAKRTLTEAMDGADVFLGLSVKGAVTKEMVKSMAKNPIIFAMANPDPEITPEEIKSVRSDAIIATGRSDYPNQV
NNVLGFPYIFRGALDVRARGINEEMKVACARALAELAREDVPDEVAAAYHGARPSFGREYIIPSPFDPRLISFVPPFVAQ
AAMDTGVARKPIADMDNYRRSLIRRADPSAAFLQGLQARARETQRRIVFAEGEEPAVVRAAYSFKNQGLGHPILIGREAQ
VERAMEQMGIPLGSLDIINARLSDKNPVYVDFLYERLQRRGYLKRDVQRLVNQDRNIFGSCMLKNGDADGMVTGVTRNYD
AALKDAMLVLDPIAGQALIGMSMVINLGKTIFIADTSVHELPDGPTLANIALEAARAVRALGFTPRVAFLSYSTFGNPMG
ERGDRVREAVAILDQRTDIDFEYEGDINADVAMNPNHRMVYPFSRLSGPANVLVMPAIHSASIATNLLEAMSRATVIGPM
LFGLEKPVQISSLGATVGDIVDLATIAAYDTDNV

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=342, Percent_Identity=26.9005847953216, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI62420882, Length=349, Percent_Identity=26.647564469914, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI62420880, Length=349, Percent_Identity=26.647564469914, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI239049447, Length=349, Percent_Identity=26.647564469914, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1788806, Length=750, Percent_Identity=46.8, Blast_Score=652, Evalue=0.0,
Organism=Escherichia coli, GI1788635, Length=325, Percent_Identity=29.5384615384615, Blast_Score=133, Evalue=4e-32,
Organism=Escherichia coli, GI1788800, Length=313, Percent_Identity=27.4760383386581, Blast_Score=96, Evalue=1e-20,
Organism=Escherichia coli, GI87081919, Length=281, Percent_Identity=27.0462633451957, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17537199, Length=362, Percent_Identity=24.8618784530387, Blast_Score=70, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6322823, Length=269, Percent_Identity=31.2267657992565, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24646388, Length=351, Percent_Identity=29.9145299145299, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24646386, Length=351, Percent_Identity=29.9145299145299, Blast_Score=91, Evalue=4e-18,
Organism=Drosophila melanogaster, GI281363505, Length=371, Percent_Identity=24.2587601078167, Blast_Score=80, Evalue=8e-15,
Organism=Drosophila melanogaster, GI78707236, Length=371, Percent_Identity=24.2587601078167, Blast_Score=80, Evalue=8e-15,
Organism=Drosophila melanogaster, GI78707232, Length=371, Percent_Identity=24.2587601078167, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI281363503, Length=371, Percent_Identity=24.2587601078167, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI78707242, Length=265, Percent_Identity=25.6603773584906, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI78707238, Length=265, Percent_Identity=25.6603773584906, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI78707240, Length=265, Percent_Identity=25.6603773584906, Blast_Score=74, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21356279, Length=345, Percent_Identity=26.9565217391304, Blast_Score=73, Evalue=7e-13,
Organism=Drosophila melanogaster, GI281362674, Length=345, Percent_Identity=26.9565217391304, Blast_Score=73, Evalue=8e-13,
Organism=Drosophila melanogaster, GI281362672, Length=345, Percent_Identity=26.9565217391304, Blast_Score=73, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 81660; Mature: 81529

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTQRPSFTDQEALDFHSHPTAGKISMVPTKPMGTQRDLSLAYSPGVAIPVLAIAENPDK
CCCCCCCCCCHHHHHCCCCCCCCEEEECCCCCCCCCCCCEEEECCCCCEEEEEEECCCCH
AYDYTSKGNLVAVISNGTAILGLGNLGPMASKPVMEGKSVLFKRFADIDSFDVEVDTTDV
HCCCCCCCCEEEEEECCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCH
EDFIRTVRNIGATWGGINLEDISSPACFIIESRLRDELDIPVFHDDQHGTAIIAAAGLIN
HHHHHHHHHCCCCCCCCCHHHCCCCCEEEEHHHHHCCCCCCEEECCCCCCEEEEHHHHHH
ACHITGRQLKDTKVAISGAGAAGLSVAGLIRHLGVKAENILICDTAGVVYEGRTEKMDQF
HHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCEEEEECCCEEECCCHHHHHHH
KSAFAVKTAKRTLTEAMDGADVFLGLSVKGAVTKEMVKSMAKNPIIFAMANPDPEITPEE
HHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHCCCEEEEEECCCCCCCHHH
IKSVRSDAIIATGRSDYPNQVNNVLGFPYIFRGALDVRARGINEEMKVACARALAELARE
HHHHHCCEEEEECCCCCCHHHHHHCCCHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHH
DVPDEVAAAYHGARPSFGREYIIPSPFDPRLISFVPPFVAQAAMDTGVARKPIADMDNYR
CCCHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHH
RSLIRRADPSAAFLQGLQARARETQRRIVFAEGEEPAVVRAAYSFKNQGLGHPILIGREA
HHHHHHCCCHHHHHHHHHHHHHHHHCEEEEECCCCCEEEEEEHHHHCCCCCCCEEECCHH
QVERAMEQMGIPLGSLDIINARLSDKNPVYVDFLYERLQRRGYLKRDVQRLVNQDRNIFG
HHHHHHHHHCCCCCCCCEEEEECCCCCCEEHHHHHHHHHHCCHHHHHHHHHHHCCCCEEE
SCMLKNGDADGMVTGVTRNYDAALKDAMLVLDPIAGQALIGMSMVINLGKTIFIADTSVH
EEEEECCCCCCEEEEECCCCHHHHHHHHHEECCCCCHHHHHHHHHHHCCCEEEEECCCHH
ELPDGPTLANIALEAARAVRALGFTPRVAFLSYSTFGNPMGERGDRVREAVAILDQRTDI
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEHHCCCCCCHHHHHHHHHHHHHHCCCCC
DFEYEGDINADVAMNPNHRMVYPFSRLSGPANVLVMPAIHSASIATNLLEAMSRATVIGP
CEEECCCCCCEEEECCCCCEEEEHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHH
MLFGLEKPVQISSLGATVGDIVDLATIAAYDTDNV
HHHCCCCCCCHHHHCCHHHHHHHHHHHEECCCCCC
>Mature Secondary Structure 
TTQRPSFTDQEALDFHSHPTAGKISMVPTKPMGTQRDLSLAYSPGVAIPVLAIAENPDK
CCCCCCCCCHHHHHCCCCCCCCEEEECCCCCCCCCCCCEEEECCCCCEEEEEEECCCCH
AYDYTSKGNLVAVISNGTAILGLGNLGPMASKPVMEGKSVLFKRFADIDSFDVEVDTTDV
HCCCCCCCCEEEEEECCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCH
EDFIRTVRNIGATWGGINLEDISSPACFIIESRLRDELDIPVFHDDQHGTAIIAAAGLIN
HHHHHHHHHCCCCCCCCCHHHCCCCCEEEEHHHHHCCCCCCEEECCCCCCEEEEHHHHHH
ACHITGRQLKDTKVAISGAGAAGLSVAGLIRHLGVKAENILICDTAGVVYEGRTEKMDQF
HHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCEEEEECCCEEECCCHHHHHHH
KSAFAVKTAKRTLTEAMDGADVFLGLSVKGAVTKEMVKSMAKNPIIFAMANPDPEITPEE
HHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHCCCEEEEEECCCCCCCHHH
IKSVRSDAIIATGRSDYPNQVNNVLGFPYIFRGALDVRARGINEEMKVACARALAELARE
HHHHHCCEEEEECCCCCCHHHHHHCCCHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHH
DVPDEVAAAYHGARPSFGREYIIPSPFDPRLISFVPPFVAQAAMDTGVARKPIADMDNYR
CCCHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHH
RSLIRRADPSAAFLQGLQARARETQRRIVFAEGEEPAVVRAAYSFKNQGLGHPILIGREA
HHHHHHCCCHHHHHHHHHHHHHHHHCEEEEECCCCCEEEEEEHHHHCCCCCCCEEECCHH
QVERAMEQMGIPLGSLDIINARLSDKNPVYVDFLYERLQRRGYLKRDVQRLVNQDRNIFG
HHHHHHHHHCCCCCCCCEEEEECCCCCCEEHHHHHHHHHHCCHHHHHHHHHHHCCCCEEE
SCMLKNGDADGMVTGVTRNYDAALKDAMLVLDPIAGQALIGMSMVINLGKTIFIADTSVH
EEEEECCCCCCEEEEECCCCHHHHHHHHHEECCCCCHHHHHHHHHHHCCCEEEEECCCHH
ELPDGPTLANIALEAARAVRALGFTPRVAFLSYSTFGNPMGERGDRVREAVAILDQRTDI
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEHHCCCCCCHHHHHHHHHHHHHHCCCCC
DFEYEGDINADVAMNPNHRMVYPFSRLSGPANVLVMPAIHSASIATNLLEAMSRATVIGP
CEEECCCCCCEEEECCCCCEEEEHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHH
MLFGLEKPVQISSLGATVGDIVDLATIAAYDTDNV
HHHCCCCCCCHHHHCCHHHHHHHHHHHEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9535928; 11481430; 10407149 [H]