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The map label for this gene is xylB [H]

Identifier: 114797810

GI number: 114797810

Start: 3619995

End: 3621095

Strand: Direct

Name: xylB [H]

Synonym: HNE_3486

Alternate gene names: 114797810

Gene position: 3619995-3621095 (Clockwise)

Preceding gene: 114798593

Following gene: 114799952

Centisome position: 97.71

GC content: 63.4

Gene sequence:

>1101_bases
ATGAAAGCTGCTGTGATGCGGGCGCCCAAGGCGCCGCTGTCGATCGAAGACGTCACCATCTCCAAGCCAGGCCCGCGCGA
AGTGCTCGTCCGGCTCAAAGCCATCGGCGTTTGCCATTCGGACGTTCACTTCTGGGACGGCGCGTTCCCGGCTGAGCTTC
CCGTGATCCTCGGCCATGAAAGCGCCGGCGTGGTCGAACAGGTCGGCTCGATGGTCTCGGCGGTGAAGCCCGGCGACCAT
GTGATCTCGATCCTTTCGCCCTTCTGCGGCACCTGCGAATATTGCCTCACGGGCCATATGTCGGTCTGCCATACGGTGAA
CCGGGAGCTTTTCCAGCGCGATCTGACCGAGGCGCCGCGCCTCTCGATCGGCAAGGAAAAGGTCGGCCAGTTCTTGAACC
TCTCTTCCTTTGCCGAGCAGATTCTCGTGCACGAAAACGCGCTCTGCGTTGTCGACAAGGACATGCCGATGGACCGCGCC
TGCCTCATCGGCTGCGGCGTGATCACCGGCGTCGGCTCGGTGTTCCATTCCGCGCAGGTGGAACCGGGCTCGACCGTCGC
CGTGCTCGGCTGTGGCGGCGTGGGCCTTGCCGCGATCAACGGCGCCGCGATTGCCGGGGCAAGCCGCGTCATCGCCGTCG
ACCTCTCTGACGAGAAGCTGCAACTTGCCAAGCGCTTCGGGGCGACCGATCTGGTCAATCCCGGCAAGGTCAACGCCATT
GAAGCGGTCAAGGAGCTGACCAAAGGCGGGGTGCATTATTCCTTCGAATGCGTCGGCCTGAAACAGACCGCCGAGCAGGC
CTATCACATGCTCCGCCCGCGCGGCGTGGCGACGATCATCGGCATGATCCCGCCCGGCGTGAACATCGAGATTCCCGGCA
TCGAACTGCTCGTCACCGAGAAGCGCCTACAAGGCGCCGTGATGGGCTCCAACCGCTTCCGGGTGGATTTCCCGCGCCTT
GTCGAACTCTACAAGCAGGGCCGCCTGCACCTGGACGATCTGATCTCTGACCGGATTGGCCTGGATGGCATCACCGCTGC
CATGCAGAACCTCAAGGACAACAAGGGCACCGTTGCCCGCCAGGTGGTTGTACTCGACTGA

Upstream 100 bases:

>100_bases
AGCCTCGGCACCTGACACTTCCCCTCGCGTCACACTGGCCAAAGCCCGCGCGCTGCGTAACACTTCGCGCAAAATACATA
CCGGGAGGAAAGAGACCGCC

Downstream 100 bases:

>100_bases
TTGCGGCCCCGCCCGCACCCCGCTAGACAGGGCGCTTCGCATCATAACGGAGCGCCCTGATGGCCCGCACCTCGCCCGCC
AAACCCAAACGCTCGCTTGT

Product: class III alcohol dehydrogenase

Products: NA

Alternate protein names: Benzyl alcohol dehydrogenase; BADH [H]

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MKAAVMRAPKAPLSIEDVTISKPGPREVLVRLKAIGVCHSDVHFWDGAFPAELPVILGHESAGVVEQVGSMVSAVKPGDH
VISILSPFCGTCEYCLTGHMSVCHTVNRELFQRDLTEAPRLSIGKEKVGQFLNLSSFAEQILVHENALCVVDKDMPMDRA
CLIGCGVITGVGSVFHSAQVEPGSTVAVLGCGGVGLAAINGAAIAGASRVIAVDLSDEKLQLAKRFGATDLVNPGKVNAI
EAVKELTKGGVHYSFECVGLKQTAEQAYHMLRPRGVATIIGMIPPGVNIEIPGIELLVTEKRLQGAVMGSNRFRVDFPRL
VELYKQGRLHLDDLISDRIGLDGITAAMQNLKDNKGTVARQVVVLD

Sequences:

>Translated_366_residues
MKAAVMRAPKAPLSIEDVTISKPGPREVLVRLKAIGVCHSDVHFWDGAFPAELPVILGHESAGVVEQVGSMVSAVKPGDH
VISILSPFCGTCEYCLTGHMSVCHTVNRELFQRDLTEAPRLSIGKEKVGQFLNLSSFAEQILVHENALCVVDKDMPMDRA
CLIGCGVITGVGSVFHSAQVEPGSTVAVLGCGGVGLAAINGAAIAGASRVIAVDLSDEKLQLAKRFGATDLVNPGKVNAI
EAVKELTKGGVHYSFECVGLKQTAEQAYHMLRPRGVATIIGMIPPGVNIEIPGIELLVTEKRLQGAVMGSNRFRVDFPRL
VELYKQGRLHLDDLISDRIGLDGITAAMQNLKDNKGTVARQVVVLD
>Mature_366_residues
MKAAVMRAPKAPLSIEDVTISKPGPREVLVRLKAIGVCHSDVHFWDGAFPAELPVILGHESAGVVEQVGSMVSAVKPGDH
VISILSPFCGTCEYCLTGHMSVCHTVNRELFQRDLTEAPRLSIGKEKVGQFLNLSSFAEQILVHENALCVVDKDMPMDRA
CLIGCGVITGVGSVFHSAQVEPGSTVAVLGCGGVGLAAINGAAIAGASRVIAVDLSDEKLQLAKRFGATDLVNPGKVNAI
EAVKELTKGGVHYSFECVGLKQTAEQAYHMLRPRGVATIIGMIPPGVNIEIPGIELLVTEKRLQGAVMGSNRFRVDFPRL
VELYKQGRLHLDDLISDRIGLDGITAAMQNLKDNKGTVARQVVVLD

Specific function: Oxidizes primary alcohols with an aromatic or cyclohex- 1-ene ring. It is highly specific for benzyl alcohol [H]

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=358, Percent_Identity=39.1061452513966, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI4501929, Length=358, Percent_Identity=38.268156424581, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI4501933, Length=358, Percent_Identity=37.7094972067039, Blast_Score=235, Evalue=6e-62,
Organism=Homo sapiens, GI4501939, Length=359, Percent_Identity=35.933147632312, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI156523966, Length=358, Percent_Identity=35.7541899441341, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI71565152, Length=375, Percent_Identity=34.6666666666667, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI71565154, Length=362, Percent_Identity=35.0828729281768, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI71743840, Length=371, Percent_Identity=34.2318059299191, Blast_Score=215, Evalue=4e-56,
Organism=Homo sapiens, GI262073058, Length=371, Percent_Identity=34.2318059299191, Blast_Score=215, Evalue=5e-56,
Organism=Homo sapiens, GI156627571, Length=361, Percent_Identity=26.5927977839335, Blast_Score=103, Evalue=3e-22,
Organism=Escherichia coli, GI1786552, Length=363, Percent_Identity=36.0881542699724, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI1788073, Length=369, Percent_Identity=26.8292682926829, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI1788407, Length=336, Percent_Identity=29.1666666666667, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI87081918, Length=304, Percent_Identity=28.9473684210526, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI1788075, Length=349, Percent_Identity=26.0744985673352, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87082125, Length=260, Percent_Identity=26.9230769230769, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1790045, Length=362, Percent_Identity=23.2044198895028, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786518, Length=318, Percent_Identity=27.9874213836478, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI226510992, Length=341, Percent_Identity=23.4604105571848, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787863, Length=369, Percent_Identity=25.7452574525745, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI25146526, Length=374, Percent_Identity=36.8983957219251, Blast_Score=237, Evalue=7e-63,
Organism=Caenorhabditis elegans, GI71997431, Length=376, Percent_Identity=36.7021276595745, Blast_Score=234, Evalue=7e-62,
Organism=Caenorhabditis elegans, GI17565904, Length=335, Percent_Identity=37.3134328358209, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17562876, Length=353, Percent_Identity=29.7450424929178, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17562878, Length=350, Percent_Identity=27.7142857142857, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17562584, Length=366, Percent_Identity=28.1420765027322, Blast_Score=121, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI71988145, Length=334, Percent_Identity=29.0419161676647, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17562582, Length=358, Percent_Identity=24.8603351955307, Blast_Score=107, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6320033, Length=375, Percent_Identity=36.2666666666667, Blast_Score=236, Evalue=5e-63,
Organism=Saccharomyces cerevisiae, GI6323729, Length=331, Percent_Identity=27.4924471299094, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6319621, Length=369, Percent_Identity=29.2682926829268, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6319258, Length=355, Percent_Identity=29.5774647887324, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6323961, Length=369, Percent_Identity=26.2872628726287, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6324486, Length=331, Percent_Identity=26.5861027190332, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6323099, Length=367, Percent_Identity=26.158038147139, Blast_Score=96, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6319257, Length=378, Percent_Identity=24.0740740740741, Blast_Score=92, Evalue=9e-20,
Organism=Drosophila melanogaster, GI17737895, Length=369, Percent_Identity=36.5853658536585, Blast_Score=233, Evalue=1e-61,
Organism=Drosophila melanogaster, GI17137530, Length=355, Percent_Identity=25.3521126760563, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI17737897, Length=352, Percent_Identity=24.7159090909091, Blast_Score=86, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.90 [H]

Molecular weight: Translated: 38999; Mature: 38999

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAAVMRAPKAPLSIEDVTISKPGPREVLVRLKAIGVCHSDVHFWDGAFPAELPVILGHE
CCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHEECCCCCCCCCCCCCCCCEEECCC
SAGVVEQVGSMVSAVKPGDHVISILSPFCGTCEYCLTGHMSVCHTVNRELFQRDLTEAPR
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHCCCC
LSIGKEKVGQFLNLSSFAEQILVHENALCVVDKDMPMDRACLIGCGVITGVGSVFHSAQV
CCCCHHHHHHHHCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCC
EPGSTVAVLGCGGVGLAAINGAAIAGASRVIAVDLSDEKLQLAKRFGATDLVNPGKVNAI
CCCCEEEEEECCCCCHHHCCCCEEECCCEEEEEECCHHHHHHHHHCCCCCCCCCCCCHHH
EAVKELTKGGVHYSFECVGLKQTAEQAYHMLRPRGVATIIGMIPPGVNIEIPGIELLVTE
HHHHHHHHCCCEEEEEEECHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEECCEEEEEEH
KRLQGAVMGSNRFRVDFPRLVELYKQGRLHLDDLISDRIGLDGITAAMQNLKDNKGTVAR
HHHCCEEECCCCEEECHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHCCCCCCCEEE
QVVVLD
EEEEEC
>Mature Secondary Structure
MKAAVMRAPKAPLSIEDVTISKPGPREVLVRLKAIGVCHSDVHFWDGAFPAELPVILGHE
CCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHEECCCCCCCCCCCCCCCCEEECCC
SAGVVEQVGSMVSAVKPGDHVISILSPFCGTCEYCLTGHMSVCHTVNRELFQRDLTEAPR
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHCCCC
LSIGKEKVGQFLNLSSFAEQILVHENALCVVDKDMPMDRACLIGCGVITGVGSVFHSAQV
CCCCHHHHHHHHCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCC
EPGSTVAVLGCGGVGLAAINGAAIAGASRVIAVDLSDEKLQLAKRFGATDLVNPGKVNAI
CCCCEEEEEECCCCCHHHCCCCEEECCCEEEEEECCHHHHHHHHHCCCCCCCCCCCCHHH
EAVKELTKGGVHYSFECVGLKQTAEQAYHMLRPRGVATIIGMIPPGVNIEIPGIELLVTE
HHHHHHHHCCCEEEEEEECHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEECCEEEEEEH
KRLQGAVMGSNRFRVDFPRLVELYKQGRLHLDDLISDRIGLDGITAAMQNLKDNKGTVAR
HHHCCEEECCCCEEECHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHCCCCCCCEEE
QVVVLD
EEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8496150; 1989592 [H]