BacMap

Definition	Hyphomonas neptunium ATCC 15444 chromosome, complete genome.
Accession	NC_008358
Length	3,705,021

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The map label for this gene is kduD [H]

Identifier: 114797788

GI number: 114797788

Start: 2946035

End: 2946820

Strand: Direct

Name: kduD [H]

Synonym: HNE_2783

Alternate gene names: 114797788

Gene position: 2946035-2946820 (Clockwise)

Preceding gene: 114798768

Following gene: 114799889

Centisome position: 79.51

GC content: 63.61

Gene sequence:

>786_bases
ATGGTCTACAAACCCTTTGATATGAGCGGCAAAGTCTGTGTCGTCACCGGCGGCAACAAGGGCATCGGCCTCGGCATGGT
CGAGGCACTGGCCGCCTCAAACGCCGATGTTGTGATCTGGGGCCGCAAGACGGCCGACAACGACGCCGCCGTCAAATCCG
CCTCGGGCCTCGGCACCGGCAAGGTCAAGGCCTGGGCCGTCGATGTCGGCGAAGAATCCCAGGTTATCAAGGCGATGAAA
GAGGCTGAAGAAGAATTCGGCCGCATCGACGCCTGCATCGCAAACGCCGGCGTTGGCCGGGGCGCTGCCTCCTTCGAGAC
GATGACGCTGGAAACCTGGGAGTATAACGCCCGGATCAACTCCGTCGGCGCCTTCTTCACCCTGCGCGAAGCGGCCAAGT
CGATGGTCGCCCGCGCCAAGAAGGGCGATCTCGGCGGCAGCCTCGTTGGCACCGCCTCCCTCGCCGGCATCGAAGGCGCT
GGCCGCAACCAGGCTTACGCCCACACCAAAGGTGGCCTCATCGCCATGATGAACGCCTGCGCCGTCGAATACGGCCGCTA
TGGTATCCGCGCCAATTCCATCCTGCCGGGCTGGATCGCCACCGACATGACCGAGGGCGCGCAAGGCCAGGAAGTGTTCA
CCTCCAAGGTCATCTCCCGCGTCCCGATTCGCCGTTGGGGCGAGCCAGCAGACTTCGGCGGCATGGCCGTCTATCTCTGC
TCGGACGCCTCGAAATACCATTCGGGCGACACGCTCGTCATCGATGGCGGCTACGCAAAATTCTAG

Upstream 100 bases:

>100_bases
GCGCTCCTTATCCCCCGTTTATTTTCCTTGACCCGCCCCTGCGTCAGGTCTGTCTGTACGCTTTAAGTCATCCAGAAGAT
ACCAGGGAGGAATCAGGTTC

Downstream 100 bases:

>100_bases
CTCCTGCGGGCGGCGCCCTGCGCCGCCCCGCAAGCCACCCGCAAAGAAAAAGGCCGCTTCCCATCAGGAAGCGGCCTTAT
CTTTTAGCCGGTTACCCAGC

Product: short chain dehydrogenase/reductase family oxidoreductase

Products: NA

Alternate protein names: 2-keto-3-deoxygluconate 5-dehydrogenase; 2-keto-3-deoxygluconate oxidoreductase; KDG oxidoreductase [H]

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MVYKPFDMSGKVCVVTGGNKGIGLGMVEALAASNADVVIWGRKTADNDAAVKSASGLGTGKVKAWAVDVGEESQVIKAMK
EAEEEFGRIDACIANAGVGRGAASFETMTLETWEYNARINSVGAFFTLREAAKSMVARAKKGDLGGSLVGTASLAGIEGA
GRNQAYAHTKGGLIAMMNACAVEYGRYGIRANSILPGWIATDMTEGAQGQEVFTSKVISRVPIRRWGEPADFGGMAVYLC
SDASKYHSGDTLVIDGGYAKF

Sequences:

>Translated_261_residues
MVYKPFDMSGKVCVVTGGNKGIGLGMVEALAASNADVVIWGRKTADNDAAVKSASGLGTGKVKAWAVDVGEESQVIKAMK
EAEEEFGRIDACIANAGVGRGAASFETMTLETWEYNARINSVGAFFTLREAAKSMVARAKKGDLGGSLVGTASLAGIEGA
GRNQAYAHTKGGLIAMMNACAVEYGRYGIRANSILPGWIATDMTEGAQGQEVFTSKVISRVPIRRWGEPADFGGMAVYLC
SDASKYHSGDTLVIDGGYAKF
>Mature_261_residues
MVYKPFDMSGKVCVVTGGNKGIGLGMVEALAASNADVVIWGRKTADNDAAVKSASGLGTGKVKAWAVDVGEESQVIKAMK
EAEEEFGRIDACIANAGVGRGAASFETMTLETWEYNARINSVGAFFTLREAAKSMVARAKKGDLGGSLVGTASLAGIEGA
GRNQAYAHTKGGLIAMMNACAVEYGRYGIRANSILPGWIATDMTEGAQGQEVFTSKVISRVPIRRWGEPADFGGMAVYLC
SDASKYHSGDTLVIDGGYAKF

Specific function: Catalyzes the reduction of 2,5-diketo-3-deoxygluconate (DKII or 4,6-dihydroxy-2,5-dioxohexanoate) into 2-keto-3- deoxygluconate (KDG or 2-dehydro-3-deoxygluconate) with a concomitant oxidation of NADH [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254992, Length=248, Percent_Identity=30.241935483871, Blast_Score=114, Evalue=9e-26,
Organism=Homo sapiens, GI32483357, Length=250, Percent_Identity=28.8, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI7705925, Length=251, Percent_Identity=27.0916334661355, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI4758504, Length=256, Percent_Identity=29.296875, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI15277342, Length=252, Percent_Identity=28.1746031746032, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI10190704, Length=259, Percent_Identity=27.4131274131274, Blast_Score=84, Evalue=9e-17,
Organism=Homo sapiens, GI5031737, Length=249, Percent_Identity=26.1044176706827, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI126723750, Length=262, Percent_Identity=28.2442748091603, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI83715985, Length=256, Percent_Identity=27.734375, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI19923817, Length=267, Percent_Identity=27.3408239700375, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI59889578, Length=194, Percent_Identity=29.3814432989691, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI4503301, Length=260, Percent_Identity=29.2307692307692, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI31542939, Length=216, Percent_Identity=27.3148148148148, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI4504505, Length=255, Percent_Identity=27.0588235294118, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI209862901, Length=222, Percent_Identity=28.3783783783784, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI19923983, Length=222, Percent_Identity=28.3783783783784, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI66933014, Length=203, Percent_Identity=22.6600985221675, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1789208, Length=258, Percent_Identity=30.6201550387597, Blast_Score=134, Evalue=9e-33,
Organism=Escherichia coli, GI87082160, Length=253, Percent_Identity=32.0158102766798, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI87082100, Length=257, Percent_Identity=31.5175097276265, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1790717, Length=252, Percent_Identity=28.5714285714286, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI1787335, Length=253, Percent_Identity=30.0395256916996, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1788459, Length=251, Percent_Identity=28.6852589641434, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI2367175, Length=247, Percent_Identity=27.9352226720648, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1787905, Length=250, Percent_Identity=28.8, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1789057, Length=265, Percent_Identity=24.1509433962264, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1789378, Length=253, Percent_Identity=26.8774703557312, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1786812, Length=259, Percent_Identity=26.2548262548263, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI2367365, Length=254, Percent_Identity=25.9842519685039, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17560676, Length=250, Percent_Identity=29.6, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17555706, Length=254, Percent_Identity=31.496062992126, Blast_Score=98, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17561402, Length=255, Percent_Identity=29.4117647058824, Blast_Score=97, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI25147288, Length=255, Percent_Identity=28.2352941176471, Blast_Score=94, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI115534694, Length=255, Percent_Identity=27.0588235294118, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17538182, Length=254, Percent_Identity=26.3779527559055, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17562906, Length=265, Percent_Identity=28.6792452830189, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17531453, Length=271, Percent_Identity=29.1512915129151, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17536651, Length=259, Percent_Identity=23.9382239382239, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17564282, Length=219, Percent_Identity=29.6803652968037, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17562904, Length=264, Percent_Identity=25.3787878787879, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17560150, Length=264, Percent_Identity=27.2727272727273, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562990, Length=264, Percent_Identity=27.2727272727273, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17560332, Length=265, Percent_Identity=26.0377358490566, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17544670, Length=272, Percent_Identity=26.4705882352941, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI72000259, Length=268, Percent_Identity=28.3582089552239, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71994604, Length=253, Percent_Identity=26.0869565217391, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=264, Percent_Identity=26.8939393939394, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17562908, Length=264, Percent_Identity=26.8939393939394, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17563726, Length=269, Percent_Identity=27.8810408921933, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17561272, Length=241, Percent_Identity=26.1410788381743, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17538480, Length=271, Percent_Identity=25.4612546125461, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71994600, Length=255, Percent_Identity=25.0980392156863, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17568967, Length=201, Percent_Identity=32.3383084577114, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17560220, Length=268, Percent_Identity=25, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17536025, Length=261, Percent_Identity=23.7547892720307, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=260, Percent_Identity=32.3076923076923, Blast_Score=99, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6322861, Length=198, Percent_Identity=30.3030303030303, Blast_Score=63, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322227, Length=222, Percent_Identity=25.2252252252252, Blast_Score=62, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24639444, Length=252, Percent_Identity=29.7619047619048, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI21355319, Length=250, Percent_Identity=26.8, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24643142, Length=253, Percent_Identity=26.0869565217391, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17737361, Length=254, Percent_Identity=30.3149606299213, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI23397609, Length=258, Percent_Identity=27.906976744186, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI28571526, Length=258, Percent_Identity=28.2945736434109, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21357041, Length=252, Percent_Identity=26.984126984127, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24644339, Length=256, Percent_Identity=23.828125, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28571387, Length=205, Percent_Identity=28.780487804878, Blast_Score=71, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011286
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.127 [H]

Molecular weight: Translated: 27316; Mature: 27316

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVYKPFDMSGKVCVVTGGNKGIGLGMVEALAASNADVVIWGRKTADNDAAVKSASGLGTG
CCCCCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCHHHHCCCCCCCC
KVKAWAVDVGEESQVIKAMKEAEEEFGRIDACIANAGVGRGAASFETMTLETWEYNARIN
CEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEECCEEC
SVGAFFTLREAAKSMVARAKKGDLGGSLVGTASLAGIEGAGRNQAYAHTKGGLIAMMNAC
CHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHCCCCCCCCCCCEEECCCCHHHHHHHH
AVEYGRYGIRANSILPGWIATDMTEGAQGQEVFTSKVISRVPIRRWGEPADFGGMAVYLC
HHHHCCCCEEECCCCCCHHHHCCCCCCCCHHHHHHHHHHHCCHHHCCCCCCCCCEEEEEE
SDASKYHSGDTLVIDGGYAKF
CCCCHHCCCCEEEECCCCCCC
>Mature Secondary Structure
MVYKPFDMSGKVCVVTGGNKGIGLGMVEALAASNADVVIWGRKTADNDAAVKSASGLGTG
CCCCCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCHHHHCCCCCCCC
KVKAWAVDVGEESQVIKAMKEAEEEFGRIDACIANAGVGRGAASFETMTLETWEYNARIN
CEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEECCEEC
SVGAFFTLREAAKSMVARAKKGDLGGSLVGTASLAGIEGAGRNQAYAHTKGGLIAMMNAC
CHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHCCCCCCCCCCCEEECCCCHHHHHHHH
AVEYGRYGIRANSILPGWIATDMTEGAQGQEVFTSKVISRVPIRRWGEPADFGGMAVYLC
HHHHCCCCEEECCCCCCHHHHCCCCCCCCHHHHHHHHHHHCCHHHCCCCCCCCCEEEEEE
SDASKYHSGDTLVIDGGYAKF
CCCCHHCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503; 2836407; 1766386 [H]