Click here to switch to the map view.

The map label for this gene is pccB [H]

Identifier: 114797686

GI number: 114797686

Start: 1017471

End: 1019003

Strand: Direct

Name: pccB [H]

Synonym: HNE_1007

Alternate gene names: 114797686

Gene position: 1017471-1019003 (Clockwise)

Preceding gene: 114798463

Following gene: 114799091

Centisome position: 27.46

GC content: 60.6

Gene sequence:

>1533_bases
ATGCACGATCTTATCGAGGCTCTGGAGCAGAAACGGGCCGACGCCCGCATTGGCGGCGGCCAGGCCCGCATCGACAGCCA
GCATGCCAAGGGCAAGCTGACCGCGCGTGAGCGTATCCAGGTGTTGCTCGATGAGGGCAGCTTTGAAGAATACGACATGT
TCGTTGAGCATCGTTGCGCCGATTTCGGCATGGAAGAACAGAAGATTCCCGGCGACGGCGTCGTCACCGGCCATGGCACG
ATCAATGGCCGCCTCGTTTATGTGTTCTCCAAGGACTTCACCGTGTTTGGCGGCTCGCTCTCCCGCGCCCATGCCGAGAA
GATCGTCAAGGTTCAGCAGGCCGCCGTGCGCAATGGCGCCCCCGTGATCGGTCTCTTTGATGCGGGCGGCGCGCGCATTC
AGGAGGGCGTTGATTCGCTCGCCGGCTATGCCGACATCTTCATGGAAAACGTGCTCTCCTCCGGCGTGATCCCGCAGATC
TCCGTCATCATGGGCCCCTGCGCCGGCGGCGACGTTTATTCCCCCGCGATGACCGACTTCATCTTCATGGTGAAGGACAC
CTCCTACATGTATGTGACGGGTCCGGACGTTGTGAAGACCGTGACGAACGAAGAAGTGACCCACGAGACCCTCGGCGGCG
CATCTGTGCATGCCAAGAAGTCCGGCGTTGTGGACGGCGCCTTCGAGAACGACATCGAGGCGCTGACCCAGATCCGCCGC
CTGATCGACTATCTGCCCGCCTCCAATCGCGACAAGCCGCCCATTCGGCCTGTGCATGACGCGTTTGACCGCGCCGAGGC
GAGCCTTGACACGCTGGTGCCGCCCAATCCGAACACGCCCTATGACATGAAAGAGCTGATCACCAAGGTGGTCGATGAGG
GCGATTTCTTTGAGATCAGCCCGCAATTTGGCGGCAACATCCTCTGCGGCTTTGGCCGCATCGAAGGCTCGACCGTGGGC
GTGGTGGCAAACCAGCCGATGACGCTGGCGGGCGTTCTGGACATTGACGCCAGCCGCAAGGCGGCGCGGTTTGTGCGCTT
CTGCGACTGTTTCAATATTCCCCTGGTCACCTTCGTGGACGTGCCGGGCTTCATGCCGGGCACGAAGCAGGAGTATGGCG
GTCTCATCAAGCACGGCGCGAAGCTGCTGTTTGCGTATGCCGAGGCGACTGTTCCGAAAGTGACCGTCATTACACGGAAG
GCCTATGGCGGCGCGTATGACGTGATGAGCTCCAAGCATTTGCGCGGCGACGTGAACTATGCCTGGCCAACGGCAGAGAT
CGCCGTGATGGGTGCCAAGGGCGCGGTCGAGATCATCTTCCGCAAGGAAGCCGGCGACCCGGAAAAGCTGGCCGCGCGCA
CCAAGGAATACGAAACCAACTTCGCCAACCCCTATGTGGCTGCGAAGCGGGGCTATATCGACGACATCATCATGCCCCAC
AACACCCGCAAGCGGATCGCCAACTCCCTCCGTACGCTGAAGAACAAATCTCTCAGCAATCCGTGGAAAAAGCACGATAA
TATTCCGCTTTAG

Upstream 100 bases:

>100_bases
ATAGCTTTGTTGACCTTGCGCGAGCTTGCCAAGCGGCGCGGAGGGGCTATTCAGTCACGCGGAAACAGCAAAATCTGACG
GATTGAAGGAGCAGCGCGGC

Downstream 100 bases:

>100_bases
GAAATGGTGAGAGTAGGGTGGGTTGAGCGGAGCGAGACCCACCCTGCGATTTACGGCAGACCTTCCCACCTCCGCCCCAA
TGTGCCACCAATGCCTCTAA

Product: putative propionyl-CoA carboxylase subunit beta

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MHDLIEALEQKRADARIGGGQARIDSQHAKGKLTARERIQVLLDEGSFEEYDMFVEHRCADFGMEEQKIPGDGVVTGHGT
INGRLVYVFSKDFTVFGGSLSRAHAEKIVKVQQAAVRNGAPVIGLFDAGGARIQEGVDSLAGYADIFMENVLSSGVIPQI
SVIMGPCAGGDVYSPAMTDFIFMVKDTSYMYVTGPDVVKTVTNEEVTHETLGGASVHAKKSGVVDGAFENDIEALTQIRR
LIDYLPASNRDKPPIRPVHDAFDRAEASLDTLVPPNPNTPYDMKELITKVVDEGDFFEISPQFGGNILCGFGRIEGSTVG
VVANQPMTLAGVLDIDASRKAARFVRFCDCFNIPLVTFVDVPGFMPGTKQEYGGLIKHGAKLLFAYAEATVPKVTVITRK
AYGGAYDVMSSKHLRGDVNYAWPTAEIAVMGAKGAVEIIFRKEAGDPEKLAARTKEYETNFANPYVAAKRGYIDDIIMPH
NTRKRIANSLRTLKNKSLSNPWKKHDNIPL

Sequences:

>Translated_510_residues
MHDLIEALEQKRADARIGGGQARIDSQHAKGKLTARERIQVLLDEGSFEEYDMFVEHRCADFGMEEQKIPGDGVVTGHGT
INGRLVYVFSKDFTVFGGSLSRAHAEKIVKVQQAAVRNGAPVIGLFDAGGARIQEGVDSLAGYADIFMENVLSSGVIPQI
SVIMGPCAGGDVYSPAMTDFIFMVKDTSYMYVTGPDVVKTVTNEEVTHETLGGASVHAKKSGVVDGAFENDIEALTQIRR
LIDYLPASNRDKPPIRPVHDAFDRAEASLDTLVPPNPNTPYDMKELITKVVDEGDFFEISPQFGGNILCGFGRIEGSTVG
VVANQPMTLAGVLDIDASRKAARFVRFCDCFNIPLVTFVDVPGFMPGTKQEYGGLIKHGAKLLFAYAEATVPKVTVITRK
AYGGAYDVMSSKHLRGDVNYAWPTAEIAVMGAKGAVEIIFRKEAGDPEKLAARTKEYETNFANPYVAAKRGYIDDIIMPH
NTRKRIANSLRTLKNKSLSNPWKKHDNIPL
>Mature_510_residues
MHDLIEALEQKRADARIGGGQARIDSQHAKGKLTARERIQVLLDEGSFEEYDMFVEHRCADFGMEEQKIPGDGVVTGHGT
INGRLVYVFSKDFTVFGGSLSRAHAEKIVKVQQAAVRNGAPVIGLFDAGGARIQEGVDSLAGYADIFMENVLSSGVIPQI
SVIMGPCAGGDVYSPAMTDFIFMVKDTSYMYVTGPDVVKTVTNEEVTHETLGGASVHAKKSGVVDGAFENDIEALTQIRR
LIDYLPASNRDKPPIRPVHDAFDRAEASLDTLVPPNPNTPYDMKELITKVVDEGDFFEISPQFGGNILCGFGRIEGSTVG
VVANQPMTLAGVLDIDASRKAARFVRFCDCFNIPLVTFVDVPGFMPGTKQEYGGLIKHGAKLLFAYAEATVPKVTVITRK
AYGGAYDVMSSKHLRGDVNYAWPTAEIAVMGAKGAVEIIFRKEAGDPEKLAARTKEYETNFANPYVAAKRGYIDDIIMPH
NTRKRIANSLRTLKNKSLSNPWKKHDNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=507, Percent_Identity=66.4694280078895, Blast_Score=696, Evalue=0.0,
Organism=Homo sapiens, GI295821216, Length=527, Percent_Identity=63.9468690702087, Blast_Score=684, Evalue=0.0,
Organism=Homo sapiens, GI11545863, Length=524, Percent_Identity=32.0610687022901, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI38679971, Length=341, Percent_Identity=26.099706744868, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI38679960, Length=341, Percent_Identity=26.099706744868, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI38679977, Length=341, Percent_Identity=26.099706744868, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI38679967, Length=341, Percent_Identity=26.099706744868, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI38679974, Length=341, Percent_Identity=26.099706744868, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI134142062, Length=398, Percent_Identity=24.3718592964824, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1788655, Length=189, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI25147359, Length=503, Percent_Identity=64.8111332007952, Blast_Score=701, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147362, Length=503, Percent_Identity=64.8111332007952, Blast_Score=701, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17552936, Length=524, Percent_Identity=33.206106870229, Blast_Score=258, Evalue=6e-69,
Organism=Caenorhabditis elegans, GI71997163, Length=325, Percent_Identity=23.6923076923077, Blast_Score=76, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6323863, Length=365, Percent_Identity=21.9178082191781, Blast_Score=63, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24586065, Length=531, Percent_Identity=34.2749529190207, Blast_Score=261, Evalue=1e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 55640; Mature: 55640

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDLIEALEQKRADARIGGGQARIDSQHAKGKLTARERIQVLLDEGSFEEYDMFVEHRCA
CCHHHHHHHHHHCCCCCCCCCCEECCHHCCCCCCHHHHHHEEECCCCCHHHHHHHHHHHH
DFGMEEQKIPGDGVVTGHGTINGRLVYVFSKDFTVFGGSLSRAHAEKIVKVQQAAVRNGA
HCCCCCCCCCCCCEEECCCCCCCEEEEEEECCCEEECCCHHHHHHHHHHHHHHHHHHCCC
PVIGLFDAGGARIQEGVDSLAGYADIFMENVLSSGVIPQISVIMGPCAGGDVYSPAMTDF
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCHHHHE
IFMVKDTSYMYVTGPDVVKTVTNEEVTHETLGGASVHAKKSGVVDGAFENDIEALTQIRR
EEEEECCCEEEEECCHHHHHHCCCHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHH
LIDYLPASNRDKPPIRPVHDAFDRAEASLDTLVPPNPNTPYDMKELITKVVDEGDFFEIS
HHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEC
PQFGGNILCGFGRIEGSTVGVVANQPMTLAGVLDIDASRKAARFVRFCDCFNIPLVTFVD
CCCCCEEEEEECCCCCCEEEEEECCCEEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEEC
VPGFMPGTKQEYGGLIKHGAKLLFAYAEATVPKVTVITRKAYGGAYDVMSSKHLRGDVNY
CCCCCCCCHHHHHHHHHHHHHHEEEHHHCCCCEEEEEEECCCCCHHHHHCCCCCCCCCCC
AWPTAEIAVMGAKGAVEIIFRKEAGDPEKLAARTKEYETNFANPYVAAKRGYIDDIIMPH
CCCCEEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCC
NTRKRIANSLRTLKNKSLSNPWKKHDNIPL
CHHHHHHHHHHHHHHCCCCCCHHCCCCCCC
>Mature Secondary Structure
MHDLIEALEQKRADARIGGGQARIDSQHAKGKLTARERIQVLLDEGSFEEYDMFVEHRCA
CCHHHHHHHHHHCCCCCCCCCCEECCHHCCCCCCHHHHHHEEECCCCCHHHHHHHHHHHH
DFGMEEQKIPGDGVVTGHGTINGRLVYVFSKDFTVFGGSLSRAHAEKIVKVQQAAVRNGA
HCCCCCCCCCCCCEEECCCCCCCEEEEEEECCCEEECCCHHHHHHHHHHHHHHHHHHCCC
PVIGLFDAGGARIQEGVDSLAGYADIFMENVLSSGVIPQISVIMGPCAGGDVYSPAMTDF
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCHHHHE
IFMVKDTSYMYVTGPDVVKTVTNEEVTHETLGGASVHAKKSGVVDGAFENDIEALTQIRR
EEEEECCCEEEEECCHHHHHHCCCHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHH
LIDYLPASNRDKPPIRPVHDAFDRAEASLDTLVPPNPNTPYDMKELITKVVDEGDFFEIS
HHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEC
PQFGGNILCGFGRIEGSTVGVVANQPMTLAGVLDIDASRKAARFVRFCDCFNIPLVTFVD
CCCCCEEEEEECCCCCCEEEEEECCCEEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEEC
VPGFMPGTKQEYGGLIKHGAKLLFAYAEATVPKVTVITRKAYGGAYDVMSSKHLRGDVNY
CCCCCCCCHHHHHHHHHHHHHHEEEHHHCCCCEEEEEEECCCCCHHHHHCCCCCCCCCCC
AWPTAEIAVMGAKGAVEIIFRKEAGDPEKLAARTKEYETNFANPYVAAKRGYIDDIIMPH
CCCCEEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCC
NTRKRIANSLRTLKNKSLSNPWKKHDNIPL
CHHHHHHHHHHHHHHCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]