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The map label for this gene is adk

Identifier: 114797627

GI number: 114797627

Start: 2992574

End: 2993143

Strand: Reverse

Name: adk

Synonym: HNE_2830

Alternate gene names: 114797627

Gene position: 2993143-2992574 (Counterclockwise)

Preceding gene: 114797687

Following gene: 114800366

Centisome position: 80.79

GC content: 62.11

Gene sequence:

>570_bases
GTGAACCTGATACTGTTTGGTCCGCCGGCTGCGGGCAAGGGCACGCAGGCCAAGCGACTCGTTGAGCAGCGTGGCTTTGT
GCAACTTTCCACCGGCGACATGCTCCGCGCCGCCAGGGCGTCCGGGTCCGAACTCGGCCAGCGGGTGGCGAAGATCATGG
ATGAGGGCGGTCTGGTCTCCGATGAGATCGTGATTGCGCTGATCGAGGAACAATTGACGGTTCAGGCTGGTGCGCCGGGG
TTCATCTTTGATGGCTTCCCCCGCACCATCGGCCAGGCCGAGGCGCTCGACAGCCTGCTGGAATCGCGGGAATCGAAGGT
CGATCTGGTCATCCGCATGATTGTGGACGACACACGCCTGCTTGAGCGGGTTACCAAGCGCTTTGAGGAGCAGGGAAGGG
CGGATGACAATCCGGCCACCTTCTCGCGCCGTCTGGAGCGTTACTACGAAGATACCGCGCCCCTCGTACCTATGTACGCG
GAGCGGGGTGTGCTGGTCGAGATCGACGGAATGGGCTCAATTGAGGCCGTCTCCGCAGAAATCGATGCGGCCCTGAAACA
ATCCGCGTGA

Upstream 100 bases:

>100_bases
TTTCGGTGACTATGGACACTGTCACGCAGATCCAGTCACACCTGATCGCCCACCAGTATGAGGGGATGATCAAGAAGTCG
AAACTCGGGGGCAAGAAGAA

Downstream 100 bases:

>100_bases
ACGGCGCAGTTCTGCTGTTGACGGGGAGAAAACCGTGGCTATAAGCCTCAAAACTTAGCTTCAGGCTTAACCGCCGGTGC
GCGCGACGGGTATTCTTCCC

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 189; Mature: 189

Protein sequence:

>189_residues
MNLILFGPPAAGKGTQAKRLVEQRGFVQLSTGDMLRAARASGSELGQRVAKIMDEGGLVSDEIVIALIEEQLTVQAGAPG
FIFDGFPRTIGQAEALDSLLESRESKVDLVIRMIVDDTRLLERVTKRFEEQGRADDNPATFSRRLERYYEDTAPLVPMYA
ERGVLVEIDGMGSIEAVSAEIDAALKQSA

Sequences:

>Translated_189_residues
MNLILFGPPAAGKGTQAKRLVEQRGFVQLSTGDMLRAARASGSELGQRVAKIMDEGGLVSDEIVIALIEEQLTVQAGAPG
FIFDGFPRTIGQAEALDSLLESRESKVDLVIRMIVDDTRLLERVTKRFEEQGRADDNPATFSRRLERYYEDTAPLVPMYA
ERGVLVEIDGMGSIEAVSAEIDAALKQSA
>Mature_189_residues
MNLILFGPPAAGKGTQAKRLVEQRGFVQLSTGDMLRAARASGSELGQRVAKIMDEGGLVSDEIVIALIEEQLTVQAGAPG
FIFDGFPRTIGQAEALDSLLESRESKVDLVIRMIVDDTRLLERVTKRFEEQGRADDNPATFSRRLERYYEDTAPLVPMYA
ERGVLVEIDGMGSIEAVSAEIDAALKQSA

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI4502013, Length=212, Percent_Identity=41.5094339622642, Blast_Score=156, Evalue=1e-38,
Organism=Homo sapiens, GI7524346, Length=212, Percent_Identity=41.5094339622642, Blast_Score=155, Evalue=1e-38,
Organism=Homo sapiens, GI4502011, Length=184, Percent_Identity=33.695652173913, Blast_Score=127, Evalue=6e-30,
Organism=Homo sapiens, GI7706497, Length=184, Percent_Identity=32.0652173913043, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI28144897, Length=184, Percent_Identity=34.2391304347826, Blast_Score=104, Evalue=5e-23,
Organism=Homo sapiens, GI28144899, Length=184, Percent_Identity=34.2391304347826, Blast_Score=104, Evalue=5e-23,
Organism=Homo sapiens, GI310110345, Length=194, Percent_Identity=30.4123711340206, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI53832003, Length=194, Percent_Identity=30.4123711340206, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI8051579, Length=194, Percent_Identity=30.4123711340206, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI53832001, Length=194, Percent_Identity=30.4123711340206, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI19923437, Length=194, Percent_Identity=29.3814432989691, Blast_Score=88, Evalue=5e-18,
Organism=Escherichia coli, GI1786680, Length=217, Percent_Identity=38.2488479262673, Blast_Score=126, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI17552384, Length=206, Percent_Identity=39.8058252427184, Blast_Score=145, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17567503, Length=188, Percent_Identity=36.7021276595745, Blast_Score=125, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17533833, Length=190, Percent_Identity=31.0526315789474, Blast_Score=103, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17550688, Length=168, Percent_Identity=31.547619047619, Blast_Score=97, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI25147457, Length=183, Percent_Identity=25.1366120218579, Blast_Score=73, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6320432, Length=207, Percent_Identity=38.1642512077295, Blast_Score=139, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6322828, Length=190, Percent_Identity=31.0526315789474, Blast_Score=105, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6321018, Length=198, Percent_Identity=29.7979797979798, Blast_Score=93, Evalue=3e-20,
Organism=Drosophila melanogaster, GI22026816, Length=214, Percent_Identity=39.2523364485981, Blast_Score=155, Evalue=2e-38,
Organism=Drosophila melanogaster, GI17647141, Length=192, Percent_Identity=32.2916666666667, Blast_Score=100, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24663208, Length=192, Percent_Identity=32.2916666666667, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI17737899, Length=194, Percent_Identity=30.9278350515464, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24645822, Length=194, Percent_Identity=30.9278350515464, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI221459597, Length=184, Percent_Identity=30.9782608695652, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21356893, Length=184, Percent_Identity=30.9782608695652, Blast_Score=91, Evalue=4e-19,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_HYPNA (Q0BYD5)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_761508.1
- ProteinModelPortal:   Q0BYD5
- SMR:   Q0BYD5
- STRING:   Q0BYD5
- GeneID:   4288649
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_2830
- NMPDR:   fig|228405.5.peg.2712
- TIGR:   HNE_2830
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   TRLMEYY
- ProtClustDB:   PRK14532
- BioCyc:   HNEP81032:HNE_2830-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK

EC number: =2.7.4.3

Molecular weight: Translated: 20600; Mature: 20600

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLILFGPPAAGKGTQAKRLVEQRGFVQLSTGDMLRAARASGSELGQRVAKIMDEGGLVS
CCEEEECCCCCCCCHHHHHHHHHCCCEEECCCHHHHHHHCCHHHHHHHHHHHHHCCCCCC
DEIVIALIEEQLTVQAGAPGFIFDGFPRTIGQAEALDSLLESRESKVDLVIRMIVDDTRL
HHHHHHHHHHHHHEECCCCCCEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
LERVTKRFEEQGRADDNPATFSRRLERYYEDTAPLVPMYAERGVLVEIDGMGSIEAVSAE
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHCCCEEEEECCCCCHHHHHHH
IDAALKQSA
HHHHHHCCC
>Mature Secondary Structure
MNLILFGPPAAGKGTQAKRLVEQRGFVQLSTGDMLRAARASGSELGQRVAKIMDEGGLVS
CCEEEECCCCCCCCHHHHHHHHHCCCEEECCCHHHHHHHCCHHHHHHHHHHHHHCCCCCC
DEIVIALIEEQLTVQAGAPGFIFDGFPRTIGQAEALDSLLESRESKVDLVIRMIVDDTRL
HHHHHHHHHHHHHEECCCCCCEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
LERVTKRFEEQGRADDNPATFSRRLERYYEDTAPLVPMYAERGVLVEIDGMGSIEAVSAE
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHCCCEEEEECCCCCHHHHHHH
IDAALKQSA
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA