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The map label for this gene is tesB [H]

Identifier: 114797509

GI number: 114797509

Start: 2725323

End: 2726207

Strand: Direct

Name: tesB [H]

Synonym: HNE_2571

Alternate gene names: 114797509

Gene position: 2725323-2726207 (Clockwise)

Preceding gene: 114797265

Following gene: 114799345

Centisome position: 73.56

GC content: 65.2

Gene sequence:

>885_bases
ATGGCGAAGGACCCGGTTGGAGATCTCCTCACCTTGCTCGATCTCGAGCGCCTCGAACTCGACCTTTTCCGCGGCCAGAG
CCCGGACGAGGAAGAGAGCCAGCGCGTCTTCGGCGGCCAGGTCATCGCCCAGTCGCTGGTCGCCGCCTACCGCACAGTGC
CCGATGACCGTCTCTGCCACTCGCTGCATTGCTATTTCATCCGCCCGGGCGATCCATCCGTGCCGATCATCTATCAGGTC
GACCATTCCCGCGATGGCGGCTCCTTCACCACCCGCCGCGTCGTCGCCATCCAGCATGGCAAGCAGATCTTCAACCTCGC
CGCCTCCTTCCATGTCGTCGAAGACAGCTGGCACCACCAGCACGAGATGCCCGAAGTCGACCCGCCCGAATCGGTGGGCG
ACCGGATCGAATGGCGCCGCAAATTCGCCGAGCAGGTGCCAGAGCGTCATCGCGGCCACTTCCTGCGCGACCGCCCAGTG
GAAATGCGCGAGATCGACCCGCTCGATCCCCTCAAGCCCGCCAAGGCCAGCGACCAGCAGAACCTCTGGTTCCGCGTCGC
CCGCCCCATCGATGAAGCGCCCTGGCTCCACCATTGCCTGATGGCTTATGCGTCCGACATGGCCTTGCTCGGCACCGGCA
ACCGCCCCCACGGCATCTCCTGGATGACCGGCGAGTTGATGTCCGCCAGCCTCGACCACGCCATGTGGTTCCACGCGCCC
ACCAAGTTCGATGAGTGGCACCTCTATTCGATGGACAGCCCCTATGCCGGCGGCGCGCGCAGCTTCAACCGTGGCTCGAT
CTATGACTCGACCGGCCGCCTGGTTGCCTCCGTTGCCCAGGAAGGCCTGATGCGCCGCGTGGAGCGCAAACCGCGCAAAA
GCTGA

Upstream 100 bases:

>100_bases
ATTTCGCTAACCATAACAGGGAATTTCCGGCAGGTTTGCGTTCTGCGCGAGGTCTGGTAAATGCTGCGCCGCACAAGAGA
ACAATAAGGAACATAGGCCC

Downstream 100 bases:

>100_bases
CCGGATCTGTCCCGTTCTGTCCGAATGTGTCCGGATTTGTCCGGGAAGTGTCCCGCGCCTGACCGGCCTTAACCGGCCCT
GACCTCGCGCCGGTACGCCC

Product: acyl-CoA thioesterase II

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MAKDPVGDLLTLLDLERLELDLFRGQSPDEEESQRVFGGQVIAQSLVAAYRTVPDDRLCHSLHCYFIRPGDPSVPIIYQV
DHSRDGGSFTTRRVVAIQHGKQIFNLAASFHVVEDSWHHQHEMPEVDPPESVGDRIEWRRKFAEQVPERHRGHFLRDRPV
EMREIDPLDPLKPAKASDQQNLWFRVARPIDEAPWLHHCLMAYASDMALLGTGNRPHGISWMTGELMSASLDHAMWFHAP
TKFDEWHLYSMDSPYAGGARSFNRGSIYDSTGRLVASVAQEGLMRRVERKPRKS

Sequences:

>Translated_294_residues
MAKDPVGDLLTLLDLERLELDLFRGQSPDEEESQRVFGGQVIAQSLVAAYRTVPDDRLCHSLHCYFIRPGDPSVPIIYQV
DHSRDGGSFTTRRVVAIQHGKQIFNLAASFHVVEDSWHHQHEMPEVDPPESVGDRIEWRRKFAEQVPERHRGHFLRDRPV
EMREIDPLDPLKPAKASDQQNLWFRVARPIDEAPWLHHCLMAYASDMALLGTGNRPHGISWMTGELMSASLDHAMWFHAP
TKFDEWHLYSMDSPYAGGARSFNRGSIYDSTGRLVASVAQEGLMRRVERKPRKS
>Mature_293_residues
AKDPVGDLLTLLDLERLELDLFRGQSPDEEESQRVFGGQVIAQSLVAAYRTVPDDRLCHSLHCYFIRPGDPSVPIIYQVD
HSRDGGSFTTRRVVAIQHGKQIFNLAASFHVVEDSWHHQHEMPEVDPPESVGDRIEWRRKFAEQVPERHRGHFLRDRPVE
MREIDPLDPLKPAKASDQQNLWFRVARPIDEAPWLHHCLMAYASDMALLGTGNRPHGISWMTGELMSASLDHAMWFHAPT
KFDEWHLYSMDSPYAGGARSFNRGSIYDSTGRLVASVAQEGLMRRVERKPRKS

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=295, Percent_Identity=40.3389830508475, Blast_Score=205, Evalue=3e-53,
Organism=Escherichia coli, GI1786657, Length=271, Percent_Identity=43.9114391143911, Blast_Score=233, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI71988741, Length=294, Percent_Identity=37.7551020408163, Blast_Score=179, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17558508, Length=315, Percent_Identity=34.9206349206349, Blast_Score=154, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI212645202, Length=287, Percent_Identity=33.1010452961672, Blast_Score=137, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI115532456, Length=278, Percent_Identity=34.8920863309352, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17531889, Length=278, Percent_Identity=34.8920863309352, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17531885, Length=278, Percent_Identity=34.8920863309352, Blast_Score=128, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI71982224, Length=274, Percent_Identity=29.5620437956204, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6322480, Length=302, Percent_Identity=28.476821192053, Blast_Score=96, Evalue=8e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 33654; Mature: 33523

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKDPVGDLLTLLDLERLELDLFRGQSPDEEESQRVFGGQVIAQSLVAAYRTVPDDRLCH
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHC
SLHCYFIRPGDPSVPIIYQVDHSRDGGSFTTRRVVAIQHGKQIFNLAASFHVVEDSWHHQ
EEEEEEECCCCCCCCEEEEECCCCCCCCCHHEEEEEHHHHHHHHHHHHHHHEECCCHHHH
HEMPEVDPPESVGDRIEWRRKFAEQVPERHRGHFLRDRPVEMREIDPLDPLKPAKASDQQ
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCCCCCCCC
NLWFRVARPIDEAPWLHHCLMAYASDMALLGTGNRPHGISWMTGELMSASLDHAMWFHAP
CEEEEECCCCCCCHHHHHHHHHHHCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHEECCC
TKFDEWHLYSMDSPYAGGARSFNRGSIYDSTGRLVASVAQEGLMRRVERKPRKS
CCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AKDPVGDLLTLLDLERLELDLFRGQSPDEEESQRVFGGQVIAQSLVAAYRTVPDDRLCH
CCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHC
SLHCYFIRPGDPSVPIIYQVDHSRDGGSFTTRRVVAIQHGKQIFNLAASFHVVEDSWHHQ
EEEEEEECCCCCCCCEEEEECCCCCCCCCHHEEEEEHHHHHHHHHHHHHHHEECCCHHHH
HEMPEVDPPESVGDRIEWRRKFAEQVPERHRGHFLRDRPVEMREIDPLDPLKPAKASDQQ
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCCCCCCCC
NLWFRVARPIDEAPWLHHCLMAYASDMALLGTGNRPHGISWMTGELMSASLDHAMWFHAP
CEEEEECCCCCCCHHHHHHHHHHHCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHEECCC
TKFDEWHLYSMDSPYAGGARSFNRGSIYDSTGRLVASVAQEGLMRRVERKPRKS
CCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]