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The map label for this gene is degP [H]

Identifier: 114797410

GI number: 114797410

Start: 2804024

End: 2805445

Strand: Reverse

Name: degP [H]

Synonym: HNE_2644

Alternate gene names: 114797410

Gene position: 2805445-2804024 (Counterclockwise)

Preceding gene: 114798092

Following gene: 114800296

Centisome position: 75.72

GC content: 64.28

Gene sequence:

>1422_bases
ATGACCCGACACGTTTCCAAGCTGCTCGCGGCTGCCTTCCTCGCCGCGCTCATGGCATTGATGATGGCCATCATGCCTGT
GTTTGCCCAAGGCATGCCCGAAGGCGCGCCGGTTGAGCGTGTGCCCGCCTCCACGTCCGAGATCAGCCTCACCTTCGCGC
CGCTGGTGCGCCAGGCGTCTCCGGCTGTCGTCAACGTCTATACAGAGAAGAATGTCTCCCAGCGCGGCATGACGCTGGAA
CAGCTGATGTTCGGCGTTGCCCCACAAAGCCGTGTGCAGAACTCGCTCGGGTCCGGTGTCATCGTCGGCGCTGACGGCAT
CATCGTCACCAACAATCACGTCATCCAGGGCGCTGACACGTTCCGCGTAGTCCTCAGCGACCGGCGTGAATATCCCGCCG
AGCTGCTGCTGGGCGACGAGCGCACAGACCTTGCTGTCCTGAAGATCAACACCGACGGCCGCAGCCTTCCGGTGCTGCCC
TTCGCTGATACCCGCGACGCGCAGGTGGGCGATCTCGTCCTCGCCATCGGTAACCCCTTCGGTGTCGGCCAGACGGTCAC
CAACGGCATCATCTCCGCCACCGCCCGCACGGATGTTGGCATCAACGACTACTCGTTCTTCATCCAGACCGACGCAGCGG
TGAACCCCGGCAATTCGGGCGGCGCCCTCGTCAACACGCGCGGCGAACTCGTCGGCGTCAACACGGCGATCTTCTCGCGC
ACCGGTGGCTCGGTCGGCATCGGCTTTGCGATCCCCGCCGAAATGGTCAAGCGCGTCGTTGATGCGGCCGTCAATGGCGG
CACCTTCGTGCGCCCCTGGCTCGGCCTTGCCGCCCAGTCGGTCAGCTTCGACATCGCCAAGGCGCAAGGCCTTGATCGCC
CGGTGGGCGTAATGGTCACCGAGGTTTATCCTGATGGCCCGGCAGAGCGCGCGGGCCTGCGCCGCGGAGACCTCGTCACC
GCCATCGACGACCGCGAAGTGTTCGATGAAAAGGGCCTCAAATTCCTCGCCGCCATCCGCAATCCGGGGGAGCGCGCCAA
GCTCTCCGTGCTGCGCGGCGGCAAGGCCCAGACGATCAATGTTCAAGTCCAGCCCCCACCAGGCGCGACAGAGGCCGATG
TTGTCCTCCTCACCAACGGCTCGGTCTTCAACGGCGCCCGCGTGATTGAGCTCTCGCCCCGCCTCGCCGAAGAGAATGGC
CTTGATCCCTTCACGCGCGGCTCGGGCATCTATGTCCACTCCGTCACGCGTGGCACCATCTCGCGCAACTATTTCCGCCC
CGGCGACATCATTCGCTCCGTGAACGGAAAACAGACCAAGACGGTGAAGGAAATTCAGGACGTCCTGAAAGCCAACACCC
GCGAATGGGACATCGAAATCGAACGCAACGGCCGCGTGGTGCGAGGCACAGTGCGCACCTGA

Upstream 100 bases:

>100_bases
CTTCCCTGCGGCGGTATGACCTGTCTGAAATGTCATGCGGGCGCGATTGCGCCATAATTCGCTCCGCAATAGAGCCATGA
TCATGACCCATCTCATGAAC

Downstream 100 bases:

>100_bases
TCCCGTGAAGTGTCATCCCGGACGGCCCAAAGGGCCGATCCGGGACCTTGGCTCGTTATAATGTGTGCCTTTTGTTTTAG
GCGGACCCGATCGTCGTGCG

Product: Do family protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MTRHVSKLLAAAFLAALMALMMAIMPVFAQGMPEGAPVERVPASTSEISLTFAPLVRQASPAVVNVYTEKNVSQRGMTLE
QLMFGVAPQSRVQNSLGSGVIVGADGIIVTNNHVIQGADTFRVVLSDRREYPAELLLGDERTDLAVLKINTDGRSLPVLP
FADTRDAQVGDLVLAIGNPFGVGQTVTNGIISATARTDVGINDYSFFIQTDAAVNPGNSGGALVNTRGELVGVNTAIFSR
TGGSVGIGFAIPAEMVKRVVDAAVNGGTFVRPWLGLAAQSVSFDIAKAQGLDRPVGVMVTEVYPDGPAERAGLRRGDLVT
AIDDREVFDEKGLKFLAAIRNPGERAKLSVLRGGKAQTINVQVQPPPGATEADVVLLTNGSVFNGARVIELSPRLAEENG
LDPFTRGSGIYVHSVTRGTISRNYFRPGDIIRSVNGKQTKTVKEIQDVLKANTREWDIEIERNGRVVRGTVRT

Sequences:

>Translated_473_residues
MTRHVSKLLAAAFLAALMALMMAIMPVFAQGMPEGAPVERVPASTSEISLTFAPLVRQASPAVVNVYTEKNVSQRGMTLE
QLMFGVAPQSRVQNSLGSGVIVGADGIIVTNNHVIQGADTFRVVLSDRREYPAELLLGDERTDLAVLKINTDGRSLPVLP
FADTRDAQVGDLVLAIGNPFGVGQTVTNGIISATARTDVGINDYSFFIQTDAAVNPGNSGGALVNTRGELVGVNTAIFSR
TGGSVGIGFAIPAEMVKRVVDAAVNGGTFVRPWLGLAAQSVSFDIAKAQGLDRPVGVMVTEVYPDGPAERAGLRRGDLVT
AIDDREVFDEKGLKFLAAIRNPGERAKLSVLRGGKAQTINVQVQPPPGATEADVVLLTNGSVFNGARVIELSPRLAEENG
LDPFTRGSGIYVHSVTRGTISRNYFRPGDIIRSVNGKQTKTVKEIQDVLKANTREWDIEIERNGRVVRGTVRT
>Mature_472_residues
TRHVSKLLAAAFLAALMALMMAIMPVFAQGMPEGAPVERVPASTSEISLTFAPLVRQASPAVVNVYTEKNVSQRGMTLEQ
LMFGVAPQSRVQNSLGSGVIVGADGIIVTNNHVIQGADTFRVVLSDRREYPAELLLGDERTDLAVLKINTDGRSLPVLPF
ADTRDAQVGDLVLAIGNPFGVGQTVTNGIISATARTDVGINDYSFFIQTDAAVNPGNSGGALVNTRGELVGVNTAIFSRT
GGSVGIGFAIPAEMVKRVVDAAVNGGTFVRPWLGLAAQSVSFDIAKAQGLDRPVGVMVTEVYPDGPAERAGLRRGDLVTA
IDDREVFDEKGLKFLAAIRNPGERAKLSVLRGGKAQTINVQVQPPPGATEADVVLLTNGSVFNGARVIELSPRLAEENGL
DPFTRGSGIYVHSVTRGTISRNYFRPGDIIRSVNGKQTKTVKEIQDVLKANTREWDIEIERNGRVVRGTVRT

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=290, Percent_Identity=34.4827586206897, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI22129776, Length=352, Percent_Identity=31.25, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI7019477, Length=289, Percent_Identity=35.2941176470588, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI24308541, Length=245, Percent_Identity=33.8775510204082, Blast_Score=124, Evalue=2e-28,
Organism=Escherichia coli, GI1786356, Length=370, Percent_Identity=36.7567567567568, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI1789629, Length=427, Percent_Identity=34.6604215456674, Blast_Score=224, Evalue=8e-60,
Organism=Escherichia coli, GI1789630, Length=366, Percent_Identity=38.7978142076503, Blast_Score=219, Evalue=4e-58,
Organism=Drosophila melanogaster, GI24646839, Length=293, Percent_Identity=32.4232081911263, Blast_Score=127, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 50354; Mature: 50223

Theoretical pI: Translated: 8.79; Mature: 8.79

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRHVSKLLAAAFLAALMALMMAIMPVFAQGMPEGAPVERVPASTSEISLTFAPLVRQAS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEHHHHHHCCC
PAVVNVYTEKNVSQRGMTLEQLMFGVAPQSRVQNSLGSGVIVGADGIIVTNNHVIQGADT
CCEEEEEECCCCHHHCCCHHHHHHCCCCHHHHHHHCCCCEEEECCCEEEECCEEEECCCE
FRVVLSDRREYPAELLLGDERTDLAVLKINTDGRSLPVLPFADTRDAQVGDLVLAIGNPF
EEEEECCCCCCCCCEEECCCCCCEEEEEECCCCCEECEEECCCCCCCCCCEEEEEECCCC
GVGQTVTNGIISATARTDVGINDYSFFIQTDAAVNPGNSGGALVNTRGELVGVNTAIFSR
CCCHHHHHHHEEECCCCCCCCCCEEEEEEECCCCCCCCCCCEEEECCCCEEEEEEEEEEC
TGGSVGIGFAIPAEMVKRVVDAAVNGGTFVRPWLGLAAQSVSFDIAKAQGLDRPVGVMVT
CCCCEEEEEECHHHHHHHHHHHHCCCCCEEHHHHHHHHHHCEEEEHHHCCCCCCCCEEEE
EVYPDGPAERAGLRRGDLVTAIDDREVFDEKGLKFLAAIRNPGERAKLSVLRGGKAQTIN
EECCCCCHHHCCCCCCCEEEEECCHHHHHHHCCEEEEHHCCCCCCEEEEEEECCCEEEEE
VQVQPPPGATEADVVLLTNGSVFNGARVIELSPRLAEENGLDPFTRGSGIYVHSVTRGTI
EEEECCCCCCCCCEEEEECCCEECCEEEEEECCCHHCCCCCCCCCCCCCEEEEEEECCCC
SRNYFRPGDIIRSVNGKQTKTVKEIQDVLKANTREWDIEIERNGRVVRGTVRT
CCCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEECC
>Mature Secondary Structure 
TRHVSKLLAAAFLAALMALMMAIMPVFAQGMPEGAPVERVPASTSEISLTFAPLVRQAS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEHHHHHHCCC
PAVVNVYTEKNVSQRGMTLEQLMFGVAPQSRVQNSLGSGVIVGADGIIVTNNHVIQGADT
CCEEEEEECCCCHHHCCCHHHHHHCCCCHHHHHHHCCCCEEEECCCEEEECCEEEECCCE
FRVVLSDRREYPAELLLGDERTDLAVLKINTDGRSLPVLPFADTRDAQVGDLVLAIGNPF
EEEEECCCCCCCCCEEECCCCCCEEEEEECCCCCEECEEECCCCCCCCCCEEEEEECCCC
GVGQTVTNGIISATARTDVGINDYSFFIQTDAAVNPGNSGGALVNTRGELVGVNTAIFSR
CCCHHHHHHHEEECCCCCCCCCCEEEEEEECCCCCCCCCCCEEEECCCCEEEEEEEEEEC
TGGSVGIGFAIPAEMVKRVVDAAVNGGTFVRPWLGLAAQSVSFDIAKAQGLDRPVGVMVT
CCCCEEEEEECHHHHHHHHHHHHCCCCCEEHHHHHHHHHHCEEEEHHHCCCCCCCCEEEE
EVYPDGPAERAGLRRGDLVTAIDDREVFDEKGLKFLAAIRNPGERAKLSVLRGGKAQTIN
EECCCCCHHHCCCCCCCEEEEECCHHHHHHHCCEEEEHHCCCCCCEEEEEEECCCEEEEE
VQVQPPPGATEADVVLLTNGSVFNGARVIELSPRLAEENGLDPFTRGSGIYVHSVTRGTI
EEEECCCCCCCCCEEEEECCCEECCEEEEEECCCHHCCCCCCCCCCCCCEEEEEEECCCC
SRNYFRPGDIIRSVNGKQTKTVKEIQDVLKANTREWDIEIERNGRVVRGTVRT
CCCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7861951 [H]