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The map label for this gene is phoP [H]

Identifier: 114797342

GI number: 114797342

Start: 3686223

End: 3686909

Strand: Reverse

Name: phoP [H]

Synonym: HNE_3550

Alternate gene names: 114797342

Gene position: 3686909-3686223 (Counterclockwise)

Preceding gene: 114799476

Following gene: 114797202

Centisome position: 99.51

GC content: 61.43

Gene sequence:

>687_bases
ATGACAGCCAATAAATTCATTCTGATCGTCGATGACGAGGAGGATCTGCGGGAAACACTGGCCGAACAGTTCGAGCTGAC
GGACGGATTTACGGCCATGGTGGCGGCGTCGGGTGAAGAAGCGCTCCGTAAGGCGGCCGAAGAACGCGTCGATCTGGTGA
TCCTGGATGTCGACATGCCGGGAATGAACGGCCGCGAGGTTTGCCGCCAGCTGCGCGAAAAAGGCATCCGCGTGCCCGTC
ATCATGCTTACCGGCCGGTCCGGTGAAAGCGATACGGTGGCCGGGCTCGAGGCAGGTGCCAATGACTACGTCGCCAAGCC
CTTCAGTTTCGCCGTCCTTTTGGCCCGCGTCCGCTCGCAGCTTCGCAGCTTCGAGCAGACCGAAGACGCCACTTTTGACA
TCGGCCCTTATGAGTTCCGCCCTTCGATGAAAGTGCTGCGCACCAAGGAGGGCCGCCGCATCCGGCTCACCGAAAAGGAA
ACGGAAATCCTCAAATACCTCTACCGGGCAGGGGGTAAGTCGGTCGCCCGCGAGACGCTGCTGTCTGAGGTCTGGGGCTA
TAACGCGGCCGTCACAACCCATACGCTCGAAACCCACATCTACCGCCTCCGCCAGAAGGTCGAGCCCGATCCGTCGAACG
CCCAGCTCCTGCTGACCGATACCGGCGGCTATCGCCTTCGGCCCTGA

Upstream 100 bases:

>100_bases
CGGGCTGCGCCTCCCGTTCTTGTTATTGGATAAACAGGCGCCACCTTTCTATGCAAGCGGTTGGTGCGGGTGCCGCGCGG
CAACAGGGTGAGATACGCAG

Downstream 100 bases:

>100_bases
TCAGGCTTTCAGCGTCAGCGATACCGGTGCATGGTCGGACGGTTTCCAGCCACTGCGCCAGGCTGGATGGATGCGGTAGG
AGCTGACCTTCACGTCCTCC

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 227

Protein sequence:

>228_residues
MTANKFILIVDDEEDLRETLAEQFELTDGFTAMVAASGEEALRKAAEERVDLVILDVDMPGMNGREVCRQLREKGIRVPV
IMLTGRSGESDTVAGLEAGANDYVAKPFSFAVLLARVRSQLRSFEQTEDATFDIGPYEFRPSMKVLRTKEGRRIRLTEKE
TEILKYLYRAGGKSVARETLLSEVWGYNAAVTTHTLETHIYRLRQKVEPDPSNAQLLLTDTGGYRLRP

Sequences:

>Translated_228_residues
MTANKFILIVDDEEDLRETLAEQFELTDGFTAMVAASGEEALRKAAEERVDLVILDVDMPGMNGREVCRQLREKGIRVPV
IMLTGRSGESDTVAGLEAGANDYVAKPFSFAVLLARVRSQLRSFEQTEDATFDIGPYEFRPSMKVLRTKEGRRIRLTEKE
TEILKYLYRAGGKSVARETLLSEVWGYNAAVTTHTLETHIYRLRQKVEPDPSNAQLLLTDTGGYRLRP
>Mature_227_residues
TANKFILIVDDEEDLRETLAEQFELTDGFTAMVAASGEEALRKAAEERVDLVILDVDMPGMNGREVCRQLREKGIRVPVI
MLTGRSGESDTVAGLEAGANDYVAKPFSFAVLLARVRSQLRSFEQTEDATFDIGPYEFRPSMKVLRTKEGRRIRLTEKET
EILKYLYRAGGKSVARETLLSEVWGYNAAVTTHTLETHIYRLRQKVEPDPSNAQLLLTDTGGYRLRP

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786911, Length=230, Percent_Identity=37.3913043478261, Blast_Score=130, Evalue=7e-32,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=36.0730593607306, Blast_Score=122, Evalue=1e-29,
Organism=Escherichia coli, GI1790860, Length=228, Percent_Identity=36.4035087719298, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1789809, Length=236, Percent_Identity=32.2033898305085, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1786784, Length=213, Percent_Identity=36.6197183098592, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1786599, Length=228, Percent_Identity=32.0175438596491, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI1789402, Length=208, Percent_Identity=32.2115384615385, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=31.8777292576419, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1788394, Length=209, Percent_Identity=31.5789473684211, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI1790552, Length=203, Percent_Identity=32.0197044334975, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1787229, Length=231, Percent_Identity=33.3333333333333, Blast_Score=96, Evalue=1e-21,
Organism=Escherichia coli, GI2367329, Length=212, Percent_Identity=35.377358490566, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1787375, Length=202, Percent_Identity=28.7128712871287, Blast_Score=91, Evalue=4e-20,
Organism=Escherichia coli, GI1788550, Length=144, Percent_Identity=34.0277777777778, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI1790299, Length=123, Percent_Identity=28.4552845528455, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI145693140, Length=216, Percent_Identity=27.3148148148148, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI145693157, Length=108, Percent_Identity=31.4814814814815, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1787487, Length=103, Percent_Identity=34.9514563106796, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788521, Length=203, Percent_Identity=26.6009852216749, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1788713, Length=107, Percent_Identity=36.4485981308411, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1790437, Length=151, Percent_Identity=27.1523178807947, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25676; Mature: 25544

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTANKFILIVDDEEDLRETLAEQFELTDGFTAMVAASGEEALRKAAEERVDLVILDVDMP
CCCCEEEEEECCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCCEEEEEECCC
GMNGREVCRQLREKGIRVPVIMLTGRSGESDTVAGLEAGANDYVAKPFSFAVLLARVRSQ
CCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHH
LRSFEQTEDATFDIGPYEFRPSMKVLRTKEGRRIRLTEKETEILKYLYRAGGKSVARETL
HHHHHHCCCCEECCCCCCCCCCHHHHCCCCCCEEEECHHHHHHHHHHHHCCCHHHHHHHH
LSEVWGYNAAVTTHTLETHIYRLRQKVEPDPSNAQLLLTDTGGYRLRP
HHHHHCCCCEEEHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCEEECC
>Mature Secondary Structure 
TANKFILIVDDEEDLRETLAEQFELTDGFTAMVAASGEEALRKAAEERVDLVILDVDMP
CCCEEEEEECCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCCEEEEEECCC
GMNGREVCRQLREKGIRVPVIMLTGRSGESDTVAGLEAGANDYVAKPFSFAVLLARVRSQ
CCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHH
LRSFEQTEDATFDIGPYEFRPSMKVLRTKEGRRIRLTEKETEILKYLYRAGGKSVARETL
HHHHHHCCCCEECCCCCCCCCCHHHHCCCCCCEEEECHHHHHHHHHHHHCCCHHHHHHHH
LSEVWGYNAAVTTHTLETHIYRLRQKVEPDPSNAQLLLTDTGGYRLRP
HHHHHCCCCEEEHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]