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The map label for this gene is folP [H]

Identifier: 114797314

GI number: 114797314

Start: 2464315

End: 2465148

Strand: Reverse

Name: folP [H]

Synonym: HNE_2366

Alternate gene names: 114797314

Gene position: 2465148-2464315 (Counterclockwise)

Preceding gene: 114797299

Following gene: 114800304

Centisome position: 66.54

GC content: 64.51

Gene sequence:

>834_bases
ATGATTGATACTGAGCGGCGCGACAGGACACTCGCCCGTGTGCGCAACGAACCTGTCATCATGGGCATTCTCAATGTGAC
GCCCGACAGCTTCTCCGATGGCGGACGGCATACCACACTGGAGGCAGCAGAGGCGCAGGCCCTGCGGATGCTGGCCGAGG
GCGCAGGCATCATCGACATTGGCGGGGAGTCCACGCGCCCCGGCGCGGCGCAGGTGTCGGCGGCGGAGGAGCTTGTCCGT
GTCCTCCCCATCATCCGGCATCTGGCCTCGCGAATGGACGCGCCGATCTCCATCGACACAGTCAAAGCCTCCGTCGCCCG
CGCAGCGATCGAGGCCGGGGCCGTCATCATCAATGACGTGACCGGCATGACCGGCGACCCGGAGATGCCCGCGGCTGTGG
CCGAAACGGGCGCGGCGGTCGTCATCACCTATCATCGCGGCACAGCCGACGAAGCAATCGATGCCGTCGCCGATATGCAC
GCCTTTTTCGACCGCTCTTTTGAAACAGCAGCGCGCGTTGCCATTGCTAAAGACCGCATCTGGCTCGACCCCGGTGTCGG
CTTCGCCAAGACGCCCCGGCAGAACCTTGAAGTGATCGCGCAGCTCGATACGCTGGCGCGGTATGGCTGCCCTGTCCTGG
TGGGGCTTTCCCGCAAGAGCTTTATCGGCCATGTCACGGGCCGGGCCGTAGATGATCGCCTTGCTGGCACGCTCACTGCC
CATCTGATGGCGCTGCAGCGGGGCGCTCGCGTCCTGCGGGTGCATGATGTAGCTGAGCACACCGATTTGCTGCGCCTGTA
TCAGGCGATCGAAGGGGCAGGGCATGAAAACTGA

Upstream 100 bases:

>100_bases
ATCTTTCAGCCTGTCAGCGAGTTTGCCGGGCAGGCATTCGAAACGGAATTGCCCGCCGCCCTGATCGGCCTCGGCAAAAC
CCTTCTGGAGGGAGGTTTCG

Downstream 100 bases:

>100_bases
GATCATCATCCGCAATCTCCGCATTCACGGCTATCACGGCCTGAAAGAAGCAGAGAAGGCGCTCGGCCAGATCTTCGAGG
TCGACATCACCTGCGACATG

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MIDTERRDRTLARVRNEPVIMGILNVTPDSFSDGGRHTTLEAAEAQALRMLAEGAGIIDIGGESTRPGAAQVSAAEELVR
VLPIIRHLASRMDAPISIDTVKASVARAAIEAGAVIINDVTGMTGDPEMPAAVAETGAAVVITYHRGTADEAIDAVADMH
AFFDRSFETAARVAIAKDRIWLDPGVGFAKTPRQNLEVIAQLDTLARYGCPVLVGLSRKSFIGHVTGRAVDDRLAGTLTA
HLMALQRGARVLRVHDVAEHTDLLRLYQAIEGAGHEN

Sequences:

>Translated_277_residues
MIDTERRDRTLARVRNEPVIMGILNVTPDSFSDGGRHTTLEAAEAQALRMLAEGAGIIDIGGESTRPGAAQVSAAEELVR
VLPIIRHLASRMDAPISIDTVKASVARAAIEAGAVIINDVTGMTGDPEMPAAVAETGAAVVITYHRGTADEAIDAVADMH
AFFDRSFETAARVAIAKDRIWLDPGVGFAKTPRQNLEVIAQLDTLARYGCPVLVGLSRKSFIGHVTGRAVDDRLAGTLTA
HLMALQRGARVLRVHDVAEHTDLLRLYQAIEGAGHEN
>Mature_277_residues
MIDTERRDRTLARVRNEPVIMGILNVTPDSFSDGGRHTTLEAAEAQALRMLAEGAGIIDIGGESTRPGAAQVSAAEELVR
VLPIIRHLASRMDAPISIDTVKASVARAAIEAGAVIINDVTGMTGDPEMPAAVAETGAAVVITYHRGTADEAIDAVADMH
AFFDRSFETAARVAIAKDRIWLDPGVGFAKTPRQNLEVIAQLDTLARYGCPVLVGLSRKSFIGHVTGRAVDDRLAGTLTA
HLMALQRGARVLRVHDVAEHTDLLRLYQAIEGAGHEN

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=260, Percent_Identity=41.9230769230769, Blast_Score=204, Evalue=7e-54,
Organism=Saccharomyces cerevisiae, GI6324073, Length=325, Percent_Identity=32.3076923076923, Blast_Score=132, Evalue=6e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 29552; Mature: 29552

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDTERRDRTLARVRNEPVIMGILNVTPDSFSDGGRHTTLEAAEAQALRMLAEGAGIIDI
CCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCEEEE
GGESTRPGAAQVSAAEELVRVLPIIRHLASRMDAPISIDTVKASVARAAIEAGAVIINDV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEECC
TGMTGDPEMPAAVAETGAAVVITYHRGTADEAIDAVADMHAFFDRSFETAARVAIAKDRI
CCCCCCCCCCHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCE
WLDPGVGFAKTPRQNLEVIAQLDTLARYGCPVLVGLSRKSFIGHVTGRAVDDRLAGTLTA
EECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCHHHHHHHHHHHH
HLMALQRGARVLRVHDVAEHTDLLRLYQAIEGAGHEN
HHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MIDTERRDRTLARVRNEPVIMGILNVTPDSFSDGGRHTTLEAAEAQALRMLAEGAGIIDI
CCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCEEEE
GGESTRPGAAQVSAAEELVRVLPIIRHLASRMDAPISIDTVKASVARAAIEAGAVIINDV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEECC
TGMTGDPEMPAAVAETGAAVVITYHRGTADEAIDAVADMHAFFDRSFETAARVAIAKDRI
CCCCCCCCCCHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCE
WLDPGVGFAKTPRQNLEVIAQLDTLARYGCPVLVGLSRKSFIGHVTGRAVDDRLAGTLTA
EECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCHHHHHHHHHHHH
HLMALQRGARVLRVHDVAEHTDLLRLYQAIEGAGHEN
HHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2123867; 7584024; 9384377 [H]