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The map label for this gene is algA [H]

Identifier: 114797309

GI number: 114797309

Start: 785452

End: 786522

Strand: Reverse

Name: algA [H]

Synonym: HNE_0775

Alternate gene names: 114797309

Gene position: 786522-785452 (Counterclockwise)

Preceding gene: 114799988

Following gene: 114799344

Centisome position: 21.23

GC content: 55.0

Gene sequence:

>1071_bases
ATGAGTATTCACCCTGTGATTATGTGCGGCGGTGCTGGCACACGTCTTTGGCCGGCATCTGATAAGGCCTGTCCCAAACA
GTTTCACCGACTCGTCTCGAATCATTCTGTTTTTCAGGAAACAGTGCTGCGTTTCCGCGCCGCAGAGGACGAAGAGGTCT
TTGCTGCCCCGATCATAATCAGTAATGCCGCTTACATCGAACTCATCGAAACACAACTCGCTGAAATCGGTGTGGAGGCC
TGCGCAATCCTGCTGGAGCCGGAGGGCAAGAATACCGCCGCGGTGGCCGCCTTGGCCGCGCGCTTCATCGCCGGAAAGTT
TCCCGGTGGATTGGGCCTGCTTCTTCCATCCGATCATTATATCGGTCAGCCATCTGTCTTTATTAATGCTATCCGAAAAG
CCGCAGAAACGGCTCAGAAAGGCTACATCACAACCTTTGGTATCGCCGTGAGCCGACCGGAAACGGGCTTTGGATATATT
CACGCTGGCTCACCTCTGGACGGGCCGGTCTCAACGGTTGCTGCATTTCGCGAGAAGCCGGATTCAGCAACGGCCGCCAG
CTATCTGGCTGCTGGCGATTATAGCTGGAATGCGGGAATTTTTCTCTTTGAAGCGGACACCCTGCTCATCGAGCTGGAAG
CCCACGCACCAGATATTCTGGAGATTTCTGGCCTGGCACTCAGCAAGGCACGACACGACGGCAATAAAATTTTCCTCGAT
CCAGGCTACTTTACCAGCATTCGCAGTACATCGATCGACTATGCCATAATGGAAAAGACCCACCGGGCCGCCGTGTACGC
GCCGCTCGAATGTGCGTGGAGTGATATCGGCACCTGGGCGATGATCGGTGATGTATCTGATCGCGCTAACTCACCTGAAG
CGATCAGCGTTGCGTCGGGTGAATGCCTTGTACATGCCGCTGAGGGGATCCTCGTCGCACTGGTCGGCGTCGAGAATCTT
ATCGTGGTCGCCGATGGAAACCGCGTTCTGATCACTACCAAAGAGCGCTCCCAGGATGTTGGGAAAGTGGTTCAGGAACT
CAGGGCACGAGGTCTTGACGCCTATCTATGA

Upstream 100 bases:

>100_bases
CAGCGGCATCTGAAACAGGTGCTGATTGCGCTCAGGCAAAGTGTTGCATGAAGGGCGCAAATGCGCCATCCCGCCTTCAG
TTTGATTAGATGAGTAAAGC

Downstream 100 bases:

>100_bases
TATCAGATACCGCGCCGCTCCAACCGAAATAAGCGATTATCATCCGTCCGACGGCGGATCGTTGTCAGTTATTTCGGCGC
TTGTGGCGCGGCGGGCCATC

Product: mannose-1-phosphate guanylyltransferase

Products: NA

Alternate protein names: Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; Mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; GMP; GMPP; GTP--mannose-1-phosphate guanylyltransferase [H]

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MSIHPVIMCGGAGTRLWPASDKACPKQFHRLVSNHSVFQETVLRFRAAEDEEVFAAPIIISNAAYIELIETQLAEIGVEA
CAILLEPEGKNTAAVAALAARFIAGKFPGGLGLLLPSDHYIGQPSVFINAIRKAAETAQKGYITTFGIAVSRPETGFGYI
HAGSPLDGPVSTVAAFREKPDSATAASYLAAGDYSWNAGIFLFEADTLLIELEAHAPDILEISGLALSKARHDGNKIFLD
PGYFTSIRSTSIDYAIMEKTHRAAVYAPLECAWSDIGTWAMIGDVSDRANSPEAISVASGECLVHAAEGILVALVGVENL
IVVADGNRVLITTKERSQDVGKVVQELRARGLDAYL

Sequences:

>Translated_356_residues
MSIHPVIMCGGAGTRLWPASDKACPKQFHRLVSNHSVFQETVLRFRAAEDEEVFAAPIIISNAAYIELIETQLAEIGVEA
CAILLEPEGKNTAAVAALAARFIAGKFPGGLGLLLPSDHYIGQPSVFINAIRKAAETAQKGYITTFGIAVSRPETGFGYI
HAGSPLDGPVSTVAAFREKPDSATAASYLAAGDYSWNAGIFLFEADTLLIELEAHAPDILEISGLALSKARHDGNKIFLD
PGYFTSIRSTSIDYAIMEKTHRAAVYAPLECAWSDIGTWAMIGDVSDRANSPEAISVASGECLVHAAEGILVALVGVENL
IVVADGNRVLITTKERSQDVGKVVQELRARGLDAYL
>Mature_355_residues
SIHPVIMCGGAGTRLWPASDKACPKQFHRLVSNHSVFQETVLRFRAAEDEEVFAAPIIISNAAYIELIETQLAEIGVEAC
AILLEPEGKNTAAVAALAARFIAGKFPGGLGLLLPSDHYIGQPSVFINAIRKAAETAQKGYITTFGIAVSRPETGFGYIH
AGSPLDGPVSTVAAFREKPDSATAASYLAAGDYSWNAGIFLFEADTLLIELEAHAPDILEISGLALSKARHDGNKIFLDP
GYFTSIRSTSIDYAIMEKTHRAAVYAPLECAWSDIGTWAMIGDVSDRANSPEAISVASGECLVHAAEGILVALVGVENLI
VVADGNRVLITTKERSQDVGKVVQELRARGLDAYL

Specific function: Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=363, Percent_Identity=38.2920110192837, Blast_Score=219, Evalue=2e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =5.3.1.8; =2.7.7.13 [H]

Molecular weight: Translated: 37942; Mature: 37810

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIHPVIMCGGAGTRLWPASDKACPKQFHRLVSNHSVFQETVLRFRAAEDEEVFAAPIII
CCCCCEEEECCCCCEECCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEEEEE
SNAAYIELIETQLAEIGVEACAILLEPEGKNTAAVAALAARFIAGKFPGGLGLLLPSDHY
CCCHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCC
IGQPSVFINAIRKAAETAQKGYITTFGIAVSRPETGFGYIHAGSPLDGPVSTVAAFREKP
CCCHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCEEEECCCCCCCHHHHHHHHHCCC
DSATAASYLAAGDYSWNAGIFLFEADTLLIELEAHAPDILEISGLALSKARHDGNKIFLD
CCHHHHHHHCCCCCCCCCCEEEEECCEEEEEEECCCCCEEEECCEEEEHHCCCCCEEEEC
PGYFTSIRSTSIDYAIMEKTHRAAVYAPLECAWSDIGTWAMIGDVSDRANSPEAISVASG
CCCEEEHHCCCCCHHHHHCCCCEEEEECHHHHHCCCCCEEEEECCHHCCCCCCEEEEECC
ECLVHAAEGILVALVGVENLIVVADGNRVLITTKERSQDVGKVVQELRARGLDAYL
CEEEEECCCEEEEEECCCEEEEEECCCEEEEEECHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SIHPVIMCGGAGTRLWPASDKACPKQFHRLVSNHSVFQETVLRFRAAEDEEVFAAPIII
CCCCEEEECCCCCEECCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEEEEE
SNAAYIELIETQLAEIGVEACAILLEPEGKNTAAVAALAARFIAGKFPGGLGLLLPSDHY
CCCHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCC
IGQPSVFINAIRKAAETAQKGYITTFGIAVSRPETGFGYIHAGSPLDGPVSTVAAFREKP
CCCHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCEEEECCCCCCCHHHHHHHHHCCC
DSATAASYLAAGDYSWNAGIFLFEADTLLIELEAHAPDILEISGLALSKARHDGNKIFLD
CCHHHHHHHCCCCCCCCCCEEEEECCEEEEEEECCCCCEEEECCEEEEHHCCCCCEEEEC
PGYFTSIRSTSIDYAIMEKTHRAAVYAPLECAWSDIGTWAMIGDVSDRANSPEAISVASG
CCCEEEHHCCCCCHHHHHCCCCEEEEECHHHHHCCCCCEEEEECCHHCCCCCCEEEEECC
ECLVHAAEGILVALVGVENLIVVADGNRVLITTKERSQDVGKVVQELRARGLDAYL
CEEEEECCCEEEEEECCCEEEEEECCCEEEEEECHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3089876; 10984043; 1846611 [H]