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The map label for this gene is hppA [H]

Identifier: 114797162

GI number: 114797162

Start: 1169681

End: 1171858

Strand: Direct

Name: hppA [H]

Synonym: HNE_1158

Alternate gene names: 114797162

Gene position: 1169681-1171858 (Clockwise)

Preceding gene: 114798043

Following gene: 114799108

Centisome position: 31.57

GC content: 61.2

Gene sequence:

>2178_bases
ATGACATGGTACGCCCTGGCACTTGGTGCAGGTATACTGTCAGTCTTATACGGTTGGGTTCAGATCCAATCGATCATGAA
AGCCCCTGCGGGCAATGCCCGCATGCTGGAAATTGCCGCCGCCATTCAGGAAGGCGCAAACGCCTATCTGAAGCGTCAGT
ATCGCACCATCGGCATCGTCGGCGTGGTTGTCGCGATTGTGCTGGTGATCCTGCTCGGCTGGAAAGCTGCGCTGGGATTT
GTCATTGGCGCGGTGCTCTCCGGGGCAGCGGGCTATATCGGCATGCTGGTTTCGGTGCGGGCAAACGTGCGCACGACGGA
GGCGTCACGCCACGGCCTGAATGAAGGCCTCAAGATGGCGTTCAAGTCCGGCGCGGTCACGGGCATGCTCGTGGTTGGCC
TCGCGCTGATCGGCATCGTTGGCTATTACGGCCTGCTGACCGGGCCGCTGGGGCTCAGCCTCGGGGACGAAGACCAGAAG
CGCGAAATCATTGACGCGCTGGTGTCGCTGGGCTTTGGCGCCTCGCTGATTTCGATCTTCGCCCGTCTGGGCGGAGGTAT
CTTCACCAAGGGCGCAGACGTTGGCGGCGACATGGTCGGCAAGGTTGAAGCCGGCATTCCCGAGGACGATCCCCGCAACC
CGGCAACGATTGCCGATAACGTGGGCGACAATGTTGGCGACTGTGCCGGCATGGCGGCGGACCTGTTCGAGACCTATGCA
GTGACCCTGGTGGCCACGATGGTGCTTGGCGGGATCTATTTCGCAGCCACGCCTTACATCGCCGAGATCATGATGCTGCC
CCTCGCCATCGGCGCGGTGTGTATCGTTACCTCCATCATTGGCTCTTTCTTTGCCACCCTGTCCAAAGGGTCCACCAATG
TCATGGGCGCGCTCTACAAGGCGCTCAACGTGACCGGCGTGCTCTCCATTGGCGGTCTGGCCATTGCCATTCATACCGTC
CTTCCGGGCGGTCTGGGCGGCACGCTGGAAGGCGCGGGCGCCTTGCTCGGTCTCGTCGATCCTGCAACCGGCCAGGCAGC
AGATATTACGGGCTGGCACCTCTTCGCCTGCGGCGTGGTGGGTCTGTTCGTCACCCTGCTGATCGTTGTGATCACGGCCT
ATTACACCGAGACGAAGTATCGTCCGGTGCGCTCCATTGCGAAAGCTTCGGAGTCCGGCCACGGCACCAACGTCATTCAG
GGTCTGGCCGTTTCGCTGGAAGCGACTGCTCTGCCAGCGCTGACCATCATTGGCGGCATCCTGCTGACCTACAACCTGGC
AGGTCTCTATGGCATTGCCATTGCCACCACGACGATGCTGGCGCTGGCTGGCATGATCGTGGCGCTCGACGCATTTGGTC
CGGTGACGGACAATGCGGGCGGTATTGCCGAAATGGCAGAACTGCCTTCTGAGGTGCGCACCACCACAGACGCGCTGGAC
GCTGTCGGCAACACGACCAAGGCGGTTACCAAAGGCTACGCGATCGGCTCTGCCGGTCTCGGCGCACTGGTGCTGTTTGC
GGCGTATGCAGAGGATTTGAGTTACTTTACCGCTCGTGCGACAGAGGGCTCGTTCTTCTACAACATCACGGTCGACTTCT
CGATTGCCAATCCCTACGTCGTGGTTGGTCTGCTGTTCGGCGGCCTTTTGCCGTTCCTGTTCGGTGGCATGTCGATGATG
GCTGTGGGCCGCGCGGCGCAAGCCGTCGTTGAAGAGGTTCGCCGCCAGTTCCGCGAAATGCCGGGCATCATGAAGGGCGA
AGTAAAGCCCGATTATGGCCGGGCCGTGGATATGCTGACACAAGCGGCGATCAAGGAAATGATCATTCCTTCGCTTCTGC
CGGTGCTGTCTCCGATCATTCTGTTCGGTGTCATCCTGGTGATCGGCGGACCGGGCGAGGCGCTTGCCTCGGTCGGCGCA
ATGCTGCTGGGCGTGATCGTAACCGGCCTGTTCGTTGCCATCTCGATGACCTCGGGCGGCGGCGCATGGGACAACGCCAA
GAAGTATATCGAAGACGGCCATCATGGCGGCAAGGGCTCTGAAGCCCACAAGGCCGCTGTGACGGGCGACACGGTGGGTG
ATCCCTACAAGGACACTGCCGGCCCCGCCGTGAACCCGATGATCAAGATCACGAACATCGTGGCCCTTCTGATGCTGGCG
GTTCTTGCCGGACACTGA

Upstream 100 bases:

>100_bases
GTCCGGCCCGGCTGGCAGGCAAGTCGGTCTAAGAAGAAAAAAAGACCAGACCGGAATCAATCCGGCTGAGTTTTCTCGGG
GAAAGCAAGGAGGAAAGCCT

Downstream 100 bases:

>100_bases
GTGTCAGAGGTGAATTCAATGAAAACTCCCGGAGGCGACTCCGGGAGTTTTTGTTTGTGCGCCGCTCATATCGGCAAATC
CTATAGGGGCGCGGTTTCGT

Product: membrane-bound proton-translocating pyrophosphatase

Products: NA

Alternate protein names: Membrane-bound proton-translocating pyrophosphatase; Pyrophosphate-energized inorganic pyrophosphatase; H(+)-PPase [H]

Number of amino acids: Translated: 725; Mature: 724

Protein sequence:

>725_residues
MTWYALALGAGILSVLYGWVQIQSIMKAPAGNARMLEIAAAIQEGANAYLKRQYRTIGIVGVVVAIVLVILLGWKAALGF
VIGAVLSGAAGYIGMLVSVRANVRTTEASRHGLNEGLKMAFKSGAVTGMLVVGLALIGIVGYYGLLTGPLGLSLGDEDQK
REIIDALVSLGFGASLISIFARLGGGIFTKGADVGGDMVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYA
VTLVATMVLGGIYFAATPYIAEIMMLPLAIGAVCIVTSIIGSFFATLSKGSTNVMGALYKALNVTGVLSIGGLAIAIHTV
LPGGLGGTLEGAGALLGLVDPATGQAADITGWHLFACGVVGLFVTLLIVVITAYYTETKYRPVRSIAKASESGHGTNVIQ
GLAVSLEATALPALTIIGGILLTYNLAGLYGIAIATTTMLALAGMIVALDAFGPVTDNAGGIAEMAELPSEVRTTTDALD
AVGNTTKAVTKGYAIGSAGLGALVLFAAYAEDLSYFTARATEGSFFYNITVDFSIANPYVVVGLLFGGLLPFLFGGMSMM
AVGRAAQAVVEEVRRQFREMPGIMKGEVKPDYGRAVDMLTQAAIKEMIIPSLLPVLSPIILFGVILVIGGPGEALASVGA
MLLGVIVTGLFVAISMTSGGGAWDNAKKYIEDGHHGGKGSEAHKAAVTGDTVGDPYKDTAGPAVNPMIKITNIVALLMLA
VLAGH

Sequences:

>Translated_725_residues
MTWYALALGAGILSVLYGWVQIQSIMKAPAGNARMLEIAAAIQEGANAYLKRQYRTIGIVGVVVAIVLVILLGWKAALGF
VIGAVLSGAAGYIGMLVSVRANVRTTEASRHGLNEGLKMAFKSGAVTGMLVVGLALIGIVGYYGLLTGPLGLSLGDEDQK
REIIDALVSLGFGASLISIFARLGGGIFTKGADVGGDMVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYA
VTLVATMVLGGIYFAATPYIAEIMMLPLAIGAVCIVTSIIGSFFATLSKGSTNVMGALYKALNVTGVLSIGGLAIAIHTV
LPGGLGGTLEGAGALLGLVDPATGQAADITGWHLFACGVVGLFVTLLIVVITAYYTETKYRPVRSIAKASESGHGTNVIQ
GLAVSLEATALPALTIIGGILLTYNLAGLYGIAIATTTMLALAGMIVALDAFGPVTDNAGGIAEMAELPSEVRTTTDALD
AVGNTTKAVTKGYAIGSAGLGALVLFAAYAEDLSYFTARATEGSFFYNITVDFSIANPYVVVGLLFGGLLPFLFGGMSMM
AVGRAAQAVVEEVRRQFREMPGIMKGEVKPDYGRAVDMLTQAAIKEMIIPSLLPVLSPIILFGVILVIGGPGEALASVGA
MLLGVIVTGLFVAISMTSGGGAWDNAKKYIEDGHHGGKGSEAHKAAVTGDTVGDPYKDTAGPAVNPMIKITNIVALLMLA
VLAGH
>Mature_724_residues
TWYALALGAGILSVLYGWVQIQSIMKAPAGNARMLEIAAAIQEGANAYLKRQYRTIGIVGVVVAIVLVILLGWKAALGFV
IGAVLSGAAGYIGMLVSVRANVRTTEASRHGLNEGLKMAFKSGAVTGMLVVGLALIGIVGYYGLLTGPLGLSLGDEDQKR
EIIDALVSLGFGASLISIFARLGGGIFTKGADVGGDMVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYAV
TLVATMVLGGIYFAATPYIAEIMMLPLAIGAVCIVTSIIGSFFATLSKGSTNVMGALYKALNVTGVLSIGGLAIAIHTVL
PGGLGGTLEGAGALLGLVDPATGQAADITGWHLFACGVVGLFVTLLIVVITAYYTETKYRPVRSIAKASESGHGTNVIQG
LAVSLEATALPALTIIGGILLTYNLAGLYGIAIATTTMLALAGMIVALDAFGPVTDNAGGIAEMAELPSEVRTTTDALDA
VGNTTKAVTKGYAIGSAGLGALVLFAAYAEDLSYFTARATEGSFFYNITVDFSIANPYVVVGLLFGGLLPFLFGGMSMMA
VGRAAQAVVEEVRRQFREMPGIMKGEVKPDYGRAVDMLTQAAIKEMIIPSLLPVLSPIILFGVILVIGGPGEALASVGAM
LLGVIVTGLFVAISMTSGGGAWDNAKKYIEDGHHGGKGSEAHKAAVTGDTVGDPYKDTAGPAVNPMIKITNIVALLMLAV
LAGH

Specific function: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force [H]

COG id: COG3808

COG function: function code C; Inorganic pyrophosphatase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004131 [H]

Pfam domain/function: PF03030 H_PPase [H]

EC number: =3.6.1.1 [H]

Molecular weight: Translated: 74191; Mature: 74060

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTWYALALGAGILSVLYGWVQIQSIMKAPAGNARMLEIAAAIQEGANAYLKRQYRTIGIV
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVVVAIVLVILLGWKAALGFVIGAVLSGAAGYIGMLVSVRANVRTTEASRHGLNEGLKMA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCEECHHHHHCHHHHHHHH
FKSGAVTGMLVVGLALIGIVGYYGLLTGPLGLSLGDEDQKREIIDALVSLGFGASLISIF
HHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHH
ARLGGGIFTKGADVGGDMVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYA
HHHCCCEEECCCCCCCCHHHHHCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHH
VTLVATMVLGGIYFAATPYIAEIMMLPLAIGAVCIVTSIIGSFFATLSKGSTNVMGALYK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
ALNVTGVLSIGGLAIAIHTVLPGGLGGTLEGAGALLGLVDPATGQAADITGWHLFACGVV
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHEEECCCCCCCCCCCHHHHHHHHHH
GLFVTLLIVVITAYYTETKYRPVRSIAKASESGHGTNVIQGLAVSLEATALPALTIIGGI
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LLTYNLAGLYGIAIATTTMLALAGMIVALDAFGPVTDNAGGIAEMAELPSEVRTTTDALD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCHHHHHHHHHHHH
AVGNTTKAVTKGYAIGSAGLGALVLFAAYAEDLSYFTARATEGSFFYNITVDFSIANPYV
HHCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCHHH
VVGLLFGGLLPFLFGGMSMMAVGRAAQAVVEEVRRQFREMPGIMKGEVKPDYGRAVDMLT
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
QAAIKEMIIPSLLPVLSPIILFGVILVIGGPGEALASVGAMLLGVIVTGLFVAISMTSGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHEECCCC
GAWDNAKKYIEDGHHGGKGSEAHKAAVTGDTVGDPYKDTAGPAVNPMIKITNIVALLMLA
CCCHHHHHHHHCCCCCCCCCCCCHHEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
VLAGH
HHHCC
>Mature Secondary Structure 
TWYALALGAGILSVLYGWVQIQSIMKAPAGNARMLEIAAAIQEGANAYLKRQYRTIGIV
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVVVAIVLVILLGWKAALGFVIGAVLSGAAGYIGMLVSVRANVRTTEASRHGLNEGLKMA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCEECHHHHHCHHHHHHHH
FKSGAVTGMLVVGLALIGIVGYYGLLTGPLGLSLGDEDQKREIIDALVSLGFGASLISIF
HHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHH
ARLGGGIFTKGADVGGDMVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYA
HHHCCCEEECCCCCCCCHHHHHCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHH
VTLVATMVLGGIYFAATPYIAEIMMLPLAIGAVCIVTSIIGSFFATLSKGSTNVMGALYK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
ALNVTGVLSIGGLAIAIHTVLPGGLGGTLEGAGALLGLVDPATGQAADITGWHLFACGVV
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHEEECCCCCCCCCCCHHHHHHHHHH
GLFVTLLIVVITAYYTETKYRPVRSIAKASESGHGTNVIQGLAVSLEATALPALTIIGGI
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LLTYNLAGLYGIAIATTTMLALAGMIVALDAFGPVTDNAGGIAEMAELPSEVRTTTDALD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCHHHHHHHHHHHH
AVGNTTKAVTKGYAIGSAGLGALVLFAAYAEDLSYFTARATEGSFFYNITVDFSIANPYV
HHCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCHHH
VVGLLFGGLLPFLFGGMSMMAVGRAAQAVVEEVRRQFREMPGIMKGEVKPDYGRAVDMLT
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
QAAIKEMIIPSLLPVLSPIILFGVILVIGGPGEALASVGAMLLGVIVTGLFVAISMTSGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHEECCCC
GAWDNAKKYIEDGHHGGKGSEAHKAAVTGDTVGDPYKDTAGPAVNPMIKITNIVALLMLA
CCCHHHHHHHHCCCCCCCCCCCCHHEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
VLAGH
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]