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The map label for this gene is nrdB [H]

Identifier: 114332419

GI number: 114332419

Start: 2591630

End: 2592763

Strand: Direct

Name: nrdB [H]

Synonym: Neut_2468

Alternate gene names: 114332419

Gene position: 2591630-2592763 (Clockwise)

Preceding gene: 114332418

Following gene: 114332420

Centisome position: 97.39

GC content: 46.3

Gene sequence:

>1134_bases
ATGTTGAATTTTGAAGATGAAGTATTTCAGCCGAGAAATATCCCAGCAAGCGTCCCCACACAAAAAACAACTGCTGAACA
GCAAGGGCTGCACGAAGAAATATCAGCAGAAAATCATCGCCGGGTTTCCGTAGAAGACAAGCGCATTATTAATTGCAAGG
CGGATGTTAATCAGCTGGTGCCATTTAAATACAAATGGGCATGGGAAAAATATCTGTCAGCCTGTGCCAACCACTGGATG
CCGCAAGAAATCAACATGACGCGTGATATTGCCCTGTGGAAAGATCCCAATGGGTTGACTGAGGACGAGCGCCGTATCGT
CAAGCGTAACCTCGGTTTTTTCGTCACGGCTGATTCACTGGCGGCCAACAATATCGTGCTGGGAACCTACCGGCACATTA
CCAATCCCGAATGCCGCCAGTATTTATTGCGTCAGGCTTTTGAGGAAGCAATCCACACGCACGCTTATCAATATATTGTC
GAATCGATTGGCCTGGATGAAGGCGAAATCTTTAATGCCTATCATGAAATCAAATCGATTCGTGACAAGGACGAATTTCT
GATTCCCTTCATCGACACATTGACGAATCCCACGTTTCAGACAGGCACGCTGGAAACTGATCAGCAGCTGCTAAAAAGTC
TGATTGTGTTTGCCTGCATTATGGAAGGGCTGTTTTTCTATGTTGGATTTGTGCAGATTCTGTCCCTTGGCCGGCAAAAC
AAGATGACCGGGGCTGCTGAGCAGTATCAGTACATCCTGCGTGATGAATCCATGCATTGTAATTTTGGCATTGATGTTAT
CAACCAGATAAAGCTGGAAAATCCACATTTATGGACGCGCGAGTTTCGGGAAGAAATCAGTGCACTCATGCGCAAGGCGG
TGGAGCTGGAGTACCGTTACGCGGAAGATACCATGCCGCGCGGCGTACTGGGATTGAATGCACCCATGTTCAAGGAATAT
CTGCGCTTCATTATCAATCGCCGTAGCCATCAGATCGGGCTTGATCCATTATTTCCCGAAGCAGGCAATCCTTTTCCGTG
GATGTCAGAAATGGTTGATTTGAAAAAAGAAAAAAACTTCTTTGAAACTCGTGTAATTGAATACCAGACGGGAGGCGTAT
TAAGCTGGGATTGA

Upstream 100 bases:

>100_bases
CACAAAACAGTGCGCGATCGACGATCCTGAATGTGAAGCGTGTCAGTAAGTATTGAAAAATTTCCCCAGATAATTCAAAA
ATATAAAGAGGAATAAAAGG

Downstream 100 bases:

>100_bases
AATACTGATCAATCGATTGCTGATTGAAAAATGGTGTAGAATATTGGACGGGCCGGCTGGTTCACTTTAAAATTCAAAAA
TAGAGGTGACCAGCCTTTTT

Product: ribonucleotide-diphosphate reductase subunit beta

Products: NA

Alternate protein names: Ribonucleotide reductase small subunit [H]

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MLNFEDEVFQPRNIPASVPTQKTTAEQQGLHEEISAENHRRVSVEDKRIINCKADVNQLVPFKYKWAWEKYLSACANHWM
PQEINMTRDIALWKDPNGLTEDERRIVKRNLGFFVTADSLAANNIVLGTYRHITNPECRQYLLRQAFEEAIHTHAYQYIV
ESIGLDEGEIFNAYHEIKSIRDKDEFLIPFIDTLTNPTFQTGTLETDQQLLKSLIVFACIMEGLFFYVGFVQILSLGRQN
KMTGAAEQYQYILRDESMHCNFGIDVINQIKLENPHLWTREFREEISALMRKAVELEYRYAEDTMPRGVLGLNAPMFKEY
LRFIINRRSHQIGLDPLFPEAGNPFPWMSEMVDLKKEKNFFETRVIEYQTGGVLSWD

Sequences:

>Translated_377_residues
MLNFEDEVFQPRNIPASVPTQKTTAEQQGLHEEISAENHRRVSVEDKRIINCKADVNQLVPFKYKWAWEKYLSACANHWM
PQEINMTRDIALWKDPNGLTEDERRIVKRNLGFFVTADSLAANNIVLGTYRHITNPECRQYLLRQAFEEAIHTHAYQYIV
ESIGLDEGEIFNAYHEIKSIRDKDEFLIPFIDTLTNPTFQTGTLETDQQLLKSLIVFACIMEGLFFYVGFVQILSLGRQN
KMTGAAEQYQYILRDESMHCNFGIDVINQIKLENPHLWTREFREEISALMRKAVELEYRYAEDTMPRGVLGLNAPMFKEY
LRFIINRRSHQIGLDPLFPEAGNPFPWMSEMVDLKKEKNFFETRVIEYQTGGVLSWD
>Mature_377_residues
MLNFEDEVFQPRNIPASVPTQKTTAEQQGLHEEISAENHRRVSVEDKRIINCKADVNQLVPFKYKWAWEKYLSACANHWM
PQEINMTRDIALWKDPNGLTEDERRIVKRNLGFFVTADSLAANNIVLGTYRHITNPECRQYLLRQAFEEAIHTHAYQYIV
ESIGLDEGEIFNAYHEIKSIRDKDEFLIPFIDTLTNPTFQTGTLETDQQLLKSLIVFACIMEGLFFYVGFVQILSLGRQN
KMTGAAEQYQYILRDESMHCNFGIDVINQIKLENPHLWTREFREEISALMRKAVELEYRYAEDTMPRGVLGLNAPMFKEY
LRFIINRRSHQIGLDPLFPEAGNPFPWMSEMVDLKKEKNFFETRVIEYQTGGVLSWD

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0208

COG function: function code F; Ribonucleotide reductase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribonucleoside diphosphate reductase small chain family [H]

Homologues:

Organism=Homo sapiens, GI42544136, Length=320, Percent_Identity=26.25, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI289177074, Length=320, Percent_Identity=25.9375, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI4557845, Length=362, Percent_Identity=26.5193370165746, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI260064013, Length=362, Percent_Identity=26.5193370165746, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI289177076, Length=296, Percent_Identity=26.0135135135135, Blast_Score=117, Evalue=2e-26,
Organism=Escherichia coli, GI1788567, Length=292, Percent_Identity=25, Blast_Score=94, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17551968, Length=319, Percent_Identity=27.2727272727273, Blast_Score=128, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI193206379, Length=304, Percent_Identity=21.3815789473684, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6322434, Length=331, Percent_Identity=29.9093655589124, Blast_Score=149, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6321619, Length=319, Percent_Identity=23.1974921630094, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI18079279, Length=320, Percent_Identity=27.5, Blast_Score=141, Evalue=7e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009078
- InterPro:   IPR012348
- InterPro:   IPR000358 [H]

Pfam domain/function: PF00268 Ribonuc_red_sm [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 44095; Mature: 44095

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNFEDEVFQPRNIPASVPTQKTTAEQQGLHEEISAENHRRVSVEDKRIINCKADVNQLV
CCCCCCHHCCCCCCCCCCCCCHHHHHHHCCHHHHCCCCCCEEEECCCEEEECHHCHHHCC
PFKYKWAWEKYLSACANHWMPQEINMTRDIALWKDPNGLTEDERRIVKRNLGFFVTADSL
CCEEHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCEEEEECCC
AANNIVLGTYRHITNPECRQYLLRQAFEEAIHTHAYQYIVESIGLDEGEIFNAYHEIKSI
CCCCEEEECHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
RDKDEFLIPFIDTLTNPTFQTGTLETDQQLLKSLIVFACIMEGLFFYVGFVQILSLGRQN
CCCCCEEHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
KMTGAAEQYQYILRDESMHCNFGIDVINQIKLENPHLWTREFREEISALMRKAVELEYRY
CCCCHHHHHHHHHCCCCCCCCCCHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AEDTMPRGVLGLNAPMFKEYLRFIINRRSHQIGLDPLFPEAGNPFPWMSEMVDLKKEKNF
HCCCCCCCEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCH
FETRVIEYQTGGVLSWD
HHHHEEEEECCCEECCC
>Mature Secondary Structure
MLNFEDEVFQPRNIPASVPTQKTTAEQQGLHEEISAENHRRVSVEDKRIINCKADVNQLV
CCCCCCHHCCCCCCCCCCCCCHHHHHHHCCHHHHCCCCCCEEEECCCEEEECHHCHHHCC
PFKYKWAWEKYLSACANHWMPQEINMTRDIALWKDPNGLTEDERRIVKRNLGFFVTADSL
CCEEHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCEEEEECCC
AANNIVLGTYRHITNPECRQYLLRQAFEEAIHTHAYQYIVESIGLDEGEIFNAYHEIKSI
CCCCEEEECHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
RDKDEFLIPFIDTLTNPTFQTGTLETDQQLLKSLIVFACIMEGLFFYVGFVQILSLGRQN
CCCCCEEHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
KMTGAAEQYQYILRDESMHCNFGIDVINQIKLENPHLWTREFREEISALMRKAVELEYRY
CCCCHHHHHHHHHCCCCCCCCCCHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AEDTMPRGVLGLNAPMFKEYLRFIINRRSHQIGLDPLFPEAGNPFPWMSEMVDLKKEKNF
HCCCCCCCEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCH
FETRVIEYQTGGVLSWD
HHHHEEEEECCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]