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The map label for this gene is rfbD [H]

Identifier: 114332357

GI number: 114332357

Start: 2515069

End: 2515956

Strand: Direct

Name: rfbD [H]

Synonym: Neut_2401

Alternate gene names: 114332357

Gene position: 2515069-2515956 (Clockwise)

Preceding gene: 114332356

Following gene: 114332361

Centisome position: 94.51

GC content: 47.07

Gene sequence:

>888_bases
TTGCTCTTTGGTAAAAATGGCCAGGTCGGCTGGGAGCTACAGCGTAGCCTGGCTCCGTTGGGCAAATTGATTGCGCTGGA
TCGACGGGATTTACACTATTGCGGCGATCTGACAAATCTGGCAGGAATGACACATACGCTGCAGGCTATTCGCCCTGACG
TTATCGTCAATGCAGCAGCGTATACCGCGGTTGACCAGGCAGAAAATGAGCCAGAACTAGCTTTTCGCATCAATACCGAG
GCGCCTGAATTACTAGCGCAACTGGCTGAACAAATGGGTGCCTGGCTGATTCATTATTCTACCGATTATGTATTCGATGG
TAGTGGTGAGCGCCCATGGTTGGAAACAGATCCAACTTTACCCGTTAATATTTATGGCCAGAGTAAATTACGGGGTGAAG
AATCAATCCGGAAATCAAACTGCAAGCACCTGATTTTACGCACCAGTTGGGTCTACGCAGCTCGCGGAAAGAATTTCATA
AGAACCATTTTGCGACTCGCGCAAGAAAAAGAGCAGCTGACAATTATTGATGACCAGATCGGAGCGCCTACAGGTGCGGA
ACTACTGGCTGATGTAACAGCTCAGGCCATTCCACAATTACTGAGGCATCCTGAAAAATCAGGTATCTATCATGTTACGG
CTAATGGAGAAGTTTCCTGGTGCAACTACGCACAATTTTTGCTGAACTTTGCTTGTGAACACAATCTTCTGGTCAAGGTC
CGCCCAAGTGCAGTCACTCCGATTCACAGCAAGGCTTTTGTAACGTCTGCCAAACGCCCTTTAAATTCGCGTTTGAATAC
AGATAAGTTGCGCAATACTTTCAATCTCTATCTCCCACACTGGCAAACCGGAGTGACTCGTATGCTAAGTGAAATTTACT
CACAGTAA

Upstream 100 bases:

>100_bases
AATGGTATCTGGAAAATCATGACTGGGTTGCAGAAGTGCAATCGGGCGACTACCGGAAATGGGTTGAAATTAACTATACC
GGGCGATCACAGTGAAAATA

Downstream 100 bases:

>100_bases
AACCAGCACTCAGCGGATAAGCCACGCAAATCTAGTATCGGTCAGTAAATCTGTTGCGACCCGACCAAACCGCTTGGCAA
AGCGTTCTGTAATCCCTTCC

Product: dTDP-4-dehydrorhamnose reductase

Products: NA

Alternate protein names: dTDP-4-keto-L-rhamnose reductase; dTDP-6-deoxy-L-lyxo-4-hexulose reductase; dTDP-6-deoxy-L-mannose dehydrogenase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MLFGKNGQVGWELQRSLAPLGKLIALDRRDLHYCGDLTNLAGMTHTLQAIRPDVIVNAAAYTAVDQAENEPELAFRINTE
APELLAQLAEQMGAWLIHYSTDYVFDGSGERPWLETDPTLPVNIYGQSKLRGEESIRKSNCKHLILRTSWVYAARGKNFI
RTILRLAQEKEQLTIIDDQIGAPTGAELLADVTAQAIPQLLRHPEKSGIYHVTANGEVSWCNYAQFLLNFACEHNLLVKV
RPSAVTPIHSKAFVTSAKRPLNSRLNTDKLRNTFNLYLPHWQTGVTRMLSEIYSQ

Sequences:

>Translated_295_residues
MLFGKNGQVGWELQRSLAPLGKLIALDRRDLHYCGDLTNLAGMTHTLQAIRPDVIVNAAAYTAVDQAENEPELAFRINTE
APELLAQLAEQMGAWLIHYSTDYVFDGSGERPWLETDPTLPVNIYGQSKLRGEESIRKSNCKHLILRTSWVYAARGKNFI
RTILRLAQEKEQLTIIDDQIGAPTGAELLADVTAQAIPQLLRHPEKSGIYHVTANGEVSWCNYAQFLLNFACEHNLLVKV
RPSAVTPIHSKAFVTSAKRPLNSRLNTDKLRNTFNLYLPHWQTGVTRMLSEIYSQ
>Mature_295_residues
MLFGKNGQVGWELQRSLAPLGKLIALDRRDLHYCGDLTNLAGMTHTLQAIRPDVIVNAAAYTAVDQAENEPELAFRINTE
APELLAQLAEQMGAWLIHYSTDYVFDGSGERPWLETDPTLPVNIYGQSKLRGEESIRKSNCKHLILRTSWVYAARGKNFI
RTILRLAQEKEQLTIIDDQIGAPTGAELLADVTAQAIPQLLRHPEKSGIYHVTANGEVSWCNYAQFLLNFACEHNLLVKV
RPSAVTPIHSKAFVTSAKRPLNSRLNTDKLRNTFNLYLPHWQTGVTRMLSEIYSQ

Specific function: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose. RmlD uses NADH and NADPH nearly equally well [H]

COG id: COG1091

COG function: function code M; dTDP-4-dehydrorhamnose reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose reductase family [H]

Homologues:

Organism=Homo sapiens, GI11034825, Length=242, Percent_Identity=29.3388429752066, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI33519455, Length=239, Percent_Identity=29.2887029288703, Blast_Score=95, Evalue=6e-20,
Organism=Escherichia coli, GI1788352, Length=294, Percent_Identity=54.0816326530612, Blast_Score=342, Evalue=2e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005913
- InterPro:   IPR016040 [H]

Pfam domain/function: PF04321 RmlD_sub_bind [H]

EC number: =1.1.1.133 [H]

Molecular weight: Translated: 33164; Mature: 33164

Theoretical pI: Translated: 7.63; Mature: 7.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFGKNGQVGWELQRSLAPLGKLIALDRRDLHYCGDLTNLAGMTHTLQAIRPDVIVNAAA
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHCCCCEEEHHH
YTAVDQAENEPELAFRINTEAPELLAQLAEQMGAWLIHYSTDYVFDGSGERPWLETDPTL
HHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHCCEEEEECCCEEECCCCCCCCCCCCCCC
PVNIYGQSKLRGEESIRKSNCKHLILRTSWVYAARGKNFIRTILRLAQEKEQLTIIDDQI
EEEECCCCCCCCHHHHHHCCCCEEEEEEEEEEECCCCHHHHHHHHHHHCCCCEEEEECCC
GAPTGAELLADVTAQAIPQLLRHPEKSGIYHVTANGEVSWCNYAQFLLNFACEHNLLVKV
CCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEE
RPSAVTPIHSKAFVTSAKRPLNSRLNTDKLRNTFNLYLPHWQTGVTRMLSEIYSQ
CCCCCCCCCHHHHHHHHCCCHHCCCCHHHHHCEEEEECCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLFGKNGQVGWELQRSLAPLGKLIALDRRDLHYCGDLTNLAGMTHTLQAIRPDVIVNAAA
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHCCCCEEEHHH
YTAVDQAENEPELAFRINTEAPELLAQLAEQMGAWLIHYSTDYVFDGSGERPWLETDPTL
HHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHCCEEEEECCCEEECCCCCCCCCCCCCCC
PVNIYGQSKLRGEESIRKSNCKHLILRTSWVYAARGKNFIRTILRLAQEKEQLTIIDDQI
EEEECCCCCCCCHHHHHHCCCCEEEEEEEEEEECCCCHHHHHHHHHHHCCCCEEEEECCC
GAPTGAELLADVTAQAIPQLLRHPEKSGIYHVTANGEVSWCNYAQFLLNFACEHNLLVKV
CCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEE
RPSAVTPIHSKAFVTSAKRPLNSRLNTDKLRNTFNLYLPHWQTGVTRMLSEIYSQ
CCCCCCCCCHHHHHHHHCCCHHCCCCHHHHHCEEEEECCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1710759; 11677609 [H]