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The map label for this gene is hprK [H]

Identifier: 114332266

GI number: 114332266

Start: 2430738

End: 2431709

Strand: Direct

Name: hprK [H]

Synonym: Neut_2306

Alternate gene names: 114332266

Gene position: 2430738-2431709 (Clockwise)

Preceding gene: 114332265

Following gene: 114332267

Centisome position: 91.34

GC content: 46.91

Gene sequence:

>972_bases
ATGTCTCAGGTTAGCGTCAAACAACTATTTGAAGAAAACAAGGAAAAATTATGTCTGCAATGGGGTGAACCGCCGCCTGC
CATAGACAGGCGGCTTGAGAATCACCTGATCGCCAGCTCAACACAGGAACTGATCGGTCATCTCAACTTTGTTCATCCCA
ACTGGATACAGGTTCTGAACCAGATATCCGTCAAATATCTTGAACAGCTTGATGATTTTTCTCTTCAAAAAAGGCTAAAT
CAACTAGCTAGAAGTCAACTTTCCTGTCTGATCGTAGCAGACGGTGCGCCAATCCCGTATTCCATCAGACAGTTCGTGAA
TGAACACTCTATCCCGCTGATTCGTTCAGAAATTGCCAGCCTTGAGATTATCTGGGGATTGCAAACCTATCTTGTGAGAG
TACTGGCGCCCGTTATCAGTCGGCATGGTGTATTACTGGATGTACTTGGAATGGGTGTCATGATCACCGGAGAGAGTGGC
GTTGGTAAAAGTGAACTCGCTCTGGAGCTTATCAGCCGCGGACACGGCCTGGTTGCAGATGATGTCGTCGAATTACGCCG
TATTGGCCCTGAAACGCTGGAAGGCAGGTGTCCGCCGCTGTTGCGAGATTTTCTTGAAGTACGCGGACTGGGATTGCTGA
ATATTCGTACCATATTCGGAGAAACTGCAATTCGGCGACACAAAAATATGAAGCTGATCGTGCAGCTTGAAAAAACTGCT
GGCAGTAGTATTAATGCTTATGAACGACTGCCACTGAGTAACCTCAACGAAATTATTCTGAATGTCAGTATCCGCAAGGT
GACTATTCCAGTTGCCGCCGGCCGTAATCTGGCAGTATTGGTAGAAGCAGCAGTCCGGAATTATATTTTGCAACTCCGGG
GAATTGACAGTACCCAGGAATTTGTCCGCCGACATGAATCAGAAATGAATGGGAATACCGCAGAGCACTTCGACGATCCT
CATACTGAATGA

Upstream 100 bases:

>100_bases
CTAGCACAAATGTTTAGTAATAAAAGCTTCCGCGAAAAACTGCGCCATGGCCGGAGTGCTAAAGAAATTCATCAACTCAT
CTCCGAGTGGACGCCTGAAC

Downstream 100 bases:

>100_bases
AGTGTAAAGTAAAAATCTGCCATATAACTACCTTGCTTCTATATGAAAACTCTGGAAAAAGAACAGGCTATGACAAAGCA
AATCCAGATAAAATATACGA

Product: HPr kinase/phosphorylase

Products: NA

Alternate protein names: HPrK/P; HPr(Ser) kinase/phosphorylase [H]

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MSQVSVKQLFEENKEKLCLQWGEPPPAIDRRLENHLIASSTQELIGHLNFVHPNWIQVLNQISVKYLEQLDDFSLQKRLN
QLARSQLSCLIVADGAPIPYSIRQFVNEHSIPLIRSEIASLEIIWGLQTYLVRVLAPVISRHGVLLDVLGMGVMITGESG
VGKSELALELISRGHGLVADDVVELRRIGPETLEGRCPPLLRDFLEVRGLGLLNIRTIFGETAIRRHKNMKLIVQLEKTA
GSSINAYERLPLSNLNEIILNVSIRKVTIPVAAGRNLAVLVEAAVRNYILQLRGIDSTQEFVRRHESEMNGNTAEHFDDP
HTE

Sequences:

>Translated_323_residues
MSQVSVKQLFEENKEKLCLQWGEPPPAIDRRLENHLIASSTQELIGHLNFVHPNWIQVLNQISVKYLEQLDDFSLQKRLN
QLARSQLSCLIVADGAPIPYSIRQFVNEHSIPLIRSEIASLEIIWGLQTYLVRVLAPVISRHGVLLDVLGMGVMITGESG
VGKSELALELISRGHGLVADDVVELRRIGPETLEGRCPPLLRDFLEVRGLGLLNIRTIFGETAIRRHKNMKLIVQLEKTA
GSSINAYERLPLSNLNEIILNVSIRKVTIPVAAGRNLAVLVEAAVRNYILQLRGIDSTQEFVRRHESEMNGNTAEHFDDP
HTE
>Mature_322_residues
SQVSVKQLFEENKEKLCLQWGEPPPAIDRRLENHLIASSTQELIGHLNFVHPNWIQVLNQISVKYLEQLDDFSLQKRLNQ
LARSQLSCLIVADGAPIPYSIRQFVNEHSIPLIRSEIASLEIIWGLQTYLVRVLAPVISRHGVLLDVLGMGVMITGESGV
GKSELALELISRGHGLVADDVVELRRIGPETLEGRCPPLLRDFLEVRGLGLLNIRTIFGETAIRRHKNMKLIVQLEKTAG
SSINAYERLPLSNLNEIILNVSIRKVTIPVAAGRNLAVLVEAAVRNYILQLRGIDSTQEFVRRHESEMNGNTAEHFDDPH
TE

Specific function: Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-pr

COG id: COG1493

COG function: function code T; Serine kinase of the HPr protein, regulates carbohydrate metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPrK/P family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002078
- InterPro:   IPR003755
- InterPro:   IPR011104
- InterPro:   IPR011126 [H]

Pfam domain/function: PF07475 Hpr_kinase_C; PF02603 Hpr_kinase_N [H]

EC number: NA

Molecular weight: Translated: 36255; Mature: 36123

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00675 SIGMA54_INTERACT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQVSVKQLFEENKEKLCLQWGEPPPAIDRRLENHLIASSTQELIGHLNFVHPNWIQVLN
CCCCHHHHHHHCCHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
QISVKYLEQLDDFSLQKRLNQLARSQLSCLIVADGAPIPYSIRQFVNEHSIPLIRSEIAS
HHHHHHHHHHCCHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHCCCCCCHHHHHHHH
LEIIWGLQTYLVRVLAPVISRHGVLLDVLGMGVMITGESGVGKSELALELISRGHGLVAD
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCEEEECCCCCCHHHHHHHHHHCCCCCHHH
DVVELRRIGPETLEGRCPPLLRDFLEVRGLGLLNIRTIFGETAIRRHKNMKLIVQLEKTA
HHHHHHHCCCHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCC
GSSINAYERLPLSNLNEIILNVSIRKVTIPVAAGRNLAVLVEAAVRNYILQLRGIDSTQE
CCCCCHHHCCCCCHHHHHHHEEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHH
FVRRHESEMNGNTAEHFDDPHTE
HHHHHHHHCCCCCHHHCCCCCCC
>Mature Secondary Structure 
SQVSVKQLFEENKEKLCLQWGEPPPAIDRRLENHLIASSTQELIGHLNFVHPNWIQVLN
CCCHHHHHHHCCHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
QISVKYLEQLDDFSLQKRLNQLARSQLSCLIVADGAPIPYSIRQFVNEHSIPLIRSEIAS
HHHHHHHHHHCCHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHCCCCCCHHHHHHHH
LEIIWGLQTYLVRVLAPVISRHGVLLDVLGMGVMITGESGVGKSELALELISRGHGLVAD
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCEEEECCCCCCHHHHHHHHHHCCCCCHHH
DVVELRRIGPETLEGRCPPLLRDFLEVRGLGLLNIRTIFGETAIRRHKNMKLIVQLEKTA
HHHHHHHCCCHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCC
GSSINAYERLPLSNLNEIILNVSIRKVTIPVAAGRNLAVLVEAAVRNYILQLRGIDSTQE
CCCCCHHHCCCCCHHHHHHHEEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHH
FVRRHESEMNGNTAEHFDDPHTE
HHHHHHHHCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12700255 [H]