Click here to switch to the map view.

The map label for this gene is folK [H]

Identifier: 114332255

GI number: 114332255

Start: 2420657

End: 2421169

Strand: Reverse

Name: folK [H]

Synonym: Neut_2295

Alternate gene names: 114332255

Gene position: 2421169-2420657 (Counterclockwise)

Preceding gene: 114332256

Following gene: 114332254

Centisome position: 90.99

GC content: 47.95

Gene sequence:

>513_bases
ATGACATCTGATTTTCATCCTGAATCTATCAGCCGTATTTTTATTGCATTAGGCAGCAACCTGGAAAATCCTTTGTCTCA
GGTCAGGCGTGGAATACTGCTGTTAGCCGAGCTGGAACATTCACGTCTGGTAAAACGTTCTTCGTTTTACCGCACTGCTC
CGATTGGCAATACCGATCAGCCCGATTTCATCAATGCGGTAGTACAGATGGAAACAAATCTGACACCGCATCACCTGCTC
GATACTCTACTGGAAATCGAGCGTGCTTGCGGTCGTGTGCGTACTTTTCCCAACGCCCCACGCATCCTTGATCTGGATAT
TCTGTTATTTGGAAACCTGCAACACAGTGATACAAAACTGGTGTTGCCACATCCACGTATGCATGAGCGCGCTTTTGTAC
TGCAACCCTTGCTGGAAATCGCAGCAGATTGCGTGATTCCGGGAAGAGGCCCAGCTGCCGCTTGTCTGGCTGCGTGTATG
AAACAACCATTGGAGTATATTGCATCATCATGA

Upstream 100 bases:

>100_bases
TGTTGCTGCAGGAAGCCCCGACAAAACGTCGCAGAAAACGTCGCCGTAGCAGTCAATCGGAAAGTGTAAAAGTAGACTCT
CCCATTAATCAGGATATTTC

Downstream 100 bases:

>100_bases
ATCTTGAGCGCTGCCGCTATATTGTTGTTGAAGGACCTGTCGGTGCGGGTAAGACCAGCCTTGCCCGTAATATGGCAACC
CGTTTGAACTGTTCACTTAT

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 170; Mature: 169

Protein sequence:

>170_residues
MTSDFHPESISRIFIALGSNLENPLSQVRRGILLLAELEHSRLVKRSSFYRTAPIGNTDQPDFINAVVQMETNLTPHHLL
DTLLEIERACGRVRTFPNAPRILDLDILLFGNLQHSDTKLVLPHPRMHERAFVLQPLLEIAADCVIPGRGPAAACLAACM
KQPLEYIASS

Sequences:

>Translated_170_residues
MTSDFHPESISRIFIALGSNLENPLSQVRRGILLLAELEHSRLVKRSSFYRTAPIGNTDQPDFINAVVQMETNLTPHHLL
DTLLEIERACGRVRTFPNAPRILDLDILLFGNLQHSDTKLVLPHPRMHERAFVLQPLLEIAADCVIPGRGPAAACLAACM
KQPLEYIASS
>Mature_169_residues
TSDFHPESISRIFIALGSNLENPLSQVRRGILLLAELEHSRLVKRSSFYRTAPIGNTDQPDFINAVVQMETNLTPHHLLD
TLLEIERACGRVRTFPNAPRILDLDILLFGNLQHSDTKLVLPHPRMHERAFVLQPLLEIAADCVIPGRGPAAACLAACMK
QPLEYIASS

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=135, Percent_Identity=47.4074074074074, Blast_Score=122, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6324073, Length=135, Percent_Identity=39.2592592592593, Blast_Score=93, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 18941; Mature: 18810

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSDFHPESISRIFIALGSNLENPLSQVRRGILLLAELEHSRLVKRSSFYRTAPIGNTDQ
CCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCC
PDFINAVVQMETNLTPHHLLDTLLEIERACGRVRTFPNAPRILDLDILLFGNLQHSDTKL
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCCCEE
VLPHPRMHERAFVLQPLLEIAADCVIPGRGPAAACLAACMKQPLEYIASS
ECCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSDFHPESISRIFIALGSNLENPLSQVRRGILLLAELEHSRLVKRSSFYRTAPIGNTDQ
CCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCC
PDFINAVVQMETNLTPHHLLDTLLEIERACGRVRTFPNAPRILDLDILLFGNLQHSDTKL
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCCCEE
VLPHPRMHERAFVLQPLLEIAADCVIPGRGPAAACLAACMKQPLEYIASS
ECCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10080886 [H]