Click here to switch to the map view.

The map label for this gene is purM

Identifier: 114332237

GI number: 114332237

Start: 2403703

End: 2404761

Strand: Direct

Name: purM

Synonym: Neut_2277

Alternate gene names: 114332237

Gene position: 2403703-2404761 (Clockwise)

Preceding gene: 114332234

Following gene: 114332238

Centisome position: 90.33

GC content: 50.33

Gene sequence:

>1059_bases
TTGACCGTATCCAATTCTACAGATCCTGACAAAAACCATATTTCCTACCGCACATCCGGTGTTGATATCGATGCGGGAAA
CCGCCTGGTGGAGATAATCAAACCTTTTGCACAGCGCACCCTACGCCCGGAAGCGCTGGGAGGGATCGGTGGATTTGGCG
CATTGTTCGAAGTCCCTGGAAAATATCGACAACCGGTACTGGTATCCGGAACGGATGGAGTCGGCACCAAACTCAAGCTG
GCATTCCAGTATGCACGACATGCAACTATTGGCATTGATCTGGTTGCCATGAGTGTGAACGATATTCTGGTACAAGGTGC
TGAACCACTATTCTTTCTGGATTATTTTGCCTGTGGCAAACTGGATGTAGAAACTGCTGCACAGGTGATTCAAGGCATTG
CGCACGGCTGTGAGCAAGCCGGCTGTGCGCTGATTGGAGGGGAAACAGCAGAGATGCCTGGCATGTACCCGGAAGGCGAA
TATGATTTGGCTGGTTTTGCTGTAGGTGTAGTGGAAAAAGATCAGATCATCGATGGTTCCAGCATCCGAGAAAACGATCT
TGTGCTGGGGATCGCCTCAAGCGGGCCGCATTCCAATGGATTTTCACTGATCCGCAAAATACTTGATCGTCATGCAGGGC
AACCTGATACTGGGCTTGATGAAACCTGGCTCGTAGATGCGCTCCTGGCACCGACTCGAATTTATGTGAAATCAATACTG
GCATTGCTGGCAGAATTGCCCGTCAAAGGATTGGCGCATATTACCGGTGGTGGGCTGCTTGAGAATATTCCACGTATCTT
GCCAGATAGCGTCATGGCCCATATCGACCAGAGTGCCTGGGTGCGCCCTCCCCTGTTTGACTGGCTGCAACAACATGGCA
ATGTCACGGACGAGGAAATGCTGCATGTTTTTAATTGTGGAATTGGCATGATTGTAATCGTAGCACCGGAGCATGCTTTG
ACTGCCACTAATATCCTGCGCAGCGGTGGTGAAACCGTGTGGCAAATCGGTGATATCAAATCGCGTAAACCTGGAACGCC
ATCTATCGTCATTACCTGA

Upstream 100 bases:

>100_bases
TACCAGAAAAAACGGGAATCCGGGGAATATTTGTTGTCCATTTACGGTAAAATCATGCCTCAAAGGCTGCACTCTAGTCT
TAATACTGCGAGAACTCAAC

Downstream 100 bases:

>100_bases
AGGAAAGGATCATGAAATCAATGGTGATCCTTATTTCCGGTCGCGGTAGCAATATGCAAGCGTTACTGAAGGCCGGGCTA
CCAGTTGCAGCAGTAATCAG

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MTVSNSTDPDKNHISYRTSGVDIDAGNRLVEIIKPFAQRTLRPEALGGIGGFGALFEVPGKYRQPVLVSGTDGVGTKLKL
AFQYARHATIGIDLVAMSVNDILVQGAEPLFFLDYFACGKLDVETAAQVIQGIAHGCEQAGCALIGGETAEMPGMYPEGE
YDLAGFAVGVVEKDQIIDGSSIRENDLVLGIASSGPHSNGFSLIRKILDRHAGQPDTGLDETWLVDALLAPTRIYVKSIL
ALLAELPVKGLAHITGGGLLENIPRILPDSVMAHIDQSAWVRPPLFDWLQQHGNVTDEEMLHVFNCGIGMIVIVAPEHAL
TATNILRSGGETVWQIGDIKSRKPGTPSIVIT

Sequences:

>Translated_352_residues
MTVSNSTDPDKNHISYRTSGVDIDAGNRLVEIIKPFAQRTLRPEALGGIGGFGALFEVPGKYRQPVLVSGTDGVGTKLKL
AFQYARHATIGIDLVAMSVNDILVQGAEPLFFLDYFACGKLDVETAAQVIQGIAHGCEQAGCALIGGETAEMPGMYPEGE
YDLAGFAVGVVEKDQIIDGSSIRENDLVLGIASSGPHSNGFSLIRKILDRHAGQPDTGLDETWLVDALLAPTRIYVKSIL
ALLAELPVKGLAHITGGGLLENIPRILPDSVMAHIDQSAWVRPPLFDWLQQHGNVTDEEMLHVFNCGIGMIVIVAPEHAL
TATNILRSGGETVWQIGDIKSRKPGTPSIVIT
>Mature_351_residues
TVSNSTDPDKNHISYRTSGVDIDAGNRLVEIIKPFAQRTLRPEALGGIGGFGALFEVPGKYRQPVLVSGTDGVGTKLKLA
FQYARHATIGIDLVAMSVNDILVQGAEPLFFLDYFACGKLDVETAAQVIQGIAHGCEQAGCALIGGETAEMPGMYPEGEY
DLAGFAVGVVEKDQIIDGSSIRENDLVLGIASSGPHSNGFSLIRKILDRHAGQPDTGLDETWLVDALLAPTRIYVKSILA
LLAELPVKGLAHITGGGLLENIPRILPDSVMAHIDQSAWVRPPLFDWLQQHGNVTDEEMLHVFNCGIGMIVIVAPEHALT
ATNILRSGGETVWQIGDIKSRKPGTPSIVIT

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=345, Percent_Identity=52.7536231884058, Blast_Score=355, Evalue=4e-98,
Organism=Homo sapiens, GI209869995, Length=345, Percent_Identity=52.7536231884058, Blast_Score=355, Evalue=4e-98,
Organism=Homo sapiens, GI209869993, Length=345, Percent_Identity=52.7536231884058, Blast_Score=355, Evalue=4e-98,
Organism=Escherichia coli, GI1788845, Length=333, Percent_Identity=60.0600600600601, Blast_Score=409, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17567511, Length=343, Percent_Identity=44.0233236151604, Blast_Score=265, Evalue=3e-71,
Organism=Saccharomyces cerevisiae, GI6321203, Length=356, Percent_Identity=48.314606741573, Blast_Score=326, Evalue=4e-90,
Organism=Drosophila melanogaster, GI24582400, Length=305, Percent_Identity=41.6393442622951, Blast_Score=232, Evalue=2e-61,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_NITEC (Q0ADT8)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_748459.1
- ProteinModelPortal:   Q0ADT8
- SMR:   Q0ADT8
- STRING:   Q0ADT8
- GeneID:   4274041
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_2277
- NMPDR:   fig|335283.3.peg.46
- eggNOG:   COG0150
- HOGENOM:   HBG531222
- OMA:   HYDLAGF
- PhylomeDB:   Q0ADT8
- ProtClustDB:   PRK05385
- BioCyc:   NEUT335283:NEUT_2277-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00741_B
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 37637; Mature: 37505

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVSNSTDPDKNHISYRTSGVDIDAGNRLVEIIKPFAQRTLRPEALGGIGGFGALFEVPG
CCCCCCCCCCCCCEEEEECCEEECCCHHHHHHHHHHHHHCCCHHHHCCCCCCHHHHHCCC
KYRQPVLVSGTDGVGTKLKLAFQYARHATIGIDLVAMSVNDILVQGAEPLFFLDYFACGK
CCCCCEEEECCCCCCCHHHHHHHHHHCCEEEEEEEEEEHHHHHHCCCCCEEEEHHHHCCC
LDVETAAQVIQGIAHGCEQAGCALIGGETAEMPGMYPEGEYDLAGFAVGVVEKDQIIDGS
CCHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCC
SIRENDLVLGIASSGPHSNGFSLIRKILDRHAGQPDTGLDETWLVDALLAPTRIYVKSIL
CCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ALLAELPVKGLAHITGGGLLENIPRILPDSVMAHIDQSAWVRPPLFDWLQQHGNVTDEEM
HHHHHCCHHHHHHHCCCHHHHHHHHHCHHHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHH
LHVFNCGIGMIVIVAPEHALTATNILRSGGETVWQIGDIKSRKPGTPSIVIT
HHHHHCCCCEEEEECCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEC
>Mature Secondary Structure 
TVSNSTDPDKNHISYRTSGVDIDAGNRLVEIIKPFAQRTLRPEALGGIGGFGALFEVPG
CCCCCCCCCCCCEEEEECCEEECCCHHHHHHHHHHHHHCCCHHHHCCCCCCHHHHHCCC
KYRQPVLVSGTDGVGTKLKLAFQYARHATIGIDLVAMSVNDILVQGAEPLFFLDYFACGK
CCCCCEEEECCCCCCCHHHHHHHHHHCCEEEEEEEEEEHHHHHHCCCCCEEEEHHHHCCC
LDVETAAQVIQGIAHGCEQAGCALIGGETAEMPGMYPEGEYDLAGFAVGVVEKDQIIDGS
CCHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCC
SIRENDLVLGIASSGPHSNGFSLIRKILDRHAGQPDTGLDETWLVDALLAPTRIYVKSIL
CCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ALLAELPVKGLAHITGGGLLENIPRILPDSVMAHIDQSAWVRPPLFDWLQQHGNVTDEEM
HHHHHCCHHHHHHHCCCHHHHHHHHHCHHHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHH
LHVFNCGIGMIVIVAPEHALTATNILRSGGETVWQIGDIKSRKPGTPSIVIT
HHHHHCCCCEEEEECCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA