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The map label for this gene is patA [H]

Identifier: 114332139

GI number: 114332139

Start: 2303880

End: 2305268

Strand: Direct

Name: patA [H]

Synonym: Neut_2174

Alternate gene names: 114332139

Gene position: 2303880-2305268 (Clockwise)

Preceding gene: 114332125

Following gene: 114332143

Centisome position: 86.58

GC content: 49.46

Gene sequence:

>1389_bases
ATGAAAATCCAGGATCTTATCCAGAATCGCGGCAGAGAAAATTTCTCCCTGCACGACAAGTACCTCAACAGCCAGATGGT
CAAGGTACTTAAAACAATCGATTTTGACCGTCATTATGTCAGAGCCCAGGGCGCTTACCTGTTTGATGATCAGGACAACC
GCTACCTGGATTTGTTGAGTGGTTTTGGTGTTTTCGCATTGGGACGCAACCACGCGGAGATCGTCGAAGTGCTTAAAAGC
ACAATGGAAGCTGATTTACCCAATCTCGTCCAGCTCGACGTATCGTTACTGGCCGGATTGTTAGCAGAAAAACTGGTCAA
GTTGACTCCGGGTGGATTAAATCGTGTTTTTTTTGCCAACTCAGGCACTGAAACAGTCGAAGCAGCGATTAAATTCAGCC
GTTATGCCACCGGAAAATCCAAAGTCATTTTCTGCCATGGTTGCTACCACGGACTGAGCCTCGGTTCGCTCTCCGCCACA
GGAGATGATCATTACAAAAAAGGTTTTGGCCCACTGGTACCTGATTTCATTGAAATCCCGTTCAACGATCTTGAAGCGCT
GGAGCAAGCACTTGCCCAAGGAGATGTTGCCGCCTTTATTACCGAACCGATTCAAGGACACGGCGTGTGGATACCGGATG
ATGACTATCTGCCGCAGGCAGCAAAGCTCGCCCGTAAATATGGTGCCGTATTCATCGTCGATGAAATACAAACCGGGCTG
GGTCGAACCGGTAAATGGTGGGCAGTTGAACACTGGTCGGTCGAGCCCGATATTATATGCATCTCCAAGACACTGTCCGG
AGGATTCGTTCCGGTAGGTGCATTGGTCTGCAGGGAATGGATCTTTGATCGTGTTTTCAATCGCATGGACCGTGCTGTCG
TCCATGGCAGTACATTTGGCAAAAACAATCTTGCAATGGCTGCCGGCCTGGCCACACTGGAAGTGCTGGAATCAGAAAAC
CTGATCGAACATTCCGCTCGCACTGGCACTGCCATCATGGAAGCACTAACCCCTCTGACGGAGCAATATGAATGCTTCAA
GGAAGTACGCGGCAAAGGAATGATGATTGCACTGGAATTTACCGAGCCGACAAAAAGCCTTTCGCTGAAACTGTCATGGA
AAATGCTTGAAGCTGCCAACAAAGGATTGTTTTCGCAGCTGATAACCGTCCCATTATTTAGGCAGCACCGGATTTTGTCC
CAGGTGGCCGGTCGCGATATGAATATCGTCAAGTTCATCCCGCCACTCATCCTGACGGAATCAGATGTGCAATGGATTGT
TTCAGCAGTCAGTGATGTTGTGGCCAGCGCGCATCGGGGCCCCGCTGCAGTCTGGGATTTTGGTAAAGTACTGGCAACCC
AGGCGCTTCGTACAAAACTACATACCTAA

Upstream 100 bases:

>100_bases
GCAGACGCATAACTCTGCTTAGATTAATGTAGAATGGCGCTGATTTTTTATACTCTTATACCCGCTTACCAGCATCCGTC
TCGCTCCGGAGTCCCCATTC

Downstream 100 bases:

>100_bases
GGAATTCCAAATTAATTTTGACTGTTCCATAAACAATTTCCCTTGCTTTCCGTATTAATACGCTCCAACAGCCGATCATG
CAACTCAAGTTCTGTTTGGC

Product: aminotransferase class-III

Products: NA

Alternate protein names: Putrescine--2-oxoglutaric acid transaminase; PAT; PATase [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MKIQDLIQNRGRENFSLHDKYLNSQMVKVLKTIDFDRHYVRAQGAYLFDDQDNRYLDLLSGFGVFALGRNHAEIVEVLKS
TMEADLPNLVQLDVSLLAGLLAEKLVKLTPGGLNRVFFANSGTETVEAAIKFSRYATGKSKVIFCHGCYHGLSLGSLSAT
GDDHYKKGFGPLVPDFIEIPFNDLEALEQALAQGDVAAFITEPIQGHGVWIPDDDYLPQAAKLARKYGAVFIVDEIQTGL
GRTGKWWAVEHWSVEPDIICISKTLSGGFVPVGALVCREWIFDRVFNRMDRAVVHGSTFGKNNLAMAAGLATLEVLESEN
LIEHSARTGTAIMEALTPLTEQYECFKEVRGKGMMIALEFTEPTKSLSLKLSWKMLEAANKGLFSQLITVPLFRQHRILS
QVAGRDMNIVKFIPPLILTESDVQWIVSAVSDVVASAHRGPAAVWDFGKVLATQALRTKLHT

Sequences:

>Translated_462_residues
MKIQDLIQNRGRENFSLHDKYLNSQMVKVLKTIDFDRHYVRAQGAYLFDDQDNRYLDLLSGFGVFALGRNHAEIVEVLKS
TMEADLPNLVQLDVSLLAGLLAEKLVKLTPGGLNRVFFANSGTETVEAAIKFSRYATGKSKVIFCHGCYHGLSLGSLSAT
GDDHYKKGFGPLVPDFIEIPFNDLEALEQALAQGDVAAFITEPIQGHGVWIPDDDYLPQAAKLARKYGAVFIVDEIQTGL
GRTGKWWAVEHWSVEPDIICISKTLSGGFVPVGALVCREWIFDRVFNRMDRAVVHGSTFGKNNLAMAAGLATLEVLESEN
LIEHSARTGTAIMEALTPLTEQYECFKEVRGKGMMIALEFTEPTKSLSLKLSWKMLEAANKGLFSQLITVPLFRQHRILS
QVAGRDMNIVKFIPPLILTESDVQWIVSAVSDVVASAHRGPAAVWDFGKVLATQALRTKLHT
>Mature_462_residues
MKIQDLIQNRGRENFSLHDKYLNSQMVKVLKTIDFDRHYVRAQGAYLFDDQDNRYLDLLSGFGVFALGRNHAEIVEVLKS
TMEADLPNLVQLDVSLLAGLLAEKLVKLTPGGLNRVFFANSGTETVEAAIKFSRYATGKSKVIFCHGCYHGLSLGSLSAT
GDDHYKKGFGPLVPDFIEIPFNDLEALEQALAQGDVAAFITEPIQGHGVWIPDDDYLPQAAKLARKYGAVFIVDEIQTGL
GRTGKWWAVEHWSVEPDIICISKTLSGGFVPVGALVCREWIFDRVFNRMDRAVVHGSTFGKNNLAMAAGLATLEVLESEN
LIEHSARTGTAIMEALTPLTEQYECFKEVRGKGMMIALEFTEPTKSLSLKLSWKMLEAANKGLFSQLITVPLFRQHRILS
QVAGRDMNIVKFIPPLILTESDVQWIVSAVSDVVASAHRGPAAVWDFGKVLATQALRTKLHT

Specific function: Catalyzes the aminotransferase reaction from putrescine to 2-oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. Is also able to transaminate cadaverine and, in lower extent, spermidine, but not ornithi

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. Putrescine aminotransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=406, Percent_Identity=34.4827586206897, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI284507298, Length=327, Percent_Identity=36.3914373088685, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI13994255, Length=405, Percent_Identity=29.6296296296296, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI37574042, Length=422, Percent_Identity=27.0142180094787, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI24119277, Length=423, Percent_Identity=28.3687943262411, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI226442705, Length=422, Percent_Identity=26.0663507109005, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI226442709, Length=360, Percent_Identity=26.6666666666667, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI188536080, Length=479, Percent_Identity=25.0521920668058, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI38679950, Length=479, Percent_Identity=25.0521920668058, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI38679946, Length=479, Percent_Identity=25.0521920668058, Blast_Score=108, Evalue=9e-24,
Organism=Escherichia coli, GI145693181, Length=400, Percent_Identity=37.5, Blast_Score=258, Evalue=5e-70,
Organism=Escherichia coli, GI1789759, Length=410, Percent_Identity=31.219512195122, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1788044, Length=421, Percent_Identity=32.3040380047506, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1787560, Length=418, Percent_Identity=28.7081339712919, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI1789016, Length=397, Percent_Identity=28.9672544080605, Blast_Score=142, Evalue=5e-35,
Organism=Escherichia coli, GI1786349, Length=309, Percent_Identity=32.0388349514563, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1786991, Length=420, Percent_Identity=28.3333333333333, Blast_Score=119, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI25144271, Length=406, Percent_Identity=31.0344827586207, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI25144274, Length=297, Percent_Identity=35.3535353535354, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI71992977, Length=439, Percent_Identity=28.246013667426, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI32564660, Length=444, Percent_Identity=28.3783783783784, Blast_Score=141, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI17541228, Length=416, Percent_Identity=27.4038461538462, Blast_Score=94, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323470, Length=420, Percent_Identity=29.2857142857143, Blast_Score=169, Evalue=9e-43,
Organism=Saccharomyces cerevisiae, GI6324432, Length=342, Percent_Identity=32.1637426900585, Blast_Score=152, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6324386, Length=337, Percent_Identity=25.8160237388724, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6321456, Length=174, Percent_Identity=29.3103448275862, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21357415, Length=405, Percent_Identity=30.6172839506173, Blast_Score=192, Evalue=4e-49,
Organism=Drosophila melanogaster, GI28574759, Length=433, Percent_Identity=27.9445727482679, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI161085790, Length=428, Percent_Identity=27.5700934579439, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI21356575, Length=411, Percent_Identity=28.9537712895377, Blast_Score=151, Evalue=7e-37,
Organism=Drosophila melanogaster, GI281366494, Length=397, Percent_Identity=24.1813602015113, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24667139, Length=397, Percent_Identity=24.1813602015113, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24667143, Length=397, Percent_Identity=24.1813602015113, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR010164
- InterPro:   IPR017747
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.82 [H]

Molecular weight: Translated: 51155; Mature: 51155

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIQDLIQNRGRENFSLHDKYLNSQMVKVLKTIDFDRHYVRAQGAYLFDDQDNRYLDLLS
CCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHEECCCEEEECCCCHHHHHHH
GFGVFALGRNHAEIVEVLKSTMEADLPNLVQLDVSLLAGLLAEKLVKLTPGGLNRVFFAN
CCCEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEC
SGTETVEAAIKFSRYATGKSKVIFCHGCYHGLSLGSLSATGDDHYKKGFGPLVPDFIEIP
CCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHCC
FNDLEALEQALAQGDVAAFITEPIQGHGVWIPDDDYLPQAAKLARKYGAVFIVDEIQTGL
CHHHHHHHHHHHCCCEEEEEECCCCCCEEECCCCCCCCHHHHHHHHHCCEEEEECHHHCC
GRTGKWWAVEHWSVEPDIICISKTLSGGFVPVGALVCREWIFDRVFNRMDRAVVHGSTFG
CCCCCEEEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
KNNLAMAAGLATLEVLESENLIEHSARTGTAIMEALTPLTEQYECFKEVRGKGMMIALEF
CCCHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
TEPTKSLSLKLSWKMLEAANKGLFSQLITVPLFRQHRILSQVAGRDMNIVKFIPPLILTE
CCCCCCEEEEEHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCHHCCC
SDVQWIVSAVSDVVASAHRGPAAVWDFGKVLATQALRTKLHT
CHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKIQDLIQNRGRENFSLHDKYLNSQMVKVLKTIDFDRHYVRAQGAYLFDDQDNRYLDLLS
CCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHEECCCEEEECCCCHHHHHHH
GFGVFALGRNHAEIVEVLKSTMEADLPNLVQLDVSLLAGLLAEKLVKLTPGGLNRVFFAN
CCCEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEC
SGTETVEAAIKFSRYATGKSKVIFCHGCYHGLSLGSLSATGDDHYKKGFGPLVPDFIEIP
CCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHCC
FNDLEALEQALAQGDVAAFITEPIQGHGVWIPDDDYLPQAAKLARKYGAVFIVDEIQTGL
CHHHHHHHHHHHCCCEEEEEECCCCCCEEECCCCCCCCHHHHHHHHHCCEEEEECHHHCC
GRTGKWWAVEHWSVEPDIICISKTLSGGFVPVGALVCREWIFDRVFNRMDRAVVHGSTFG
CCCCCEEEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
KNNLAMAAGLATLEVLESENLIEHSARTGTAIMEALTPLTEQYECFKEVRGKGMMIALEF
CCCHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
TEPTKSLSLKLSWKMLEAANKGLFSQLITVPLFRQHRILSQVAGRDMNIVKFIPPLILTE
CCCCCCEEEEEHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCHHCCC
SDVQWIVSAVSDVVASAHRGPAAVWDFGKVLATQALRTKLHT
CHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA