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The map label for this gene is lysC [H]

Identifier: 114332049

GI number: 114332049

Start: 2205818

End: 2207065

Strand: Reverse

Name: lysC [H]

Synonym: Neut_2084

Alternate gene names: 114332049

Gene position: 2207065-2205818 (Counterclockwise)

Preceding gene: 114332050

Following gene: 114332048

Centisome position: 82.94

GC content: 46.71

Gene sequence:

>1248_bases
GTGGCGTTCCTTGTTCAAAAGTATGGCGGCACTTCGGTAGGCAGCGTTGAGCGCATTAAGCAGGTTGCGCGCCGAGTGGC
TGAATTCTGGGCGCAGGGACACAAACTGGTGATTGTTGTGTCTGCCATGAGTGGGGAGACAAATCGCCTTATCTCTTTGG
CAAAGGAAATTCAAACCAATCCAAATCCTCGTGAACTGGATGTTGTTCTGGCAACGGGTGAGCAGGTTACGATCGGGCTG
CTGGCAATGGCTTTGCGTGAACTGGGTATCAAGGCAAAAAGTTATACCGGCTCCCAGGTCAGTATTACAACTGATAGTGC
TCATACCAAGGCGCGTATCCTGAAGATTGATGAAGATCATATTCGTGCTGATTTGACTGCTGGCAATGTGATTATCGTTG
CCGGATTCCAGGGTAGGGACGAAGCAGGTGATATCACTACACTCGGGCGAGGTGGCTCAGATACGACTGCAGTGGCACTT
GCTGCAGCACTCAAAGCTGATGAATGCCAAATCTATACGGACGTCAATGGTATTTACACAACAGATCCACGAGTAGTGCC
GGAAGCTCGAAAACTGAATACTATTACCTTTGAAGAAATGCTTGAGATGGCCAGTTTAGGCTCCAAGGTGCTGCAGATAC
GTTCGGTAGAATTTGCCGGGAAATACAAGGTCAAGCTAAGGGTTCTTTCCAGTTTTGAAGAGGGTGAAGGTACGCTGATC
ACGTTTGAGGAAGATAACAAGATGGAACAGCCTATAATCTCAGGGATTGCATTTAATCGTGACGAATCGAAGATCACGGT
TGTTGGTGTGCCAGATCATCCGGGTATTGCTTATCAGATACTGGGTCCGGTTGCAGATGCCAATATCGACGTGGATATGA
TCATTCAAAATATAGGGCGTGACGGTACCACTGATTTTTCATTCACGGTTAACCGCAATGAATACACCCGGACAATGGAT
ATCCTGAAAGAACAGGTGTTGCCGCATATTGGTGCTCGTGATGTGATTGGTGGAGAAAAGATAGCCAAGATTTCGGTGAT
TGGTGTAGGGATGCGTTCTTATGCTGGCATAGCCAGTAAAATGTTTCGTGTTCTGGCTGAGGAAGGGATTAATATTCGAA
TGATCGCAACTTCAGAAATCAAGATTTCTGTCGTAGTAGATGAGAAATATATGGAGCTGGCTGTCCGGGTTTTGCATAAG
GCCTTTGATCTGGATCAGGCGAACAACATTGATGTGAAATCGTGTTAA

Upstream 100 bases:

>100_bases
AAGCCTGGTATTTTTGTTCAGAATCCTGAAATAGAATTATTCCAAAGAACTGTGTAGAATTCCCGACCGTTTAATTATTT
ATTTCTGAGAGATATCTTTC

Downstream 100 bases:

>100_bases
TATTGTTAACTTTTTAAATTATAAGCCGTCGTAAGAAGCTGCAAGAAATATCATTTACGGAGAGATGGCCGAGAGGTCGA
AGGCGCTCCCCTGCTAAGGG

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 415; Mature: 414

Protein sequence:

>415_residues
MAFLVQKYGGTSVGSVERIKQVARRVAEFWAQGHKLVIVVSAMSGETNRLISLAKEIQTNPNPRELDVVLATGEQVTIGL
LAMALRELGIKAKSYTGSQVSITTDSAHTKARILKIDEDHIRADLTAGNVIIVAGFQGRDEAGDITTLGRGGSDTTAVAL
AAALKADECQIYTDVNGIYTTDPRVVPEARKLNTITFEEMLEMASLGSKVLQIRSVEFAGKYKVKLRVLSSFEEGEGTLI
TFEEDNKMEQPIISGIAFNRDESKITVVGVPDHPGIAYQILGPVADANIDVDMIIQNIGRDGTTDFSFTVNRNEYTRTMD
ILKEQVLPHIGARDVIGGEKIAKISVIGVGMRSYAGIASKMFRVLAEEGINIRMIATSEIKISVVVDEKYMELAVRVLHK
AFDLDQANNIDVKSC

Sequences:

>Translated_415_residues
MAFLVQKYGGTSVGSVERIKQVARRVAEFWAQGHKLVIVVSAMSGETNRLISLAKEIQTNPNPRELDVVLATGEQVTIGL
LAMALRELGIKAKSYTGSQVSITTDSAHTKARILKIDEDHIRADLTAGNVIIVAGFQGRDEAGDITTLGRGGSDTTAVAL
AAALKADECQIYTDVNGIYTTDPRVVPEARKLNTITFEEMLEMASLGSKVLQIRSVEFAGKYKVKLRVLSSFEEGEGTLI
TFEEDNKMEQPIISGIAFNRDESKITVVGVPDHPGIAYQILGPVADANIDVDMIIQNIGRDGTTDFSFTVNRNEYTRTMD
ILKEQVLPHIGARDVIGGEKIAKISVIGVGMRSYAGIASKMFRVLAEEGINIRMIATSEIKISVVVDEKYMELAVRVLHK
AFDLDQANNIDVKSC
>Mature_414_residues
AFLVQKYGGTSVGSVERIKQVARRVAEFWAQGHKLVIVVSAMSGETNRLISLAKEIQTNPNPRELDVVLATGEQVTIGLL
AMALRELGIKAKSYTGSQVSITTDSAHTKARILKIDEDHIRADLTAGNVIIVAGFQGRDEAGDITTLGRGGSDTTAVALA
AALKADECQIYTDVNGIYTTDPRVVPEARKLNTITFEEMLEMASLGSKVLQIRSVEFAGKYKVKLRVLSSFEEGEGTLIT
FEEDNKMEQPIISGIAFNRDESKITVVGVPDHPGIAYQILGPVADANIDVDMIIQNIGRDGTTDFSFTVNRNEYTRTMDI
LKEQVLPHIGARDVIGGEKIAKISVIGVGMRSYAGIASKMFRVLAEEGINIRMIATSEIKISVVVDEKYMELAVRVLHKA
FDLDQANNIDVKSC

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=357, Percent_Identity=31.9327731092437, Blast_Score=154, Evalue=9e-39,
Organism=Escherichia coli, GI1790455, Length=463, Percent_Identity=27.4298056155508, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1790376, Length=111, Percent_Identity=32.4324324324324, Blast_Score=72, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6320893, Length=490, Percent_Identity=24.6938775510204, Blast_Score=110, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 45191; Mature: 45059

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFLVQKYGGTSVGSVERIKQVARRVAEFWAQGHKLVIVVSAMSGETNRLISLAKEIQTN
CEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHCCC
PNPRELDVVLATGEQVTIGLLAMALRELGIKAKSYTGSQVSITTDSAHTKARILKIDEDH
CCCCEEEEEEECCCCHHHHHHHHHHHHHCCEEECCCCCEEEEEECCCCCEEEEEEECHHH
IRADLTAGNVIIVAGFQGRDEAGDITTLGRGGSDTTAVALAAALKADECQIYTDVNGIYT
HEEEEECCCEEEEEECCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCEEEEEECCCEEE
TDPRVVPEARKLNTITFEEMLEMASLGSKVLQIRSVEFAGKYKVKLRVLSSFEEGEGTLI
CCCCCCCCCHHCCEEEHHHHHHHHHCCHHHEEEEEEEECCEEEEEEEEEECCCCCCCEEE
TFEEDNKMEQPIISGIAFNRDESKITVVGVPDHPGIAYQILGPVADANIDVDMIIQNIGR
EEECCCCCCCHHHHCEEECCCCCEEEEEECCCCCCEEEEEECCCCCCCCCHHHHHHHCCC
DGTTDFSFTVNRNEYTRTMDILKEQVLPHIGARDVIGGEKIAKISVIGVGMRSYAGIASK
CCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEECHHHHHHHHHH
MFRVLAEEGINIRMIATSEIKISVVVDEKYMELAVRVLHKAFDLDQANNIDVKSC
HHHHHHHCCCEEEEEEECCEEEEEEECHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
AFLVQKYGGTSVGSVERIKQVARRVAEFWAQGHKLVIVVSAMSGETNRLISLAKEIQTN
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHCCC
PNPRELDVVLATGEQVTIGLLAMALRELGIKAKSYTGSQVSITTDSAHTKARILKIDEDH
CCCCEEEEEEECCCCHHHHHHHHHHHHHCCEEECCCCCEEEEEECCCCCEEEEEEECHHH
IRADLTAGNVIIVAGFQGRDEAGDITTLGRGGSDTTAVALAAALKADECQIYTDVNGIYT
HEEEEECCCEEEEEECCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCEEEEEECCCEEE
TDPRVVPEARKLNTITFEEMLEMASLGSKVLQIRSVEFAGKYKVKLRVLSSFEEGEGTLI
CCCCCCCCCHHCCEEEHHHHHHHHHCCHHHEEEEEEEECCEEEEEEEEEECCCCCCCEEE
TFEEDNKMEQPIISGIAFNRDESKITVVGVPDHPGIAYQILGPVADANIDVDMIIQNIGR
EEECCCCCCCHHHHCEEECCCCCEEEEEECCCCCCEEEEEECCCCCCCCCHHHHHHHCCC
DGTTDFSFTVNRNEYTRTMDILKEQVLPHIGARDVIGGEKIAKISVIGVGMRSYAGIASK
CCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEECHHHHHHHHHH
MFRVLAEEGINIRMIATSEIKISVVVDEKYMELAVRVLHKAFDLDQANNIDVKSC
HHHHHHHCCCEEEEEEECCEEEEEEECHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]