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The map label for this gene is pyrH

Identifier: 114331999

GI number: 114331999

Start: 2148628

End: 2149341

Strand: Reverse

Name: pyrH

Synonym: Neut_2033

Alternate gene names: 114331999

Gene position: 2149341-2148628 (Counterclockwise)

Preceding gene: 114332000

Following gene: 114331998

Centisome position: 80.77

GC content: 44.68

Gene sequence:

>714_bases
ATGCCAGCCGTCTATAAACGTATTTTATTGAAGTTGTCGGGCGAGGCTCTTATGGGTGATGCGCAGTATGGCATTGATCG
TACAGTGGTTGAGCGTATCGTTGTCGAGATTGCCGGAGTGTTGCAGTTAGGCGTTGAGGTTGCGATTGTGGTAGGTGGGG
GTAATATTTTTCGTGGCATGAAATCCGCGGGAGATGGCATGGATCGCGTAACAGCTGACTATATGGGAATGCTTGCTACC
ACCATGAATGCTTTAGCATTACACGATGCGATGAGGCGGAATGGCGTCGTCTCACGGGTACAATCAGCTTTGCGGATAGA
TCAGGTCGTGGAACCTTATATTCGTGGCAAGGCTTTACGTTATTTAAATGAACGTAAAGTGGTCATATTTGCTGCGGGGA
CTGGTAATCCTTTTTTTACTACGGATACAGCAGCTGCCTTGCGTGGTATGGAAATGAATGCCAACATAGTTCTCAAGGCG
ACCAAAGTTGATGGGATTTATACCAGTGACCCTTTTGAAAATAAAGATGCACAACGTTTTCGTAACCTGACTTTTGATGA
GGCAATTAATAAAAACCTTCAGGTAATGGATGCTACTGCACTGACCTTGTGCCGTGATCAGAAACTTCCCATCAATGTAT
TCAGTATTTTTAAGACCGGAGCACTCAAACGAGTTATCATGGGTGAAGATGAAGGGACTTTGGTAATTATTTGA

Upstream 100 bases:

>100_bases
AATCTCAACAGAATCTGGAGTGGCTGTTGATGGTGTATGAATAGCGGCGTGATCAATTTTCAGGAAGACGTTACGATAAA
TCTCCATTACACGAGCATAT

Downstream 100 bases:

>100_bases
ATTTTTGGACATTATCTAAAATATCGTTATTCCTCGCGGTATATGGCAGAGCACATGTGCATTGTTGTAATCGCTTTTTA
ATGTCAATATCTACTTAAAT

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 237; Mature: 236

Protein sequence:

>237_residues
MPAVYKRILLKLSGEALMGDAQYGIDRTVVERIVVEIAGVLQLGVEVAIVVGGGNIFRGMKSAGDGMDRVTADYMGMLAT
TMNALALHDAMRRNGVVSRVQSALRIDQVVEPYIRGKALRYLNERKVVIFAAGTGNPFFTTDTAAALRGMEMNANIVLKA
TKVDGIYTSDPFENKDAQRFRNLTFDEAINKNLQVMDATALTLCRDQKLPINVFSIFKTGALKRVIMGEDEGTLVII

Sequences:

>Translated_237_residues
MPAVYKRILLKLSGEALMGDAQYGIDRTVVERIVVEIAGVLQLGVEVAIVVGGGNIFRGMKSAGDGMDRVTADYMGMLAT
TMNALALHDAMRRNGVVSRVQSALRIDQVVEPYIRGKALRYLNERKVVIFAAGTGNPFFTTDTAAALRGMEMNANIVLKA
TKVDGIYTSDPFENKDAQRFRNLTFDEAINKNLQVMDATALTLCRDQKLPINVFSIFKTGALKRVIMGEDEGTLVII
>Mature_236_residues
PAVYKRILLKLSGEALMGDAQYGIDRTVVERIVVEIAGVLQLGVEVAIVVGGGNIFRGMKSAGDGMDRVTADYMGMLATT
MNALALHDAMRRNGVVSRVQSALRIDQVVEPYIRGKALRYLNERKVVIFAAGTGNPFFTTDTAAALRGMEMNANIVLKAT
KVDGIYTSDPFENKDAQRFRNLTFDEAINKNLQVMDATALTLCRDQKLPINVFSIFKTGALKRVIMGEDEGTLVII

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=232, Percent_Identity=53.8793103448276, Blast_Score=260, Evalue=5e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_NITEC (Q0AEH6)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_748221.1
- ProteinModelPortal:   Q0AEH6
- SMR:   Q0AEH6
- STRING:   Q0AEH6
- GeneID:   4273245
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_2033
- NMPDR:   fig|335283.3.peg.2494
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- PhylomeDB:   Q0AEH6
- ProtClustDB:   PRK00358
- BioCyc:   NEUT335283:NEUT_2033-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 25922; Mature: 25790

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: NA

Important sites: BINDING 53-53 BINDING 54-54 BINDING 58-58 BINDING 73-73 BINDING 161-161 BINDING 167-167 BINDING 170-170

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAVYKRILLKLSGEALMGDAQYGIDRTVVERIVVEIAGVLQLGVEVAIVVGGGNIFRGM
CCHHHHHHHHHHCCCEEECCHHHCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHH
KSAGDGMDRVTADYMGMLATTMNALALHDAMRRNGVVSRVQSALRIDQVVEPYIRGKALR
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHH
YLNERKVVIFAAGTGNPFFTTDTAAALRGMEMNANIVLKATKVDGIYTSDPFENKDAQRF
HHCCCEEEEEEECCCCCCEECCHHHHHHCCCCCCEEEEEEEEECCEECCCCCCCCHHHHH
RNLTFDEAINKNLQVMDATALTLCRDQKLPINVFSIFKTGALKRVIMGEDEGTLVII
HCCCHHHHHCCCCEEEHHHHHHHHCCCCCCCHHHHHHHHHHHHEEEECCCCCCEEEC
>Mature Secondary Structure 
PAVYKRILLKLSGEALMGDAQYGIDRTVVERIVVEIAGVLQLGVEVAIVVGGGNIFRGM
CHHHHHHHHHHCCCEEECCHHHCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHH
KSAGDGMDRVTADYMGMLATTMNALALHDAMRRNGVVSRVQSALRIDQVVEPYIRGKALR
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHH
YLNERKVVIFAAGTGNPFFTTDTAAALRGMEMNANIVLKATKVDGIYTSDPFENKDAQRF
HHCCCEEEEEEECCCCCCEECCHHHHHHCCCCCCEEEEEEEEECCEECCCCCCCCHHHHH
RNLTFDEAINKNLQVMDATALTLCRDQKLPINVFSIFKTGALKRVIMGEDEGTLVII
HCCCHHHHHCCCCEEEHHHHHHHHCCCCCCCHHHHHHHHHHHHEEEECCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA