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The map label for this gene is nadB1 [H]

Identifier: 114331970

GI number: 114331970

Start: 2117485

End: 2119068

Strand: Reverse

Name: nadB1 [H]

Synonym: Neut_2004

Alternate gene names: 114331970

Gene position: 2119068-2117485 (Counterclockwise)

Preceding gene: 114331989

Following gene: 114331969

Centisome position: 79.63

GC content: 52.9

Gene sequence:

>1584_bases
ATGCAACCACCTCGTTTCGATGCACTGATTATCGGCAGCGGTCTCGCCGGGCTGACACTCGCCCTGAAGCTGGCTGAAAC
TCAAAAAGTCGTGCTGATTACCAAGCGGACACTCTACGATAGTTCTAGTGCCTGGGCGCAAGGAGGGATTGCAGCTGTAC
TTTCGATGGAAGACTCGCTGGAAGCACATATCAGCGATACGCTGATTGCTGGTGCGGGGCTGTGTAACGAAGCCATGACA
CGTCATATTGTAGAGAACGGCCCGCGAGCGGTCAGGTGGCTGATTGAACGAGGGGTTAATTTTACACGCGATGATCACAA
TAAAACCGGTTATCACCTGACGCGCGAAGGCGGCCATAGTGTTCGCCGTATCATCCATTCTGATGATGCGACCGGTAAGG
TAGTGCAACTCACGCTCACCAGGCAGGCGGCTCAGCACCCGAACATTACCGTGCTGGAACATCATATTGCAGTGGATCTG
ATCACCAGTGAGAAACTATCTCATGCCCGGGGCAGTAATCGCTGTTACGGTGCTTATGTGCTTGATATTCATGCCGGAAA
AGTACGTACGATAGCGGCGCAAAATACAATTCTGGCTACTGGCGGGGCAGGCAAGGTCTACCTGTACACCACCAATCCGG
ATGTAGCAACCGGAGACGGTATTGCCATGGGATGGCGTGCGGGTTGCCGGGTTGCCAACATGGAATTTATCCAGTTTCAC
CCCACCTGCCTGTATCACCCGCATGCAAAATCCTTTTTGATCACTGAAGCAGTGAGAGGAGAGGGCGGGGTGCTGAAATT
GCCCGATGGCGAGCGTTTTATGCTTAAACACGATGAGCGAGCTGAACTTGCTCCGCGCGATGTCGTGGCGCGTGCAATCG
ATTTTGAAATGAAAAAACGTGGACTGGATTGCGTGTTTCTGGATATATCGCACCAGTCAGCCGATTTTCTGGTGCAGCAT
TTTCCGACAATCTATCAGCGCTGTCTGGAGCTGGGCATCGATATCACACGCGAACCCATTCCGGTAGTTCCCGCAGCGCA
CTATACCTGCGGCGGCATCGTGATCGATCAACGTGGAAGAACGGATCTCGATAATCTGTACGCGATTGGTGAAACCGCGC
ACACTGGATTGCATGGCGCCAACCGGCTGGCCAGTAACTCTTTACTGGAATGTCTGGTAACCGGTCTTTCAGCGGTTGAA
GATATCCTTACCCGATCGCCTGCGCCGGATTTTCCATTGCCTGACTGGGATGAAAGTCGGGTGACGGATGCGGATGAAGA
AGTCGTTATCTCCCATAACTGGGATGAGCTGCGTCGTTTCATGTGGAATTATGTCGGTATCGTGCGCACCAACAAGCGAT
TGCAGCGGGCACAACACCGCATCAGACTGCTGAGCGGGGAAATTGATGAGTACTATTCCAATTTCCGGGTAACCAGCGAT
TTGCTTGAGCTGCGTAATCTCGTATGTACTTCAGATCTGATTGTTCGCAGCGCCATGCTGCGGCATGAAAGTCGCGGATT
GCACTCCAGCCGGGATTACCCGGAAGCCTTGCCACGAGCCACTGATACGATCTTGTCACGATAG

Upstream 100 bases:

>100_bases
ACGCCAGCACAGTTTGATGGATTCGAAATCCTGGCAAAAAGTGTGGTAATTTCAGGAAGTATTTTCACTTTCAATTATTT
TTGAGTAATTATTGCTATCT

Downstream 100 bases:

>100_bases
CGGCAAAAATAAGGCGTGGCTGATCAAGCGTTCTCGCTTGATTTACCTGCCTCACAGGTTTGATAGTCCGTCTGCCCATA
TTCATTGCATCGTAATAATG

Product: L-aspartate oxidase

Products: NA

Alternate protein names: LASPO 1; Quinolinate synthase B 1 [H]

Number of amino acids: Translated: 527; Mature: 527

Protein sequence:

>527_residues
MQPPRFDALIIGSGLAGLTLALKLAETQKVVLITKRTLYDSSSAWAQGGIAAVLSMEDSLEAHISDTLIAGAGLCNEAMT
RHIVENGPRAVRWLIERGVNFTRDDHNKTGYHLTREGGHSVRRIIHSDDATGKVVQLTLTRQAAQHPNITVLEHHIAVDL
ITSEKLSHARGSNRCYGAYVLDIHAGKVRTIAAQNTILATGGAGKVYLYTTNPDVATGDGIAMGWRAGCRVANMEFIQFH
PTCLYHPHAKSFLITEAVRGEGGVLKLPDGERFMLKHDERAELAPRDVVARAIDFEMKKRGLDCVFLDISHQSADFLVQH
FPTIYQRCLELGIDITREPIPVVPAAHYTCGGIVIDQRGRTDLDNLYAIGETAHTGLHGANRLASNSLLECLVTGLSAVE
DILTRSPAPDFPLPDWDESRVTDADEEVVISHNWDELRRFMWNYVGIVRTNKRLQRAQHRIRLLSGEIDEYYSNFRVTSD
LLELRNLVCTSDLIVRSAMLRHESRGLHSSRDYPEALPRATDTILSR

Sequences:

>Translated_527_residues
MQPPRFDALIIGSGLAGLTLALKLAETQKVVLITKRTLYDSSSAWAQGGIAAVLSMEDSLEAHISDTLIAGAGLCNEAMT
RHIVENGPRAVRWLIERGVNFTRDDHNKTGYHLTREGGHSVRRIIHSDDATGKVVQLTLTRQAAQHPNITVLEHHIAVDL
ITSEKLSHARGSNRCYGAYVLDIHAGKVRTIAAQNTILATGGAGKVYLYTTNPDVATGDGIAMGWRAGCRVANMEFIQFH
PTCLYHPHAKSFLITEAVRGEGGVLKLPDGERFMLKHDERAELAPRDVVARAIDFEMKKRGLDCVFLDISHQSADFLVQH
FPTIYQRCLELGIDITREPIPVVPAAHYTCGGIVIDQRGRTDLDNLYAIGETAHTGLHGANRLASNSLLECLVTGLSAVE
DILTRSPAPDFPLPDWDESRVTDADEEVVISHNWDELRRFMWNYVGIVRTNKRLQRAQHRIRLLSGEIDEYYSNFRVTSD
LLELRNLVCTSDLIVRSAMLRHESRGLHSSRDYPEALPRATDTILSR
>Mature_527_residues
MQPPRFDALIIGSGLAGLTLALKLAETQKVVLITKRTLYDSSSAWAQGGIAAVLSMEDSLEAHISDTLIAGAGLCNEAMT
RHIVENGPRAVRWLIERGVNFTRDDHNKTGYHLTREGGHSVRRIIHSDDATGKVVQLTLTRQAAQHPNITVLEHHIAVDL
ITSEKLSHARGSNRCYGAYVLDIHAGKVRTIAAQNTILATGGAGKVYLYTTNPDVATGDGIAMGWRAGCRVANMEFIQFH
PTCLYHPHAKSFLITEAVRGEGGVLKLPDGERFMLKHDERAELAPRDVVARAIDFEMKKRGLDCVFLDISHQSADFLVQH
FPTIYQRCLELGIDITREPIPVVPAAHYTCGGIVIDQRGRTDLDNLYAIGETAHTGLHGANRLASNSLLECLVTGLSAVE
DILTRSPAPDFPLPDWDESRVTDADEEVVISHNWDELRRFMWNYVGIVRTNKRLQRAQHRIRLLSGEIDEYYSNFRVTSD
LLELRNLVCTSDLIVRSAMLRHESRGLHSSRDYPEALPRATDTILSR

Specific function: Catalyzes the oxidation of L-aspartate to iminoaspartate [H]

COG id: COG0029

COG function: function code H; Aspartate oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=520, Percent_Identity=32.8846153846154, Blast_Score=218, Evalue=1e-56,
Organism=Escherichia coli, GI1788928, Length=526, Percent_Identity=60.8365019011407, Blast_Score=643, Evalue=0.0,
Organism=Escherichia coli, GI1790597, Length=524, Percent_Identity=32.4427480916031, Blast_Score=230, Evalue=2e-61,
Organism=Escherichia coli, GI1786942, Length=555, Percent_Identity=32.6126126126126, Blast_Score=207, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17550100, Length=537, Percent_Identity=31.6573556797021, Blast_Score=214, Evalue=7e-56,
Organism=Caenorhabditis elegans, GI17505833, Length=536, Percent_Identity=31.7164179104478, Blast_Score=212, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI71986328, Length=459, Percent_Identity=27.2331154684096, Blast_Score=107, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6322701, Length=551, Percent_Identity=33.5753176043557, Blast_Score=214, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6322416, Length=554, Percent_Identity=32.3104693140794, Blast_Score=202, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6320788, Length=486, Percent_Identity=27.5720164609054, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6322511, Length=481, Percent_Identity=27.027027027027, Blast_Score=106, Evalue=7e-24,
Organism=Drosophila melanogaster, GI17137288, Length=554, Percent_Identity=32.3104693140794, Blast_Score=222, Evalue=6e-58,
Organism=Drosophila melanogaster, GI24655642, Length=554, Percent_Identity=32.3104693140794, Blast_Score=222, Evalue=6e-58,
Organism=Drosophila melanogaster, GI24655647, Length=554, Percent_Identity=32.3104693140794, Blast_Score=222, Evalue=6e-58,
Organism=Drosophila melanogaster, GI24663005, Length=555, Percent_Identity=31.5315315315315, Blast_Score=207, Evalue=1e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR005288 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.4.3.16 [H]

Molecular weight: Translated: 58537; Mature: 58537

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPPRFDALIIGSGLAGLTLALKLAETQKVVLITKRTLYDSSSAWAQGGIAAVLSMEDSL
CCCCCCCEEEEECCHHHHHEEEEECCCCEEEEEEEEECCCCCCCHHCCCEEEEEECCHHH
EAHISDTLIAGAGLCNEAMTRHIVENGPRAVRWLIERGVNFTRDDHNKTGYHLTREGGHS
HHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCHH
VRRIIHSDDATGKVVQLTLTRQAAQHPNITVLEHHIAVDLITSEKLSHARGSNRCYGAYV
HHHHHHCCCCCCCEEEEEEEHHHHCCCCEEEEEEEEEEEEEEHHHHHHCCCCCCEEEEEE
LDIHAGKVRTIAAQNTILATGGAGKVYLYTTNPDVATGDGIAMGWRAGCRVANMEFIQFH
EEEECCCEEEEEECCEEEEECCCCEEEEEECCCCCCCCCCEEECHHCCCEEECEEEEEEC
PTCLYHPHAKSFLITEAVRGEGGVLKLPDGERFMLKHDERAELAPRDVVARAIDFEMKKR
CEEEECCCCCCEEEEHHHCCCCCEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHC
GLDCVFLDISHQSADFLVQHFPTIYQRCLELGIDITREPIPVVPAAHYTCGGIVIDQRGR
CCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCEEECCCCC
TDLDNLYAIGETAHTGLHGANRLASNSLLECLVTGLSAVEDILTRSPAPDFPLPDWDESR
CCHHHHEEECCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
VTDADEEVVISHNWDELRRFMWNYVGIVRTNKRLQRAQHRIRLLSGEIDEYYSNFRVTSD
CCCCCCCEEEECCHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHCCCHHHHHHCCCHHHH
LLELRNLVCTSDLIVRSAMLRHESRGLHSSRDYPEALPRATDTILSR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MQPPRFDALIIGSGLAGLTLALKLAETQKVVLITKRTLYDSSSAWAQGGIAAVLSMEDSL
CCCCCCCEEEEECCHHHHHEEEEECCCCEEEEEEEEECCCCCCCHHCCCEEEEEECCHHH
EAHISDTLIAGAGLCNEAMTRHIVENGPRAVRWLIERGVNFTRDDHNKTGYHLTREGGHS
HHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCHH
VRRIIHSDDATGKVVQLTLTRQAAQHPNITVLEHHIAVDLITSEKLSHARGSNRCYGAYV
HHHHHHCCCCCCCEEEEEEEHHHHCCCCEEEEEEEEEEEEEEHHHHHHCCCCCCEEEEEE
LDIHAGKVRTIAAQNTILATGGAGKVYLYTTNPDVATGDGIAMGWRAGCRVANMEFIQFH
EEEECCCEEEEEECCEEEEECCCCEEEEEECCCCCCCCCCEEECHHCCCEEECEEEEEEC
PTCLYHPHAKSFLITEAVRGEGGVLKLPDGERFMLKHDERAELAPRDVVARAIDFEMKKR
CEEEECCCCCCEEEEHHHCCCCCEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHC
GLDCVFLDISHQSADFLVQHFPTIYQRCLELGIDITREPIPVVPAAHYTCGGIVIDQRGR
CCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCEEECCCCC
TDLDNLYAIGETAHTGLHGANRLASNSLLECLVTGLSAVEDILTRSPAPDFPLPDWDESR
CCHHHHEEECCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
VTDADEEVVISHNWDELRRFMWNYVGIVRTNKRLQRAQHRIRLLSGEIDEYYSNFRVTSD
CCCCCCCEEEECCHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHCCCHHHHHHCCCHHHH
LLELRNLVCTSDLIVRSAMLRHESRGLHSSRDYPEALPRATDTILSR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]