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The map label for this gene is eryA [H]

Identifier: 114331969

GI number: 114331969

Start: 2114880

End: 2116862

Strand: Reverse

Name: eryA [H]

Synonym: Neut_2003

Alternate gene names: 114331969

Gene position: 2116862-2114880 (Counterclockwise)

Preceding gene: 114331970

Following gene: 114331968

Centisome position: 79.55

GC content: 53.05

Gene sequence:

>1983_bases
ATGACCTCAAAAGCGGTTGCAATTATTGGTATCGGCTTCCGATTCCCTGGTGATCTTGGTGACGAAACAGATTTCTGGAA
TGCACTGAAGCAAAAACGTGATCTTGTAACCAGTATCCCGCCCGAGCGTTGGGCGATCAGTGAGCTTCAGCATGACAAAC
GTTCCGAGCCTGGTCGCAGCATTACTTATTCAGCAGGCGTTCTGTCGCGTATCGATGAATTTGACGCGAGCTTCTTTGGT
ATTTCTCCGCGCGAAGCAGCCTGGATGGACCCTCAACAGCGGCTTCTGCTCGAATTATCCTGGGAGGCCATGGAAAATGC
AGGTATTCCGCCTTCATCCATGTCCGGTTCCAATTGTGCAGTCTATGTGGGTATTTCCGGCCTGGATTACGGCACGCGCG
GACTGGATGATCTGGCGTCGCTCTCGCCCCACATGATGACCGGCAACACGCTCAGCATTGCCGCCAATCGTCTTTCCTAT
GTTTTCAATCTGCATGGCCCTTCGCTGGCGGTTGACACGGCCTGTTCATCGTCGCTGGTTGCATTGCATCATGCTTGTCA
GGCCCTGCAAACTGGTGAGGCAGGCACTGCGCTGGTGGGAGGGGTTAATTTATTGTTGCATCCCTATCCCTTCGTTGGTT
TTACCAAAGCATCCATGCTGTCTGCTGATGGCCGCTGTAAGGCTTTCGATGCTTCCGGTAGTGGTTATGTACGTGCCGAA
GGCGGGGCAGTCTTGCTGCTCAAGCCGTTTGAACAGGCGATTGCAGAGGGCGACGATATTCAGGCGGTGATCCTGGCCAC
TGGTATCAATACGGATGGCGCACGCAAGGCTGGCATTACCATTCCCAGCCGTGATGGACAATCCGAGCTCATGATGAGCG
TCCTCGCCAAAACCAGTCTGTCAGCACGAGACATCGATTTTATCGAAGCGCATGGCACAGGTACGGCGGTGGGAGATCCT
GTTGAAACAGCAGCAATTGGTGAAGTCTATGGCAAAAAGCGCGAAAAACCTTTGCCGATCGGATCGGTCAAGGCCAATCT
TGGACACATGGAACCGGCTTCCGGCATGGCAGGAATCATCAAGGCAATTCTGGCGCTCAAGCATCATGCTCTGCCACCAC
AGATTCATCTGGAAACGCCCAATCCAAATATTGATTTTCTCGGCTTGAATCTGAGGCCGGTGACCGAGTATCTGGAACTG
GCGAAAAAGAATAATCGAGCTCTGATTGCCGGTGTGAATTCCTTCGGCTTTGGTGGTGCCAATGCGCATGTGCTGCTGCA
GGAATATCGTTGCCGTGATCTGGCAACGACGGAACCGCTACCGGCATCCTTGCCACCTCTTTTTCTGTCAGCCCGTTCCG
AAACAGCACTAAAAGAGCTGGCGGGTCGTTATGCAGATCTGTTACACGATAAATCCGGGCAGGATTTCTATGACGTGGCA
CATGCTGCTGTCAATCAGCGTGATCGTATGGAAAAACGGCTCGCGCTCCATTCCGGCTCTGTTGAATCGACAATTCATTT
GCTGCAGCAATATGCGTTGGATAATGTTTCAGCGGATATCTTCATTGAGGATAGCCTGCCACAAAGTGGCGATGTGGCGT
TTATCTATTCAGGTAACGGCGCGCAGTGGGCTGGTATGGGGCGTGCGCTGCTGACTGAATCCTCCCGGTTTGAAGAAATT
CTTACGGAAATCGATATCGCCATGCGCCCCTTGACAGATTTTTCTCTGCTTGAGACGCTGCAATCCGAAAGTGAGCTTGC
CAGGCTTAGTAACACAGCTGTCGCGCAGCCTCTGCTGTTCGCTATTCAGGTTGCAGTCACACTTCTACTGAGAGAGCAGG
GGGTGACACCATCCGCTGTCGCCGGCCATAGCGTGGGTGAAATCGCCGCTGCCTGGGCGGCCGGTGCGCTGGATCTTGAA
CCGCCCCGGGTTTTGAGGAGGCTCCACTATCTGAGAAGATGGAGCCATGAACAAATCAAATAA

Upstream 100 bases:

>100_bases
AACTGATTCAAGTTTCAATAAGGGGATGGTGATCGCAATAAATCCGAAGAACTTCCCTGAGTTAACGTGAAGCGGATTGC
ATGGATATTGATCTGGAGAT

Downstream 100 bases:

>100_bases
ATATTCCCCCGAAGTAAGAGCGCGCGCAGTCCGTCTGGTGCAGGAACACCGCAGTGAGTATCCCTCGCTGTGGTCGACGA
TTGAATCCATTGCGCCGAAG

Product: beta-ketoacyl synthase

Products: NA

Alternate protein names: 6-deoxyerythronolide B synthase II; DEBS 2; ORF 2 [H]

Number of amino acids: Translated: 660; Mature: 659

Protein sequence:

>660_residues
MTSKAVAIIGIGFRFPGDLGDETDFWNALKQKRDLVTSIPPERWAISELQHDKRSEPGRSITYSAGVLSRIDEFDASFFG
ISPREAAWMDPQQRLLLELSWEAMENAGIPPSSMSGSNCAVYVGISGLDYGTRGLDDLASLSPHMMTGNTLSIAANRLSY
VFNLHGPSLAVDTACSSSLVALHHACQALQTGEAGTALVGGVNLLLHPYPFVGFTKASMLSADGRCKAFDASGSGYVRAE
GGAVLLLKPFEQAIAEGDDIQAVILATGINTDGARKAGITIPSRDGQSELMMSVLAKTSLSARDIDFIEAHGTGTAVGDP
VETAAIGEVYGKKREKPLPIGSVKANLGHMEPASGMAGIIKAILALKHHALPPQIHLETPNPNIDFLGLNLRPVTEYLEL
AKKNNRALIAGVNSFGFGGANAHVLLQEYRCRDLATTEPLPASLPPLFLSARSETALKELAGRYADLLHDKSGQDFYDVA
HAAVNQRDRMEKRLALHSGSVESTIHLLQQYALDNVSADIFIEDSLPQSGDVAFIYSGNGAQWAGMGRALLTESSRFEEI
LTEIDIAMRPLTDFSLLETLQSESELARLSNTAVAQPLLFAIQVAVTLLLREQGVTPSAVAGHSVGEIAAAWAAGALDLE
PPRVLRRLHYLRRWSHEQIK

Sequences:

>Translated_660_residues
MTSKAVAIIGIGFRFPGDLGDETDFWNALKQKRDLVTSIPPERWAISELQHDKRSEPGRSITYSAGVLSRIDEFDASFFG
ISPREAAWMDPQQRLLLELSWEAMENAGIPPSSMSGSNCAVYVGISGLDYGTRGLDDLASLSPHMMTGNTLSIAANRLSY
VFNLHGPSLAVDTACSSSLVALHHACQALQTGEAGTALVGGVNLLLHPYPFVGFTKASMLSADGRCKAFDASGSGYVRAE
GGAVLLLKPFEQAIAEGDDIQAVILATGINTDGARKAGITIPSRDGQSELMMSVLAKTSLSARDIDFIEAHGTGTAVGDP
VETAAIGEVYGKKREKPLPIGSVKANLGHMEPASGMAGIIKAILALKHHALPPQIHLETPNPNIDFLGLNLRPVTEYLEL
AKKNNRALIAGVNSFGFGGANAHVLLQEYRCRDLATTEPLPASLPPLFLSARSETALKELAGRYADLLHDKSGQDFYDVA
HAAVNQRDRMEKRLALHSGSVESTIHLLQQYALDNVSADIFIEDSLPQSGDVAFIYSGNGAQWAGMGRALLTESSRFEEI
LTEIDIAMRPLTDFSLLETLQSESELARLSNTAVAQPLLFAIQVAVTLLLREQGVTPSAVAGHSVGEIAAAWAAGALDLE
PPRVLRRLHYLRRWSHEQIK
>Mature_659_residues
TSKAVAIIGIGFRFPGDLGDETDFWNALKQKRDLVTSIPPERWAISELQHDKRSEPGRSITYSAGVLSRIDEFDASFFGI
SPREAAWMDPQQRLLLELSWEAMENAGIPPSSMSGSNCAVYVGISGLDYGTRGLDDLASLSPHMMTGNTLSIAANRLSYV
FNLHGPSLAVDTACSSSLVALHHACQALQTGEAGTALVGGVNLLLHPYPFVGFTKASMLSADGRCKAFDASGSGYVRAEG
GAVLLLKPFEQAIAEGDDIQAVILATGINTDGARKAGITIPSRDGQSELMMSVLAKTSLSARDIDFIEAHGTGTAVGDPV
ETAAIGEVYGKKREKPLPIGSVKANLGHMEPASGMAGIIKAILALKHHALPPQIHLETPNPNIDFLGLNLRPVTEYLELA
KKNNRALIAGVNSFGFGGANAHVLLQEYRCRDLATTEPLPASLPPLFLSARSETALKELAGRYADLLHDKSGQDFYDVAH
AAVNQRDRMEKRLALHSGSVESTIHLLQQYALDNVSADIFIEDSLPQSGDVAFIYSGNGAQWAGMGRALLTESSRFEEIL
TEIDIAMRPLTDFSLLETLQSESELARLSNTAVAQPLLFAIQVAVTLLLREQGVTPSAVAGHSVGEIAAAWAAGALDLEP
PRVLRRLHYLRRWSHEQIK

Specific function: Catalyzes The Condensation Reaction Of Fatty Acid Synthesis By The Addition To An Acyl Acceptor Of Two Carbons From Malonyl-Acp. Has A Preference For Short Chain Acid Substrates And May Function To Supply The Octanoic Substrates For Lipoic Acid Biosynthe

COG id: COG3321

COG function: function code Q; Polyketide synthase modules and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 acyl carrier domains [H]

Homologues:

Organism=Homo sapiens, GI41872631, Length=644, Percent_Identity=35.8695652173913, Blast_Score=342, Evalue=7e-94,
Organism=Homo sapiens, GI8923559, Length=307, Percent_Identity=29.9674267100977, Blast_Score=133, Evalue=6e-31,
Organism=Homo sapiens, GI310129082, Length=117, Percent_Identity=36.7521367521368, Blast_Score=84, Evalue=6e-16,
Organism=Homo sapiens, GI310109937, Length=117, Percent_Identity=36.7521367521368, Blast_Score=84, Evalue=6e-16,
Organism=Homo sapiens, GI239744023, Length=115, Percent_Identity=37.3913043478261, Blast_Score=83, Evalue=8e-16,
Organism=Homo sapiens, GI223972627, Length=150, Percent_Identity=32, Blast_Score=70, Evalue=7e-12,
Organism=Escherichia coli, GI1787337, Length=299, Percent_Identity=28.4280936454849, Blast_Score=116, Evalue=4e-27,
Organism=Escherichia coli, GI1788663, Length=306, Percent_Identity=30.0653594771242, Blast_Score=111, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI212642053, Length=666, Percent_Identity=34.0840840840841, Blast_Score=328, Evalue=7e-90,
Organism=Caenorhabditis elegans, GI17550940, Length=422, Percent_Identity=34.8341232227488, Blast_Score=214, Evalue=9e-56,
Organism=Caenorhabditis elegans, GI71983541, Length=293, Percent_Identity=27.6450511945392, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71983535, Length=270, Percent_Identity=28.8888888888889, Blast_Score=110, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6320904, Length=357, Percent_Identity=27.1708683473389, Blast_Score=121, Evalue=5e-28,
Organism=Drosophila melanogaster, GI221330659, Length=648, Percent_Identity=34.8765432098765, Blast_Score=330, Evalue=2e-90,
Organism=Drosophila melanogaster, GI19920632, Length=585, Percent_Identity=36.0683760683761, Blast_Score=329, Evalue=3e-90,
Organism=Drosophila melanogaster, GI24581345, Length=650, Percent_Identity=33.3846153846154, Blast_Score=307, Evalue=1e-83,
Organism=Drosophila melanogaster, GI24644341, Length=361, Percent_Identity=30.4709141274238, Blast_Score=131, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR009081
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR000794
- InterPro:   IPR002198
- InterPro:   IPR015357
- InterPro:   IPR011032
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016036
- InterPro:   IPR016040
- InterPro:   IPR006163
- InterPro:   IPR020842
- InterPro:   IPR020801
- InterPro:   IPR020841
- InterPro:   IPR020807
- InterPro:   IPR020843
- InterPro:   IPR020806
- InterPro:   IPR015083
- InterPro:   IPR006162
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00698 Acyl_transf_1; PF08240 ADH_N; PF00106 adh_short; PF00107 ADH_zinc_N; PF08990 Docking; PF09277 Erythro-docking; PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C; PF00550 PP-binding [H]

EC number: =2.3.1.94 [H]

Molecular weight: Translated: 70874; Mature: 70743

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSKAVAIIGIGFRFPGDLGDETDFWNALKQKRDLVTSIPPERWAISELQHDKRSEPGRS
CCCCEEEEEEECEECCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCE
ITYSAGVLSRIDEFDASFFGISPREAAWMDPQQRLLLELSWEAMENAGIPPSSMSGSNCA
EEEHHHHHHHHHHHCCHHCCCCCCCCCCCCHHHHHHHHCCHHHHHCCCCCCCCCCCCCCE
VYVGISGLDYGTRGLDDLASLSPHMMTGNTLSIAANRLSYVFNLHGPSLAVDTACSSSLV
EEEEECCCCCCCCCHHHHHHCCCCEECCCCHHHHHHCEEEEEEECCCCEEEHHHCCHHHH
ALHHACQALQTGEAGTALVGGVNLLLHPYPFVGFTKASMLSADGRCKAFDASGSGYVRAE
HHHHHHHHHHCCCCCCCHHCCCEEEECCCCCCCCCHHHHHCCCCCEEEEECCCCCEEEEC
GGAVLLLKPFEQAIAEGDDIQAVILATGINTDGARKAGITIPSRDGQSELMMSVLAKTSL
CCEEEEECCHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
SARDIDFIEAHGTGTAVGDPVETAAIGEVYGKKREKPLPIGSVKANLGHMEPASGMAGII
CCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCCHHHHH
KAILALKHHALPPQIHLETPNPNIDFLGLNLRPVTEYLELAKKNNRALIAGVNSFGFGGA
HHHHHHHHCCCCCEEEEECCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCCCCCC
NAHVLLQEYRCRDLATTEPLPASLPPLFLSARSETALKELAGRYADLLHDKSGQDFYDVA
CHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
HAAVNQRDRMEKRLALHSGSVESTIHLLQQYALDNVSADIFIEDSLPQSGDVAFIYSGNG
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEECCCC
AQWAGMGRALLTESSRFEEILTEIDIAMRPLTDFSLLETLQSESELARLSNTAVAQPLLF
CEECCCCHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIQVAVTLLLREQGVTPSAVAGHSVGEIAAAWAAGALDLEPPRVLRRLHYLRRWSHEQIK
HHHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHCCC
>Mature Secondary Structure 
TSKAVAIIGIGFRFPGDLGDETDFWNALKQKRDLVTSIPPERWAISELQHDKRSEPGRS
CCCEEEEEEECEECCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCE
ITYSAGVLSRIDEFDASFFGISPREAAWMDPQQRLLLELSWEAMENAGIPPSSMSGSNCA
EEEHHHHHHHHHHHCCHHCCCCCCCCCCCCHHHHHHHHCCHHHHHCCCCCCCCCCCCCCE
VYVGISGLDYGTRGLDDLASLSPHMMTGNTLSIAANRLSYVFNLHGPSLAVDTACSSSLV
EEEEECCCCCCCCCHHHHHHCCCCEECCCCHHHHHHCEEEEEEECCCCEEEHHHCCHHHH
ALHHACQALQTGEAGTALVGGVNLLLHPYPFVGFTKASMLSADGRCKAFDASGSGYVRAE
HHHHHHHHHHCCCCCCCHHCCCEEEECCCCCCCCCHHHHHCCCCCEEEEECCCCCEEEEC
GGAVLLLKPFEQAIAEGDDIQAVILATGINTDGARKAGITIPSRDGQSELMMSVLAKTSL
CCEEEEECCHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
SARDIDFIEAHGTGTAVGDPVETAAIGEVYGKKREKPLPIGSVKANLGHMEPASGMAGII
CCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCCHHHHH
KAILALKHHALPPQIHLETPNPNIDFLGLNLRPVTEYLELAKKNNRALIAGVNSFGFGGA
HHHHHHHHCCCCCEEEEECCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCCCCCC
NAHVLLQEYRCRDLATTEPLPASLPPLFLSARSETALKELAGRYADLLHDKSGQDFYDVA
CHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
HAAVNQRDRMEKRLALHSGSVESTIHLLQQYALDNVSADIFIEDSLPQSGDVAFIYSGNG
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEECCCC
AQWAGMGRALLTESSRFEEILTEIDIAMRPLTDFSLLETLQSESELARLSNTAVAQPLLF
CEECCCCHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIQVAVTLLLREQGVTPSAVAGHSVGEIAAAWAAGALDLEPPRVLRRLHYLRRWSHEQIK
HHHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2024119; 1740151 [H]