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The map label for this gene is hisI

Identifier: 114331885

GI number: 114331885

Start: 2024228

End: 2024617

Strand: Direct

Name: hisI

Synonym: Neut_1910

Alternate gene names: 114331885

Gene position: 2024228-2024617 (Clockwise)

Preceding gene: 114331884

Following gene: 114331886

Centisome position: 76.07

GC content: 48.21

Gene sequence:

>390_bases
ATGACAGATGAATGGCTTGATACAATAAACTGGTCAGTTGACGGCCTCATCCCGGTAATCGCACAGGATGAAAACGGTGG
CAAGATTTTGATGGTGGCCTGGATGAACCGCGACGCGCTCAAACGTACTGTCGAAACTGGTGAAGCAGTTTACTGGTCGC
GCTCCAGAAAGAAGCTGTGGCACAAAGGTGAGGAATCCGGCCATACCCAGATAGTCCAGGCAATCCATCTGGATTGTGAT
AAAGATGTCCTCCTCCTCAGTGTGGAACAAAAAGGGGGGATTGCTTGCCATACAGGTAGGCAAAGCTGCTTTTTCCGCCA
ATTGAAAAATGGGGAATGGGTAATCACAGAGCCCGTTATCAAAGACCCATCACAAATTTATACCCAATGA

Upstream 100 bases:

>100_bases
TACCATGGAGGCCGTTTTTCCTACGGTATTCCCACATTTTGCAAGTATTCCTGAAACTGTTAAGATCGCCCTGAAAGCAG
CAGCACACAAGGAACAGCTA

Downstream 100 bases:

>100_bases
CCTCCTCTTCAACGATATTACAGCGACTGACTCAGACGATTGAAGCACGCAAAAGCGCCGACCCTGCTCATTCCTACATC
GCAAAACTGCTAAGCAGCAA

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 129; Mature: 128

Protein sequence:

>129_residues
MTDEWLDTINWSVDGLIPVIAQDENGGKILMVAWMNRDALKRTVETGEAVYWSRSRKKLWHKGEESGHTQIVQAIHLDCD
KDVLLLSVEQKGGIACHTGRQSCFFRQLKNGEWVITEPVIKDPSQIYTQ

Sequences:

>Translated_129_residues
MTDEWLDTINWSVDGLIPVIAQDENGGKILMVAWMNRDALKRTVETGEAVYWSRSRKKLWHKGEESGHTQIVQAIHLDCD
KDVLLLSVEQKGGIACHTGRQSCFFRQLKNGEWVITEPVIKDPSQIYTQ
>Mature_128_residues
TDEWLDTINWSVDGLIPVIAQDENGGKILMVAWMNRDALKRTVETGEAVYWSRSRKKLWHKGEESGHTQIVQAIHLDCDK
DVLLLSVEQKGGIACHTGRQSCFFRQLKNGEWVITEPVIKDPSQIYTQ

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=135, Percent_Identity=37.037037037037, Blast_Score=92, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6319819, Length=120, Percent_Identity=32.5, Blast_Score=68, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_NITEC (Q0AEU0)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_748107.1
- ProteinModelPortal:   Q0AEU0
- SMR:   Q0AEU0
- STRING:   Q0AEU0
- GeneID:   4273694
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_1910
- NMPDR:   fig|335283.3.peg.1034
- eggNOG:   COG0139
- HOGENOM:   HBG294308
- OMA:   LWLKGES
- PhylomeDB:   Q0AEU0
- ProtClustDB:   PRK00051
- BioCyc:   NEUT335283:NEUT_1910-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 14739; Mature: 14608

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDEWLDTINWSVDGLIPVIAQDENGGKILMVAWMNRDALKRTVETGEAVYWSRSRKKLW
CCCHHHHHCCCCCCCEEEEEEECCCCCEEEEEEECCCHHHHHHHHCCCEEEEECHHHHHH
HKGEESGHTQIVQAIHLDCDKDVLLLSVEQKGGIACHTGRQSCFFRQLKNGEWVITEPVI
CCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCEEEECCCHHHHHHHHCCCCEEEECCCC
KDPSQIYTQ
CCCHHHHCC
>Mature Secondary Structure 
TDEWLDTINWSVDGLIPVIAQDENGGKILMVAWMNRDALKRTVETGEAVYWSRSRKKLW
CCHHHHHCCCCCCCEEEEEEECCCCCEEEEEEECCCHHHHHHHHCCCEEEEECHHHHHH
HKGEESGHTQIVQAIHLDCDKDVLLLSVEQKGGIACHTGRQSCFFRQLKNGEWVITEPVI
CCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCEEEECCCHHHHHHHHCCCCEEEECCCC
KDPSQIYTQ
CCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA