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The map label for this gene is ahcY

Identifier: 114331867

GI number: 114331867

Start: 2007260

End: 2008696

Strand: Reverse

Name: ahcY

Synonym: Neut_1892

Alternate gene names: 114331867

Gene position: 2008696-2007260 (Counterclockwise)

Preceding gene: 114331868

Following gene: 114331866

Centisome position: 75.48

GC content: 51.15

Gene sequence:

>1437_bases
ATGAGTGCAACAATCAACCCCGTAGTGGACAACTCTGTTTTTACCGACTGCGAGGTGGCTGATTTGTCATTGGCAGATTG
GGGCAGAAAGGAAATTGCCATTGCCGAAACTGAAATGCCCGGTTTGATGGCGCTGCGCGAACAGTATGCCGGCAAGAAGC
CGCTGGCAGGGGCCAGAATTGCCGGTTCCCTGCACATGACTATCCAGACCGCCGTGTTAATTGAAACACTGGTGGCACTG
GGTGCAGAAGTCCGCTGGGCTTCCTGCAATATTTTCTCCACCCAGGATCATGCTGCTGCGGCGATTGCCGCCCGCGATAT
TCCAGTATTTGCCTACAAGGGAGAATCACTGAAGGAATATTGGGACTACGCTCACCAGATATTTGAATGGACCAGTGATG
GCTCGCATGCCGCCAATATGATTCTGGATGATGGCGGGGATGCCACCTTACTGCTCATCCTTGGCAGCAGGGCTGAACGC
GATCCTTCCGTGATTGCCAATCCGTCCAATGAGGAAGAACAGGTACTGTTTGCTTCCATCCGTAGCCGTCTTACCAGCCA
TCCGGGCTGGTACTCGCGTAACCTTGCCGGAATTCGCGGTGTGACAGAAGAAACCACAACCGGTGTACATCGCCTGTACG
AAATGGAAAAGAAAGGTGAACTTCCATTCCCGGCGATCAATGTCAATGATTCAGTCACCAAATCCAAATTCGATAATCTT
TATGGTTGCCGTGAATCATTGGTGGATGGCATCAAACGCGCAACCGATGTAATGATTGCCGGAAAAATAGCTGTGATTTG
TGGTTATGGCGATGTCGGCAAAGGCTGTGCGCAGTCATTGCGCGGCCTGGGAGCAACTGTCTGGATTACCGAGATTGATC
CAATCTGTGCATTGCAGGCGGCGATGGAAGGATATCGTGTGGTGACCATGGACGATGCCTGTGATAAAGCAGATATTTTC
GTCACCGCCACCGGCAATCTGCGTGTGATCACCCATGACCACATGCTGAAAATGAAGAATCAGGCGATCGTATGCAACAT
CGGCCACTTCGATTCTGAAATCGATATTGCCTCAGTTCAGAAGTACCAGTGGGAAAACATCAAGCCACAGGTTGATCATG
TCATCTTCCCGACTGGCCGCCGCATCATCGTGCTGGCACAAGGACGTCTCGTTAATCTGGGGTGTGCTACCGGCCATCCG
TCTTTTGTCATGTCCAGCTCCTTCACCAATCAGGTGCTGGCGCAGATGGAACTCTGGCAAAACGGTAAAGATTACCAGAA
GAAGGTGTATGTACTTCCTAAACAGCTGGATGAAATGGTTGCGCGTCTGCATCTGGGTAAACTGGGTGTGAAGCTGACCG
AACTGACCGACGAGCAGGCGCACTACCTCAATCTCGATAAAAACGGACCTTATAAACCCGAGATGTACCGTTATTGA

Upstream 100 bases:

>100_bases
TTCCATTTGTACCGAGGAGCGCTGCAACGGTCTATCTCGTGAGGCTCGGACAAATGAACAACCCAACAACGGCGCTCTTT
CACTTCTCAGGAGATGTGTT

Downstream 100 bases:

>100_bases
GTTTGAGTGGTTGAACTGATTGAAGCCGGAGAAATCGCTGTCAAAGCGACAGTTGTATTCCCCCGGCTTTATCCCGGGTT
CTTCATCAGGGCAGAAGATG

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase

Number of amino acids: Translated: 478; Mature: 477

Protein sequence:

>478_residues
MSATINPVVDNSVFTDCEVADLSLADWGRKEIAIAETEMPGLMALREQYAGKKPLAGARIAGSLHMTIQTAVLIETLVAL
GAEVRWASCNIFSTQDHAAAAIAARDIPVFAYKGESLKEYWDYAHQIFEWTSDGSHAANMILDDGGDATLLLILGSRAER
DPSVIANPSNEEEQVLFASIRSRLTSHPGWYSRNLAGIRGVTEETTTGVHRLYEMEKKGELPFPAINVNDSVTKSKFDNL
YGCRESLVDGIKRATDVMIAGKIAVICGYGDVGKGCAQSLRGLGATVWITEIDPICALQAAMEGYRVVTMDDACDKADIF
VTATGNLRVITHDHMLKMKNQAIVCNIGHFDSEIDIASVQKYQWENIKPQVDHVIFPTGRRIIVLAQGRLVNLGCATGHP
SFVMSSSFTNQVLAQMELWQNGKDYQKKVYVLPKQLDEMVARLHLGKLGVKLTELTDEQAHYLNLDKNGPYKPEMYRY

Sequences:

>Translated_478_residues
MSATINPVVDNSVFTDCEVADLSLADWGRKEIAIAETEMPGLMALREQYAGKKPLAGARIAGSLHMTIQTAVLIETLVAL
GAEVRWASCNIFSTQDHAAAAIAARDIPVFAYKGESLKEYWDYAHQIFEWTSDGSHAANMILDDGGDATLLLILGSRAER
DPSVIANPSNEEEQVLFASIRSRLTSHPGWYSRNLAGIRGVTEETTTGVHRLYEMEKKGELPFPAINVNDSVTKSKFDNL
YGCRESLVDGIKRATDVMIAGKIAVICGYGDVGKGCAQSLRGLGATVWITEIDPICALQAAMEGYRVVTMDDACDKADIF
VTATGNLRVITHDHMLKMKNQAIVCNIGHFDSEIDIASVQKYQWENIKPQVDHVIFPTGRRIIVLAQGRLVNLGCATGHP
SFVMSSSFTNQVLAQMELWQNGKDYQKKVYVLPKQLDEMVARLHLGKLGVKLTELTDEQAHYLNLDKNGPYKPEMYRY
>Mature_477_residues
SATINPVVDNSVFTDCEVADLSLADWGRKEIAIAETEMPGLMALREQYAGKKPLAGARIAGSLHMTIQTAVLIETLVALG
AEVRWASCNIFSTQDHAAAAIAARDIPVFAYKGESLKEYWDYAHQIFEWTSDGSHAANMILDDGGDATLLLILGSRAERD
PSVIANPSNEEEQVLFASIRSRLTSHPGWYSRNLAGIRGVTEETTTGVHRLYEMEKKGELPFPAINVNDSVTKSKFDNLY
GCRESLVDGIKRATDVMIAGKIAVICGYGDVGKGCAQSLRGLGATVWITEIDPICALQAAMEGYRVVTMDDACDKADIFV
TATGNLRVITHDHMLKMKNQAIVCNIGHFDSEIDIASVQKYQWENIKPQVDHVIFPTGRRIIVLAQGRLVNLGCATGHPS
FVMSSSFTNQVLAQMELWQNGKDYQKKVYVLPKQLDEMVARLHLGKLGVKLTELTDEQAHYLNLDKNGPYKPEMYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family

Homologues:

Organism=Homo sapiens, GI9951915, Length=463, Percent_Identity=61.5550755939525, Blast_Score=537, Evalue=1e-153,
Organism=Homo sapiens, GI239937451, Length=442, Percent_Identity=61.5384615384615, Blast_Score=511, Evalue=1e-145,
Organism=Homo sapiens, GI195539337, Length=470, Percent_Identity=49.7872340425532, Blast_Score=469, Evalue=1e-132,
Organism=Homo sapiens, GI24308043, Length=470, Percent_Identity=49.7872340425532, Blast_Score=469, Evalue=1e-132,
Organism=Homo sapiens, GI298286489, Length=470, Percent_Identity=49.7872340425532, Blast_Score=469, Evalue=1e-132,
Organism=Homo sapiens, GI195539349, Length=470, Percent_Identity=49.7872340425532, Blast_Score=467, Evalue=1e-131,
Organism=Homo sapiens, GI21361647, Length=466, Percent_Identity=49.7854077253219, Blast_Score=453, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI17506425, Length=467, Percent_Identity=59.3147751605996, Blast_Score=525, Evalue=1e-149,
Organism=Saccharomyces cerevisiae, GI6320882, Length=478, Percent_Identity=57.5313807531381, Blast_Score=511, Evalue=1e-145,
Organism=Drosophila melanogaster, GI24642172, Length=463, Percent_Identity=59.8272138228942, Blast_Score=519, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24656245, Length=458, Percent_Identity=50, Blast_Score=454, Evalue=1e-128,
Organism=Drosophila melanogaster, GI45553387, Length=466, Percent_Identity=50.4291845493562, Blast_Score=444, Evalue=1e-125,
Organism=Drosophila melanogaster, GI45553385, Length=465, Percent_Identity=50.3225806451613, Blast_Score=442, Evalue=1e-124,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SAHH_NITEC (Q0AEV8)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_748089.1
- ProteinModelPortal:   Q0AEV8
- SMR:   Q0AEV8
- STRING:   Q0AEV8
- GeneID:   4274138
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_1892
- NMPDR:   fig|335283.3.peg.1016
- eggNOG:   COG0499
- HOGENOM:   HBG352029
- OMA:   VITHDHM
- PhylomeDB:   Q0AEV8
- ProtClustDB:   PRK05476
- BioCyc:   NEUT335283:NEUT_1892-MONOMER
- GO:   GO:0005737
- GO:   GO:0005488
- HAMAP:   MF_00563
- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082
- PANTHER:   PTHR23420
- PIRSF:   PIRSF001109
- TIGRFAMs:   TIGR00936

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD

EC number: =3.3.1.1

Molecular weight: Translated: 52733; Mature: 52602

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS00738 ADOHCYASE_1; PS00739 ADOHCYASE_2

Important sites: BINDING 67-67 BINDING 144-144 BINDING 204-204 BINDING 234-234 BINDING 238-238 BINDING 239-239 BINDING 291-291 BINDING 326-326 BINDING 392-392

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSATINPVVDNSVFTDCEVADLSLADWGRKEIAIAETEMPGLMALREQYAGKKPLAGARI
CCCCCCCCCCCCCCCCCCEECCCHHCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCEE
AGSLHMTIQTAVLIETLVALGAEVRWASCNIFSTQDHAAAAIAARDIPVFAYKGESLKEY
ECEEEEHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCHHHEEEECCCEEEEECCCHHHHH
WDYAHQIFEWTSDGSHAANMILDDGGDATLLLILGSRAERDPSVIANPSNEEEQVLFASI
HHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEEECCCCCCCCCEEECCCCCHHHHHHHHH
RSRLTSHPGWYSRNLAGIRGVTEETTTGVHRLYEMEKKGELPFPAINVNDSVTKSKFDNL
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHH
YGCRESLVDGIKRATDVMIAGKIAVICGYGDVGKGCAQSLRGLGATVWITEIDPICALQA
HHHHHHHHHHHHHHHHEEEECEEEEEECCCCCCHHHHHHHHHCCEEEEEEECCHHHHHHH
AMEGYRVVTMDDACDKADIFVTATGNLRVITHDHMLKMKNQAIVCNIGHFDSEIDIASVQ
HHCCCEEEEECCCCCCCCEEEEECCCEEEEECHHHHEECCCEEEEEECCCCCCCCHHHHH
KYQWENIKPQVDHVIFPTGRRIIVLAQGRLVNLGCATGHPSFVMSSSFTNQVLAQMELWQ
HHHCCCCCCCCCEEEECCCCEEEEEECCEEEEEEECCCCCCEEEECHHHHHHHHHHHHHC
NGKDYQKKVYVLPKQLDEMVARLHLGKLGVKLTELTDEQAHYLNLDKNGPYKPEMYRY
CCCCCCCEEEECHHHHHHHHHHHHHHHCCEEEEECCCCCCEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
SATINPVVDNSVFTDCEVADLSLADWGRKEIAIAETEMPGLMALREQYAGKKPLAGARI
CCCCCCCCCCCCCCCCCEECCCHHCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCEE
AGSLHMTIQTAVLIETLVALGAEVRWASCNIFSTQDHAAAAIAARDIPVFAYKGESLKEY
ECEEEEHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCHHHEEEECCCEEEEECCCHHHHH
WDYAHQIFEWTSDGSHAANMILDDGGDATLLLILGSRAERDPSVIANPSNEEEQVLFASI
HHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEEECCCCCCCCCEEECCCCCHHHHHHHHH
RSRLTSHPGWYSRNLAGIRGVTEETTTGVHRLYEMEKKGELPFPAINVNDSVTKSKFDNL
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHH
YGCRESLVDGIKRATDVMIAGKIAVICGYGDVGKGCAQSLRGLGATVWITEIDPICALQA
HHHHHHHHHHHHHHHHEEEECEEEEEECCCCCCHHHHHHHHHCCEEEEEEECCHHHHHHH
AMEGYRVVTMDDACDKADIFVTATGNLRVITHDHMLKMKNQAIVCNIGHFDSEIDIASVQ
HHCCCEEEEECCCCCCCCEEEEECCCEEEEECHHHHEECCCEEEEEECCCCCCCCHHHHH
KYQWENIKPQVDHVIFPTGRRIIVLAQGRLVNLGCATGHPSFVMSSSFTNQVLAQMELWQ
HHHCCCCCCCCCEEEECCCCEEEEEECCEEEEEEECCCCCCEEEECHHHHHHHHHHHHHC
NGKDYQKKVYVLPKQLDEMVARLHLGKLGVKLTELTDEQAHYLNLDKNGPYKPEMYRY
CCCCCCCEEEECHHHHHHHHHHHHHHHCCEEEEECCCCCCEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA