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The map label for this gene is sbcB [H]

Identifier: 114331862

GI number: 114331862

Start: 2002029

End: 2003489

Strand: Reverse

Name: sbcB [H]

Synonym: Neut_1887

Alternate gene names: 114331862

Gene position: 2003489-2002029 (Counterclockwise)

Preceding gene: 114331863

Following gene: 114331861

Centisome position: 75.29

GC content: 52.98

Gene sequence:

>1461_bases
ATGCGAATGGATACCTCAACACTCTACTGGCACGATTATGAAACCTCCGGTGCGAACCCTCGTCAGGATCGGCCGGTTCA
GTTTGCTGGGCTGAGGACGGATGAAGCGCTCAATGAAATTGGCGATCCGCTGGTGATTTATTGCAAACCGGCGCGTGATC
GGCTGCCGCATCCGGAAGCTTGTCTGCTTACCGGTATCACACCACAAATGGCAGCAACCAGAGGGTTGCCGGAACCGGAA
TTCATCGCACTGATTCATGCACAGCTGGCACAACCGGGTACCTGCGGGGTGGGCTATAACACGCTACGGTTTGATGATGA
AGTCACCCGCTTTGCGCTGTATCGCAATTTCTACGATCCCTATGCACGCGAATGGCAGTCCGGCAATTCGCGCTGGGATG
TGATCGACCTCGCCCGCATGACTTTTGCTCTGCGTCCGGAAGGCATCAACTGGCCGGTCAATGGGGAAGGGAAGCCTAGT
TTCCGATTGGAGGATATTACCGCTGCCAACGGGTTAATGCATGATAGTGCGCACGATGCGTTATCCGATGTTCGCGCCAC
CATCGCACTGGCTCGCTTGCTACGTGACCGGCAGCCGCGTTTGTATGACTGGCTGTTCCGTTTGCGGGATAAGCGTGAAG
CATCTCATCTGCTCGATCTGACAGCACATACCCCGGTATTGCATACCTCGCGTATGTATCCATCCGAACAAGGTTGCACC
ACGCTGGTGATGCCGCTGCTGCCTGAAACAGGCAATACCAACAGTATTCTGGTTTACGACTTGCGGCATGATCCTGCTGA
ATTTATGCAGCTGAATGTTGATGCGCTGGTGGAACGTCTGTTCACGCCCAAATTGGAATTGGCGGAAGGGCAGCAGCGCC
TGCCGGTCAAGACGATTAGGCTGAACAAATGTCCGGCACTGGCGCCACAGAAAGTTCTTAATGATGAGATTGCCAAACGA
ATCGGACTGAATGACGAACAATGTCAGCAACACTGGCAACTGTTACTGCAGCATCCGGATTTCATGCAGCGGATCAGGCA
AGCGTATTCAAATGGCAAGATTTTTCCAGAAAATGATGCTGATCTGGCGTTGTACGATGGTTTTGCAAACGATCACGACC
GTAACCTGTTCCCGCTCGTGCGCGATTCAGAACCGGAGAGACTGATTGATCTCTCAGAAGAATTTCAGGATGGACGTTAT
GCTGAACTGCTGTTTCGCTATCGTGCCCGCAACTTTCCCGATACCTTGTCGGCCCAGGAAAAACACCGCTGGCAAGTCCA
TTGCCGTAGACAGCTCGGTGAAGATGCTATCAACGGTAGCCTGACATTAAACAAATACCGTCAGAAGCTGATACAACTGC
GTACCGATTGTCCGCAACAGGCACAGCAGGAAATCCTGAACGAACTGGAAGCATGGGGCAGGGCGCTGGCACAGGAAAAT
GATCTGCCCTGGCCCGATTAA

Upstream 100 bases:

>100_bases
ATCAGGATTGATTCGAGATTTTTGTTAAGACCCGGTTATTCAGGAATGGATCGGGAAAATAAATCCGCGTTTTCCAACCT
GTTACGGACTAACCACCATT

Downstream 100 bases:

>100_bases
CTGTTCTTCTATGAGCAATGCCGATGCGAAATTGGGTTACATCAAAAATTTCCGGATTTTTTAATATCTATCAATGACTA
CAGCAATTTTGAGTGCTTTG

Product: exonuclease I

Products: NA

Alternate protein names: Exonuclease I; DNA deoxyribophosphodiesterase; dRPase [H]

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MRMDTSTLYWHDYETSGANPRQDRPVQFAGLRTDEALNEIGDPLVIYCKPARDRLPHPEACLLTGITPQMAATRGLPEPE
FIALIHAQLAQPGTCGVGYNTLRFDDEVTRFALYRNFYDPYAREWQSGNSRWDVIDLARMTFALRPEGINWPVNGEGKPS
FRLEDITAANGLMHDSAHDALSDVRATIALARLLRDRQPRLYDWLFRLRDKREASHLLDLTAHTPVLHTSRMYPSEQGCT
TLVMPLLPETGNTNSILVYDLRHDPAEFMQLNVDALVERLFTPKLELAEGQQRLPVKTIRLNKCPALAPQKVLNDEIAKR
IGLNDEQCQQHWQLLLQHPDFMQRIRQAYSNGKIFPENDADLALYDGFANDHDRNLFPLVRDSEPERLIDLSEEFQDGRY
AELLFRYRARNFPDTLSAQEKHRWQVHCRRQLGEDAINGSLTLNKYRQKLIQLRTDCPQQAQQEILNELEAWGRALAQEN
DLPWPD

Sequences:

>Translated_486_residues
MRMDTSTLYWHDYETSGANPRQDRPVQFAGLRTDEALNEIGDPLVIYCKPARDRLPHPEACLLTGITPQMAATRGLPEPE
FIALIHAQLAQPGTCGVGYNTLRFDDEVTRFALYRNFYDPYAREWQSGNSRWDVIDLARMTFALRPEGINWPVNGEGKPS
FRLEDITAANGLMHDSAHDALSDVRATIALARLLRDRQPRLYDWLFRLRDKREASHLLDLTAHTPVLHTSRMYPSEQGCT
TLVMPLLPETGNTNSILVYDLRHDPAEFMQLNVDALVERLFTPKLELAEGQQRLPVKTIRLNKCPALAPQKVLNDEIAKR
IGLNDEQCQQHWQLLLQHPDFMQRIRQAYSNGKIFPENDADLALYDGFANDHDRNLFPLVRDSEPERLIDLSEEFQDGRY
AELLFRYRARNFPDTLSAQEKHRWQVHCRRQLGEDAINGSLTLNKYRQKLIQLRTDCPQQAQQEILNELEAWGRALAQEN
DLPWPD
>Mature_486_residues
MRMDTSTLYWHDYETSGANPRQDRPVQFAGLRTDEALNEIGDPLVIYCKPARDRLPHPEACLLTGITPQMAATRGLPEPE
FIALIHAQLAQPGTCGVGYNTLRFDDEVTRFALYRNFYDPYAREWQSGNSRWDVIDLARMTFALRPEGINWPVNGEGKPS
FRLEDITAANGLMHDSAHDALSDVRATIALARLLRDRQPRLYDWLFRLRDKREASHLLDLTAHTPVLHTSRMYPSEQGCT
TLVMPLLPETGNTNSILVYDLRHDPAEFMQLNVDALVERLFTPKLELAEGQQRLPVKTIRLNKCPALAPQKVLNDEIAKR
IGLNDEQCQQHWQLLLQHPDFMQRIRQAYSNGKIFPENDADLALYDGFANDHDRNLFPLVRDSEPERLIDLSEEFQDGRY
AELLFRYRARNFPDTLSAQEKHRWQVHCRRQLGEDAINGSLTLNKYRQKLIQLRTDCPQQAQQEILNELEAWGRALAQEN
DLPWPD

Specific function: Also functions as a DNA deoxyribophosphodiesterase that releases deoxyribose-phosphate moieties following the cleavage DNA at an apurinic/apyrimidinic (AP) site by either an AP endonuclease AP lyase [H]

COG id: COG2925

COG function: function code L; Exonuclease I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1788321, Length=435, Percent_Identity=46.6666666666667, Blast_Score=407, Evalue=1e-115,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013620
- InterPro:   IPR013520
- InterPro:   IPR012337 [H]

Pfam domain/function: PF00929 Exonuc_X-T; PF08411 Exonuc_X-T_C [H]

EC number: =3.1.11.1 [H]

Molecular weight: Translated: 56074; Mature: 56074

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMDTSTLYWHDYETSGANPRQDRPVQFAGLRTDEALNEIGDPLVIYCKPARDRLPHPEA
CCCCCCEEEEECCCCCCCCCCCCCCEEEECCCCHHHHHHCCCCEEEEEECHHCCCCCCCC
CLLTGITPQMAATRGLPEPEFIALIHAQLAQPGTCGVGYNTLRFDDEVTRFALYRNFYDP
EEEECCCHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHHHHCCH
YAREWQSGNSRWDVIDLARMTFALRPEGINWPVNGEGKPSFRLEDITAANGLMHDSAHDA
HHHHHCCCCCCCHHHHHHHHHHEECCCCCCCCCCCCCCCCEEEEHHHHHCCCCCCHHHHH
LSDVRATIALARLLRDRQPRLYDWLFRLRDKREASHLLDLTAHTPVLHTSRMYPSEQGCT
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCC
TLVMPLLPETGNTNSILVYDLRHDPAEFMQLNVDALVERLFTPKLELAEGQQRLPVKTIR
EEEEECCCCCCCCCEEEEEECCCCHHHHHHCCHHHHHHHHCCCCHHHHCCCCCCCEEEEE
LNKCPALAPQKVLNDEIAKRIGLNDEQCQQHWQLLLQHPDFMQRIRQAYSNGKIFPENDA
ECCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCC
DLALYDGFANDHDRNLFPLVRDSEPERLIDLSEEFQDGRYAELLFRYRARNFPDTLSAQE
CEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHH
KHRWQVHCRRQLGEDAINGSLTLNKYRQKLIQLRTDCPQQAQQEILNELEAWGRALAQEN
HHHHHHHHHHHHCHHHCCCCEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCC
DLPWPD
CCCCCC
>Mature Secondary Structure
MRMDTSTLYWHDYETSGANPRQDRPVQFAGLRTDEALNEIGDPLVIYCKPARDRLPHPEA
CCCCCCEEEEECCCCCCCCCCCCCCEEEECCCCHHHHHHCCCCEEEEEECHHCCCCCCCC
CLLTGITPQMAATRGLPEPEFIALIHAQLAQPGTCGVGYNTLRFDDEVTRFALYRNFYDP
EEEECCCHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHHHHCCH
YAREWQSGNSRWDVIDLARMTFALRPEGINWPVNGEGKPSFRLEDITAANGLMHDSAHDA
HHHHHCCCCCCCHHHHHHHHHHEECCCCCCCCCCCCCCCCEEEEHHHHHCCCCCCHHHHH
LSDVRATIALARLLRDRQPRLYDWLFRLRDKREASHLLDLTAHTPVLHTSRMYPSEQGCT
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCC
TLVMPLLPETGNTNSILVYDLRHDPAEFMQLNVDALVERLFTPKLELAEGQQRLPVKTIR
EEEEECCCCCCCCCEEEEEECCCCHHHHHHCCHHHHHHHHCCCCHHHHCCCCCCCEEEEE
LNKCPALAPQKVLNDEIAKRIGLNDEQCQQHWQLLLQHPDFMQRIRQAYSNGKIFPENDA
ECCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCC
DLALYDGFANDHDRNLFPLVRDSEPERLIDLSEEFQDGRYAELLFRYRARNFPDTLSAQE
CEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHH
KHRWQVHCRRQLGEDAINGSLTLNKYRQKLIQLRTDCPQQAQQEILNELEAWGRALAQEN
HHHHHHHHHHHHCHHHCCCCEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCC
DLPWPD
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3539937; 9097040; 9278503; 1329027 [H]