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The map label for this gene is mtnN [H]

Identifier: 114331861

GI number: 114331861

Start: 2001182

End: 2001955

Strand: Reverse

Name: mtnN [H]

Synonym: Neut_1886

Alternate gene names: 114331861

Gene position: 2001955-2001182 (Counterclockwise)

Preceding gene: 114331862

Following gene: 114331860

Centisome position: 75.23

GC content: 55.56

Gene sequence:

>774_bases
ATGACTACAGCAATTTTGAGTGCTTTGCCAGAAGAACAGGGCGGTTTGGTACAGGCGCTGGAGCAACGGGAGCAGTTTCA
GTATGCGGGGCGTGTATTTTGGCGCGGTCGTCTGCATGGCCAGACAGTGGTGCTGGGATTATCTGGCATTGGCAAGGTGG
CAGCGGCGACAACAGCTGTTGTGCTGTTTGAACGATTGGGTGCGCAGCGCATCGTGTTTACGGGTGTGGCTGGTGGTATG
GGGGAAGGTGTGCAGGTGGGTGATGTGGTCATCGCTACGCAATTTCTGCAGCACGATATGGATGCATCGCCCATTTTCCC
GCGTTGGGAAGTACCAGGTTATGGCTGTACACAATTTGCCTGCGATCCGGAACTGTCTACTCTATTATTTGCAGCGGCGC
ACGCTTATCTGACAAATACCCAAGCTGATATACCTCGGAGCAGTGGTGTCGCGCGCACTCATTTAGCGCGGGTGCACCAG
GGTTTAATCGTCAGTGGAGATCGTTTTGTCAGTACCTTGGCTGAATCAATTGCGCTGCGTACCACGCTCGCCGCAGCCGG
CCACCAGGCGCTCGCTGTCGAGATGGAAGGCGCTGCAGTAGCACAGGTGTGCAGTGACTTTGGCAAACCGTTCGCTGCCG
TGCGCACCATTTCTGATCGCGCCGATGACAGCGCTCACATCGATTTCCCGCGCTTCATCTGTGAGGTTGCACGACCTTAT
GCAGATCACATCATCGCAGGCTTTTTGCAGCGACAGTTGGTCGGGGTTGCATAG

Upstream 100 bases:

>100_bases
GAAAATGATCTGCCCTGGCCCGATTAACTGTTCTTCTATGAGCAATGCCGATGCGAAATTGGGTTACATCAAAAATTTCC
GGATTTTTTAATATCTATCA

Downstream 100 bases:

>100_bases
AATCAAAGATGAGCGGAGTGACTGGTGAGCGAGCAGATCAAGCTGGGAGATCTTACGATTTTCATGCAGCGCAAGAGAGT
GAAACATATTTACTTGAGGG

Product: 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase

Products: NA

Alternate protein names: MTA/SAH nucleosidase; MTAN; 5'-methylthioadenosine nucleosidase; MTA nucleosidase; S-adenosylhomocysteine nucleosidase; AdoHcy nucleosidase; SAH nucleosidase; SRH nucleosidase [H]

Number of amino acids: Translated: 257; Mature: 256

Protein sequence:

>257_residues
MTTAILSALPEEQGGLVQALEQREQFQYAGRVFWRGRLHGQTVVLGLSGIGKVAAATTAVVLFERLGAQRIVFTGVAGGM
GEGVQVGDVVIATQFLQHDMDASPIFPRWEVPGYGCTQFACDPELSTLLFAAAHAYLTNTQADIPRSSGVARTHLARVHQ
GLIVSGDRFVSTLAESIALRTTLAAAGHQALAVEMEGAAVAQVCSDFGKPFAAVRTISDRADDSAHIDFPRFICEVARPY
ADHIIAGFLQRQLVGVA

Sequences:

>Translated_257_residues
MTTAILSALPEEQGGLVQALEQREQFQYAGRVFWRGRLHGQTVVLGLSGIGKVAAATTAVVLFERLGAQRIVFTGVAGGM
GEGVQVGDVVIATQFLQHDMDASPIFPRWEVPGYGCTQFACDPELSTLLFAAAHAYLTNTQADIPRSSGVARTHLARVHQ
GLIVSGDRFVSTLAESIALRTTLAAAGHQALAVEMEGAAVAQVCSDFGKPFAAVRTISDRADDSAHIDFPRFICEVARPY
ADHIIAGFLQRQLVGVA
>Mature_256_residues
TTAILSALPEEQGGLVQALEQREQFQYAGRVFWRGRLHGQTVVLGLSGIGKVAAATTAVVLFERLGAQRIVFTGVAGGMG
EGVQVGDVVIATQFLQHDMDASPIFPRWEVPGYGCTQFACDPELSTLLFAAAHAYLTNTQADIPRSSGVARTHLARVHQG
LIVSGDRFVSTLAESIALRTTLAAAGHQALAVEMEGAAVAQVCSDFGKPFAAVRTISDRADDSAHIDFPRFICEVARPYA
DHIIAGFLQRQLVGVA

Specific function: Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively [H]

COG id: COG0775

COG function: function code F; Nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/UDP phosphorylase family. MtnN subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786354, Length=240, Percent_Identity=33.75, Blast_Score=104, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010049
- InterPro:   IPR018017
- InterPro:   IPR000845 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: =3.2.2.9 [H]

Molecular weight: Translated: 27376; Mature: 27244

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTAILSALPEEQGGLVQALEQREQFQYAGRVFWRGRLHGQTVVLGLSGIGKVAAATTAV
CCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHEEECEECCCEEEEECCCCCHHHHHHHHH
VLFERLGAQRIVFTGVAGGMGEGVQVGDVVIATQFLQHDMDASPIFPRWEVPGYGCTQFA
HHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
CDPELSTLLFAAAHAYLTNTQADIPRSSGVARTHLARVHQGLIVSGDRFVSTLAESIALR
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCEEECCHHHHHHHHHHHHHH
TTLAAAGHQALAVEMEGAAVAQVCSDFGKPFAAVRTISDRADDSAHIDFPRFICEVARPY
HHHHHCCCCEEEEEECCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
ADHIIAGFLQRQLVGVA
HHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TTAILSALPEEQGGLVQALEQREQFQYAGRVFWRGRLHGQTVVLGLSGIGKVAAATTAV
CHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHEEECEECCCEEEEECCCCCHHHHHHHHH
VLFERLGAQRIVFTGVAGGMGEGVQVGDVVIATQFLQHDMDASPIFPRWEVPGYGCTQFA
HHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
CDPELSTLLFAAAHAYLTNTQADIPRSSGVARTHLARVHQGLIVSGDRFVSTLAESIALR
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCEEECCHHHHHHHHHHHHHH
TTLAAAGHQALAVEMEGAAVAQVCSDFGKPFAAVRTISDRADDSAHIDFPRFICEVARPY
HHHHHCCCCEEEEEECCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
ADHIIAGFLQRQLVGVA
HHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]