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The map label for this gene is ggt [H]

Identifier: 114331819

GI number: 114331819

Start: 1953058

End: 1954830

Strand: Reverse

Name: ggt [H]

Synonym: Neut_1843

Alternate gene names: 114331819

Gene position: 1954830-1953058 (Counterclockwise)

Preceding gene: 114331820

Following gene: 114331818

Centisome position: 73.46

GC content: 53.92

Gene sequence:

>1773_bases
TTGCTCATTCGCAACCTCTTCTTGCTGTTAAGCAATATTTCCCTGATTCTGCTGACGGCATGCAGCACGACTCCAACCGT
TCCGCTAACGACCCCCCCGTCTGTATCACAAACTACCGCAGCCGCAATAATCTACGACTGGGATATGGATATATTCCATC
CTGTCGTGGCGCGGCATGGCATGGTGGCCACCGAACAAAAGCTGGCTTCCAGAATCGGGGTGGACATTCTCAAAGCGGGC
GGCAATGCGATTGATGCCGCCGTGGCGATTGGCTTTGGTCTGGCGGTAACGTTACCCAATGCGGGCAATATTGGCGGCGG
GGGATTTATGCTGGTTCATGACGCCCAAACTGGGCGATCAACCGCGTTGGATTTTCGTGAAACTGCTCCGGCAGCCGCCA
GCCGTGATATGTATCTGGATTCGGCAGGGAATGTCATAAATAAAAAATCACTTTTCAGTCACGCAGCGGTGGGGGTTCCA
GGTACAGTTGCCGGAATGATCCACGCATTGCAACGCTGGGGCTCCATGCCGCTGGCAAAAGTGATGCAACCGGCGATCAC
ACTGGCGGAAGAAGGTTATCCAGTCAGCAAAACGCTCGCTAAAGGGTTGCAGTATTCAGCGGGCAACATGGGGAAGTGGC
CAGCCACCCGGGCAATCTTCTGGAAAAATGATATGCCGTTGAAAACGGGTGATAAGCTGGTACAGCAAGATCTGGCCAAT
TCGCTGCGTTTAATTGCACGCGATGGCGCCAGGGCGTTTTATGCAGGAGAGATTGCGCATAGGATTGCTGCGGATATGGC
CAGAAACGGCAGCCCGATGACAATGGAAGATCTGGAAAATTACCGGATAACTGAGCGCGAGCCGGTACGTGGCACCTATC
GCGGTTATGAGATCGTTACCATGCCGCCGCCTTCTTCAGGCGGTGTGCATCTGGTACAGATGCTTAATATGCTGGAGCAT
TGGCCGCTCAGGGAGTGGGGGCACAACAGTGCACGAACGATTCATCATATGACGGAAGCCATGAAGCTGGCTTATGCTGA
TCGATCTGAATATCTGGGAGATCCGGATTTTGTCAACGTCCCGCTCACTGGCCTGATCAGCAAAGCTTATGCTGAGGCGC
TGGTATCACACATTGATCCGGATCACGCTCGTGTCGCAGAGGCCATCAAACCAGGCCAGCCGCAATTCCATGAAAGCAAT
CAGACTACGCACTTTTCGGTGATGGATTCAGCCGGCAATATGGTTGCCGTCACTTATACGCTCAACACCAATTTTGGCAG
CGGTATTGTCGCACCCGGCACGGGCATCGTGCTCAATAATGAAATGGATGATTTTTCAATCAAACCAGGGATGCCCAACG
TGTACGGCGTCATCGGCGGCGAGGCCAATGCGGTTGCCGCAGGCAAACGCCCGCTTTCATCCATGACGCCTGCGTTTGTT
TTCAAGGCGGGCAAACCCTGGTTGGTGACTGGCAGCCCCGGCGGGCCACGCATTATTACCACGGTGTTGCAGCAAATCGT
AAACGGTATCGACTTTGCCATGAATCCTGCTGAAGCAGCCTCAGCTGCACGCTTCCACCATCAGTGGACACCGGACGAAC
TGCGACTGGAAAAAGGGATTTCGCCTGATACCTTGCGTCTTTTACAGGAAAAAGGGCATCGCATTGTTATCAAGCCCACC
ATGGGCCGTACCCAGACTATCCAGCTGCACGGTGATGAACTTTGGGGCTATTCCGACCCGCGCAATCCAGATGGAGCAAC
CGTGGGGTTTTGA

Upstream 100 bases:

>100_bases
CGTGGGAGAGCATGCTGTCTATCATAACCACTACCCGCCATCCCATTGCGTGGATTGCCGGCTGCATTGAGCAGCATGGG
ATTAAAAAAGGAGTATCCAT

Downstream 100 bases:

>100_bases
GGGGCCGTCGAAATTTTTCTAAAGCCAAAAAAACGATCGCCGTTATACTCCCCAGCAGTATTCATCAGCGCACCAAGCTG
TAACCAGCGAATTCTATTTT

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 590; Mature: 590

Protein sequence:

>590_residues
MLIRNLFLLLSNISLILLTACSTTPTVPLTTPPSVSQTTAAAIIYDWDMDIFHPVVARHGMVATEQKLASRIGVDILKAG
GNAIDAAVAIGFGLAVTLPNAGNIGGGGFMLVHDAQTGRSTALDFRETAPAAASRDMYLDSAGNVINKKSLFSHAAVGVP
GTVAGMIHALQRWGSMPLAKVMQPAITLAEEGYPVSKTLAKGLQYSAGNMGKWPATRAIFWKNDMPLKTGDKLVQQDLAN
SLRLIARDGARAFYAGEIAHRIAADMARNGSPMTMEDLENYRITEREPVRGTYRGYEIVTMPPPSSGGVHLVQMLNMLEH
WPLREWGHNSARTIHHMTEAMKLAYADRSEYLGDPDFVNVPLTGLISKAYAEALVSHIDPDHARVAEAIKPGQPQFHESN
QTTHFSVMDSAGNMVAVTYTLNTNFGSGIVAPGTGIVLNNEMDDFSIKPGMPNVYGVIGGEANAVAAGKRPLSSMTPAFV
FKAGKPWLVTGSPGGPRIITTVLQQIVNGIDFAMNPAEAASAARFHHQWTPDELRLEKGISPDTLRLLQEKGHRIVIKPT
MGRTQTIQLHGDELWGYSDPRNPDGATVGF

Sequences:

>Translated_590_residues
MLIRNLFLLLSNISLILLTACSTTPTVPLTTPPSVSQTTAAAIIYDWDMDIFHPVVARHGMVATEQKLASRIGVDILKAG
GNAIDAAVAIGFGLAVTLPNAGNIGGGGFMLVHDAQTGRSTALDFRETAPAAASRDMYLDSAGNVINKKSLFSHAAVGVP
GTVAGMIHALQRWGSMPLAKVMQPAITLAEEGYPVSKTLAKGLQYSAGNMGKWPATRAIFWKNDMPLKTGDKLVQQDLAN
SLRLIARDGARAFYAGEIAHRIAADMARNGSPMTMEDLENYRITEREPVRGTYRGYEIVTMPPPSSGGVHLVQMLNMLEH
WPLREWGHNSARTIHHMTEAMKLAYADRSEYLGDPDFVNVPLTGLISKAYAEALVSHIDPDHARVAEAIKPGQPQFHESN
QTTHFSVMDSAGNMVAVTYTLNTNFGSGIVAPGTGIVLNNEMDDFSIKPGMPNVYGVIGGEANAVAAGKRPLSSMTPAFV
FKAGKPWLVTGSPGGPRIITTVLQQIVNGIDFAMNPAEAASAARFHHQWTPDELRLEKGISPDTLRLLQEKGHRIVIKPT
MGRTQTIQLHGDELWGYSDPRNPDGATVGF
>Mature_590_residues
MLIRNLFLLLSNISLILLTACSTTPTVPLTTPPSVSQTTAAAIIYDWDMDIFHPVVARHGMVATEQKLASRIGVDILKAG
GNAIDAAVAIGFGLAVTLPNAGNIGGGGFMLVHDAQTGRSTALDFRETAPAAASRDMYLDSAGNVINKKSLFSHAAVGVP
GTVAGMIHALQRWGSMPLAKVMQPAITLAEEGYPVSKTLAKGLQYSAGNMGKWPATRAIFWKNDMPLKTGDKLVQQDLAN
SLRLIARDGARAFYAGEIAHRIAADMARNGSPMTMEDLENYRITEREPVRGTYRGYEIVTMPPPSSGGVHLVQMLNMLEH
WPLREWGHNSARTIHHMTEAMKLAYADRSEYLGDPDFVNVPLTGLISKAYAEALVSHIDPDHARVAEAIKPGQPQFHESN
QTTHFSVMDSAGNMVAVTYTLNTNFGSGIVAPGTGIVLNNEMDDFSIKPGMPNVYGVIGGEANAVAAGKRPLSSMTPAFV
FKAGKPWLVTGSPGGPRIITTVLQQIVNGIDFAMNPAEAASAARFHHQWTPDELRLEKGISPDTLRLLQEKGHRIVIKPT
MGRTQTIQLHGDELWGYSDPRNPDGATVGF

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=509, Percent_Identity=32.8094302554028, Blast_Score=250, Evalue=3e-66,
Organism=Homo sapiens, GI73915090, Length=509, Percent_Identity=32.8094302554028, Blast_Score=250, Evalue=3e-66,
Organism=Homo sapiens, GI73915096, Length=509, Percent_Identity=32.8094302554028, Blast_Score=250, Evalue=3e-66,
Organism=Homo sapiens, GI73915094, Length=509, Percent_Identity=32.8094302554028, Blast_Score=250, Evalue=3e-66,
Organism=Homo sapiens, GI113429324, Length=509, Percent_Identity=31.041257367387, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI113429326, Length=514, Percent_Identity=30.7392996108949, Blast_Score=216, Evalue=5e-56,
Organism=Homo sapiens, GI109148539, Length=576, Percent_Identity=30.0347222222222, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI153266885, Length=555, Percent_Identity=28.4684684684685, Blast_Score=180, Evalue=4e-45,
Organism=Homo sapiens, GI153266901, Length=556, Percent_Identity=28.7769784172662, Blast_Score=179, Evalue=6e-45,
Organism=Homo sapiens, GI153266907, Length=555, Percent_Identity=27.2072072072072, Blast_Score=159, Evalue=9e-39,
Organism=Homo sapiens, GI30581157, Length=200, Percent_Identity=32, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI30581155, Length=200, Percent_Identity=32, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI218505805, Length=199, Percent_Identity=30.1507537688442, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI310124095, Length=200, Percent_Identity=29.5, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1789856, Length=591, Percent_Identity=54.6531302876481, Blast_Score=651, Evalue=0.0,
Organism=Caenorhabditis elegans, GI212646519, Length=535, Percent_Identity=33.8317757009346, Blast_Score=253, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI72000294, Length=534, Percent_Identity=33.3333333333333, Blast_Score=253, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI193208247, Length=526, Percent_Identity=32.5095057034221, Blast_Score=238, Evalue=9e-63,
Organism=Caenorhabditis elegans, GI193208245, Length=526, Percent_Identity=32.5095057034221, Blast_Score=237, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17506189, Length=513, Percent_Identity=32.943469785575, Blast_Score=235, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI17542894, Length=548, Percent_Identity=31.2043795620438, Blast_Score=230, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17564448, Length=449, Percent_Identity=27.6169265033408, Blast_Score=97, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6323330, Length=529, Percent_Identity=29.8676748582231, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI161077496, Length=509, Percent_Identity=32.8094302554028, Blast_Score=229, Evalue=4e-60,
Organism=Drosophila melanogaster, GI161077880, Length=519, Percent_Identity=32.1772639691715, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI24642670, Length=519, Percent_Identity=32.1772639691715, Blast_Score=226, Evalue=4e-59,
Organism=Drosophila melanogaster, GI24642666, Length=519, Percent_Identity=32.1772639691715, Blast_Score=226, Evalue=4e-59,
Organism=Drosophila melanogaster, GI45551474, Length=519, Percent_Identity=32.1772639691715, Blast_Score=226, Evalue=5e-59,
Organism=Drosophila melanogaster, GI161077878, Length=519, Percent_Identity=32.1772639691715, Blast_Score=225, Evalue=6e-59,
Organism=Drosophila melanogaster, GI18859893, Length=516, Percent_Identity=30.2325581395349, Blast_Score=216, Evalue=4e-56,
Organism=Drosophila melanogaster, GI18859741, Length=545, Percent_Identity=29.5412844036697, Blast_Score=181, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 63543; Mature: 63543

Theoretical pI: Translated: 7.21; Mature: 7.21

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00462 G_GLU_TRANSPEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIRNLFLLLSNISLILLTACSTTPTVPLTTPPSVSQTTAAAIIYDWDMDIFHPVVARHG
CHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHCC
MVATEQKLASRIGVDILKAGGNAIDAAVAIGFGLAVTLPNAGNIGGGGFMLVHDAQTGRS
CHHHHHHHHHHHCHHHHHCCCCHHHHHHHHHCCEEEECCCCCCCCCCCEEEEEECCCCCC
TALDFRETAPAAASRDMYLDSAGNVINKKSLFSHAAVGVPGTVAGMIHALQRWGSMPLAK
CCCCHHHCCCCCCCCCEEECCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHH
VMQPAITLAEEGYPVSKTLAKGLQYSAGNMGKWPATRAIFWKNDMPLKTGDKLVQQDLAN
HHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHH
SLRLIARDGARAFYAGEIAHRIAADMARNGSPMTMEDLENYRITEREPVRGTYRGYEIVT
HHHHHHCCCCCEEHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCCCCCCEEEEE
MPPPSSGGVHLVQMLNMLEHWPLREWGHNSARTIHHMTEAMKLAYADRSEYLGDPDFVNV
ECCCCCCCHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCEECC
PLTGLISKAYAEALVSHIDPDHARVAEAIKPGQPQFHESNQTTHFSVMDSAGNMVAVTYT
CHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCEEEEEEE
LNTNFGSGIVAPGTGIVLNNEMDDFSIKPGMPNVYGVIGGEANAVAAGKRPLSSMTPAFV
EECCCCCCEECCCCCEEECCCCCCCCCCCCCCCEEEEECCCCCEEECCCCCCCCCCCEEE
FKAGKPWLVTGSPGGPRIITTVLQQIVNGIDFAMNPAEAASAARFHHQWTPDELRLEKGI
EECCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHCCC
SPDTLRLLQEKGHRIVIKPTMGRTQTIQLHGDELWGYSDPRNPDGATVGF
CHHHHHHHHHCCCEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLIRNLFLLLSNISLILLTACSTTPTVPLTTPPSVSQTTAAAIIYDWDMDIFHPVVARHG
CHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHCC
MVATEQKLASRIGVDILKAGGNAIDAAVAIGFGLAVTLPNAGNIGGGGFMLVHDAQTGRS
CHHHHHHHHHHHCHHHHHCCCCHHHHHHHHHCCEEEECCCCCCCCCCCEEEEEECCCCCC
TALDFRETAPAAASRDMYLDSAGNVINKKSLFSHAAVGVPGTVAGMIHALQRWGSMPLAK
CCCCHHHCCCCCCCCCEEECCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHH
VMQPAITLAEEGYPVSKTLAKGLQYSAGNMGKWPATRAIFWKNDMPLKTGDKLVQQDLAN
HHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHH
SLRLIARDGARAFYAGEIAHRIAADMARNGSPMTMEDLENYRITEREPVRGTYRGYEIVT
HHHHHHCCCCCEEHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCCCCCCEEEEE
MPPPSSGGVHLVQMLNMLEHWPLREWGHNSARTIHHMTEAMKLAYADRSEYLGDPDFVNV
ECCCCCCCHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCEECC
PLTGLISKAYAEALVSHIDPDHARVAEAIKPGQPQFHESNQTTHFSVMDSAGNMVAVTYT
CHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCEEEEEEE
LNTNFGSGIVAPGTGIVLNNEMDDFSIKPGMPNVYGVIGGEANAVAAGKRPLSSMTPAFV
EECCCCCCEECCCCCEEECCCCCCCCCCCCCCCEEEEECCCCCEEECCCCCCCCCCCEEE
FKAGKPWLVTGSPGGPRIITTVLQQIVNGIDFAMNPAEAASAARFHHQWTPDELRLEKGI
EECCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHCCC
SPDTLRLLQEKGHRIVIKPTMGRTQTIQLHGDELWGYSDPRNPDGATVGF
CHHHHHHHHHCCCEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]