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The map label for this gene is mutL [H]

Identifier: 114331804

GI number: 114331804

Start: 1935509

End: 1937335

Strand: Reverse

Name: mutL [H]

Synonym: Neut_1828

Alternate gene names: 114331804

Gene position: 1937335-1935509 (Counterclockwise)

Preceding gene: 114331808

Following gene: 114331803

Centisome position: 72.8

GC content: 54.68

Gene sequence:

>1827_bases
ATGCGCGCGATCAAATTACTTCCCGATGGATTAATCAGTCAGATAGCAGCTGGAGAAGTCATCGAACGCCCGGCTTCAGT
GCTGAAAGAATTACTGGAAAATTCCATCGATGCCGGTGCGACTGAAATTACGGTCAATATCGCACAGGGTGGATTGAAAC
TGATCCGTGTGACCGATAACGGCAGCGGCATTCCCGCAGAAGAACTGCCGCTTGCACTCACACGTCACGCAACCAGCAAA
ATTGCCAGCCAGGAGGATTTGCACAGCATCACCAGCCTGGGATTCCGGGGGGAAGGGCTGGCCAGTATCGCGTCAGTTTC
GTATTTGTCGCTCATCAGTCATCAACCCGCTGGCAAACATGCCTGGGAAATCCGCAGTGAGGGGACACGGTTAATGTCGC
CGGAGCCTTCATCCCACATGGCGGGCACTACGGTTGAAGTCCGGGATCTGTTTTTCAACCTGCCTGCCCGCCGCAAATTT
CTTAAAACAGAAGCTACAGAGTTTGCCCACTGCGAAGAAGTTTTTCGGCGGATGGCACTTTCCCACGCTGATATTACCTT
TACGCTGCGGCACAATGGAAACCTGCGCAGCCACTGGCAGGCGGCAGAGGCTGCAGAGCGCATCGGAGCCGTGCTTGGCG
AGGAATTTTCCGGAGCGGCTACCTGGATGGACGAACAATCCGCCGGCATCGGCCTGCAGGGGATGCTGGCATTGCCCGCG
TATTCACGTGCCACCCGCGACATGCAGTATTTTTTTGTTAACGGACGCTTCATCCGCGACAAGCTGATTACCCATGCCCT
GCGTGAAGCCTATCGTGATGTGCTGCACCTTGATCGTCATGCCGCTTTCGTGCTGTATCTGGCGATTGATCCTGAACAGG
TGGATGTCAACGTACATCCGACGAAAACCGAAGTCCGCTTTCGCGAAGCGCGGGCCATCCACCAATTTATTTACCACGGC
GTCAGCAAGGCGCTGGCTCTACCCCGCTCGGGTGTAGCATCCTCCTCGCCTGTTGGGGCCGTGTGGCCAGGTGCGCAGGA
TGCATCTGTTGATCCAACGCGCACCGGTTTTACACCGGCTGTGCCGACGTTGAACTACCCCAGGCAAGCACGGCTGCCAT
CAGAAAGGGTGGCGCAGCCTTTTAACTTTTATCAGGTTCTAACCGGCGGAGAATCCGGCGCCACTGCCATGCAGAATCAA
CTCCGACAAACCGGGGAAGGGGAAAGCGATGAAAATCCGGCCATGCCCCCGCTGGGCTTTGCGTTGGGGCTGCTTCGCGG
CATCTATATCCTGGCGCAAAACCAAAAAGGATTGGTGATTGTAGACATGCACGCCGCGCACGAACGCATTGTCTACGAGC
AGTTGAAGACACAACTGGATCAACAAGTATTATCCGCACAACGATTGCTGATACCGGTTACATTTCACGCAGATAGCCTC
GACATCGCGACAGTGGAGGAAAATCAGGCGCTTTTGCAGCAACTGTGTTTTGAAGTGAGCACGCTGTCCGCTACCACACT
TGTTATACGCACAGTCCCCACCACACTGCAGCATGCTGATGCGGAAAAACTGGTACGTGCTCTGCTGGATGAAATCAGGA
ATGGCGATCCCGCTCAACTGCTTGCCGCCCGTCGTAATGAATTACTGGCCACCATGGCCTGTCACGGTGCCGTTCGCGCT
AACCGGCAATTAACGCTGATTGAAATGAATGAACTGCTGCGCAAAATGGAAGTAACCGAGCGCTCGGATCAATGCAATCA
CGGCCGACCTACCTGGTTTGAAATCAGCCTGGCTGAACTGGATAAAATGTTTATGCGCGGCAAATAG

Upstream 100 bases:

>100_bases
TCCCCTGTTTGACAGCAAGCGTATCATAACTTGGTGACAGTATAATTACCGATTCAGTGAGTTTTTCCGCATATTTATTC
TATTCCAGCCCCGGTTTTCA

Downstream 100 bases:

>100_bases
CCATGGGCTCATTACTTCTAAAAGCTTATTTATCTTGCTGCTTGAGATCGCGATAAAAATCATCGTGCGGATGGACCAAA
GGACAGCAGTTTCAGGCAAT

Product: DNA mismatch repair protein MutL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 608; Mature: 608

Protein sequence:

>608_residues
MRAIKLLPDGLISQIAAGEVIERPASVLKELLENSIDAGATEITVNIAQGGLKLIRVTDNGSGIPAEELPLALTRHATSK
IASQEDLHSITSLGFRGEGLASIASVSYLSLISHQPAGKHAWEIRSEGTRLMSPEPSSHMAGTTVEVRDLFFNLPARRKF
LKTEATEFAHCEEVFRRMALSHADITFTLRHNGNLRSHWQAAEAAERIGAVLGEEFSGAATWMDEQSAGIGLQGMLALPA
YSRATRDMQYFFVNGRFIRDKLITHALREAYRDVLHLDRHAAFVLYLAIDPEQVDVNVHPTKTEVRFREARAIHQFIYHG
VSKALALPRSGVASSSPVGAVWPGAQDASVDPTRTGFTPAVPTLNYPRQARLPSERVAQPFNFYQVLTGGESGATAMQNQ
LRQTGEGESDENPAMPPLGFALGLLRGIYILAQNQKGLVIVDMHAAHERIVYEQLKTQLDQQVLSAQRLLIPVTFHADSL
DIATVEENQALLQQLCFEVSTLSATTLVIRTVPTTLQHADAEKLVRALLDEIRNGDPAQLLAARRNELLATMACHGAVRA
NRQLTLIEMNELLRKMEVTERSDQCNHGRPTWFEISLAELDKMFMRGK

Sequences:

>Translated_608_residues
MRAIKLLPDGLISQIAAGEVIERPASVLKELLENSIDAGATEITVNIAQGGLKLIRVTDNGSGIPAEELPLALTRHATSK
IASQEDLHSITSLGFRGEGLASIASVSYLSLISHQPAGKHAWEIRSEGTRLMSPEPSSHMAGTTVEVRDLFFNLPARRKF
LKTEATEFAHCEEVFRRMALSHADITFTLRHNGNLRSHWQAAEAAERIGAVLGEEFSGAATWMDEQSAGIGLQGMLALPA
YSRATRDMQYFFVNGRFIRDKLITHALREAYRDVLHLDRHAAFVLYLAIDPEQVDVNVHPTKTEVRFREARAIHQFIYHG
VSKALALPRSGVASSSPVGAVWPGAQDASVDPTRTGFTPAVPTLNYPRQARLPSERVAQPFNFYQVLTGGESGATAMQNQ
LRQTGEGESDENPAMPPLGFALGLLRGIYILAQNQKGLVIVDMHAAHERIVYEQLKTQLDQQVLSAQRLLIPVTFHADSL
DIATVEENQALLQQLCFEVSTLSATTLVIRTVPTTLQHADAEKLVRALLDEIRNGDPAQLLAARRNELLATMACHGAVRA
NRQLTLIEMNELLRKMEVTERSDQCNHGRPTWFEISLAELDKMFMRGK
>Mature_608_residues
MRAIKLLPDGLISQIAAGEVIERPASVLKELLENSIDAGATEITVNIAQGGLKLIRVTDNGSGIPAEELPLALTRHATSK
IASQEDLHSITSLGFRGEGLASIASVSYLSLISHQPAGKHAWEIRSEGTRLMSPEPSSHMAGTTVEVRDLFFNLPARRKF
LKTEATEFAHCEEVFRRMALSHADITFTLRHNGNLRSHWQAAEAAERIGAVLGEEFSGAATWMDEQSAGIGLQGMLALPA
YSRATRDMQYFFVNGRFIRDKLITHALREAYRDVLHLDRHAAFVLYLAIDPEQVDVNVHPTKTEVRFREARAIHQFIYHG
VSKALALPRSGVASSSPVGAVWPGAQDASVDPTRTGFTPAVPTLNYPRQARLPSERVAQPFNFYQVLTGGESGATAMQNQ
LRQTGEGESDENPAMPPLGFALGLLRGIYILAQNQKGLVIVDMHAAHERIVYEQLKTQLDQQVLSAQRLLIPVTFHADSL
DIATVEENQALLQQLCFEVSTLSATTLVIRTVPTTLQHADAEKLVRALLDEIRNGDPAQLLAARRNELLATMACHGAVRA
NRQLTLIEMNELLRKMEVTERSDQCNHGRPTWFEISLAELDKMFMRGK

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=328, Percent_Identity=34.4512195121951, Blast_Score=198, Evalue=1e-50,
Organism=Homo sapiens, GI4505911, Length=327, Percent_Identity=29.3577981651376, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI189458898, Length=327, Percent_Identity=29.3577981651376, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI4505913, Length=345, Percent_Identity=27.8260869565217, Blast_Score=126, Evalue=6e-29,
Organism=Homo sapiens, GI310128478, Length=345, Percent_Identity=27.8260869565217, Blast_Score=126, Evalue=6e-29,
Organism=Homo sapiens, GI189458896, Length=317, Percent_Identity=28.391167192429, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI263191589, Length=234, Percent_Identity=27.7777777777778, Blast_Score=100, Evalue=8e-21,
Organism=Homo sapiens, GI91992160, Length=347, Percent_Identity=26.8011527377522, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI91992162, Length=347, Percent_Identity=26.8011527377522, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI310128480, Length=296, Percent_Identity=26.0135135135135, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI1790612, Length=556, Percent_Identity=40.1079136690648, Blast_Score=349, Evalue=4e-97,
Organism=Caenorhabditis elegans, GI71991825, Length=323, Percent_Identity=35.6037151702786, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17562796, Length=335, Percent_Identity=25.3731343283582, Blast_Score=113, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6323819, Length=345, Percent_Identity=35.3623188405797, Blast_Score=196, Evalue=9e-51,
Organism=Saccharomyces cerevisiae, GI6324247, Length=374, Percent_Identity=28.0748663101604, Blast_Score=127, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6325093, Length=714, Percent_Identity=22.2689075630252, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6323063, Length=363, Percent_Identity=25.6198347107438, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17136968, Length=309, Percent_Identity=34.6278317152104, Blast_Score=189, Evalue=6e-48,
Organism=Drosophila melanogaster, GI17136970, Length=357, Percent_Identity=26.890756302521, Blast_Score=109, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 67055; Mature: 67055

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAIKLLPDGLISQIAAGEVIERPASVLKELLENSIDAGATEITVNIAQGGLKLIRVTDN
CCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEEEECC
GSGIPAEELPLALTRHATSKIASQEDLHSITSLGFRGEGLASIASVSYLSLISHQPAGKH
CCCCCHHHCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCC
AWEIRSEGTRLMSPEPSSHMAGTTVEVRDLFFNLPARRKFLKTEATEFAHCEEVFRRMAL
CHHHHCCCCEECCCCCCCCCCCCEEHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SHADITFTLRHNGNLRSHWQAAEAAERIGAVLGEEFSGAATWMDEQSAGIGLQGMLALPA
CCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCEEECCC
YSRATRDMQYFFVNGRFIRDKLITHALREAYRDVLHLDRHAAFVLYLAIDPEQVDVNVHP
HHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCEEEEEECC
TKTEVRFREARAIHQFIYHGVSKALALPRSGVASSSPVGAVWPGAQDASVDPTRTGFTPA
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
VPTLNYPRQARLPSERVAQPFNFYQVLTGGESGATAMQNQLRQTGEGESDENPAMPPLGF
CCCCCCCCCCCCCHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHH
ALGLLRGIYILAQNQKGLVIVDMHAAHERIVYEQLKTQLDQQVLSAQRLLIPVTFHADSL
HHHHHHHEEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCC
DIATVEENQALLQQLCFEVSTLSATTLVIRTVPTTLQHADAEKLVRALLDEIRNGDPAQL
EEEEECHHHHHHHHHHHHHHHHHHHEEEEEECCHHHHHCCHHHHHHHHHHHHCCCCHHHH
LAARRNELLATMACHGAVRANRQLTLIEMNELLRKMEVTERSDQCNHGRPTWFEISLAEL
HHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHH
DKMFMRGK
HHHHHCCC
>Mature Secondary Structure
MRAIKLLPDGLISQIAAGEVIERPASVLKELLENSIDAGATEITVNIAQGGLKLIRVTDN
CCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEEEECC
GSGIPAEELPLALTRHATSKIASQEDLHSITSLGFRGEGLASIASVSYLSLISHQPAGKH
CCCCCHHHCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCC
AWEIRSEGTRLMSPEPSSHMAGTTVEVRDLFFNLPARRKFLKTEATEFAHCEEVFRRMAL
CHHHHCCCCEECCCCCCCCCCCCEEHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SHADITFTLRHNGNLRSHWQAAEAAERIGAVLGEEFSGAATWMDEQSAGIGLQGMLALPA
CCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCEEECCC
YSRATRDMQYFFVNGRFIRDKLITHALREAYRDVLHLDRHAAFVLYLAIDPEQVDVNVHP
HHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCEEEEEECC
TKTEVRFREARAIHQFIYHGVSKALALPRSGVASSSPVGAVWPGAQDASVDPTRTGFTPA
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
VPTLNYPRQARLPSERVAQPFNFYQVLTGGESGATAMQNQLRQTGEGESDENPAMPPLGF
CCCCCCCCCCCCCHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHH
ALGLLRGIYILAQNQKGLVIVDMHAAHERIVYEQLKTQLDQQVLSAQRLLIPVTFHADSL
HHHHHHHEEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCC
DIATVEENQALLQQLCFEVSTLSATTLVIRTVPTTLQHADAEKLVRALLDEIRNGDPAQL
EEEEECHHHHHHHHHHHHHHHHHHHEEEEEECCHHHHHCCHHHHHHHHHHHHCCCCHHHH
LAARRNELLATMACHGAVRANRQLTLIEMNELLRKMEVTERSDQCNHGRPTWFEISLAEL
HHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHH
DKMFMRGK
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA