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The map label for this gene is degP [H]

Identifier: 114331669

GI number: 114331669

Start: 1780489

End: 1781628

Strand: Reverse

Name: degP [H]

Synonym: Neut_1685

Alternate gene names: 114331669

Gene position: 1781628-1780489 (Counterclockwise)

Preceding gene: 114331672

Following gene: 114331668

Centisome position: 66.95

GC content: 50.18

Gene sequence:

>1140_bases
ATGCAAAAACTCTGGCTGCTTTTCACACAAACCATCACTGTTCTCCTCGCCATCTTTTTTGTTGTTTCAACCTTGCGCCC
GGAATTATTGCCGTGGACGCCGCGCGGCAAGCTGGCGACCATCCGTGAAGCAGTCAAGGCTGATGGCGGAAAAGCACTTG
ATACTGGTAGTTTTCATACAGCAGCGGAAGTGGCGATGCCTTCCGTGGTGAATGTATTTACCAGCAAGGAGGTAAGAGTA
CCCTCCCATCCGTTTATGGATGATCCTGTCTTTCAGCAATTTTTTGGCAATCGTTTTAGTCCGAGAACTGAGCGTACTTC
CAGCTTGGGATCCGGAGTAATCGTCAGCCCGGAAGGATATATTCTCACGAACCATCACGTGGTGGAAGCGGCTAACGAGA
TTCAGGTGGCGTTAATGGATGGAAGAAAAGCCGAAGCAAACTTGATTGGCTCGGATCCTGAGAGTGACCTGGCGGTTCTG
AAAATTGATCTGGACAAGCTCCCCAGTATTGCCTTCGGCGATTCTGAAAAAGCTAGAGTGGGGGATATCGTGCTGGCAAT
CGGTAATCCGTTTGGTGTAGGGCAAACAATGACGATGGGAATTATCGGTGCACTGGGGCGTTCCCAGGTAGGGCTCAGCA
CATTCGAAAATTTTATTCAGACCGATGCGGCAATCAATCCCGGTAACTCCGGTGGTGCGTTGACCGATATTTCCGGTAAT
TTGATCGGGATCAATACCGCGATCTATTCACGTTCCGGCGGCTCGCTTGGCATCGGATTCGCTATCCCGGTGGATGCGGC
TAAACAAATCATGCAGCAGATTATCGAAACAGGTAGCGTTACGCGCGGCTGGCTTGGTGTGAGTATGCAAGATATAACGC
CGGAGTTGGCGGAGTCCCTAAAGCTGAAGAAAACTGATGGAGCTCTGATTGCGGGCGTACTTAAGAATGGGCCAGCGGAT
GATGCCGGAATCAAACCGGGGGATATTTTAGCGGCAGTGAATGGCAAGCCTGTTTTCAATGCTTCCGAAATGCTGAATAT
TGTGGCATCTCTTCCCCCAGGTAAAGCAGCAACGCTAACTATTCTCCGTAATGGAGAAGAGCTGGATATTCAGGTGCAAA
TTGGTAAACGTCCAGGCTGA

Upstream 100 bases:

>100_bases
ATCACGGAATTGCTGAACGTCCAGCAGATCATTCAGGTAATTTTCCAGTATATTTTGGTGCATAATACTTTTTTTGTTCA
TTTGGGATGTAGGATTTTCC

Downstream 100 bases:

>100_bases
CTACATACCGAGTGAATATCGAATTTGCCACACGATTACCCGCCGCACTGTTTCGGTGGATTGATCTCAATTTACTGACT
CTGGGCAGGGAAATGCGTCT

Product: peptidase S1 and S6, chymotrypsin/Hap

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MQKLWLLFTQTITVLLAIFFVVSTLRPELLPWTPRGKLATIREAVKADGGKALDTGSFHTAAEVAMPSVVNVFTSKEVRV
PSHPFMDDPVFQQFFGNRFSPRTERTSSLGSGVIVSPEGYILTNHHVVEAANEIQVALMDGRKAEANLIGSDPESDLAVL
KIDLDKLPSIAFGDSEKARVGDIVLAIGNPFGVGQTMTMGIIGALGRSQVGLSTFENFIQTDAAINPGNSGGALTDISGN
LIGINTAIYSRSGGSLGIGFAIPVDAAKQIMQQIIETGSVTRGWLGVSMQDITPELAESLKLKKTDGALIAGVLKNGPAD
DAGIKPGDILAAVNGKPVFNASEMLNIVASLPPGKAATLTILRNGEELDIQVQIGKRPG

Sequences:

>Translated_379_residues
MQKLWLLFTQTITVLLAIFFVVSTLRPELLPWTPRGKLATIREAVKADGGKALDTGSFHTAAEVAMPSVVNVFTSKEVRV
PSHPFMDDPVFQQFFGNRFSPRTERTSSLGSGVIVSPEGYILTNHHVVEAANEIQVALMDGRKAEANLIGSDPESDLAVL
KIDLDKLPSIAFGDSEKARVGDIVLAIGNPFGVGQTMTMGIIGALGRSQVGLSTFENFIQTDAAINPGNSGGALTDISGN
LIGINTAIYSRSGGSLGIGFAIPVDAAKQIMQQIIETGSVTRGWLGVSMQDITPELAESLKLKKTDGALIAGVLKNGPAD
DAGIKPGDILAAVNGKPVFNASEMLNIVASLPPGKAATLTILRNGEELDIQVQIGKRPG
>Mature_379_residues
MQKLWLLFTQTITVLLAIFFVVSTLRPELLPWTPRGKLATIREAVKADGGKALDTGSFHTAAEVAMPSVVNVFTSKEVRV
PSHPFMDDPVFQQFFGNRFSPRTERTSSLGSGVIVSPEGYILTNHHVVEAANEIQVALMDGRKAEANLIGSDPESDLAVL
KIDLDKLPSIAFGDSEKARVGDIVLAIGNPFGVGQTMTMGIIGALGRSQVGLSTFENFIQTDAAINPGNSGGALTDISGN
LIGINTAIYSRSGGSLGIGFAIPVDAAKQIMQQIIETGSVTRGWLGVSMQDITPELAESLKLKKTDGALIAGVLKNGPAD
DAGIKPGDILAAVNGKPVFNASEMLNIVASLPPGKAATLTILRNGEELDIQVQIGKRPG

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=292, Percent_Identity=35.2739726027397, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI22129776, Length=264, Percent_Identity=36.7424242424242, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI24308541, Length=278, Percent_Identity=32.3741007194245, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI7019477, Length=285, Percent_Identity=33.3333333333333, Blast_Score=135, Evalue=8e-32,
Organism=Escherichia coli, GI1786356, Length=340, Percent_Identity=43.8235294117647, Blast_Score=262, Evalue=3e-71,
Organism=Escherichia coli, GI1789629, Length=319, Percent_Identity=44.5141065830721, Blast_Score=260, Evalue=1e-70,
Organism=Escherichia coli, GI1789630, Length=326, Percent_Identity=41.1042944785276, Blast_Score=223, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24646839, Length=288, Percent_Identity=34.0277777777778, Blast_Score=150, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 39924; Mature: 39924

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKLWLLFTQTITVLLAIFFVVSTLRPELLPWTPRGKLATIREAVKADGGKALDTGSFHT
CCHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCHHHHHHHHHCCCCCEECCCCCCH
AAEVAMPSVVNVFTSKEVRVPSHPFMDDPVFQQFFGNRFSPRTERTSSLGSGVIVSPEGY
HHHHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHHCCCCCCCHHHHHHCCCCEEECCCCE
ILTNHHVVEAANEIQVALMDGRKAEANLIGSDPESDLAVLKIDLDKLPSIAFGDSEKARV
EEECCHHEECCCCEEEEEECCCCCCCCCCCCCCCCCEEEEEEEHHHCCCEEECCCCCCEE
GDIVLAIGNPFGVGQTMTMGIIGALGRSQVGLSTFENFIQTDAAINPGNSGGALTDISGN
CEEEEEECCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCC
LIGINTAIYSRSGGSLGIGFAIPVDAAKQIMQQIIETGSVTRGWLGVSMQDITPELAESL
EEEEEEEEEECCCCCEEEEEEECHHHHHHHHHHHHHCCCCCCCEECCCHHHCCHHHHHHE
KLKKTDGALIAGVLKNGPADDAGIKPGDILAAVNGKPVFNASEMLNIVASLPPGKAATLT
EEECCCCCEEEHHHCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCCCCEEEE
ILRNGEELDIQVQIGKRPG
EEECCCEEEEEEEECCCCC
>Mature Secondary Structure
MQKLWLLFTQTITVLLAIFFVVSTLRPELLPWTPRGKLATIREAVKADGGKALDTGSFHT
CCHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCHHHHHHHHHCCCCCEECCCCCCH
AAEVAMPSVVNVFTSKEVRVPSHPFMDDPVFQQFFGNRFSPRTERTSSLGSGVIVSPEGY
HHHHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHHCCCCCCCHHHHHHCCCCEEECCCCE
ILTNHHVVEAANEIQVALMDGRKAEANLIGSDPESDLAVLKIDLDKLPSIAFGDSEKARV
EEECCHHEECCCCEEEEEECCCCCCCCCCCCCCCCCEEEEEEEHHHCCCEEECCCCCCEE
GDIVLAIGNPFGVGQTMTMGIIGALGRSQVGLSTFENFIQTDAAINPGNSGGALTDISGN
CEEEEEECCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCC
LIGINTAIYSRSGGSLGIGFAIPVDAAKQIMQQIIETGSVTRGWLGVSMQDITPELAESL
EEEEEEEEEECCCCCEEEEEEECHHHHHHHHHHHHHCCCCCCCEECCCHHHCCHHHHHHE
KLKKTDGALIAGVLKNGPADDAGIKPGDILAAVNGKPVFNASEMLNIVASLPPGKAATLT
EEECCCCCEEEHHHCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCCCCEEEE
ILRNGEELDIQVQIGKRPG
EEECCCEEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]