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The map label for this gene is ubiH [H]

Identifier: 114331205

GI number: 114331205

Start: 1261718

End: 1262893

Strand: Direct

Name: ubiH [H]

Synonym: Neut_1207

Alternate gene names: 114331205

Gene position: 1261718-1262893 (Clockwise)

Preceding gene: 114331204

Following gene: 114331206

Centisome position: 47.41

GC content: 47.19

Gene sequence:

>1176_bases
ATGATTGATCAGCAATTCGATATTGTCATTGTTGGAGGCGGTCCGGTTGGAATGGCCCTGGCATTAGCATTGCGTGAACA
TAAGCTCTCGATTTTGCTGCTTGAAGCACGTGAGTTACCAGAAGAAGTGGACGATCCGCGACCGCTAGCTCTTTCATATG
GTAGCCGTTTAATTCTGCAACACCTGGGTATTTGGAAAAATCTGACACAACCTACGCCAATTACCACAATTCATATTTCG
AATTTCGGTCATTTTGGCCATACCGTGCTTACGCCTGATGATGCAGGAGTTCCAGCACTGGGCTATGTGGTCAATTATCA
TAACCTTTACCATACCATGGGTCGATCCGTGCGAGATTATGGTGTCGTATACCGAACAAATGCGCTGGTTACGACCATAC
AGACAGGTCAACAACAAGCCCGGATAACATACCGGCAAAATGAGACAGAAAAACAGATTCAAGCCAAATTACTGGTGCTG
GCGGATGGTGGAAAACTTGCGGAGCAGATTGATGGCATCCGTTATCGTGTTCATGATTACCGGCATACGGCGATTGTGGC
TAACGTCAAAACCGAATCGTCCCGACCAGGAACAGCTTTTGAACGTTTTACCCTGAACGGGCCATTGGCTCTGCTGCCAT
CTGGCGATAAATATGCGTTGGTATGGACAATGCCGACTGCCGAAGCAAAAAAAATACTGAGGCTTGATGACAGACTGTTT
CTGCTGCATTTACACGAACAATTTGGAGATCGTCTGGGTAATTTTATTCACGCAGGTAAGCGATCAAGTTTCCCACTGAT
ACTCAAACATGCGTCAACAATTATCGGCCATCGGTCAGTAATAATAGGCAATGCTGCACAAACACTCCATCCGGTTGCCG
GGCAGGGTTTTAATCTTGGATTGAGAGACGCATGGGAGCTGGCCAGTGAAATTAGTCACATCCCTTCTGGTGCGCCTGGT
GAGCCAGGATCAAGCAGAATGCTGTCTGTCTATAGCAAACGGCGCCAGCGTGACAAGCATATGGGCAGAGTGTTTACGGA
TTCCCTGATAAAACTGTTTACAGCCGATTTGCCACTGATACAAACTTGCAACGGAATAGGATTGACTGTTCTGGATTGTC
TGCCGCCCGCAAAACGCCTGGTTGCACGGCAAATGATATTCGGTACAAAAAACTGA

Upstream 100 bases:

>100_bases
GGCACACGCCAGATCTGCTGAGTTCCGTTATCGATAGATCACAAGTCCAAATGTCTGTGATCAATCTGTCTGCATGATTC
TATTGCTTATATGAACGGTC

Downstream 100 bases:

>100_bases
TTACTAGAATAAGCGAAACACGCTGGTGTGCTATAAAAATCTGATAATCCAGTTCCGGATTAAAATTTGGATCTGATTTT
TCAATAATTTTCATTAACAG

Product: ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MIDQQFDIVIVGGGPVGMALALALREHKLSILLLEARELPEEVDDPRPLALSYGSRLILQHLGIWKNLTQPTPITTIHIS
NFGHFGHTVLTPDDAGVPALGYVVNYHNLYHTMGRSVRDYGVVYRTNALVTTIQTGQQQARITYRQNETEKQIQAKLLVL
ADGGKLAEQIDGIRYRVHDYRHTAIVANVKTESSRPGTAFERFTLNGPLALLPSGDKYALVWTMPTAEAKKILRLDDRLF
LLHLHEQFGDRLGNFIHAGKRSSFPLILKHASTIIGHRSVIIGNAAQTLHPVAGQGFNLGLRDAWELASEISHIPSGAPG
EPGSSRMLSVYSKRRQRDKHMGRVFTDSLIKLFTADLPLIQTCNGIGLTVLDCLPPAKRLVARQMIFGTKN

Sequences:

>Translated_391_residues
MIDQQFDIVIVGGGPVGMALALALREHKLSILLLEARELPEEVDDPRPLALSYGSRLILQHLGIWKNLTQPTPITTIHIS
NFGHFGHTVLTPDDAGVPALGYVVNYHNLYHTMGRSVRDYGVVYRTNALVTTIQTGQQQARITYRQNETEKQIQAKLLVL
ADGGKLAEQIDGIRYRVHDYRHTAIVANVKTESSRPGTAFERFTLNGPLALLPSGDKYALVWTMPTAEAKKILRLDDRLF
LLHLHEQFGDRLGNFIHAGKRSSFPLILKHASTIIGHRSVIIGNAAQTLHPVAGQGFNLGLRDAWELASEISHIPSGAPG
EPGSSRMLSVYSKRRQRDKHMGRVFTDSLIKLFTADLPLIQTCNGIGLTVLDCLPPAKRLVARQMIFGTKN
>Mature_391_residues
MIDQQFDIVIVGGGPVGMALALALREHKLSILLLEARELPEEVDDPRPLALSYGSRLILQHLGIWKNLTQPTPITTIHIS
NFGHFGHTVLTPDDAGVPALGYVVNYHNLYHTMGRSVRDYGVVYRTNALVTTIQTGQQQARITYRQNETEKQIQAKLLVL
ADGGKLAEQIDGIRYRVHDYRHTAIVANVKTESSRPGTAFERFTLNGPLALLPSGDKYALVWTMPTAEAKKILRLDDRLF
LLHLHEQFGDRLGNFIHAGKRSSFPLILKHASTIIGHRSVIIGNAAQTLHPVAGQGFNLGLRDAWELASEISHIPSGAPG
EPGSSRMLSVYSKRRQRDKHMGRVFTDSLIKLFTADLPLIQTCNGIGLTVLDCLPPAKRLVARQMIFGTKN

Specific function: Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone [H]

COG id: COG0654

COG function: function code HC; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiH/COQ6 family [H]

Homologues:

Organism=Homo sapiens, GI32967305, Length=430, Percent_Identity=25.3488372093023, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI1789274, Length=392, Percent_Identity=37.5, Blast_Score=234, Evalue=6e-63,
Organism=Escherichia coli, GI1789273, Length=394, Percent_Identity=27.9187817258883, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1786883, Length=382, Percent_Identity=27.4869109947644, Blast_Score=126, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI25146631, Length=428, Percent_Identity=25.4672897196262, Blast_Score=108, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002938
- InterPro:   IPR003042
- InterPro:   IPR018168
- InterPro:   IPR010971
- InterPro:   IPR011295 [H]

Pfam domain/function: PF01494 FAD_binding_3 [H]

EC number: 1.14.13.-

Molecular weight: Translated: 43301; Mature: 43301

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: PS01304 UBIH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDQQFDIVIVGGGPVGMALALALREHKLSILLLEARELPEEVDDPRPLALSYGSRLILQ
CCCCEEEEEEECCCHHHHHHHHHHHHCCEEEEEEECHHCHHHCCCCCCEEHHHCHHHHHH
HLGIWKNLTQPTPITTIHISNFGHFGHTVLTPDDAGVPALGYVVNYHNLYHTMGRSVRDY
HHHHHHCCCCCCCEEEEEEECCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHCCCHHHC
GVVYRTNALVTTIQTGQQQARITYRQNETEKQIQAKLLVLADGGKLAEQIDGIRYRVHDY
CEEEECCEEEEEEECCCCCEEEEECCCCHHHHHEEEEEEEECCCHHHHHHCCCEEEEECC
RHTAIVANVKTESSRPGTAFERFTLNGPLALLPSGDKYALVWTMPTAEAKKILRLDDRLF
EEEEEEEEEECCCCCCCCCEEEEEECCCEEEEECCCCEEEEEECCCHHHHHHHHHCCEEE
LLHLHEQFGDRLGNFIHAGKRSSFPLILKHASTIIGHRSVIIGNAAQTLHPVAGQGFNLG
EEHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHCCCEEEEECCHHHHCCCCCCCCCCC
LRDAWELASEISHIPSGAPGEPGSSRMLSVYSKRRQRDKHMGRVFTDSLIKLFTADLPLI
HHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
QTCNGIGLTVLDCLPPAKRLVARQMIFGTKN
HCCCCCCEEHHHCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIDQQFDIVIVGGGPVGMALALALREHKLSILLLEARELPEEVDDPRPLALSYGSRLILQ
CCCCEEEEEEECCCHHHHHHHHHHHHCCEEEEEEECHHCHHHCCCCCCEEHHHCHHHHHH
HLGIWKNLTQPTPITTIHISNFGHFGHTVLTPDDAGVPALGYVVNYHNLYHTMGRSVRDY
HHHHHHCCCCCCCEEEEEEECCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHCCCHHHC
GVVYRTNALVTTIQTGQQQARITYRQNETEKQIQAKLLVLADGGKLAEQIDGIRYRVHDY
CEEEECCEEEEEEECCCCCEEEEECCCCHHHHHEEEEEEEECCCHHHHHHCCCEEEEECC
RHTAIVANVKTESSRPGTAFERFTLNGPLALLPSGDKYALVWTMPTAEAKKILRLDDRLF
EEEEEEEEEECCCCCCCCCEEEEEECCCEEEEECCCCEEEEEECCCHHHHHHHHHCCEEE
LLHLHEQFGDRLGNFIHAGKRSSFPLILKHASTIIGHRSVIIGNAAQTLHPVAGQGFNLG
EEHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHCCCEEEEECCHHHHCCCCCCCCCCC
LRDAWELASEISHIPSGAPGEPGSSRMLSVYSKRRQRDKHMGRVFTDSLIKLFTADLPLI
HHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
QTCNGIGLTVLDCLPPAKRLVARQMIFGTKN
HCCCCCCEEHHHCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1339425; 9278503 [H]