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The map label for this gene is pntAA [H]

Identifier: 114331189

GI number: 114331189

Start: 1246960

End: 1248087

Strand: Direct

Name: pntAA [H]

Synonym: Neut_1191

Alternate gene names: 114331189

Gene position: 1246960-1248087 (Clockwise)

Preceding gene: 114331188

Following gene: 114331190

Centisome position: 46.86

GC content: 49.02

Gene sequence:

>1128_bases
ATGCACATAGGCATACCTGCCGAAACGCGTGCAGGAGAAACACGCGTGGCGGCTACGCCAGAAACCGTCAAGAAATTGGT
TGCCAAGGGACTGCATACTGTTCTGGTGCAGGCAGGAGCGGGCATAAACGCCAGCATCCCTGATTCCGCATACCAGGAAG
CAGGTGCAGTAATCGTCTCCGGTGCTTCGCAGTTATATGAGCAATCCCAGATCATACTGAAGGTTCGGGGCCCTGAAGCC
AGCGAACTGGTTCATATGAAAAAAGATGCGATACTGATTGGTTTGCTTGCACCTCATCTTGCAGAAGAAATTGAGATAGT
AGCCCGGCATGGTGTCACTGCATTCGCGATGGAAAAACTACCCCGTATATCACGGGCCCAAAGTATGGATGTGCTGTCTT
CTCAGGCCAATATTGGTGGTTACAAAGCAGTTATTCTGGCTGCTAATGTATACCAGAGATTTTTTCCCATGCTGATGACG
GCAGCCGGTACGGTTAAAGCCGCACGTATGTTGATTCTAGGAGCTGGTGTGGCTGGGTTGCAGGCGATTGCAACAGCCAA
ACGCTTGGGTGCAGTGATTGAAGCATTTGATGTGAGGCCAGCAGTCAAAGAGCAGGTAGAAAGCTTGGGAGCTAAGTTTG
TGGAAGTTCCATTGACGGATGAGGAAAAAGCTAAAGCAGAGACTGCTGGCGGATACGCGGCTGAAATGTCGGAGGATTAC
AAGCGTCGGCAGAGCAATCTGATTCATGAACGTGCCGCTGCTGCAGATATTATCATTACAACTGCTTTGATTCCGGGTCG
CCCGGCTCCCATCCTGATTAGTGAAGAAACAGTCAAGGCGATGAAGCCCGGCTCGGTAATAGTGGATATGGCCGTTGAAG
CAGGTGGAAATTGTCCGTTATCAGAGCTTGGCAAAACTGTAGTTAAACACGGCGTGCATTTGGTTGGCATAGCAAATCTC
CCAGGATTGGTGGCGACAGACGCCAGTGCGTTATATGCACGTAATCTGTTAAATTTCCTAAATCTAATATTGGATACACA
GACTGGCGAGCTTAAAATAGATCGCGAAGACGAGATTGTCAAAGGAAGCCTGGTCTGTACGGCTGGAGAAATTATAGGTA
AATCATAA

Upstream 100 bases:

>100_bases
AATTTGGTATTAAATTGAATGAGTGTGATGGATTTTGCTGTGGTTGTCAGTACGACAATTTTTGATTAATGAATTAATAA
AATAACAAGGGAGAACATCC

Downstream 100 bases:

>100_bases
AAGTCGGTTGTATTGTTTACACATAAAATTTATGAATCTCTATGAGGAAAACACATGATTGGAGAAATTGATCCAACGAT
CATTAACCTGACAGTATTTG

Product: NAD(P)(+) transhydrogenase (AB-specific)

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha 1; Proton-translocating transhydrogenase component 1; Pyridine nucleotide transhydrogenase subunit alpha 1; dI [H]

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MHIGIPAETRAGETRVAATPETVKKLVAKGLHTVLVQAGAGINASIPDSAYQEAGAVIVSGASQLYEQSQIILKVRGPEA
SELVHMKKDAILIGLLAPHLAEEIEIVARHGVTAFAMEKLPRISRAQSMDVLSSQANIGGYKAVILAANVYQRFFPMLMT
AAGTVKAARMLILGAGVAGLQAIATAKRLGAVIEAFDVRPAVKEQVESLGAKFVEVPLTDEEKAKAETAGGYAAEMSEDY
KRRQSNLIHERAAAADIIITTALIPGRPAPILISEETVKAMKPGSVIVDMAVEAGGNCPLSELGKTVVKHGVHLVGIANL
PGLVATDASALYARNLLNFLNLILDTQTGELKIDREDEIVKGSLVCTAGEIIGKS

Sequences:

>Translated_375_residues
MHIGIPAETRAGETRVAATPETVKKLVAKGLHTVLVQAGAGINASIPDSAYQEAGAVIVSGASQLYEQSQIILKVRGPEA
SELVHMKKDAILIGLLAPHLAEEIEIVARHGVTAFAMEKLPRISRAQSMDVLSSQANIGGYKAVILAANVYQRFFPMLMT
AAGTVKAARMLILGAGVAGLQAIATAKRLGAVIEAFDVRPAVKEQVESLGAKFVEVPLTDEEKAKAETAGGYAAEMSEDY
KRRQSNLIHERAAAADIIITTALIPGRPAPILISEETVKAMKPGSVIVDMAVEAGGNCPLSELGKTVVKHGVHLVGIANL
PGLVATDASALYARNLLNFLNLILDTQTGELKIDREDEIVKGSLVCTAGEIIGKS
>Mature_375_residues
MHIGIPAETRAGETRVAATPETVKKLVAKGLHTVLVQAGAGINASIPDSAYQEAGAVIVSGASQLYEQSQIILKVRGPEA
SELVHMKKDAILIGLLAPHLAEEIEIVARHGVTAFAMEKLPRISRAQSMDVLSSQANIGGYKAVILAANVYQRFFPMLMT
AAGTVKAARMLILGAGVAGLQAIATAKRLGAVIEAFDVRPAVKEQVESLGAKFVEVPLTDEEKAKAETAGGYAAEMSEDY
KRRQSNLIHERAAAADIIITTALIPGRPAPILISEETVKAMKPGSVIVDMAVEAGGNCPLSELGKTVVKHGVHLVGIANL
PGLVATDASALYARNLLNFLNLILDTQTGELKIDREDEIVKGSLVCTAGEIIGKS

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=387, Percent_Identity=38.5012919896641, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI122939153, Length=387, Percent_Identity=38.5012919896641, Blast_Score=247, Evalue=1e-65,
Organism=Escherichia coli, GI1787887, Length=373, Percent_Identity=46.3806970509383, Blast_Score=311, Evalue=5e-86,
Organism=Caenorhabditis elegans, GI17550456, Length=372, Percent_Identity=43.010752688172, Blast_Score=282, Evalue=2e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 39430; Mature: 39430

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIGIPAETRAGETRVAATPETVKKLVAKGLHTVLVQAGAGINASIPDSAYQEAGAVIVS
CCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCEEEEE
GASQLYEQSQIILKVRGPEASELVHMKKDAILIGLLAPHLAEEIEIVARHGVTAFAMEKL
CHHHHHCCCEEEEEECCCCHHHHHHHHHCEEEEEHHHHHHHHHHHHHHHCCCHHHHHHHC
PRISRAQSMDVLSSQANIGGYKAVILAANVYQRFFPMLMTAAGTVKAARMLILGAGVAGL
CHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHH
QAIATAKRLGAVIEAFDVRPAVKEQVESLGAKFVEVPLTDEEKAKAETAGGYAAEMSEDY
HHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHCCCHHHHHHHHH
KRRQSNLIHERAAAADIIITTALIPGRPAPILISEETVKAMKPGSVIVDMAVEAGGNCPL
HHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEEEHHHHHHCCCCCEEEEEEECCCCCCCH
SELGKTVVKHGVHLVGIANLPGLVATDASALYARNLLNFLNLILDTQTGELKIDREDEIV
HHHHHHHHHCCCEEEEECCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCEE
KGSLVCTAGEIIGKS
ECEEEEEHHHHHCCC
>Mature Secondary Structure
MHIGIPAETRAGETRVAATPETVKKLVAKGLHTVLVQAGAGINASIPDSAYQEAGAVIVS
CCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCEEEEE
GASQLYEQSQIILKVRGPEASELVHMKKDAILIGLLAPHLAEEIEIVARHGVTAFAMEKL
CHHHHHCCCEEEEEECCCCHHHHHHHHHCEEEEEHHHHHHHHHHHHHHHCCCHHHHHHHC
PRISRAQSMDVLSSQANIGGYKAVILAANVYQRFFPMLMTAAGTVKAARMLILGAGVAGL
CHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHH
QAIATAKRLGAVIEAFDVRPAVKEQVESLGAKFVEVPLTDEEKAKAETAGGYAAEMSEDY
HHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHCCCHHHHHHHHH
KRRQSNLIHERAAAADIIITTALIPGRPAPILISEETVKAMKPGSVIVDMAVEAGGNCPL
HHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEEEHHHHHHCCCCCEEEEEEECCCCCCCH
SELGKTVVKHGVHLVGIANLPGLVATDASALYARNLLNFLNLILDTQTGELKIDREDEIV
HHHHHHHHHCCCEEEEECCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCEE
KGSLVCTAGEIIGKS
ECEEEEEHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]