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The map label for this gene is estA [H]

Identifier: 114331180

GI number: 114331180

Start: 1232806

End: 1233510

Strand: Reverse

Name: estA [H]

Synonym: Neut_1182

Alternate gene names: 114331180

Gene position: 1233510-1232806 (Counterclockwise)

Preceding gene: 114331182

Following gene: 114331179

Centisome position: 46.35

GC content: 47.38

Gene sequence:

>705_bases
ATGTCTGACAGCCTGCTTCAGCTTTCCGCAATCGATATTGCAACCGGATCGAATCCTTTATATACCGTCTTGTGGATGCA
CGGATTGGGGGCCGATGGCAATGACTTTGTACCTGTTGTACAAACACTTGATTTACCAGCGACCCCAATTCGTTTTTTAT
TCCCGCATGCTCCTCTACAACCCGTCACCATCAATGGTGGCCATACAATGAGAGCGTGGTATGACATCCAGCACACTGAT
TTTATTAAGCAGGAAGATAAAGCCGGGTTGTACAGATCACAACGCGCAATCGTAGCATTGATCGAACATGAAAACCAGAG
AGGTATTCCGTCCAGTCACATTATCCTTGCCGGGTTCTCGCAGGGCGCTGCTATGGCGCTGCACGTAGGTTTGCGCCACC
CCGACAAGCTGGCTGGCATTATGGTTCTGTCAGGATATCTTCCTCTTGTTCACGAGATCAGACAGGAGGCACATGTAGCC
AATCAATTGACTCCCATATTCATGGCTCATGGTAGTTATGATCCTGTTGTCCCTGTTAAATTAGCTCGATCTTCGCTACA
GTTGCTGCGCGATTACCATTACTCTGTTGACTGGCATGAATATCCGATGGCGCACGCTGTATGTGACCAGGAACTGATTG
ATATCTCCCGCTGGCTAAAAAACATTCTGAAGGAAGCTTTAATTTCAGATCACCAAAACAGATAG

Upstream 100 bases:

>100_bases
TGAAAAAATCTCTGCGTTTCATACGCCTCCTCATCAATGATAATATTGAACCCGATAAATTTATCGCTACCAGCCAACCA
CGTCAATTTCACGTACCCCT

Downstream 100 bases:

>100_bases
CTATGACGTACGATAACACTCACTACTCGCATCGAACCGGCTGGCTACGGGCGGCGGTACTGGGCGCCAACGATGGTATC
GTTTCCACAGCTAGCCTGAT

Product: carboxylesterase

Products: NA

Alternate protein names: Esterase I [H]

Number of amino acids: Translated: 234; Mature: 233

Protein sequence:

>234_residues
MSDSLLQLSAIDIATGSNPLYTVLWMHGLGADGNDFVPVVQTLDLPATPIRFLFPHAPLQPVTINGGHTMRAWYDIQHTD
FIKQEDKAGLYRSQRAIVALIEHENQRGIPSSHIILAGFSQGAAMALHVGLRHPDKLAGIMVLSGYLPLVHEIRQEAHVA
NQLTPIFMAHGSYDPVVPVKLARSSLQLLRDYHYSVDWHEYPMAHAVCDQELIDISRWLKNILKEALISDHQNR

Sequences:

>Translated_234_residues
MSDSLLQLSAIDIATGSNPLYTVLWMHGLGADGNDFVPVVQTLDLPATPIRFLFPHAPLQPVTINGGHTMRAWYDIQHTD
FIKQEDKAGLYRSQRAIVALIEHENQRGIPSSHIILAGFSQGAAMALHVGLRHPDKLAGIMVLSGYLPLVHEIRQEAHVA
NQLTPIFMAHGSYDPVVPVKLARSSLQLLRDYHYSVDWHEYPMAHAVCDQELIDISRWLKNILKEALISDHQNR
>Mature_233_residues
SDSLLQLSAIDIATGSNPLYTVLWMHGLGADGNDFVPVVQTLDLPATPIRFLFPHAPLQPVTINGGHTMRAWYDIQHTDF
IKQEDKAGLYRSQRAIVALIEHENQRGIPSSHIILAGFSQGAAMALHVGLRHPDKLAGIMVLSGYLPLVHEIRQEAHVAN
QLTPIFMAHGSYDPVVPVKLARSSLQLLRDYHYSVDWHEYPMAHAVCDQELIDISRWLKNILKEALISDHQNR

Specific function: Hydrolyzes carboxylic ester bonds with relatively broad substrate specificity [H]

COG id: COG0400

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase 2 family [H]

Homologues:

Organism=Homo sapiens, GI9966764, Length=226, Percent_Identity=35.3982300884956, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI5453722, Length=205, Percent_Identity=35.1219512195122, Blast_Score=128, Evalue=4e-30,
Organism=Homo sapiens, GI20270341, Length=203, Percent_Identity=25.1231527093596, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17508057, Length=199, Percent_Identity=36.1809045226131, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6323147, Length=211, Percent_Identity=36.0189573459716, Blast_Score=120, Evalue=2e-28,
Organism=Drosophila melanogaster, GI45553055, Length=204, Percent_Identity=36.7647058823529, Blast_Score=140, Evalue=9e-34,
Organism=Drosophila melanogaster, GI45553057, Length=204, Percent_Identity=36.7647058823529, Blast_Score=140, Evalue=9e-34,
Organism=Drosophila melanogaster, GI21357257, Length=204, Percent_Identity=36.7647058823529, Blast_Score=140, Evalue=9e-34,
Organism=Drosophila melanogaster, GI161078179, Length=204, Percent_Identity=26.4705882352941, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003140 [H]

Pfam domain/function: PF02230 Abhydrolase_2 [H]

EC number: =3.1.1.1 [H]

Molecular weight: Translated: 26199; Mature: 26068

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDSLLQLSAIDIATGSNPLYTVLWMHGLGADGNDFVPVVQTLDLPATPIRFLFPHAPLQ
CCCCCEEEEEEEEECCCCCEEEEEEEECCCCCCCCCCHHHEECCCCCCCHHHCCCCCCCC
PVTINGGHTMRAWYDIQHTDFIKQEDKAGLYRSQRAIVALIEHENQRGIPSSHIILAGFS
EEEECCCEEEEEEEECCHHHHHHCCHHCCHHHHCCCEEEEEECCCCCCCCCCEEEEEECC
QGAAMALHVGLRHPDKLAGIMVLSGYLPLVHEIRQEAHVANQLTPIFMAHGSYDPVVPVK
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHH
LARSSLQLLRDYHYSVDWHEYPMAHAVCDQELIDISRWLKNILKEALISDHQNR
HHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SDSLLQLSAIDIATGSNPLYTVLWMHGLGADGNDFVPVVQTLDLPATPIRFLFPHAPLQ
CCCCEEEEEEEEECCCCCEEEEEEEECCCCCCCCCCHHHEECCCCCCCHHHCCCCCCCC
PVTINGGHTMRAWYDIQHTDFIKQEDKAGLYRSQRAIVALIEHENQRGIPSSHIILAGFS
EEEECCCEEEEEEEECCHHHHHHCCHHCCHHHHCCCEEEEEECCCCCCCCCCEEEEEECC
QGAAMALHVGLRHPDKLAGIMVLSGYLPLVHEIRQEAHVANQLTPIFMAHGSYDPVVPVK
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHH
LARSSLQLLRDYHYSVDWHEYPMAHAVCDQELIDISRWLKNILKEALISDHQNR
HHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA