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The map label for this gene is ubiB [H]

Identifier: 114331162

GI number: 114331162

Start: 1211586

End: 1213100

Strand: Reverse

Name: ubiB [H]

Synonym: Neut_1164

Alternate gene names: 114331162

Gene position: 1213100-1211586 (Counterclockwise)

Preceding gene: 114331163

Following gene: 114331132

Centisome position: 45.59

GC content: 51.29

Gene sequence:

>1515_bases
ATGCGCTTTTTCCGTCTATTTAAGATTATCCTGATTGCTTATCGCTTCGGGCTAGATGAAATCCTACTCGAGCAGATTCA
TCTGCGCGCACTCAAGGTATTTTCACAGCTATTGCCGTTTCGCACTCAACTCAAACAGCCACGCGCGGTCAGATTGCGCC
TGGCACTGGAAGCACTGGGGCCCATTTCCATCAAGTTTGGGCAGATGCTATCCACCCGCAGGGATTTGCTTGCCCAGGAT
TTTGCCGATGAACTGGCTTTTCTCCAGGATCGGGTGCCGCCTTTTCCTTCGGAGCAGGCGGTAAAAATACTGGAAACCGT
CTATAGAAAGCCGGTAAATGAGGTCTTTCTCGAATTTGATATCAAGCCAGTTGCCAGCGCATCAGTTGCCCAGGTGCACT
TTGCCGTGCTGCAGGATGGCACACAAGCGGCTGTCAAGATCTTGCGACCAACCATCGCCCCCGTCATTGCACATGATGTG
GCGTTGATGGAAACCGGTGCATGGCTGCTTGAATCCATCTGGCCAGATGGCAAGCGACTAAAATTGCGCGAAGTAGTGGC
GGAGTTTGCCCGACATCTGGACGATGAACTTGATCTTATCCGGGAAGCCGCTAACTGCAGCCAGTTACGGCGTAATTTCC
TCAATTCCCCCTTGCTACAGGTGCCAGAAGTGTATTGGGATTACTGTCATCCAGAAGTCATGGTGATGGAGCGGATGATT
GGTACTCCCATCAGCCGTGTAGAGATATTACGTACACAGGGAATCGATGTTCCACAACTTGCCCGCATGGGAGTGGAGAT
CTTTTTTACCCAGGTGTTCAGGGATGGTTATTTCCATGCTGATATGCATCCTGGCAATATCTTTGTCGGGAGCGATGGCC
GCTATATCGCCGTGGATTTTGGCATTATGGGTACGCTGAGTGAACAGGATAAAAATTATCTGGCACAAAACTTCCTGGCT
TTCTTTCGCCGGGACTATCGCCGCGTGGCAGAGACGCACATTGAGGCCGGCTGGGCGCCGAGAAATACGCGCGTAGATGA
TTTCGAAGCCGCTATCCGGGCCGTGTGTGAACCGATTTTTGATCGACCTCTGAAGGAAATCTACTTTGGACGTGTCCTGC
TGCGCCTATTTCAGGCTTCCCGTCAGTTCAACGTGGAAATTCAGCCACAACTGGTTCTGCTTCAGAAAACACTGCTTAAT
ATTGAAGGTCTGGGACGTGATCTGGATCCGGATCTTGATCTCTGGAAAACTGCCAAGCCATTCCTGGAAAACTGGATGGC
CGAGCAAATCGGGCTGCGCGGACTTATTACTCACCTGCAGAAGGAAGCAACCAACTGGGCGGTGATGCTACCGCAGTTTC
CCCGCCTGATGCACTACAACCTTGATAAGCAACGTGCCCGAAATCTGGAAGACAGACTGGCCGAACTGGTCGCACAGCAA
AAACGTCAAAGCCTGATACTGACACTGGTCGCAGTGCTATTGGCTGGATTACTACTTGCCCGGGTATATCTCTAA

Upstream 100 bases:

>100_bases
CCGACCAATGATCGGAAGCCGCTCACAACTCGCCTCTGCAATCTGTGCAGATACCACCGGCCCTGTCTGCTGGTAACTTT
ATTGAACCACCAATCACTTC

Downstream 100 bases:

>100_bases
GTATTCAGTCCCAGATGATTTGAACACTCCAGACGCGATCTCTTTATAGTTTGGGCCAACAAGGCGCTTAATGGCCATAT
CAAGTCAAGTGCTTTGCTAG

Product: putative ubiquinone biosynthesis protein UbiB

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MRFFRLFKIILIAYRFGLDEILLEQIHLRALKVFSQLLPFRTQLKQPRAVRLRLALEALGPISIKFGQMLSTRRDLLAQD
FADELAFLQDRVPPFPSEQAVKILETVYRKPVNEVFLEFDIKPVASASVAQVHFAVLQDGTQAAVKILRPTIAPVIAHDV
ALMETGAWLLESIWPDGKRLKLREVVAEFARHLDDELDLIREAANCSQLRRNFLNSPLLQVPEVYWDYCHPEVMVMERMI
GTPISRVEILRTQGIDVPQLARMGVEIFFTQVFRDGYFHADMHPGNIFVGSDGRYIAVDFGIMGTLSEQDKNYLAQNFLA
FFRRDYRRVAETHIEAGWAPRNTRVDDFEAAIRAVCEPIFDRPLKEIYFGRVLLRLFQASRQFNVEIQPQLVLLQKTLLN
IEGLGRDLDPDLDLWKTAKPFLENWMAEQIGLRGLITHLQKEATNWAVMLPQFPRLMHYNLDKQRARNLEDRLAELVAQQ
KRQSLILTLVAVLLAGLLLARVYL

Sequences:

>Translated_504_residues
MRFFRLFKIILIAYRFGLDEILLEQIHLRALKVFSQLLPFRTQLKQPRAVRLRLALEALGPISIKFGQMLSTRRDLLAQD
FADELAFLQDRVPPFPSEQAVKILETVYRKPVNEVFLEFDIKPVASASVAQVHFAVLQDGTQAAVKILRPTIAPVIAHDV
ALMETGAWLLESIWPDGKRLKLREVVAEFARHLDDELDLIREAANCSQLRRNFLNSPLLQVPEVYWDYCHPEVMVMERMI
GTPISRVEILRTQGIDVPQLARMGVEIFFTQVFRDGYFHADMHPGNIFVGSDGRYIAVDFGIMGTLSEQDKNYLAQNFLA
FFRRDYRRVAETHIEAGWAPRNTRVDDFEAAIRAVCEPIFDRPLKEIYFGRVLLRLFQASRQFNVEIQPQLVLLQKTLLN
IEGLGRDLDPDLDLWKTAKPFLENWMAEQIGLRGLITHLQKEATNWAVMLPQFPRLMHYNLDKQRARNLEDRLAELVAQQ
KRQSLILTLVAVLLAGLLLARVYL
>Mature_504_residues
MRFFRLFKIILIAYRFGLDEILLEQIHLRALKVFSQLLPFRTQLKQPRAVRLRLALEALGPISIKFGQMLSTRRDLLAQD
FADELAFLQDRVPPFPSEQAVKILETVYRKPVNEVFLEFDIKPVASASVAQVHFAVLQDGTQAAVKILRPTIAPVIAHDV
ALMETGAWLLESIWPDGKRLKLREVVAEFARHLDDELDLIREAANCSQLRRNFLNSPLLQVPEVYWDYCHPEVMVMERMI
GTPISRVEILRTQGIDVPQLARMGVEIFFTQVFRDGYFHADMHPGNIFVGSDGRYIAVDFGIMGTLSEQDKNYLAQNFLA
FFRRDYRRVAETHIEAGWAPRNTRVDDFEAAIRAVCEPIFDRPLKEIYFGRVLLRLFQASRQFNVEIQPQLVLLQKTLLN
IEGLGRDLDPDLDLWKTAKPFLENWMAEQIGLRGLITHLQKEATNWAVMLPQFPRLMHYNLDKQRARNLEDRLAELVAQQ
KRQSLILTLVAVLLAGLLLARVYL

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI41393593, Length=270, Percent_Identity=31.1111111111111, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI40254938, Length=301, Percent_Identity=26.2458471760797, Blast_Score=123, Evalue=5e-28,
Organism=Homo sapiens, GI217035081, Length=243, Percent_Identity=27.1604938271605, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI32261307, Length=486, Percent_Identity=25.9259259259259, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI34147522, Length=223, Percent_Identity=28.2511210762332, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI27363457, Length=215, Percent_Identity=28.8372093023256, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI217416386, Length=159, Percent_Identity=30.8176100628931, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI2367309, Length=491, Percent_Identity=50.10183299389, Blast_Score=464, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI17559152, Length=283, Percent_Identity=27.5618374558304, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI32565180, Length=348, Percent_Identity=25.8620689655172, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6325148, Length=436, Percent_Identity=25.9174311926606, Blast_Score=113, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6323282, Length=245, Percent_Identity=28.9795918367347, Blast_Score=98, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6321319, Length=247, Percent_Identity=27.1255060728745, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI22024280, Length=278, Percent_Identity=28.7769784172662, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24662575, Length=230, Percent_Identity=29.1304347826087, Blast_Score=112, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 58168; Mature: 58168

Theoretical pI: Translated: 8.10; Mature: 8.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFFRLFKIILIAYRFGLDEILLEQIHLRALKVFSQLLPFRTQLKQPRAVRLRLALEALG
CHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHC
PISIKFGQMLSTRRDLLAQDFADELAFLQDRVPPFPSEQAVKILETVYRKPVNEVFLEFD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHCC
IKPVASASVAQVHFAVLQDGTQAAVKILRPTIAPVIAHDVALMETGAWLLESIWPDGKRL
CCHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
KLREVVAEFARHLDDELDLIREAANCSQLRRNFLNSPLLQVPEVYWDYCHPEVMVMERMI
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHH
GTPISRVEILRTQGIDVPQLARMGVEIFFTQVFRDGYFHADMHPGNIFVGSDGRYIAVDF
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEECCCCCEEEEEC
GIMGTLSEQDKNYLAQNFLAFFRRDYRRVAETHIEAGWAPRNTRVDDFEAAIRAVCEPIF
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
DRPLKEIYFGRVLLRLFQASRQFNVEIQPQLVLLQKTLLNIEGLGRDLDPDLDLWKTAKP
HCHHHHHHHHHHHHHHHHHCCCCCCEECHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
FLENWMAEQIGLRGLITHLQKEATNWAVMLPQFPRLMHYNLDKQRARNLEDRLAELVAQQ
HHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHCCCCHHHHCCHHHHHHHHHHHH
KRQSLILTLVAVLLAGLLLARVYL
HHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRFFRLFKIILIAYRFGLDEILLEQIHLRALKVFSQLLPFRTQLKQPRAVRLRLALEALG
CHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHC
PISIKFGQMLSTRRDLLAQDFADELAFLQDRVPPFPSEQAVKILETVYRKPVNEVFLEFD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHCC
IKPVASASVAQVHFAVLQDGTQAAVKILRPTIAPVIAHDVALMETGAWLLESIWPDGKRL
CCHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
KLREVVAEFARHLDDELDLIREAANCSQLRRNFLNSPLLQVPEVYWDYCHPEVMVMERMI
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHH
GTPISRVEILRTQGIDVPQLARMGVEIFFTQVFRDGYFHADMHPGNIFVGSDGRYIAVDF
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEECCCCCEEEEEC
GIMGTLSEQDKNYLAQNFLAFFRRDYRRVAETHIEAGWAPRNTRVDDFEAAIRAVCEPIF
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
DRPLKEIYFGRVLLRLFQASRQFNVEIQPQLVLLQKTLLNIEGLGRDLDPDLDLWKTAKP
HCHHHHHHHHHHHHHHHHHCCCCCCEECHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
FLENWMAEQIGLRGLITHLQKEATNWAVMLPQFPRLMHYNLDKQRARNLEDRLAELVAQQ
HHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHCCCCHHHHCCHHHHHHHHHHHH
KRQSLILTLVAVLLAGLLLARVYL
HHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA