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The map label for this gene is ilvA [H]

Identifier: 114331158

GI number: 114331158

Start: 1200426

End: 1201937

Strand: Direct

Name: ilvA [H]

Synonym: Neut_1160

Alternate gene names: 114331158

Gene position: 1200426-1201937 (Clockwise)

Preceding gene: 114331157

Following gene: 114331159

Centisome position: 45.11

GC content: 48.15

Gene sequence:

>1512_bases
ATGATTAATGATTATCTTGAAAGGATACTGACCGCGCATGTCTATGACGTTGCGGTTGAAACCCGGCTGGATCCGGCGCC
ATCATTATCTGCCCGTATTCATAACCGTGTGCTGCTCAAAAGAGAGGATATGCAGCAGGTTTTTTCCTTCAAGCTGCGTG
GTGCCTATAATAAAATGGCTAGATTGCATTCTGGTGTATTGCAGCAAGGCGTGGTCGCTGCCTCAGCGGGAAATCATGCG
CAAGGTGTAGCACTGGCAGCGCAAAAGCTGGGCTGCTCAGCCACGATCGTTATGCCAACCACCACGCCGCAGATCAAGAT
CAATGCAGTAATGGCGATGGGTGCTGCAGTACTGCTGCAGGGGGATTCCTATAATGATGCCTACGAATATGCGCTGAATC
TTGCCAGGGAAAAGGGGGTTGAATTCATTCATCCTTACGATGATCCGGATGTGATCGCCGGGCAGGGTACGATTGCTATG
GAAATTTTGCGTCAGCATCCCGGGAAAATCCATGCAATTTTTATCCCGATTGGTGGGGGAGGGTTGATTTCCGGCATTGC
TGCGTATGTGAAAAGACTTCGCCCGGATATCCGGATAATCGGAGTTGAGCCAACAGATTCAAATGCCATGTATCGTTCTC
TGCAGGCAGGTTATTGTGTTGAGCTCTCGCAAGTGGGTTTATTTGCGGATGGTGTGGCTGTTCGTCAGGTGGGACAGGAA
ACTTTCCGGCTGTGTCGTGAGCTGGTGGATGACATCCTGCTAGTAGATTCGGACGCCATTTGTGCTGCAATCAAGGATAT
ATTTGAGGACACGCGCTCCATTGTAGAACCTTCCGGTGCGCTTTCGGTTGCCGGGCTAAAGGTGTATGCGAAACAAAATA
ACTTGCTGCACGAAACCCTGATTGCAATCGCATCAGGAGCAAACATGAATTTTGACCGACTGCGCCACGTTTCTGAACGG
GCTGAACTGGGTGAACAGCGTGAAGCAATCCTTGCAGTGACGATTCCTGAAAAGCCTGGTAGCTTTAAACAGTTTTGTAA
TCTGGTGGGCGCCCGCAACATCACGGAATTTAACTATCGCTATGCGGATCCTCAAAAGGCACATGTCTTTGTGGGTATAT
CAGTCCGTAATCGCGAAGAAGCATTGAATCTGATCCAGATCCTGCATGCAAATAATTTGCGTGCAGAAGATATGACTGAC
AACGAGATGGCGAAGCTGCATATCCGCCACATGGTGGGTGGGCATTCCAGGGAAGTCAGTCATGAAGTTCTGTATCGATT
TGAATTTCCAGATCGTCCGGGAGCACTCATGAATTTTCTGAACAAAATGAGTGATCGCTGGAATATCAGTTTGTTTCATT
ATCGTAATCATGGCGCTGATTTCGGCCGTGTCCTGATCGGAATACAAGTTCTCCCACAGGACAAAGATGAATTTATGCAC
TTCCTGGATGATCTGGGTTATGAATTTGATGATGAAAGCAATAATCCTGCCTATCAGTTTTTCCTTGCCTGA

Upstream 100 bases:

>100_bases
TGGCACACACTATTCTTCTTGAAACCGGATACGACTAGCAATAAATTTTGCTACCGGTTTTCACTCACTACTACTGTGAT
ACCTCCAAAATCTTGCCATC

Downstream 100 bases:

>100_bases
TTTTCTGCCTGCATCTCCTCCTCGTTTACGAGCTTCCTGTTCATGGCAATAGTATCTTTAAATGTGATTGGACTAATACC
GCCCCGTATCGGGTGTTGGT

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MINDYLERILTAHVYDVAVETRLDPAPSLSARIHNRVLLKREDMQQVFSFKLRGAYNKMARLHSGVLQQGVVAASAGNHA
QGVALAAQKLGCSATIVMPTTTPQIKINAVMAMGAAVLLQGDSYNDAYEYALNLAREKGVEFIHPYDDPDVIAGQGTIAM
EILRQHPGKIHAIFIPIGGGGLISGIAAYVKRLRPDIRIIGVEPTDSNAMYRSLQAGYCVELSQVGLFADGVAVRQVGQE
TFRLCRELVDDILLVDSDAICAAIKDIFEDTRSIVEPSGALSVAGLKVYAKQNNLLHETLIAIASGANMNFDRLRHVSER
AELGEQREAILAVTIPEKPGSFKQFCNLVGARNITEFNYRYADPQKAHVFVGISVRNREEALNLIQILHANNLRAEDMTD
NEMAKLHIRHMVGGHSREVSHEVLYRFEFPDRPGALMNFLNKMSDRWNISLFHYRNHGADFGRVLIGIQVLPQDKDEFMH
FLDDLGYEFDDESNNPAYQFFLA

Sequences:

>Translated_503_residues
MINDYLERILTAHVYDVAVETRLDPAPSLSARIHNRVLLKREDMQQVFSFKLRGAYNKMARLHSGVLQQGVVAASAGNHA
QGVALAAQKLGCSATIVMPTTTPQIKINAVMAMGAAVLLQGDSYNDAYEYALNLAREKGVEFIHPYDDPDVIAGQGTIAM
EILRQHPGKIHAIFIPIGGGGLISGIAAYVKRLRPDIRIIGVEPTDSNAMYRSLQAGYCVELSQVGLFADGVAVRQVGQE
TFRLCRELVDDILLVDSDAICAAIKDIFEDTRSIVEPSGALSVAGLKVYAKQNNLLHETLIAIASGANMNFDRLRHVSER
AELGEQREAILAVTIPEKPGSFKQFCNLVGARNITEFNYRYADPQKAHVFVGISVRNREEALNLIQILHANNLRAEDMTD
NEMAKLHIRHMVGGHSREVSHEVLYRFEFPDRPGALMNFLNKMSDRWNISLFHYRNHGADFGRVLIGIQVLPQDKDEFMH
FLDDLGYEFDDESNNPAYQFFLA
>Mature_503_residues
MINDYLERILTAHVYDVAVETRLDPAPSLSARIHNRVLLKREDMQQVFSFKLRGAYNKMARLHSGVLQQGVVAASAGNHA
QGVALAAQKLGCSATIVMPTTTPQIKINAVMAMGAAVLLQGDSYNDAYEYALNLAREKGVEFIHPYDDPDVIAGQGTIAM
EILRQHPGKIHAIFIPIGGGGLISGIAAYVKRLRPDIRIIGVEPTDSNAMYRSLQAGYCVELSQVGLFADGVAVRQVGQE
TFRLCRELVDDILLVDSDAICAAIKDIFEDTRSIVEPSGALSVAGLKVYAKQNNLLHETLIAIASGANMNFDRLRHVSER
AELGEQREAILAVTIPEKPGSFKQFCNLVGARNITEFNYRYADPQKAHVFVGISVRNREEALNLIQILHANNLRAEDMTD
NEMAKLHIRHMVGGHSREVSHEVLYRFEFPDRPGALMNFLNKMSDRWNISLFHYRNHGADFGRVLIGIQVLPQDKDEFMH
FLDDLGYEFDDESNNPAYQFFLA

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=269, Percent_Identity=35.6877323420074, Blast_Score=155, Evalue=7e-38,
Organism=Homo sapiens, GI33469958, Length=331, Percent_Identity=27.4924471299094, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI19923959, Length=296, Percent_Identity=26.0135135135135, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1790207, Length=501, Percent_Identity=52.4950099800399, Blast_Score=509, Evalue=1e-145,
Organism=Escherichia coli, GI1789505, Length=290, Percent_Identity=38.9655172413793, Blast_Score=177, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI71991565, Length=321, Percent_Identity=34.2679127725857, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17537387, Length=376, Percent_Identity=34.3085106382979, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17508781, Length=280, Percent_Identity=31.4285714285714, Blast_Score=128, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6320930, Length=514, Percent_Identity=51.556420233463, Blast_Score=497, Evalue=1e-141,
Organism=Saccharomyces cerevisiae, GI6322631, Length=300, Percent_Identity=37, Blast_Score=172, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6319788, Length=250, Percent_Identity=28, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI21355833, Length=327, Percent_Identity=31.4984709480122, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24645328, Length=252, Percent_Identity=29.7619047619048, Blast_Score=95, Evalue=9e-20,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 55977; Mature: 55977

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINDYLERILTAHVYDVAVETRLDPAPSLSARIHNRVLLKREDMQQVFSFKLRGAYNKMA
CCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
RLHSGVLQQGVVAASAGNHAQGVALAAQKLGCSATIVMPTTTPQIKINAVMAMGAAVLLQ
HHHHHHHHHCCEEECCCCCCCHHHHHHHHCCCEEEEEECCCCCCEEEEHHHHCCEEEEEE
GDSYNDAYEYALNLAREKGVEFIHPYDDPDVIAGQGTIAMEILRQHPGKIHAIFIPIGGG
CCCCCHHHHHHHHHHHHCCCCEECCCCCCCEEECCCHHHHHHHHHCCCEEEEEEEEECCC
GLISGIAAYVKRLRPDIRIIGVEPTDSNAMYRSLQAGYCVELSQVGLFADGVAVRQVGQE
HHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHCCCCEEEHHHCCEECCCHHHHHHHHH
TFRLCRELVDDILLVDSDAICAAIKDIFEDTRSIVEPSGALSVAGLKVYAKQNNLLHETL
HHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCHHHHHH
IAIASGANMNFDRLRHVSERAELGEQREAILAVTIPEKPGSFKQFCNLVGARNITEFNYR
HHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHCCCCCEECCEE
YADPQKAHVFVGISVRNREEALNLIQILHANNLRAEDMTDNEMAKLHIRHMVGGHSREVS
ECCCCCCEEEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCHHCC
HEVLYRFEFPDRPGALMNFLNKMSDRWNISLFHYRNHGADFGRVLIGIQVLPQDKDEFMH
CEEEEEEECCCCCCHHHHHHHHCCCCCEEEEEEEECCCCCCCEEEEEEEECCCCHHHHHH
FLDDLGYEFDDESNNPAYQFFLA
HHHHCCCCCCCCCCCCCEEEEEC
>Mature Secondary Structure
MINDYLERILTAHVYDVAVETRLDPAPSLSARIHNRVLLKREDMQQVFSFKLRGAYNKMA
CCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
RLHSGVLQQGVVAASAGNHAQGVALAAQKLGCSATIVMPTTTPQIKINAVMAMGAAVLLQ
HHHHHHHHHCCEEECCCCCCCHHHHHHHHCCCEEEEEECCCCCCEEEEHHHHCCEEEEEE
GDSYNDAYEYALNLAREKGVEFIHPYDDPDVIAGQGTIAMEILRQHPGKIHAIFIPIGGG
CCCCCHHHHHHHHHHHHCCCCEECCCCCCCEEECCCHHHHHHHHHCCCEEEEEEEEECCC
GLISGIAAYVKRLRPDIRIIGVEPTDSNAMYRSLQAGYCVELSQVGLFADGVAVRQVGQE
HHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHCCCCEEEHHHCCEECCCHHHHHHHHH
TFRLCRELVDDILLVDSDAICAAIKDIFEDTRSIVEPSGALSVAGLKVYAKQNNLLHETL
HHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCHHHHHH
IAIASGANMNFDRLRHVSERAELGEQREAILAVTIPEKPGSFKQFCNLVGARNITEFNYR
HHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHCCCCCEECCEE
YADPQKAHVFVGISVRNREEALNLIQILHANNLRAEDMTDNEMAKLHIRHMVGGHSREVS
ECCCCCCEEEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCHHCC
HEVLYRFEFPDRPGALMNFLNKMSDRWNISLFHYRNHGADFGRVLIGIQVLPQDKDEFMH
CEEEEEEECCCCCCHHHHHHHHCCCCCEEEEEEEECCCCCCCEEEEEEEECCCCHHHHHH
FLDDLGYEFDDESNNPAYQFFLA
HHHHCCCCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA