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The map label for this gene is mtnP [H]

Identifier: 114330948

GI number: 114330948

Start: 975927

End: 976673

Strand: Reverse

Name: mtnP [H]

Synonym: Neut_0945

Alternate gene names: 114330948

Gene position: 976673-975927 (Counterclockwise)

Preceding gene: 114330949

Following gene: 114330947

Centisome position: 36.7

GC content: 48.06

Gene sequence:

>747_bases
ATGATTGCAATTATCGGCGGCAGACGTATGAACAAACTGGCCGGCCTAGAAGTTACCCATCGTCAGGTCATAAGGACCCC
TTATGGAGAACCGTCCGGTTCATTGATTTTTGGCACGATCTGCGAGCACGAAGTTGTTTTTCTGTCCCGGCACGGCCATG
GTATTACCATTCCGCCGCACATGGTCAACTATCGTGCCAACATCTGGGCACTGCATACCCAGCAAGTCAAAAAAATCATT
GCTGTTACATCAGTTGGCAGTATCCGTAAAGATATGGAACCTGGAAAAATCGTCATTCCTGACCAGATTATTGATTACAC
CCATAGCCGGGAAGCTACTTTTCATGATCGATCTGACAAAGCCATCACCAATACAGATTTTACACAACCCTATTGCCCTA
TTGCACGCGACTGTCTCCTAAAGGCTGCACAGGATGCGGGTGAATCAGTTATTGATGGAGGTGTTTATGCTGCAACCGAG
GGCCCCAGATTTGAAACAGCAGCAGAAATCAATCGTCTGGAACGTGATGGGGCAGATATAGTTGGGATGACGGGTATGCC
GGAGGCAATTCTCACGCGGGAATTAGGTATTTCCTACGCGACCATTGCCGCCATTGCTAATCATGCAGCCGGACGCGGGG
AAAGCAAACAAGCTATCCCGCTGCAAGCTGCGCACAAGGCACTGGAAGATGCGATGATGAATGTCAGAAATATATTGGAG
CATCTGGTAAGGAATAATGATGATTAA

Upstream 100 bases:

>100_bases
TCTTCTTGATTGCAGTTATCTTCTCTTGCACGCGTATTACGCGTACGTAGCCAGTTATAATATAAGTGTAAAAAAATAAC
TTATTACCATCAGGATCAAT

Downstream 100 bases:

>100_bases
ACCCGTATTAAAAATGGGGGACCCACGCCTGTTGCAGCCTGCGCAGAGAATTGAGCAATTTGACACACCTGTACTCAAAG
AATTATTGCAGGACATGCAA

Product: 5'-methylthioadenosine phosphorylase

Products: NA

Alternate protein names: 5'-methylthioadenosine phosphorylase; MTA phosphorylase [H]

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MIAIIGGRRMNKLAGLEVTHRQVIRTPYGEPSGSLIFGTICEHEVVFLSRHGHGITIPPHMVNYRANIWALHTQQVKKII
AVTSVGSIRKDMEPGKIVIPDQIIDYTHSREATFHDRSDKAITNTDFTQPYCPIARDCLLKAAQDAGESVIDGGVYAATE
GPRFETAAEINRLERDGADIVGMTGMPEAILTRELGISYATIAAIANHAAGRGESKQAIPLQAAHKALEDAMMNVRNILE
HLVRNNDD

Sequences:

>Translated_248_residues
MIAIIGGRRMNKLAGLEVTHRQVIRTPYGEPSGSLIFGTICEHEVVFLSRHGHGITIPPHMVNYRANIWALHTQQVKKII
AVTSVGSIRKDMEPGKIVIPDQIIDYTHSREATFHDRSDKAITNTDFTQPYCPIARDCLLKAAQDAGESVIDGGVYAATE
GPRFETAAEINRLERDGADIVGMTGMPEAILTRELGISYATIAAIANHAAGRGESKQAIPLQAAHKALEDAMMNVRNILE
HLVRNNDD
>Mature_248_residues
MIAIIGGRRMNKLAGLEVTHRQVIRTPYGEPSGSLIFGTICEHEVVFLSRHGHGITIPPHMVNYRANIWALHTQQVKKII
AVTSVGSIRKDMEPGKIVIPDQIIDYTHSREATFHDRSDKAITNTDFTQPYCPIARDCLLKAAQDAGESVIDGGVYAATE
GPRFETAAEINRLERDGADIVGMTGMPEAILTRELGISYATIAAIANHAAGRGESKQAIPLQAAHKALEDAMMNVRNILE
HLVRNNDD

Specific function: Catalyzes the formation of methylthio-D-ribose 1- phosphate (MTR-1-P) from methylthioadenosine (MTA) [H]

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=241, Percent_Identity=36.0995850622407, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71980569, Length=216, Percent_Identity=38.4259259259259, Blast_Score=138, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6323045, Length=229, Percent_Identity=27.0742358078603, Blast_Score=88, Evalue=1e-18,
Organism=Drosophila melanogaster, GI20130079, Length=245, Percent_Identity=33.469387755102, Blast_Score=144, Evalue=6e-35,
Organism=Drosophila melanogaster, GI221459247, Length=209, Percent_Identity=36.3636363636364, Blast_Score=140, Evalue=7e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: =2.4.2.28 [H]

Molecular weight: Translated: 27154; Mature: 27154

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAIIGGRRMNKLAGLEVTHRQVIRTPYGEPSGSLIFGTICEHEVVFLSRHGHGITIPPH
CEEEECCCCHHHHHCCHHHHHHHHHCCCCCCCCCEEEEEECCCEEEEEEECCCCEECCCH
MVNYRANIWALHTQQVKKIIAVTSVGSIRKDMEPGKIVIPDQIIDYTHSREATFHDRSDK
HHCCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHCCCCCCCCCCCCCCCC
AITNTDFTQPYCPIARDCLLKAAQDAGESVIDGGVYAATEGPRFETAAEINRLERDGADI
EECCCCCCCCCCHHHHHHHHHHHHHCCHHHHCCCEEECCCCCCCHHHHHHHHHHHCCCCE
VGMTGMPEAILTRELGISYATIAAIANHAAGRGESKQAIPLQAAHKALEDAMMNVRNILE
EECCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
HLVRNNDD
HHHHCCCC
>Mature Secondary Structure
MIAIIGGRRMNKLAGLEVTHRQVIRTPYGEPSGSLIFGTICEHEVVFLSRHGHGITIPPH
CEEEECCCCHHHHHCCHHHHHHHHHCCCCCCCCCEEEEEECCCEEEEEEECCCCEECCCH
MVNYRANIWALHTQQVKKIIAVTSVGSIRKDMEPGKIVIPDQIIDYTHSREATFHDRSDK
HHCCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHCCCCCCCCCCCCCCCC
AITNTDFTQPYCPIARDCLLKAAQDAGESVIDGGVYAATEGPRFETAAEINRLERDGADI
EECCCCCCCCCCHHHHHHHHHHHHHCCHHHHCCCEEECCCCCCCHHHHHHHHHHHCCCCE
VGMTGMPEAILTRELGISYATIAAIANHAAGRGESKQAIPLQAAHKALEDAMMNVRNILE
EECCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
HLVRNNDD
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]