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The map label for this gene is moeB [H]

Identifier: 114330919

GI number: 114330919

Start: 942824

End: 943585

Strand: Reverse

Name: moeB [H]

Synonym: Neut_0916

Alternate gene names: 114330919

Gene position: 943585-942824 (Counterclockwise)

Preceding gene: 114330920

Following gene: 114330917

Centisome position: 35.46

GC content: 47.9

Gene sequence:

>762_bases
GTGGATGATCAACAACTGTTACGTTACAGCCGCCACATTTTGTTACCGGAAATTGATTTTTCCGGTCAAACAAAACTAAT
ACAATCCAGTGTTTTCATTCTTGGGGCTGGTGGATTAGGCTCTCCTTCTGCTCTCTATCTTGCCGCCAGCGGGATTGGAA
GACTTGTTATTTGTGACCATGATCGGGTTGATCTGACTAATCTGCAACGCCAGATCCTGCACGACACGGCTTCGGTTGGT
GAGCTTAAAACTGATTCCGCTAGAAATACACTGCAGCGCATCAATCCAGAAATAGAAATTATCCCCCTGGCACGACATGC
CACTGTTGATTTATTAAACAGGGAAATTAGTGGTGTCGATGTCGTAATTGATGCCAGTGATAATTTCTCGGCACGCCACA
TACTCAACCAAGCCTGCCTGGATCATCGTAAACCCTTGATATCAGGCGCAGCTGTCCGGTTCACCGGGCAAGTTGCCGCA
TTCGATCTGCGTCAGAGTGATAGCCCCTGTTACCATTGCCTATTTCCTGACTCGGGAGATAGTGATGATCCCGGATGCGC
CGTAATGGGTGTATTTTCCCCACTAACAGGCATTATCGGCTGTATTCAGGCTGCCGAAGCTATCAAGGTTTTACTGGAAA
TCGGTGAAACACTCCATGGCCGCCTACTTCTCCTGGACGGGTTAGCCATGCGCTTGCGCTCATTCAAACTGAAAAAAGAT
CCACAATGTCCTGCATGTGGCTCAGCTTCAGCGAAAAAATAG

Upstream 100 bases:

>100_bases
AAAGCAATTAATCACCTGAAATCCATGTCTCAAAAATCCAAACACAAAACAGCCAAGGCAACGAAAGGCTAATTCATTCC
GAACAAGGTGGCGGAGCAAC

Downstream 100 bases:

>100_bases
CTAATATTTAATAAATAATATCAACCAGATGTTTGGAACCGTGACATGGCAAGGCGCGCATAGAGATCACTGGACTTCAT
CAATTCCGCATGCGTCCCCA

Product: UBA/THIF-type NAD/FAD binding protein

Products: NA

Alternate protein names: MoaD protein adenylase; Molybdopterin-converting factor subunit 1 adenylase [H]

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MDDQQLLRYSRHILLPEIDFSGQTKLIQSSVFILGAGGLGSPSALYLAASGIGRLVICDHDRVDLTNLQRQILHDTASVG
ELKTDSARNTLQRINPEIEIIPLARHATVDLLNREISGVDVVIDASDNFSARHILNQACLDHRKPLISGAAVRFTGQVAA
FDLRQSDSPCYHCLFPDSGDSDDPGCAVMGVFSPLTGIIGCIQAAEAIKVLLEIGETLHGRLLLLDGLAMRLRSFKLKKD
PQCPACGSASAKK

Sequences:

>Translated_253_residues
MDDQQLLRYSRHILLPEIDFSGQTKLIQSSVFILGAGGLGSPSALYLAASGIGRLVICDHDRVDLTNLQRQILHDTASVG
ELKTDSARNTLQRINPEIEIIPLARHATVDLLNREISGVDVVIDASDNFSARHILNQACLDHRKPLISGAAVRFTGQVAA
FDLRQSDSPCYHCLFPDSGDSDDPGCAVMGVFSPLTGIIGCIQAAEAIKVLLEIGETLHGRLLLLDGLAMRLRSFKLKKD
PQCPACGSASAKK
>Mature_253_residues
MDDQQLLRYSRHILLPEIDFSGQTKLIQSSVFILGAGGLGSPSALYLAASGIGRLVICDHDRVDLTNLQRQILHDTASVG
ELKTDSARNTLQRINPEIEIIPLARHATVDLLNREISGVDVVIDASDNFSARHILNQACLDHRKPLISGAAVRFTGQVAA
FDLRQSDSPCYHCLFPDSGDSDDPGCAVMGVFSPLTGIIGCIQAAEAIKVLLEIGETLHGRLLLLDGLAMRLRSFKLKKD
PQCPACGSASAKK

Specific function: Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein moaD [H]

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesA/moeB/thiF family [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=229, Percent_Identity=41.4847161572052, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI4885649, Length=166, Percent_Identity=28.9156626506024, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI23510338, Length=145, Percent_Identity=28.2758620689655, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI23510340, Length=145, Percent_Identity=28.2758620689655, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1787048, Length=247, Percent_Identity=42.914979757085, Blast_Score=204, Evalue=7e-54,
Organism=Escherichia coli, GI87082356, Length=251, Percent_Identity=41.8326693227092, Blast_Score=181, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17540406, Length=244, Percent_Identity=37.2950819672131, Blast_Score=171, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI193203301, Length=165, Percent_Identity=29.0909090909091, Blast_Score=84, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6321903, Length=251, Percent_Identity=30.2788844621514, Blast_Score=136, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6322639, Length=172, Percent_Identity=28.4883720930233, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24582879, Length=250, Percent_Identity=40.4, Blast_Score=183, Evalue=8e-47,
Organism=Drosophila melanogaster, GI24660640, Length=200, Percent_Identity=32, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24641311, Length=258, Percent_Identity=31.0077519379845, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR012730
- InterPro:   IPR016040
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 27308; Mature: 27308

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDQQLLRYSRHILLPEIDFSGQTKLIQSSVFILGAGGLGSPSALYLAASGIGRLVICDH
CCHHHHHHHHCCEEEECCCCCCCHHEEECEEEEEECCCCCCCCEEEEEECCCCEEEEECC
DRVDLTNLQRQILHDTASVGELKTDSARNTLQRINPEIEIIPLARHATVDLLNREISGVD
CCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCEEEEEECHHHHHHHHHCCCCCEE
VVIDASDNFSARHILNQACLDHRKPLISGAAVRFTGQVAAFDLRQSDSPCYHCLFPDSGD
EEEECCCCCHHHHHHHHHHHHHCCCHHCCCEEEEECCEEEEECCCCCCCEEEEECCCCCC
SDDPGCAVMGVFSPLTGIIGCIQAAEAIKVLLEIGETLHGRLLLLDGLAMRLRSFKLKKD
CCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHCCCCC
PQCPACGSASAKK
CCCCCCCCCCCCC
>Mature Secondary Structure
MDDQQLLRYSRHILLPEIDFSGQTKLIQSSVFILGAGGLGSPSALYLAASGIGRLVICDH
CCHHHHHHHHCCEEEECCCCCCCHHEEECEEEEEECCCCCCCCEEEEEECCCCEEEEECC
DRVDLTNLQRQILHDTASVGELKTDSARNTLQRINPEIEIIPLARHATVDLLNREISGVD
CCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCEEEEEECHHHHHHHHHCCCCCEE
VVIDASDNFSARHILNQACLDHRKPLISGAAVRFTGQVAAFDLRQSDSPCYHCLFPDSGD
EEEECCCCCHHHHHHHHHHHHHCCCHHCCCEEEEECCEEEEECCCCCCCEEEEECCCCCC
SDDPGCAVMGVFSPLTGIIGCIQAAEAIKVLLEIGETLHGRLLLLDGLAMRLRSFKLKKD
CCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHCCCCC
PQCPACGSASAKK
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503 [H]