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The map label for this gene is thrC [H]

Identifier: 114330870

GI number: 114330870

Start: 881388

End: 882818

Strand: Reverse

Name: thrC [H]

Synonym: Neut_0864

Alternate gene names: 114330870

Gene position: 882818-881388 (Counterclockwise)

Preceding gene: 114330871

Following gene: 114330869

Centisome position: 33.18

GC content: 47.8

Gene sequence:

>1431_bases
ATGCGTTATCTCTCGACCCGAGGCGGCATGCTGCCCAAAACATTTACTGAAATTCTGTTAGGCGGACTGGCTCCGGATGG
CGGGCTGGCCATGCCTGAATCTTATCCTAAAATCAGCCCGGCAGAGCTTGAATCCTGGCGCTCGCTTGACTACCCGTCGC
TTGCATTTGAAATTCTGTCGCGTTTTATGGATGACATCCCCGCCGACGATTTGCGCACCTTAATTACACGCACCTATACG
GACGAAATTTTTGGCAGTGAGGAGGTCACTCCTGTCCAGACACTGGAATCCAATCTGCACCTGCTGCACCTGTCTAATGG
CCCTACCCTGGCGTTCAAGGACATCGCCATGCAGTTCCTGGGCAACCTGTTCGAGTATGTGCTTGCAAAAAATAATGATG
AATTGAATATCCTGGGCGCAACTTCTGGTGATACCGGCTCCAGTGCAGAATATGCCATGCGCGGCAAACGGGGCATTCGC
GTATTCATGTTGTCACCTTACGGAAAAATGAGTGCTTTTCAGACCGCACAAATGTTCTCGTTACAGGATAACAACATTTT
CAATATTGCTATCGAAGGTGTATTTGATGATTGCCAGGATATTGTCAAAACTGTCAGTAACGACCAGGTATTCAAGCAAA
AATACCGGATCGGTGCGGTCAATTCGATCAACTGGGCGCGTATCGCCGCGCAAATTATCTATTACTTCAAGGCCTATTTT
GCAGTTACCCGCTCTAACGGGGAAGCAGTATCTTTTTCAGTCCCTTCCGGCAACTTCGGCAACATTTTTGCCGGCCATGT
CGCCCGTATGATGGGCCTACCCATCAAGCAACTGATTCTGGCAACTAATGAAAATGATGTGCTGAATGAGTTTTTTCGTA
CCGGTTTATATCGTCCCCGCACAACAACTGAAACGAAGCAAACCAGCAGCCCTTCAATGGATATCTCCAAAGCATCAAAT
TTTGAGCGGTTTATCTTCGATCTGACCGGTCGGGATGCGGCACGCATCAAAGAACTCTGGAAATTGGTTGATCAAGGAGG
ATCATTCGATCTTTCCGATACTGATCTATGGAAAAAAATCAGGGATTTTGGCATTATTTCTGGAACCAGCAACCATGCTG
AACGCATCACCACTATTCGAAAGATACACCATAAATTCAATATCCTGATTGACACACACACAGCAGATGGCCTGAAAGTG
GGTATGGAATTGCGCGAACCTGATGTTCCACTCATCTGCCTGGAAACAGCACTGCCAGTCAAGTTTGCGGACAGTATCCA
GGAAGCAGTCGGATTCGTACCGGAACAACCGGATGGATACGATAACCTGGAGAAACTGCCCCAGCGTTTTGAACGTATGA
CAGCAGATGCCGAACAAGTTAAACGGTTCATTGCCCATCAGGTTGGGCCATCAAATCAGATGCACGGATAA

Upstream 100 bases:

>100_bases
CTGTATTCATATTCAATTCAATCCTTGATTTCTTTCGGAATTGATCAGCTTCCAACGCGAAGCACCTGGTTGTTTCTTTC
CCCGTTTATCACAGACTAAT

Downstream 100 bases:

>100_bases
CGAAAAAACTGACCCCGATCCTGGTACATTGTAATCATCTTCTTAACGTTATCATAAAATCATCTGTATTCTTTCGGAAC
AAGGTATTTTTCTGATCAAA

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MRYLSTRGGMLPKTFTEILLGGLAPDGGLAMPESYPKISPAELESWRSLDYPSLAFEILSRFMDDIPADDLRTLITRTYT
DEIFGSEEVTPVQTLESNLHLLHLSNGPTLAFKDIAMQFLGNLFEYVLAKNNDELNILGATSGDTGSSAEYAMRGKRGIR
VFMLSPYGKMSAFQTAQMFSLQDNNIFNIAIEGVFDDCQDIVKTVSNDQVFKQKYRIGAVNSINWARIAAQIIYYFKAYF
AVTRSNGEAVSFSVPSGNFGNIFAGHVARMMGLPIKQLILATNENDVLNEFFRTGLYRPRTTTETKQTSSPSMDISKASN
FERFIFDLTGRDAARIKELWKLVDQGGSFDLSDTDLWKKIRDFGIISGTSNHAERITTIRKIHHKFNILIDTHTADGLKV
GMELREPDVPLICLETALPVKFADSIQEAVGFVPEQPDGYDNLEKLPQRFERMTADAEQVKRFIAHQVGPSNQMHG

Sequences:

>Translated_476_residues
MRYLSTRGGMLPKTFTEILLGGLAPDGGLAMPESYPKISPAELESWRSLDYPSLAFEILSRFMDDIPADDLRTLITRTYT
DEIFGSEEVTPVQTLESNLHLLHLSNGPTLAFKDIAMQFLGNLFEYVLAKNNDELNILGATSGDTGSSAEYAMRGKRGIR
VFMLSPYGKMSAFQTAQMFSLQDNNIFNIAIEGVFDDCQDIVKTVSNDQVFKQKYRIGAVNSINWARIAAQIIYYFKAYF
AVTRSNGEAVSFSVPSGNFGNIFAGHVARMMGLPIKQLILATNENDVLNEFFRTGLYRPRTTTETKQTSSPSMDISKASN
FERFIFDLTGRDAARIKELWKLVDQGGSFDLSDTDLWKKIRDFGIISGTSNHAERITTIRKIHHKFNILIDTHTADGLKV
GMELREPDVPLICLETALPVKFADSIQEAVGFVPEQPDGYDNLEKLPQRFERMTADAEQVKRFIAHQVGPSNQMHG
>Mature_476_residues
MRYLSTRGGMLPKTFTEILLGGLAPDGGLAMPESYPKISPAELESWRSLDYPSLAFEILSRFMDDIPADDLRTLITRTYT
DEIFGSEEVTPVQTLESNLHLLHLSNGPTLAFKDIAMQFLGNLFEYVLAKNNDELNILGATSGDTGSSAEYAMRGKRGIR
VFMLSPYGKMSAFQTAQMFSLQDNNIFNIAIEGVFDDCQDIVKTVSNDQVFKQKYRIGAVNSINWARIAAQIIYYFKAYF
AVTRSNGEAVSFSVPSGNFGNIFAGHVARMMGLPIKQLILATNENDVLNEFFRTGLYRPRTTTETKQTSSPSMDISKASN
FERFIFDLTGRDAARIKELWKLVDQGGSFDLSDTDLWKKIRDFGIISGTSNHAERITTIRKIHHKFNILIDTHTADGLKV
GMELREPDVPLICLETALPVKFADSIQEAVGFVPEQPDGYDNLEKLPQRFERMTADAEQVKRFIAHQVGPSNQMHG

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI149193323, Length=463, Percent_Identity=31.5334773218143, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI153792148, Length=436, Percent_Identity=33.4862385321101, Blast_Score=224, Evalue=1e-58,
Organism=Escherichia coli, GI1786185, Length=457, Percent_Identity=30.1969365426696, Blast_Score=192, Evalue=5e-50,
Organism=Saccharomyces cerevisiae, GI6319901, Length=512, Percent_Identity=40.625, Blast_Score=326, Evalue=5e-90,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 53313; Mature: 53313

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYLSTRGGMLPKTFTEILLGGLAPDGGLAMPESYPKISPAELESWRSLDYPSLAFEILS
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHH
RFMDDIPADDLRTLITRTYTDEIFGSEEVTPVQTLESNLHLLHLSNGPTLAFKDIAMQFL
HHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCEEEEEECCCCCCHHHHHHHHHH
GNLFEYVLAKNNDELNILGATSGDTGSSAEYAMRGKRGIRVFMLSPYGKMSAFQTAQMFS
HHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHCCCCCEEEEEECCCCCHHHHHHHHHEE
LQDNNIFNIAIEGVFDDCQDIVKTVSNDQVFKQKYRIGAVNSINWARIAAQIIYYFKAYF
ECCCCEEEEEEECHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
AVTRSNGEAVSFSVPSGNFGNIFAGHVARMMGLPIKQLILATNENDVLNEFFRTGLYRPR
HEECCCCCEEEEECCCCCCCCHHHHHHHHHHCCCHHHHHEECCCCHHHHHHHHCCCCCCC
TTTETKQTSSPSMDISKASNFERFIFDLTGRDAARIKELWKLVDQGGSFDLSDTDLWKKI
CCCCCCCCCCCCCCHHHHCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHH
RDFGIISGTSNHAERITTIRKIHHKFNILIDTHTADGLKVGMELREPDVPLICLETALPV
HHCCEECCCCHHHHHHHHHHHHHHHEEEEEECCCCCCHHCCCEECCCCCCEEEECCCCCH
KFADSIQEAVGFVPEQPDGYDNLEKLPQRFERMTADAEQVKRFIAHQVGPSNQMHG
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MRYLSTRGGMLPKTFTEILLGGLAPDGGLAMPESYPKISPAELESWRSLDYPSLAFEILS
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHH
RFMDDIPADDLRTLITRTYTDEIFGSEEVTPVQTLESNLHLLHLSNGPTLAFKDIAMQFL
HHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCEEEEEECCCCCCHHHHHHHHHH
GNLFEYVLAKNNDELNILGATSGDTGSSAEYAMRGKRGIRVFMLSPYGKMSAFQTAQMFS
HHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHCCCCCEEEEEECCCCCHHHHHHHHHEE
LQDNNIFNIAIEGVFDDCQDIVKTVSNDQVFKQKYRIGAVNSINWARIAAQIIYYFKAYF
ECCCCEEEEEEECHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
AVTRSNGEAVSFSVPSGNFGNIFAGHVARMMGLPIKQLILATNENDVLNEFFRTGLYRPR
HEECCCCCEEEEECCCCCCCCHHHHHHHHHHCCCHHHHHEECCCCHHHHHHHHCCCCCCC
TTTETKQTSSPSMDISKASNFERFIFDLTGRDAARIKELWKLVDQGGSFDLSDTDLWKKI
CCCCCCCCCCCCCCHHHHCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHH
RDFGIISGTSNHAERITTIRKIHHKFNILIDTHTADGLKVGMELREPDVPLICLETALPV
HHCCEECCCCHHHHHHHHHHHHHHHEEEEEECCCCCCHHCCCEECCCCCCEEEECCCCCH
KFADSIQEAVGFVPEQPDGYDNLEKLPQRFERMTADAEQVKRFIAHQVGPSNQMHG
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8117070 [H]