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The map label for this gene is sdhB [H]

Identifier: 114330869

GI number: 114330869

Start: 880564

End: 881259

Strand: Reverse

Name: sdhB [H]

Synonym: Neut_0863

Alternate gene names: 114330869

Gene position: 881259-880564 (Counterclockwise)

Preceding gene: 114330870

Following gene: 114330868

Centisome position: 33.12

GC content: 50.29

Gene sequence:

>696_bases
ATGCTGTTCTCGATTAGTCGCTATGATCCGGACAAGGATGAAAAACCGTACATGCAGGATTATGACGTTGAGCTCGCACC
GACAGATAAAATGCTGCTGGATGCGCTGATACGTATCAAAGCCATTGATGACAGTCTCAGTCTGCGCCGCTCCTGTCGGG
AAGGTGTGTGCGGTTCCGATGCCATGAATATCAATGGTCGAAATAATCTTGCCTGCATCACACCGCTTGCTGACCTGCGT
GAACCTGTGGAAATCCGGCCTCTACCGGGATTGCCGATTATTCGCGATCTGATTGTTGATATGAGCCAGTTTTTCAAGCA
ATATCATTCAATCAAGCCCTATCTGATCAATAATGACCCGCCGCCAGAAACCGAGCGTTTACAATCCCAGGGAGAACGCG
CTCGCCTGGATGGTCTCTATGAATGCATTCTGTGTGCCTGTTGCACCTCTGCCTGCCCTTCATTCTGGTGGAATCCCGAC
AAATTTGTCGGGCCGGCCGGATTGCTACAAGCCTATCGTTTTCTGGCCGACAGCCGGGATCAGGCCACTTCTGAACGGCT
GGATGATCTGGAGGACCCCTACCGTTTATTCCGTTGCCATTCCATCATGAATTGTGTCGATGCCTGCCCCAAGGGATTAA
ACCCGACCGCCGCGATAGAAAGTATAAAAATCATGATGCTGAATAAAACGGTATGA

Upstream 100 bases:

>100_bases
TTGTAATCATCTTCTTAACGTTATCATAAAATCATCTGTATTCTTTCGGAACAAGGTATTTTTCTGATCAAATTAAAATA
AACGGAAAAAGGAGTGCATT

Downstream 100 bases:

>100_bases
ACCACCAGGCCCGCATGCGCTGGCGTTGTCGTCGCGGCATGCTGGAACTGGATATCGTTCTGTTGCGCTTCATGGATGCT
CATTATGAACAGCTGGATGA

Product: succinate dehydrogenase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MLFSISRYDPDKDEKPYMQDYDVELAPTDKMLLDALIRIKAIDDSLSLRRSCREGVCGSDAMNINGRNNLACITPLADLR
EPVEIRPLPGLPIIRDLIVDMSQFFKQYHSIKPYLINNDPPPETERLQSQGERARLDGLYECILCACCTSACPSFWWNPD
KFVGPAGLLQAYRFLADSRDQATSERLDDLEDPYRLFRCHSIMNCVDACPKGLNPTAAIESIKIMMLNKTV

Sequences:

>Translated_231_residues
MLFSISRYDPDKDEKPYMQDYDVELAPTDKMLLDALIRIKAIDDSLSLRRSCREGVCGSDAMNINGRNNLACITPLADLR
EPVEIRPLPGLPIIRDLIVDMSQFFKQYHSIKPYLINNDPPPETERLQSQGERARLDGLYECILCACCTSACPSFWWNPD
KFVGPAGLLQAYRFLADSRDQATSERLDDLEDPYRLFRCHSIMNCVDACPKGLNPTAAIESIKIMMLNKTV
>Mature_231_residues
MLFSISRYDPDKDEKPYMQDYDVELAPTDKMLLDALIRIKAIDDSLSLRRSCREGVCGSDAMNINGRNNLACITPLADLR
EPVEIRPLPGLPIIRDLIVDMSQFFKQYHSIKPYLINNDPPPETERLQSQGERARLDGLYECILCACCTSACPSFWWNPD
KFVGPAGLLQAYRFLADSRDQATSERLDDLEDPYRLFRCHSIMNCVDACPKGLNPTAAIESIKIMMLNKTV

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=229, Percent_Identity=56.7685589519651, Blast_Score=269, Evalue=1e-72,
Organism=Escherichia coli, GI1786943, Length=234, Percent_Identity=64.957264957265, Blast_Score=315, Evalue=1e-87,
Organism=Escherichia coli, GI1790596, Length=222, Percent_Identity=37.3873873873874, Blast_Score=150, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17533915, Length=233, Percent_Identity=50.2145922746781, Blast_Score=245, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6322987, Length=225, Percent_Identity=53.3333333333333, Blast_Score=246, Evalue=3e-66,
Organism=Drosophila melanogaster, GI17137106, Length=231, Percent_Identity=51.5151515151515, Blast_Score=258, Evalue=2e-69,
Organism=Drosophila melanogaster, GI24643156, Length=231, Percent_Identity=52.8138528138528, Blast_Score=250, Evalue=6e-67,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 26213; Mature: 26213

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
8.2 %Cys+Met (Translated Protein)
4.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
8.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFSISRYDPDKDEKPYMQDYDVELAPTDKMLLDALIRIKAIDDSLSLRRSCREGVCGSD
CEECCCCCCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCC
AMNINGRNNLACITPLADLREPVEIRPLPGLPIIRDLIVDMSQFFKQYHSIKPYLINNDP
CEECCCCCCEEEECCHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCC
PPETERLQSQGERARLDGLYECILCACCTSACPSFWWNPDKFVGPAGLLQAYRFLADSRD
CCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCHH
QATSERLDDLEDPYRLFRCHSIMNCVDACPKGLNPTAAIESIKIMMLNKTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHEEECCCC
>Mature Secondary Structure
MLFSISRYDPDKDEKPYMQDYDVELAPTDKMLLDALIRIKAIDDSLSLRRSCREGVCGSD
CEECCCCCCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCC
AMNINGRNNLACITPLADLREPVEIRPLPGLPIIRDLIVDMSQFFKQYHSIKPYLINNDP
CEECCCCCCEEEECCHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCC
PPETERLQSQGERARLDGLYECILCACCTSACPSFWWNPDKFVGPAGLLQAYRFLADSRD
CCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCHH
QATSERLDDLEDPYRLFRCHSIMNCVDACPKGLNPTAAIESIKIMMLNKTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 6388571; 8905232; 9278503; 6376123; 9298646 [H]