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The map label for this gene is hemA

Identifier: 114330833

GI number: 114330833

Start: 842389

End: 843642

Strand: Direct

Name: hemA

Synonym: Neut_0826

Alternate gene names: 114330833

Gene position: 842389-843642 (Clockwise)

Preceding gene: 114330831

Following gene: 114330834

Centisome position: 31.66

GC content: 47.61

Gene sequence:

>1254_bases
ATGCAACTTTTTGCCTTTGGTGTTAACCATCATACTGCACCTTTAGATATACGCGAACATGTGGCTTTTACGGAAGAGTC
GATGCAACATGCGCTTCATGATCTGGTGGGTCACCAGCTGGTTAAAGAAGCGGCTATAATCTCAACGTGCAATCGTACTG
AAATATACTGCAATACTGATACACCCGATAAAGCTGTCGGGTGGCTAGCTGATTTTCATCATCTCCATTCTGGAGATCTT
GAGCCCTACCTTTACAAATTGTTGCGGGAGCAGGCTGTAAAGCATGCATTTCGCGTTGCCAGCGGACTGGATTCCATGGT
GTTGGGTGAGGCACAGATACTGGGGCAGATGAAGAACGCAGTGAAATCAGCTGAACAAGCGGGAACGCTGGGATTGTTAT
TACATAAAATGTTTCAGCATACATTTTTTGTAGCGAAGGAAGTGCGTACCTCTACAGAAATAGGTGCCTGTTCAGTTTCA
ATGGCTGCTGCTGCTGCACGTCTTGCCGAAAGAATTTTTGGCAATATTAGTGAACAAAAAGTGCTGTTTATCGGTGCCGG
CGAAATGATTGAGTTGTGCGCTGCTCATTTCGTTGCCAAACGCCCCGTGCATGTAACGGTTGCAAATCGTACTGTAGAGC
GAGCGGAAGCGCTGTCGCGACGTTTTAATGCGCACCCCATCTCTTTGGGTGAATTGCCGGATCAACTGGCATTGCATGAC
ATTGTTGTCACCTCAACGGCAAGCCCGCTGCCGATACTTGGCAAAGGAATGCTGGAACGAGCCATCAAGTTGCGCAAGCA
TCGCCCGATTTTCATTGTTGATCTGGCTGTGCCACGAGATGTTGAGCCGGAAGTAGCTGAGCTGGATGATGTATTTCTAT
ATTATGTGGATGATTTGGCTGATATTGTCAGGGAAGGACTGGATAGTCGTCAGGGGGCAGTAACTCAGGCAGAAACAATT
ATTGATTCAAATGTTATGGACTTTATGCATTGGGTCGCCACACGGCGGTCTGTTCCAACTATTCGCGCACTGCGCGACCA
GGCCGAGCAATTTCGTCAGCATGAGCTGAGCCGCGCCCATAAATTACTGGCGAAGGGGGAAGATCCTGTAAAAGTGCTGG
AATCACTTAGTAGTGGATTGACCAATAAATTTCTCCATTCTCCTTCTTCCGCTCTCAACCAGGTATCCAATGATGAGCGT
GAGCAACTTGTTGAGCTTGTCAATCGGTTGTATCAGTTGCGTTATCCACGATGA

Upstream 100 bases:

>100_bases
ATATTGTGCGGCGTATCGCCATGGAACTTCCATTGATTGGGGCGGTATAACTTCCGTTATAATTAGCCAATTTTGAATTG
GCGTCATCAGGATATTTTTC

Downstream 100 bases:

>100_bases
ATAAGGGAATTGTGGATCAGCTTACCCGGCTGAGTATACGACTGGAGGAATTGGACAAGCTGTTGAGCAATGAAAAGATC
ACGGCTGATCTGGATAATTA

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MQLFAFGVNHHTAPLDIREHVAFTEESMQHALHDLVGHQLVKEAAIISTCNRTEIYCNTDTPDKAVGWLADFHHLHSGDL
EPYLYKLLREQAVKHAFRVASGLDSMVLGEAQILGQMKNAVKSAEQAGTLGLLLHKMFQHTFFVAKEVRTSTEIGACSVS
MAAAAARLAERIFGNISEQKVLFIGAGEMIELCAAHFVAKRPVHVTVANRTVERAEALSRRFNAHPISLGELPDQLALHD
IVVTSTASPLPILGKGMLERAIKLRKHRPIFIVDLAVPRDVEPEVAELDDVFLYYVDDLADIVREGLDSRQGAVTQAETI
IDSNVMDFMHWVATRRSVPTIRALRDQAEQFRQHELSRAHKLLAKGEDPVKVLESLSSGLTNKFLHSPSSALNQVSNDER
EQLVELVNRLYQLRYPR

Sequences:

>Translated_417_residues
MQLFAFGVNHHTAPLDIREHVAFTEESMQHALHDLVGHQLVKEAAIISTCNRTEIYCNTDTPDKAVGWLADFHHLHSGDL
EPYLYKLLREQAVKHAFRVASGLDSMVLGEAQILGQMKNAVKSAEQAGTLGLLLHKMFQHTFFVAKEVRTSTEIGACSVS
MAAAAARLAERIFGNISEQKVLFIGAGEMIELCAAHFVAKRPVHVTVANRTVERAEALSRRFNAHPISLGELPDQLALHD
IVVTSTASPLPILGKGMLERAIKLRKHRPIFIVDLAVPRDVEPEVAELDDVFLYYVDDLADIVREGLDSRQGAVTQAETI
IDSNVMDFMHWVATRRSVPTIRALRDQAEQFRQHELSRAHKLLAKGEDPVKVLESLSSGLTNKFLHSPSSALNQVSNDER
EQLVELVNRLYQLRYPR
>Mature_417_residues
MQLFAFGVNHHTAPLDIREHVAFTEESMQHALHDLVGHQLVKEAAIISTCNRTEIYCNTDTPDKAVGWLADFHHLHSGDL
EPYLYKLLREQAVKHAFRVASGLDSMVLGEAQILGQMKNAVKSAEQAGTLGLLLHKMFQHTFFVAKEVRTSTEIGACSVS
MAAAAARLAERIFGNISEQKVLFIGAGEMIELCAAHFVAKRPVHVTVANRTVERAEALSRRFNAHPISLGELPDQLALHD
IVVTSTASPLPILGKGMLERAIKLRKHRPIFIVDLAVPRDVEPEVAELDDVFLYYVDDLADIVREGLDSRQGAVTQAETI
IDSNVMDFMHWVATRRSVPTIRALRDQAEQFRQHELSRAHKLLAKGEDPVKVLESLSSGLTNKFLHSPSSALNQVSNDER
EQLVELVNRLYQLRYPR

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=402, Percent_Identity=44.0298507462687, Blast_Score=341, Evalue=5e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_NITEC (Q0AHU2)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_747055.1
- ProteinModelPortal:   Q0AHU2
- SMR:   Q0AHU2
- STRING:   Q0AHU2
- GeneID:   4272896
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_0826
- NMPDR:   fig|335283.3.peg.2539
- eggNOG:   COG0373
- HOGENOM:   HBG732626
- OMA:   GPILNRL
- PhylomeDB:   Q0AHU2
- ProtClustDB:   PRK00045
- BioCyc:   NEUT335283:NEUT_0826-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 46560; Mature: 46560

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 50-50 BINDING 105-105 BINDING 116-116

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLFAFGVNHHTAPLDIREHVAFTEESMQHALHDLVGHQLVKEAAIISTCNRTEIYCNTD
CCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCC
TPDKAVGWLADFHHLHSGDLEPYLYKLLREQAVKHAFRVASGLDSMVLGEAQILGQMKNA
CCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
VKSAEQAGTLGLLLHKMFQHTFFVAKEVRTSTEIGACSVSMAAAAARLAERIFGNISEQK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCE
VLFIGAGEMIELCAAHFVAKRPVHVTVANRTVERAEALSRRFNAHPISLGELPDQLALHD
EEEEECCHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHCCCCCCCHHCCCHHHHHHH
IVVTSTASPLPILGKGMLERAIKLRKHRPIFIVDLAVPRDVEPEVAELDDVFLYYVDDLA
HHEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHH
DIVREGLDSRQGAVTQAETIIDSNVMDFMHWVATRRSVPTIRALRDQAEQFRQHELSRAH
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
KLLAKGEDPVKVLESLSSGLTNKFLHSPSSALNQVSNDEREQLVELVNRLYQLRYPR
HHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQLFAFGVNHHTAPLDIREHVAFTEESMQHALHDLVGHQLVKEAAIISTCNRTEIYCNTD
CCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCC
TPDKAVGWLADFHHLHSGDLEPYLYKLLREQAVKHAFRVASGLDSMVLGEAQILGQMKNA
CCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
VKSAEQAGTLGLLLHKMFQHTFFVAKEVRTSTEIGACSVSMAAAAARLAERIFGNISEQK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCE
VLFIGAGEMIELCAAHFVAKRPVHVTVANRTVERAEALSRRFNAHPISLGELPDQLALHD
EEEEECCHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHCCCCCCCHHCCCHHHHHHH
IVVTSTASPLPILGKGMLERAIKLRKHRPIFIVDLAVPRDVEPEVAELDDVFLYYVDDLA
HHEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHH
DIVREGLDSRQGAVTQAETIIDSNVMDFMHWVATRRSVPTIRALRDQAEQFRQHELSRAH
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
KLLAKGEDPVKVLESLSSGLTNKFLHSPSSALNQVSNDEREQLVELVNRLYQLRYPR
HHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA