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The map label for this gene is coaBC [H]

Identifier: 114330796

GI number: 114330796

Start: 800239

End: 801444

Strand: Direct

Name: coaBC [H]

Synonym: Neut_0783

Alternate gene names: 114330796

Gene position: 800239-801444 (Clockwise)

Preceding gene: 114330792

Following gene: 114330797

Centisome position: 30.07

GC content: 48.51

Gene sequence:

>1206_bases
ATGATTTCAACTTGCTCGCTTGCAGGAAAGCGCCTGTTATTGGGAGTAACAGGCGGTATTGCTGCCTATAAGGTAGCAGA
ACTGACCCGGTTGCTGATGCAGGAAGGAGTGGAGGTACAGGTTGTAATGACTGAATCTGCTTGCCGGTTTGTCGGCATAG
CCACGTTTCAGGGGTTAACAGGCAAAAAAGTATTTACTGAGCTTTGGGATACTGATGTACCAAACAGCATGGCACATATC
AATCTTTCCCGGGAAGCAGATGCGATTTTGATTGCACCAGCGAGTGCGGATTTCATTGCCAAAATCACGCATGGCTTGGC
TGATGATTTGCTTTCTACGCTTTGTTTAGCACGAAACTGTCCTTTGCTGATCGCCCCCGCCATGAACTTACAAATGTGGG
AAAACGCTGCAACTCGACGTAATCTGGCTACCTTGCAACAGGATGGGATCACAGTACTCGGCCCGGGTAGTGGTTATCAG
GCTTGTGGAGAAACCGGGACAGGGCGCATGCTGGAGCCGAAGAATTTGCTGGATGCGGTACAAAGTTTCTTCCAGCCCAA
ATATCTTGATGGCAGGCGGGTACTGATTACAGCCGGGCCTACTTTTGAAGCGATTGATACGGTCAGGGGGTTAACCAACC
GGAGTTCCGGGAAAATGGGATTGGCAATTGCGCAAGCTGCGCTTGCAGCTGGAGCACAAGTGACGCTTGTATGCGGCCCA
ATCTGCCTGCCATTTCCGGCCGTCCACAAACTTATTCGTATTGTTAGTACTGAAGAAATGTTTGCTGCTGTCAAAGATGA
AGTGAGCAGCAGTGATATCTTTATCAGTGTGGCAGCAGTTGCGGATTACCGTCCGGCTGAACAGCATTCTTTCAAGCTGA
AAAAGACAGCGGCGGATATTACACTGACACTGATTCCCAATCCGGATATTTTGCAATATGTGGCCAGCCTGTCCAATCCT
CCGTTTTGTGTCGGATTCGCGGCAGAAACGGATGCCGTCCAACAATATGCGGAAGAAAAAAGAAAAAGGAAAAAATTACC
ACTGATTGTTGCTAACAATGCTGTAGAAGCCATTGGCACAAATGAGAGTGCACTGATTCTACTGGATGATGACGGATCAC
ATTATTTGCCAAGAGCTGACAAGAATGCACAAGCAAGGCTGGTGATGGCGCACATTGCCGGCCTCTACGATAAACACAAA
GGATGA

Upstream 100 bases:

>100_bases
AATTTAGTGATACGAATGAACGGTCATTCTGGGTAAAAATGAATAGCTATTTGTTTTTATTCAAAAATATATCTAACCAA
CTGAATATAGATTTATTGTC

Downstream 100 bases:

>100_bases
ATTATCGCAATGAAACAAGTTGATATCAAACTGTTCGATCCACGTCTGAAAGATTGCTTTCCCGGTTATGCCACACCCGG
ATCGGCTGGCCTGGATTTGC

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MISTCSLAGKRLLLGVTGGIAAYKVAELTRLLMQEGVEVQVVMTESACRFVGIATFQGLTGKKVFTELWDTDVPNSMAHI
NLSREADAILIAPASADFIAKITHGLADDLLSTLCLARNCPLLIAPAMNLQMWENAATRRNLATLQQDGITVLGPGSGYQ
ACGETGTGRMLEPKNLLDAVQSFFQPKYLDGRRVLITAGPTFEAIDTVRGLTNRSSGKMGLAIAQAALAAGAQVTLVCGP
ICLPFPAVHKLIRIVSTEEMFAAVKDEVSSSDIFISVAAVADYRPAEQHSFKLKKTAADITLTLIPNPDILQYVASLSNP
PFCVGFAAETDAVQQYAEEKRKRKKLPLIVANNAVEAIGTNESALILLDDDGSHYLPRADKNAQARLVMAHIAGLYDKHK
G

Sequences:

>Translated_401_residues
MISTCSLAGKRLLLGVTGGIAAYKVAELTRLLMQEGVEVQVVMTESACRFVGIATFQGLTGKKVFTELWDTDVPNSMAHI
NLSREADAILIAPASADFIAKITHGLADDLLSTLCLARNCPLLIAPAMNLQMWENAATRRNLATLQQDGITVLGPGSGYQ
ACGETGTGRMLEPKNLLDAVQSFFQPKYLDGRRVLITAGPTFEAIDTVRGLTNRSSGKMGLAIAQAALAAGAQVTLVCGP
ICLPFPAVHKLIRIVSTEEMFAAVKDEVSSSDIFISVAAVADYRPAEQHSFKLKKTAADITLTLIPNPDILQYVASLSNP
PFCVGFAAETDAVQQYAEEKRKRKKLPLIVANNAVEAIGTNESALILLDDDGSHYLPRADKNAQARLVMAHIAGLYDKHK
G
>Mature_401_residues
MISTCSLAGKRLLLGVTGGIAAYKVAELTRLLMQEGVEVQVVMTESACRFVGIATFQGLTGKKVFTELWDTDVPNSMAHI
NLSREADAILIAPASADFIAKITHGLADDLLSTLCLARNCPLLIAPAMNLQMWENAATRRNLATLQQDGITVLGPGSGYQ
ACGETGTGRMLEPKNLLDAVQSFFQPKYLDGRRVLITAGPTFEAIDTVRGLTNRSSGKMGLAIAQAALAAGAQVTLVCGP
ICLPFPAVHKLIRIVSTEEMFAAVKDEVSSSDIFISVAAVADYRPAEQHSFKLKKTAADITLTLIPNPDILQYVASLSNP
PFCVGFAAETDAVQQYAEEKRKRKKLPLIVANNAVEAIGTNESALILLDDDGSHYLPRADKNAQARLVMAHIAGLYDKHK
G

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=180, Percent_Identity=35, Blast_Score=89, Evalue=5e-18,
Organism=Escherichia coli, GI87082301, Length=404, Percent_Identity=45.049504950495, Blast_Score=315, Evalue=4e-87,
Organism=Caenorhabditis elegans, GI17560194, Length=177, Percent_Identity=33.8983050847458, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6322762, Length=192, Percent_Identity=32.2916666666667, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24657262, Length=187, Percent_Identity=31.0160427807487, Blast_Score=86, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 42951; Mature: 42951

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISTCSLAGKRLLLGVTGGIAAYKVAELTRLLMQEGVEVQVVMTESACRFVGIATFQGLT
CCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEHHHCCCC
GKKVFTELWDTDVPNSMAHINLSREADAILIAPASADFIAKITHGLADDLLSTLCLARNC
CHHHHHHHHCCCCCCCEEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCC
PLLIAPAMNLQMWENAATRRNLATLQQDGITVLGPGSGYQACGETGTGRMLEPKNLLDAV
CEEEECCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHH
QSFFQPKYLDGRRVLITAGPTFEAIDTVRGLTNRSSGKMGLAIAQAALAAGAQVTLVCGP
HHHCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEEEECC
ICLPFPAVHKLIRIVSTEEMFAAVKDEVSSSDIFISVAAVADYRPAEQHSFKLKKTAADI
HHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCHHHCEEEEEEECEE
TLTLIPNPDILQYVASLSNPPFCVGFAAETDAVQQYAEEKRKRKKLPLIVANNAVEAIGT
EEEEECCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCEEEECCCEEECCC
NESALILLDDDGSHYLPRADKNAQARLVMAHIAGLYDKHKG
CCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MISTCSLAGKRLLLGVTGGIAAYKVAELTRLLMQEGVEVQVVMTESACRFVGIATFQGLT
CCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEHHHCCCC
GKKVFTELWDTDVPNSMAHINLSREADAILIAPASADFIAKITHGLADDLLSTLCLARNC
CHHHHHHHHCCCCCCCEEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCC
PLLIAPAMNLQMWENAATRRNLATLQQDGITVLGPGSGYQACGETGTGRMLEPKNLLDAV
CEEEECCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHH
QSFFQPKYLDGRRVLITAGPTFEAIDTVRGLTNRSSGKMGLAIAQAALAAGAQVTLVCGP
HHHCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEEEECC
ICLPFPAVHKLIRIVSTEEMFAAVKDEVSSSDIFISVAAVADYRPAEQHSFKLKKTAADI
HHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCHHHCEEEEEEECEE
TLTLIPNPDILQYVASLSNPPFCVGFAAETDAVQQYAEEKRKRKKLPLIVANNAVEAIGT
EEEEECCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCEEEECCCEEECCC
NESALILLDDDGSHYLPRADKNAQARLVMAHIAGLYDKHKG
CCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]