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The map label for this gene is wecB [H]

Identifier: 114330634

GI number: 114330634

Start: 629573

End: 630685

Strand: Reverse

Name: wecB [H]

Synonym: Neut_0619

Alternate gene names: 114330634

Gene position: 630685-629573 (Counterclockwise)

Preceding gene: 114330639

Following gene: 114330633

Centisome position: 23.7

GC content: 50.49

Gene sequence:

>1113_bases
ATGCAGAAAAAAATTCATCTCATTGCTGGTGCACGCCCTAATTTTATGAAAATTGCGCCAATTGTCCGCGCTTTGCAGCA
GCAGGATAAATTGGCCTACAAGATTGTTCACACCGGTCAGCATTACGACCGGGCAATGAACGATGTTTTTTTCGAGGAGC
TGGGCATCCCGCAACCAGATATCTTTATGGCAGCCGGCGGTGGCAGCCATTCACAGCAAACAGCAAAAATAATGATCGCC
TTCGAGGAATATTGCTTGGCAGAGCAACCAGATGCGGTACTGGTTGTCGGCGATGTCAATTCAACCCTGGCCTGTTCGAT
CGTCGCCAAGAAACTGCACATTCCGGTTGCGCATGTCGAGGCAGGGTTGCGCAGCGGCGATATGTGCATGCCGGAGGAAA
TTAATCGCTTGGTGACAGATAGTATTACCGACTGGTTTTTTGTGACCGAGCCGAGTGGACAACAGCATTTGTTACGAGAA
GGAAAACCGGCCTCAGCCATTCATTATGTCGGCCATGTTATGGTGGATAATCTGTTCTACCAAGTCGAACAGCTTGTCCG
AGTAGACACTTCCGGATTTGAGACCAATCCACTTAAAACGTCACTGAAAGATCGCCCGTATGGCGTTGTCACCATGCACC
GACCAAGCAATGTAGACTACCCTGAAACGCTGCAACGTATCAGCCAAGCATTGCAACAGATCGCCAAGCAGCTTCCGCTC
ATCTTTCCGGCCCATCCGCGCACACAAAACAATCTGAAAAAATTTAATATCGATCTGGGACCCAACATTACACTGATCGG
CCCACAGGCTTACATGCCCTTTCTTCATCTCTGGAAGGATGCCACCGTTGTTCTGACTGATAGTGGCGGTTTGCAGGAAG
AAACTACCGCCCTGGGAATTCCCTGTGTCACCATCCGGGAAAATACCGAACGGCCAGTCACGGTGGATGAAGGTACCAAC
ACACTGGCAGGAACCGATCCAGTACGAATACAGTCTGCGGTGGACAACATTTTACAAGGACGCGGCAAGCAGGGACGCCG
GCCGAATTTATGGGATGGCAATGCTGCACGGCGTATCGTGGAAATACTGACCAGAGAATTGGATCGCCCCTGA

Upstream 100 bases:

>100_bases
AAACTGGTAGCATCAAAATTATCTTTTGGCAGATAAAGAAACCCGGGAAGTTTTCAAGGTTTACAATCCTGCTCATTGTC
TCTGTCTCGCGGAAAAAATT

Downstream 100 bases:

>100_bases
ATTCAAAATTTCGAATGGTCAGCAAAAATCTGCCCTATTCTTCATAACCAATCTGATGCAAGCATGAAACATTCCCTTAC
CCCAGTCATTCTTTCCGGTG

Product: UDP-N-acetylglucosamine 2-epimerase

Products: NA

Alternate protein names: UDP-GlcNAc-2-epimerase [H]

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MQKKIHLIAGARPNFMKIAPIVRALQQQDKLAYKIVHTGQHYDRAMNDVFFEELGIPQPDIFMAAGGGSHSQQTAKIMIA
FEEYCLAEQPDAVLVVGDVNSTLACSIVAKKLHIPVAHVEAGLRSGDMCMPEEINRLVTDSITDWFFVTEPSGQQHLLRE
GKPASAIHYVGHVMVDNLFYQVEQLVRVDTSGFETNPLKTSLKDRPYGVVTMHRPSNVDYPETLQRISQALQQIAKQLPL
IFPAHPRTQNNLKKFNIDLGPNITLIGPQAYMPFLHLWKDATVVLTDSGGLQEETTALGIPCVTIRENTERPVTVDEGTN
TLAGTDPVRIQSAVDNILQGRGKQGRRPNLWDGNAARRIVEILTRELDRP

Sequences:

>Translated_370_residues
MQKKIHLIAGARPNFMKIAPIVRALQQQDKLAYKIVHTGQHYDRAMNDVFFEELGIPQPDIFMAAGGGSHSQQTAKIMIA
FEEYCLAEQPDAVLVVGDVNSTLACSIVAKKLHIPVAHVEAGLRSGDMCMPEEINRLVTDSITDWFFVTEPSGQQHLLRE
GKPASAIHYVGHVMVDNLFYQVEQLVRVDTSGFETNPLKTSLKDRPYGVVTMHRPSNVDYPETLQRISQALQQIAKQLPL
IFPAHPRTQNNLKKFNIDLGPNITLIGPQAYMPFLHLWKDATVVLTDSGGLQEETTALGIPCVTIRENTERPVTVDEGTN
TLAGTDPVRIQSAVDNILQGRGKQGRRPNLWDGNAARRIVEILTRELDRP
>Mature_370_residues
MQKKIHLIAGARPNFMKIAPIVRALQQQDKLAYKIVHTGQHYDRAMNDVFFEELGIPQPDIFMAAGGGSHSQQTAKIMIA
FEEYCLAEQPDAVLVVGDVNSTLACSIVAKKLHIPVAHVEAGLRSGDMCMPEEINRLVTDSITDWFFVTEPSGQQHLLRE
GKPASAIHYVGHVMVDNLFYQVEQLVRVDTSGFETNPLKTSLKDRPYGVVTMHRPSNVDYPETLQRISQALQQIAKQLPL
IFPAHPRTQNNLKKFNIDLGPNITLIGPQAYMPFLHLWKDATVVLTDSGGLQEETTALGIPCVTIRENTERPVTVDEGTN
TLAGTDPVRIQSAVDNILQGRGKQGRRPNLWDGNAARRIVEILTRELDRP

Specific function: Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) to produce UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-N-acetylglucosamine 2-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI48994967, Length=373, Percent_Identity=34.8525469168901, Blast_Score=165, Evalue=5e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: =5.1.3.14 [H]

Molecular weight: Translated: 41194; Mature: 41194

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKKIHLIAGARPNFMKIAPIVRALQQQDKLAYKIVHTGQHYDRAMNDVFFEELGIPQPD
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHHHHCCCCCC
IFMAAGGGSHSQQTAKIMIAFEEYCLAEQPDAVLVVGDVNSTLACSIVAKKLHIPVAHVE
EEEEECCCCCCCCEEEEEEEEHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHCCCHHHHH
AGLRSGDMCMPEEINRLVTDSITDWFFVTEPSGQQHLLREGKPASAIHYVGHVMVDNLFY
HCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHCCCCCHHHHHHHHHHHHHHHH
QVEQLVRVDTSGFETNPLKTSLKDRPYGVVTMHRPSNVDYPETLQRISQALQQIAKQLPL
HHHHHHHHCCCCCCCCCCHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCE
IFPAHPRTQNNLKKFNIDLGPNITLIGPQAYMPFLHLWKDATVVLTDSGGLQEETTALGI
EECCCCCCCCCCEEEEEECCCCEEEECCHHHHHHHHHHCCCEEEEECCCCCCCCCCEECC
PCVTIRENTERPVTVDEGTNTLAGTDPVRIQSAVDNILQGRGKQGRRPNLWDGNAARRIV
CEEEEECCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
EILTRELDRP
HHHHHHHCCC
>Mature Secondary Structure
MQKKIHLIAGARPNFMKIAPIVRALQQQDKLAYKIVHTGQHYDRAMNDVFFEELGIPQPD
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHHHHCCCCCC
IFMAAGGGSHSQQTAKIMIAFEEYCLAEQPDAVLVVGDVNSTLACSIVAKKLHIPVAHVE
EEEEECCCCCCCCEEEEEEEEHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHCCCHHHHH
AGLRSGDMCMPEEINRLVTDSITDWFFVTEPSGQQHLLREGKPASAIHYVGHVMVDNLFY
HCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHCCCCCHHHHHHHHHHHHHHHH
QVEQLVRVDTSGFETNPLKTSLKDRPYGVVTMHRPSNVDYPETLQRISQALQQIAKQLPL
HHHHHHHHCCCCCCCCCCHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCE
IFPAHPRTQNNLKKFNIDLGPNITLIGPQAYMPFLHLWKDATVVLTDSGGLQEETTALGI
EECCCCCCCCCCEEEEEECCCCEEEECCHHHHHHHHHHCCCEEEEECCCCCCCCCCEECC
PCVTIRENTERPVTVDEGTNTLAGTDPVRIQSAVDNILQGRGKQGRRPNLWDGNAARRIV
CEEEEECCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
EILTRELDRP
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]