Click here to switch to the map view.

The map label for this gene is maeA [H]

Identifier: 114330611

GI number: 114330611

Start: 602380

End: 603990

Strand: Direct

Name: maeA [H]

Synonym: Neut_0596

Alternate gene names: 114330611

Gene position: 602380-603990 (Clockwise)

Preceding gene: 114330610

Following gene: 114330614

Centisome position: 22.64

GC content: 49.6

Gene sequence:

>1611_bases
ATGAAATCATTATATGGCAAGACATTACTGAACGATCCGGTGCAGAACAAATCCACCGCTTTCACCCGAGAGGAGCGTGA
ACATTACGGCTTGCAAGGGTTACTGCCATACGGCGTGACGGATATTAAAAAACAGCAGCAACGGGTACTGGCCAATCTGC
GCAACAAAAGCAGCAATATCGAAAAATACATTTATCTGAATGATCTGCTCGAACGCAACCAACAGCTGTTTTACCGCACT
CTGGTCGATCATATTGGTGAAATTATGCCATTGGTCTATACGCCCACTGTGGGCGAGGCTTGTGTAAAGCTTTCACATAT
TTTCAGAAAGCCGCAAGGGTTTTACATTACGCCGGAAGATCGCGGGGAAATTATATCCCGGCTCAAAAACTGGCCAGAAA
CCGATGTGCAAATTATCGTTGTTACAGATGGCGAGCGAATTCTTGGCCTGGGTGACTTGGGAGCAAATGGTATGGGAATA
CCAATCGGCAAAATATCTCTGTATGTAGCTTGTGCCGGGATTTATCCCGATCGATGTATGCCGGTCATGCTGGATGTTGG
AACCGGTAATCAGGCACTGCGAGAGGATCCGCTCTATCTGGGTTATCCCTATCCCCGGCTGGTCGGACAGGATTATCTAT
CGCTGGTGGATGAATTTGTGGAAGCGGTACAGCATCGGTATCCGGATGCGTTGATCCAGTTTGAGGATTTCAGCAGTCGG
AATGCATTTACCTTGCTGGATCGCTATGCCGCATCAGTTCGGTGTTTCAATGATGATATTCAAGGCACAGCTGCAGTGAC
GCTGGCGGGTATCTATGCTTCCTGCCGGATTACACACAAATCGTTTGCTGATCTGAAAATCATGTTACTGGGAACTGGAT
CTGCTGCAACCGGTGTGGCCGAATTGCTGCTGCCGGCATTCAAGGCGGCCGGACTGGGTGAGGCCGAGGCTCACTCTAGA
ATTAGTTTTGTTGATAGACGGGGTTTGGTGACAGCTGCACATGAGCTGATTAAACCGCGTATTTGTCCGTTTGTGAGCGA
ACGTGAGGCAATGAGTTTCGTTGATGCGATTACCGCTATCCAGCCGGATGTGCTGATTGGCGCAACAGGAACAGCGGGTG
CGTTCAATGAAGCAGTTATTCGCGAGATGGCCCGTTGCCAGGAACGCCCCGTGATTATTGCGCTTTCCAATCCAACTTCG
CATACGGAATGTACTGCTGAACAGGCTTACCGGTGGAGTGAAGGACGGGTTATTTTTGCCAGCGGCAGCCCGTTTGCGCC
GGTAACATTTAATAAACGAACCCATTACCCGGCGCAGGGAAACAATGTATATATCTATCCTGGAATCGGGTTAGGTGTCA
TGGCCAGCCGTGCGCGTCTGGTGGTTGAACGTATGTTTCTGGTTGCTGCTGAAGAATTGGCAAATCGTGTTTTGTCTGGG
GAAATCGAGCGTGGATCAATTTATCCGGATATTGCCCGGGTACGCGATATTTCACAGGGCATTGCCATCAAAGTTTGTCA
GGTGGCTTGGCAGGATAGCCTGGCGGGTGGAAATCTGCCTGAGGATCTGGAAGCAAATGTGCAAGCTTTGATCTATGAAC
CCGGCTATTGA

Upstream 100 bases:

>100_bases
CGGGTGTCTGTTGGCACGCTAGTTGAAATCAATGCCTGACCGCTTTGGGACGTAATCAAGAGGATGGTGATATCCAACAC
ATCCTGACCAGGAAAATATC

Downstream 100 bases:

>100_bases
AACAGGAGTGGTGTCCCCCTGCCTTACGGTATAAAGCAGGGGATTGATTTACTCAAACAGGTTGAGGATACCGTCGAGAC
CGACGTGATTAAGAGAAAAG

Product: malate dehydrogenase

Products: NA

Alternate protein names: NAD-ME [H]

Number of amino acids: Translated: 536; Mature: 536

Protein sequence:

>536_residues
MKSLYGKTLLNDPVQNKSTAFTREEREHYGLQGLLPYGVTDIKKQQQRVLANLRNKSSNIEKYIYLNDLLERNQQLFYRT
LVDHIGEIMPLVYTPTVGEACVKLSHIFRKPQGFYITPEDRGEIISRLKNWPETDVQIIVVTDGERILGLGDLGANGMGI
PIGKISLYVACAGIYPDRCMPVMLDVGTGNQALREDPLYLGYPYPRLVGQDYLSLVDEFVEAVQHRYPDALIQFEDFSSR
NAFTLLDRYAASVRCFNDDIQGTAAVTLAGIYASCRITHKSFADLKIMLLGTGSAATGVAELLLPAFKAAGLGEAEAHSR
ISFVDRRGLVTAAHELIKPRICPFVSEREAMSFVDAITAIQPDVLIGATGTAGAFNEAVIREMARCQERPVIIALSNPTS
HTECTAEQAYRWSEGRVIFASGSPFAPVTFNKRTHYPAQGNNVYIYPGIGLGVMASRARLVVERMFLVAAEELANRVLSG
EIERGSIYPDIARVRDISQGIAIKVCQVAWQDSLAGGNLPEDLEANVQALIYEPGY

Sequences:

>Translated_536_residues
MKSLYGKTLLNDPVQNKSTAFTREEREHYGLQGLLPYGVTDIKKQQQRVLANLRNKSSNIEKYIYLNDLLERNQQLFYRT
LVDHIGEIMPLVYTPTVGEACVKLSHIFRKPQGFYITPEDRGEIISRLKNWPETDVQIIVVTDGERILGLGDLGANGMGI
PIGKISLYVACAGIYPDRCMPVMLDVGTGNQALREDPLYLGYPYPRLVGQDYLSLVDEFVEAVQHRYPDALIQFEDFSSR
NAFTLLDRYAASVRCFNDDIQGTAAVTLAGIYASCRITHKSFADLKIMLLGTGSAATGVAELLLPAFKAAGLGEAEAHSR
ISFVDRRGLVTAAHELIKPRICPFVSEREAMSFVDAITAIQPDVLIGATGTAGAFNEAVIREMARCQERPVIIALSNPTS
HTECTAEQAYRWSEGRVIFASGSPFAPVTFNKRTHYPAQGNNVYIYPGIGLGVMASRARLVVERMFLVAAEELANRVLSG
EIERGSIYPDIARVRDISQGIAIKVCQVAWQDSLAGGNLPEDLEANVQALIYEPGY
>Mature_536_residues
MKSLYGKTLLNDPVQNKSTAFTREEREHYGLQGLLPYGVTDIKKQQQRVLANLRNKSSNIEKYIYLNDLLERNQQLFYRT
LVDHIGEIMPLVYTPTVGEACVKLSHIFRKPQGFYITPEDRGEIISRLKNWPETDVQIIVVTDGERILGLGDLGANGMGI
PIGKISLYVACAGIYPDRCMPVMLDVGTGNQALREDPLYLGYPYPRLVGQDYLSLVDEFVEAVQHRYPDALIQFEDFSSR
NAFTLLDRYAASVRCFNDDIQGTAAVTLAGIYASCRITHKSFADLKIMLLGTGSAATGVAELLLPAFKAAGLGEAEAHSR
ISFVDRRGLVTAAHELIKPRICPFVSEREAMSFVDAITAIQPDVLIGATGTAGAFNEAVIREMARCQERPVIIALSNPTS
HTECTAEQAYRWSEGRVIFASGSPFAPVTFNKRTHYPAQGNNVYIYPGIGLGVMASRARLVVERMFLVAAEELANRVLSG
EIERGSIYPDIARVRDISQGIAIKVCQVAWQDSLAGGNLPEDLEANVQALIYEPGY

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=535, Percent_Identity=46.7289719626168, Blast_Score=490, Evalue=1e-138,
Organism=Homo sapiens, GI62420882, Length=535, Percent_Identity=44.8598130841121, Blast_Score=475, Evalue=1e-134,
Organism=Homo sapiens, GI62420880, Length=535, Percent_Identity=44.8598130841121, Blast_Score=475, Evalue=1e-134,
Organism=Homo sapiens, GI239049447, Length=535, Percent_Identity=44.8598130841121, Blast_Score=475, Evalue=1e-134,
Organism=Homo sapiens, GI4505145, Length=516, Percent_Identity=47.8682170542636, Blast_Score=463, Evalue=1e-130,
Organism=Homo sapiens, GI270265879, Length=449, Percent_Identity=50.5567928730512, Blast_Score=422, Evalue=1e-118,
Organism=Escherichia coli, GI87081919, Length=552, Percent_Identity=42.2101449275362, Blast_Score=438, Evalue=1e-124,
Organism=Escherichia coli, GI1788806, Length=397, Percent_Identity=25.6926952141058, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17537199, Length=538, Percent_Identity=45.724907063197, Blast_Score=454, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6322823, Length=554, Percent_Identity=34.6570397111913, Blast_Score=339, Evalue=7e-94,
Organism=Drosophila melanogaster, GI281362674, Length=532, Percent_Identity=47.5563909774436, Blast_Score=496, Evalue=1e-140,
Organism=Drosophila melanogaster, GI281362672, Length=532, Percent_Identity=47.5563909774436, Blast_Score=496, Evalue=1e-140,
Organism=Drosophila melanogaster, GI21356279, Length=532, Percent_Identity=47.5563909774436, Blast_Score=496, Evalue=1e-140,
Organism=Drosophila melanogaster, GI24646386, Length=523, Percent_Identity=48.1835564053537, Blast_Score=488, Evalue=1e-138,
Organism=Drosophila melanogaster, GI24646388, Length=546, Percent_Identity=47.2527472527472, Blast_Score=487, Evalue=1e-138,
Organism=Drosophila melanogaster, GI78707242, Length=525, Percent_Identity=42.4761904761905, Blast_Score=423, Evalue=1e-118,
Organism=Drosophila melanogaster, GI78707238, Length=525, Percent_Identity=42.4761904761905, Blast_Score=423, Evalue=1e-118,
Organism=Drosophila melanogaster, GI78707240, Length=495, Percent_Identity=43.2323232323232, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI281363505, Length=524, Percent_Identity=39.1221374045802, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI78707236, Length=524, Percent_Identity=39.1221374045802, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI78707232, Length=494, Percent_Identity=40.2834008097166, Blast_Score=387, Evalue=1e-107,
Organism=Drosophila melanogaster, GI281363503, Length=520, Percent_Identity=39.0384615384615, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI19922384, Length=536, Percent_Identity=33.0223880597015, Blast_Score=286, Evalue=3e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M [H]

EC number: =1.1.1.38 [H]

Molecular weight: Translated: 59181; Mature: 59181

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSLYGKTLLNDPVQNKSTAFTREEREHYGLQGLLPYGVTDIKKQQQRVLANLRNKSSNI
CCCCCCCHHHCCCCCCCCCHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHCCCCCC
EKYIYLNDLLERNQQLFYRTLVDHIGEIMPLVYTPTVGEACVKLSHIFRKPQGFYITPED
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHCEEECCCHHHHHHHHHHHHCCCCCCEECCCC
RGEIISRLKNWPETDVQIIVVTDGERILGLGDLGANGMGIPIGKISLYVACAGIYPDRCM
HHHHHHHHHCCCCCCEEEEEEECCCEEEEECCCCCCCCCCCHHHEEEEEEEECCCCCCCE
PVMLDVGTGNQALREDPLYLGYPYPRLVGQDYLSLVDEFVEAVQHRYPDALIQFEDFSSR
EEEEECCCCCHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCC
NAFTLLDRYAASVRCFNDDIQGTAAVTLAGIYASCRITHKSFADLKIMLLGTGSAATGVA
CHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHEEEECCCCCCEEEEEEECCCHHHHHH
ELLLPAFKAAGLGEAEAHSRISFVDRRGLVTAAHELIKPRICPFVSEREAMSFVDAITAI
HHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHC
QPDVLIGATGTAGAFNEAVIREMARCQERPVIIALSNPTSHTECTAEQAYRWSEGRVIFA
CCCEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHEEECCCEEEEE
SGSPFAPVTFNKRTHYPAQGNNVYIYPGIGLGVMASRARLVVERMFLVAAEELANRVLSG
CCCCCCCEEECCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
EIERGSIYPDIARVRDISQGIAIKVCQVAWQDSLAGGNLPEDLEANVQALIYEPGY
CCCCCCCCHHHHHHHHHHCCHHEEHHHHHHHHCCCCCCCCHHHCCCEEEEEECCCC
>Mature Secondary Structure
MKSLYGKTLLNDPVQNKSTAFTREEREHYGLQGLLPYGVTDIKKQQQRVLANLRNKSSNI
CCCCCCCHHHCCCCCCCCCHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHCCCCCC
EKYIYLNDLLERNQQLFYRTLVDHIGEIMPLVYTPTVGEACVKLSHIFRKPQGFYITPED
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHCEEECCCHHHHHHHHHHHHCCCCCCEECCCC
RGEIISRLKNWPETDVQIIVVTDGERILGLGDLGANGMGIPIGKISLYVACAGIYPDRCM
HHHHHHHHHCCCCCCEEEEEEECCCEEEEECCCCCCCCCCCHHHEEEEEEEECCCCCCCE
PVMLDVGTGNQALREDPLYLGYPYPRLVGQDYLSLVDEFVEAVQHRYPDALIQFEDFSSR
EEEEECCCCCHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCC
NAFTLLDRYAASVRCFNDDIQGTAAVTLAGIYASCRITHKSFADLKIMLLGTGSAATGVA
CHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHEEEECCCCCCEEEEEEECCCHHHHHH
ELLLPAFKAAGLGEAEAHSRISFVDRRGLVTAAHELIKPRICPFVSEREAMSFVDAITAI
HHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHC
QPDVLIGATGTAGAFNEAVIREMARCQERPVIIALSNPTSHTECTAEQAYRWSEGRVIFA
CCCEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHEEECCCEEEEE
SGSPFAPVTFNKRTHYPAQGNNVYIYPGIGLGVMASRARLVVERMFLVAAEELANRVLSG
CCCCCCCEEECCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
EIERGSIYPDIARVRDISQGIAIKVCQVAWQDSLAGGNLPEDLEANVQALIYEPGY
CCCCCCCCHHHHHHHHHHCCHHEEHHHHHHHHCCCCCCCCHHHCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA