Click here to switch to the map view.

The map label for this gene is nhaC [H]

Identifier: 114330560

GI number: 114330560

Start: 567050

End: 568477

Strand: Reverse

Name: nhaC [H]

Synonym: Neut_0542

Alternate gene names: 114330560

Gene position: 568477-567050 (Counterclockwise)

Preceding gene: 114330562

Following gene: 114330559

Centisome position: 21.36

GC content: 53.01

Gene sequence:

>1428_bases
ATGACACACAACGACACCACCGTAGAGGAACCGCCAAATATACACCCGCTCCCTTCCTTCTGGCAGGCACTCATTTGTTT
TACAGGAATACTGCTGCTGATTGCATCGGGTTTGTTCGTGTTTCAAATCAGCCTGCACGCACTCATTTTTCTGGCGTTGA
TCTGGGCAGGCCTGCATACCCATAGCCTGGGTTATTCGTTTACTGCTATTCGCAGCATGATGGATGAAGGCATCGTCAGG
GCATTGCCGGCGATTTACATTTTCCTGCTGATCGGCATGGTGATCGCCAGCTTTATGCAAAGCGGTACTATCGCAAGTCT
GTTGTATTTTGGTCTCGACTGGCTCAGTCCCTCCTTGTTTCTGGCAACCGGTTTCGTATTGTGCAGCTTGATGTCGGTTG
CAACCGGCACCTCCTGGGGCACCGTCGGCACCATCGGCGTAGTACTGATCGGAATCGGTAATGCCATGGGTATTCCGCTG
CCACTGGTGGCCGGCATGATCGTCTCCGGCGCAACATTTGGTGACAAGCTGTCACCGATTTCCGACACCACCAATCTCGC
GGCAATAAGTGCTGGTACGAATCTATACCGACATATCGGCTCAATGCTGTACACCACGCTGCCCACATTCATAATTGTTC
TGGCTATTTTTCTCGTATGGGGACTGCAGTACGGCGATTATCATCTTCCGCAAGCACATCTGGCAGAAATCCGCAGCGCG
CTGGCACATTCCTATCGAATGAACGGGGCGATAACGCTGTTACCCCTGCTAGTGATGCTGGGCATGAGTATGAAACGCTA
CAGTGCCGAAACCAGTATGACATGCAGCATCCTGCTGGCAATGCTGATCGCCGTGGCCTATCAAGGAAGAGATACTGTCA
ATGTCATCAACGCGCTGTGGCTGAACACACCCGGCCATACCGGCATCGCCAATATTGACGAATTACTTGGACGCGGCGGT
TTATACAGCATGGCCTGGACTTTGCTGTTATCCATCATGGCGCTAGCACTGGGCGGCATCCTGTATCGTGCCAGATTCTT
GCAAGTACTATTGATGCGGCTGATTGCGCCAATCAACCGAGCCAGTGCCCTGATTGCCGCCACTATTGCTTCCGGCCTGG
CCGGTAACCTGGTTATGGGAGAGACGTATATTTCCATCATCCTCACCTGCCAGCTGTTCAGGCAACCTTATCGGGAAAAA
CAGCTGGATCTGGCCGTGTTATCGCGTTCCACTGAAGAAGGTTCCACACTGACCGCCGGCCTGATCCCGTGGACAACAGC
AGGTGTTTTTTACGCCGCAACACTGGGTGTACCAACACTGGACTACGCCGCGTATGCTCTGCTTAACGTGCTAAATCCCC
TGGTTTCAATCATCATGGCCATGCTGGGAATCGGCCTGCTGCGTGCCAGGCACCCTGTGGAGAGTTAA

Upstream 100 bases:

>100_bases
AAGTCTGCATCCCCCCAAAAAAAGAACAAGGAAAGCAAGGTAATCAGGTAATCACGCAATGTTATTGACATTAACTGATC
CATAAATAATCACCAAAACC

Downstream 100 bases:

>100_bases
TATGATATTCCACTCCTGCCAGACATAATCTTCCCGAAAAAGTAAAATCTCTATTTATTCAGCATTTTACCAACATAAAA
ATTGTTGATAATAGATTAAC

Product: Na+/H+ antiporter NhaC

Products: NA

Alternate protein names: Sodium/hydrogen antiporter; Sodium/proton antiporter [H]

Number of amino acids: Translated: 475; Mature: 474

Protein sequence:

>475_residues
MTHNDTTVEEPPNIHPLPSFWQALICFTGILLLIASGLFVFQISLHALIFLALIWAGLHTHSLGYSFTAIRSMMDEGIVR
ALPAIYIFLLIGMVIASFMQSGTIASLLYFGLDWLSPSLFLATGFVLCSLMSVATGTSWGTVGTIGVVLIGIGNAMGIPL
PLVAGMIVSGATFGDKLSPISDTTNLAAISAGTNLYRHIGSMLYTTLPTFIIVLAIFLVWGLQYGDYHLPQAHLAEIRSA
LAHSYRMNGAITLLPLLVMLGMSMKRYSAETSMTCSILLAMLIAVAYQGRDTVNVINALWLNTPGHTGIANIDELLGRGG
LYSMAWTLLLSIMALALGGILYRARFLQVLLMRLIAPINRASALIAATIASGLAGNLVMGETYISIILTCQLFRQPYREK
QLDLAVLSRSTEEGSTLTAGLIPWTTAGVFYAATLGVPTLDYAAYALLNVLNPLVSIIMAMLGIGLLRARHPVES

Sequences:

>Translated_475_residues
MTHNDTTVEEPPNIHPLPSFWQALICFTGILLLIASGLFVFQISLHALIFLALIWAGLHTHSLGYSFTAIRSMMDEGIVR
ALPAIYIFLLIGMVIASFMQSGTIASLLYFGLDWLSPSLFLATGFVLCSLMSVATGTSWGTVGTIGVVLIGIGNAMGIPL
PLVAGMIVSGATFGDKLSPISDTTNLAAISAGTNLYRHIGSMLYTTLPTFIIVLAIFLVWGLQYGDYHLPQAHLAEIRSA
LAHSYRMNGAITLLPLLVMLGMSMKRYSAETSMTCSILLAMLIAVAYQGRDTVNVINALWLNTPGHTGIANIDELLGRGG
LYSMAWTLLLSIMALALGGILYRARFLQVLLMRLIAPINRASALIAATIASGLAGNLVMGETYISIILTCQLFRQPYREK
QLDLAVLSRSTEEGSTLTAGLIPWTTAGVFYAATLGVPTLDYAAYALLNVLNPLVSIIMAMLGIGLLRARHPVES
>Mature_474_residues
THNDTTVEEPPNIHPLPSFWQALICFTGILLLIASGLFVFQISLHALIFLALIWAGLHTHSLGYSFTAIRSMMDEGIVRA
LPAIYIFLLIGMVIASFMQSGTIASLLYFGLDWLSPSLFLATGFVLCSLMSVATGTSWGTVGTIGVVLIGIGNAMGIPLP
LVAGMIVSGATFGDKLSPISDTTNLAAISAGTNLYRHIGSMLYTTLPTFIIVLAIFLVWGLQYGDYHLPQAHLAEIRSAL
AHSYRMNGAITLLPLLVMLGMSMKRYSAETSMTCSILLAMLIAVAYQGRDTVNVINALWLNTPGHTGIANIDELLGRGGL
YSMAWTLLLSIMALALGGILYRARFLQVLLMRLIAPINRASALIAATIASGLAGNLVMGETYISIILTCQLFRQPYREKQ
LDLAVLSRSTEEGSTLTAGLIPWTTAGVFYAATLGVPTLDYAAYALLNVLNPLVSIIMAMLGIGLLRARHPVES

Specific function: Na(+)/H(+) antiporter. Involved in pH homeostasis and sodium extrusion [H]

COG id: COG1757

COG function: function code C; Na+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaC Na(+)/H(+) antiporter family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004770
- InterPro:   IPR018461 [H]

Pfam domain/function: PF03553 Na_H_antiporter [H]

EC number: NA

Molecular weight: Translated: 51014; Mature: 50883

Theoretical pI: Translated: 7.36; Mature: 7.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHNDTTVEEPPNIHPLPSFWQALICFTGILLLIASGLFVFQISLHALIFLALIWAGLHT
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HSLGYSFTAIRSMMDEGIVRALPAIYIFLLIGMVIASFMQSGTIASLLYFGLDWLSPSLF
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCHHHH
LATGFVLCSLMSVATGTSWGTVGTIGVVLIGIGNAMGIPLPLVAGMIVSGATFGDKLSPI
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCC
SDTTNLAAISAGTNLYRHIGSMLYTTLPTFIIVLAIFLVWGLQYGDYHLPQAHLAEIRSA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
LAHSYRMNGAITLLPLLVMLGMSMKRYSAETSMTCSILLAMLIAVAYQGRDTVNVINALW
HHHHHHCCCHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LNTPGHTGIANIDELLGRGGLYSMAWTLLLSIMALALGGILYRARFLQVLLMRLIAPINR
CCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
ASALIAATIASGLAGNLVMGETYISIILTCQLFRQPYREKQLDLAVLSRSTEEGSTLTAG
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCEEEC
LIPWTTAGVFYAATLGVPTLDYAAYALLNVLNPLVSIIMAMLGIGLLRARHPVES
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
THNDTTVEEPPNIHPLPSFWQALICFTGILLLIASGLFVFQISLHALIFLALIWAGLHT
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH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CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1660475; 9190799 [H]