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The map label for this gene is aroE

Identifier: 114330515

GI number: 114330515

Start: 509256

End: 510089

Strand: Reverse

Name: aroE

Synonym: Neut_0496

Alternate gene names: 114330515

Gene position: 510089-509256 (Counterclockwise)

Preceding gene: 114330516

Following gene: 114330514

Centisome position: 19.17

GC content: 51.08

Gene sequence:

>834_bases
ATGGATACTTACGCAGTCATTGGCAACCCGATCACACACAGCAAATCACCGTTTATTCATACCCAGTTTGCGCAGCAGAC
CGGACGCAGCATGTGCTATACCACCCTGCTGGCACCACTGGATGGATTTGAACGCACCGTCACCACTTTTCGCGAAAATG
GTGGCATAGGCTTAAACATCACTGTTCCCTTTAAATTTGAGGCCTACGCACTGGCTACACGGTTGACGGATCGCGCCCGT
GCCGCGCATGCAGTTAATACTTTCAGATTCGAGCAGGAGAATGAAATACTCGGCGACAATACCGATGGTGTGGGTCTGGT
GCGCGATATTACAATCAATCTGGATTTTGCTTTGCCAGGCAAACATGTTCTGCTAATGGGCGCCGGTGGCGCTGCCAGTG
GTGTCATTCTGCCGCTGCTGCAACAAAAACCTGGCCTGCTGGCTATCGCCAACCGCACGCCTGACAAAGCAATCGCCTTG
CAGCAGCAATTTGTGAACCATGGAAATATTACTGGCGGACATTATCAGGATTTTATCGGGCAACAATTCGATCTCATTAT
CAATGCCACTTCAGCCAGTCTGCACAATGCACTCCCTCCCATTCCCGCAGATTTGTTCCATGGTACTGCGCTTGTCTACG
ACATGCTGTACAGCAGCAAGTTGACACCATTTCTGGAATTTGCCAGCACGCAAGGGGTTACTAATCTGGTTGACGGCACC
GGTATGCTGGTCGAACAAGCCGCCGAATCCTTTCTGCTTTGGCACGGTATCCGTCCTGAAACACAGAACGTCATCCGACA
ACTCAGAGATGAATTGCACCTCCATGCCTCGTGA

Upstream 100 bases:

>100_bases
TACCGATATCCTGCATATTACCCGCACCTGGGTATTCTCTCGCTCGGATAAGCTGCTGAGTGAATAGCAAAATTCTCAGA
AATACTTAAAATCAGTCACG

Downstream 100 bases:

>100_bases
AACTGACCAAAACATCCCGACCAACCACACCCCAACCAGGATTGATCAGCACCTGGCTGTTACGCCCATTACTGCTGCTC
CTGGCAATTGCATTACTGTA

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MDTYAVIGNPITHSKSPFIHTQFAQQTGRSMCYTTLLAPLDGFERTVTTFRENGGIGLNITVPFKFEAYALATRLTDRAR
AAHAVNTFRFEQENEILGDNTDGVGLVRDITINLDFALPGKHVLLMGAGGAASGVILPLLQQKPGLLAIANRTPDKAIAL
QQQFVNHGNITGGHYQDFIGQQFDLIINATSASLHNALPPIPADLFHGTALVYDMLYSSKLTPFLEFASTQGVTNLVDGT
GMLVEQAAESFLLWHGIRPETQNVIRQLRDELHLHAS

Sequences:

>Translated_277_residues
MDTYAVIGNPITHSKSPFIHTQFAQQTGRSMCYTTLLAPLDGFERTVTTFRENGGIGLNITVPFKFEAYALATRLTDRAR
AAHAVNTFRFEQENEILGDNTDGVGLVRDITINLDFALPGKHVLLMGAGGAASGVILPLLQQKPGLLAIANRTPDKAIAL
QQQFVNHGNITGGHYQDFIGQQFDLIINATSASLHNALPPIPADLFHGTALVYDMLYSSKLTPFLEFASTQGVTNLVDGT
GMLVEQAAESFLLWHGIRPETQNVIRQLRDELHLHAS
>Mature_277_residues
MDTYAVIGNPITHSKSPFIHTQFAQQTGRSMCYTTLLAPLDGFERTVTTFRENGGIGLNITVPFKFEAYALATRLTDRAR
AAHAVNTFRFEQENEILGDNTDGVGLVRDITINLDFALPGKHVLLMGAGGAASGVILPLLQQKPGLLAIANRTPDKAIAL
QQQFVNHGNITGGHYQDFIGQQFDLIINATSASLHNALPPIPADLFHGTALVYDMLYSSKLTPFLEFASTQGVTNLVDGT
GMLVEQAAESFLLWHGIRPETQNVIRQLRDELHLHAS

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1789675, Length=272, Percent_Identity=49.2647058823529, Blast_Score=252, Evalue=2e-68,
Organism=Escherichia coli, GI1787983, Length=272, Percent_Identity=30.1470588235294, Blast_Score=81, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6320332, Length=284, Percent_Identity=27.8169014084507, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_NITEC (Q0AIP9)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_746737.1
- ProteinModelPortal:   Q0AIP9
- SMR:   Q0AIP9
- STRING:   Q0AIP9
- GeneID:   4272475
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_0496
- NMPDR:   fig|335283.3.peg.1373
- eggNOG:   COG0169
- HOGENOM:   HBG553408
- OMA:   ELAYGKG
- PhylomeDB:   Q0AIP9
- ProtClustDB:   CLSK585849
- BioCyc:   NEUT335283:NEUT_0496-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 30223; Mature: 30223

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: ACT_SITE 65-65

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTYAVIGNPITHSKSPFIHTQFAQQTGRSMCYTTLLAPLDGFERTVTTFRENGGIGLNI
CCCEEEECCCCCCCCCCCEEHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEE
TVPFKFEAYALATRLTDRARAAHAVNTFRFEQENEILGDNTDGVGLVRDITINLDFALPG
EEECEEHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCEEEEEEEEEEEEECCC
KHVLLMGAGGAASGVILPLLQQKPGLLAIANRTPDKAIALQQQFVNHGNITGGHYQDFIG
CEEEEEECCCCCCCHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCHHHHHHC
QQFDLIINATSASLHNALPPIPADLFHGTALVYDMLYSSKLTPFLEFASTQGVTNLVDGT
CEEEEEEEECCHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHCCC
GMLVEQAAESFLLWHGIRPETQNVIRQLRDELHLHAS
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MDTYAVIGNPITHSKSPFIHTQFAQQTGRSMCYTTLLAPLDGFERTVTTFRENGGIGLNI
CCCEEEECCCCCCCCCCCEEHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEE
TVPFKFEAYALATRLTDRARAAHAVNTFRFEQENEILGDNTDGVGLVRDITINLDFALPG
EEECEEHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCEEEEEEEEEEEEECCC
KHVLLMGAGGAASGVILPLLQQKPGLLAIANRTPDKAIALQQQFVNHGNITGGHYQDFIG
CEEEEEECCCCCCCHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCHHHHHHC
QQFDLIINATSASLHNALPPIPADLFHGTALVYDMLYSSKLTPFLEFASTQGVTNLVDGT
CEEEEEEEECCHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHCCC
GMLVEQAAESFLLWHGIRPETQNVIRQLRDELHLHAS
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA