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The map label for this gene is lysA [H]

Identifier: 114330425

GI number: 114330425

Start: 411254

End: 412507

Strand: Reverse

Name: lysA [H]

Synonym: Neut_0404

Alternate gene names: 114330425

Gene position: 412507-411254 (Counterclockwise)

Preceding gene: 114330426

Following gene: 114330424

Centisome position: 15.5

GC content: 47.37

Gene sequence:

>1254_bases
ATGAGCCATTTCAGCTCATTTAATTATCGAAACCACCAGCTTTTTGCAGAAGAAATTCCACTGACAGCAATTGCAGCTGA
GTTTGGCACCCCTTGCTATGTTTACTCAAGTGCGGCAATCCGCACGGCTTACCAAAGCTTTGATCGCGCCTTCGGTCAGA
GAAACCATCTGATCTGCTACGCAGTAAAAGCCAATTCAAATCTTGCTGTATTGAACCTGCTTGCCCGCTTGGGCAGCGGC
TTTGATATCGTCTCTGGCGGGGAATTGCAGCGAGTATTGAAAGCAGGAGGCGATCTGCAAAAAACGGTTTTCTCTGGAGT
AGGCAAAACATTTGAGGAAATTCGTATAGCACTGGCGGCCAATATTTTCTGTTTCAATGTTGAATCAGAAATGGAACTGA
TCGCATTGAATGAAATTGCCGGACAAATGGGAAAGATCGCGCCAGTCAGTCTGCGCGTCAACCCGGATGTGGATGCCAAC
ACTCACCCTTACATTTCCACAGGAATGAAGGAAAACAAGTTTGGTATCCCGGCTGCAGAGGCTGAACGGATATACGCAAT
AGCGCAACAGCTCCCCTACATCCGTGTCTCAGGGCTAGATTGTCATATTGGCTCGCAATTGACTGAAATTGCGCCATTCA
TTGAAGCAGCCCATAAAATGCTGGATTTGCTGGCACGATTACAAGCAACAGGTATTTCCATTGAGCACCTGGATCTTGGT
GGAGGACTAGGAGTTCGTTATGATCTGGAAATCCCTCCCACGATAGAGGAGTATGTCAAGGCATTATGCGCGGCTACAGA
AAATTATCCGCAGCAATTGCTTATCGAGCCCGGACGTTCAATGGTAGGGAACGCCGGACTACTGCTGACCCGAGTGCATT
ATCTCAAACACGCACCACACCGCAATTTCGCAATTGTTGATGCTGCAATGAACGACATGTTGAGGCCAGCTCTGTATCAG
GCCTATCATTCAATATTACCAATCGCCAAGCGTACAGGAGAGACAAAAATTTACCAGATCGTCGGACCTGTTTGCGAGAC
AGGCGATTTTCTCGGCCATGACCGTAACCTGACTCTGGAAAGTAATGATTTATTGGCCGTTATGTCTGCAGGCGCGTATG
GTATGAGTATGAGCTCAAATTACAATACCCGCCCACGTGCAGTTGAAGTCATGGTGGACGGCAGCTCAGTACATCTCATT
CGTGCACGTGAAACAATAGAAGATCTATATGCTCTGGAAAAGATACCAACCTGA

Upstream 100 bases:

>100_bases
TGATTCTTTTATTACAGTTGCTCCTGTCTGCCTGTGGCTATAAAAGTTCACTTTATCTCCCACAGGATCAACCCGTTAAA
AACAATAAGCAGGAAAAGTC

Downstream 100 bases:

>100_bases
AACCCGCACATAACTCCAATTATGTCGGATATCACCACACTCGACGATGCGCGCTACCAGGAATTCATTCTACAAGGCGT
ATCACGCACTTTCGCGCTCA

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MSHFSSFNYRNHQLFAEEIPLTAIAAEFGTPCYVYSSAAIRTAYQSFDRAFGQRNHLICYAVKANSNLAVLNLLARLGSG
FDIVSGGELQRVLKAGGDLQKTVFSGVGKTFEEIRIALAANIFCFNVESEMELIALNEIAGQMGKIAPVSLRVNPDVDAN
THPYISTGMKENKFGIPAAEAERIYAIAQQLPYIRVSGLDCHIGSQLTEIAPFIEAAHKMLDLLARLQATGISIEHLDLG
GGLGVRYDLEIPPTIEEYVKALCAATENYPQQLLIEPGRSMVGNAGLLLTRVHYLKHAPHRNFAIVDAAMNDMLRPALYQ
AYHSILPIAKRTGETKIYQIVGPVCETGDFLGHDRNLTLESNDLLAVMSAGAYGMSMSSNYNTRPRAVEVMVDGSSVHLI
RARETIEDLYALEKIPT

Sequences:

>Translated_417_residues
MSHFSSFNYRNHQLFAEEIPLTAIAAEFGTPCYVYSSAAIRTAYQSFDRAFGQRNHLICYAVKANSNLAVLNLLARLGSG
FDIVSGGELQRVLKAGGDLQKTVFSGVGKTFEEIRIALAANIFCFNVESEMELIALNEIAGQMGKIAPVSLRVNPDVDAN
THPYISTGMKENKFGIPAAEAERIYAIAQQLPYIRVSGLDCHIGSQLTEIAPFIEAAHKMLDLLARLQATGISIEHLDLG
GGLGVRYDLEIPPTIEEYVKALCAATENYPQQLLIEPGRSMVGNAGLLLTRVHYLKHAPHRNFAIVDAAMNDMLRPALYQ
AYHSILPIAKRTGETKIYQIVGPVCETGDFLGHDRNLTLESNDLLAVMSAGAYGMSMSSNYNTRPRAVEVMVDGSSVHLI
RARETIEDLYALEKIPT
>Mature_416_residues
SHFSSFNYRNHQLFAEEIPLTAIAAEFGTPCYVYSSAAIRTAYQSFDRAFGQRNHLICYAVKANSNLAVLNLLARLGSGF
DIVSGGELQRVLKAGGDLQKTVFSGVGKTFEEIRIALAANIFCFNVESEMELIALNEIAGQMGKIAPVSLRVNPDVDANT
HPYISTGMKENKFGIPAAEAERIYAIAQQLPYIRVSGLDCHIGSQLTEIAPFIEAAHKMLDLLARLQATGISIEHLDLGG
GLGVRYDLEIPPTIEEYVKALCAATENYPQQLLIEPGRSMVGNAGLLLTRVHYLKHAPHRNFAIVDAAMNDMLRPALYQA
YHSILPIAKRTGETKIYQIVGPVCETGDFLGHDRNLTLESNDLLAVMSAGAYGMSMSSNYNTRPRAVEVMVDGSSVHLIR
ARETIEDLYALEKIPT

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=360, Percent_Identity=25.5555555555556, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1789203, Length=431, Percent_Identity=32.7146171693735, Blast_Score=170, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17562780, Length=353, Percent_Identity=22.9461756373938, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24586472, Length=340, Percent_Identity=26.7647058823529, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24586474, Length=345, Percent_Identity=24.9275362318841, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45709; Mature: 45578

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHFSSFNYRNHQLFAEEIPLTAIAAEFGTPCYVYSSAAIRTAYQSFDRAFGQRNHLICY
CCCCCCCCCCCCCHHHHHCCHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHCCCCCEEEE
AVKANSNLAVLNLLARLGSGFDIVSGGELQRVLKAGGDLQKTVFSGVGKTFEEIRIALAA
EEECCCCHHHHHHHHHHCCCCEECCCHHHHHHHHCCCCHHHHHHHHHCHHHHHHHHHHEE
NIFCFNVESEMELIALNEIAGQMGKIAPVSLRVNPDVDANTHPYISTGMKENKFGIPAAE
EEEEEECCCCCCEEEHHHHHHHCCCCEEEEEEECCCCCCCCCCCEECCCCCCCCCCCCHH
AERIYAIAQQLPYIRVSGLDCHIGSQLTEIAPFIEAAHKMLDLLARLQATGISIEHLDLG
HHHHHHHHHHCCEEEEECCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
GGLGVRYDLEIPPTIEEYVKALCAATENYPQQLLIEPGRSMVGNAGLLLTRVHYLKHAPH
CCCCEEEECCCCCCHHHHHHHHHHHHCCCCHHHEECCCCHHHCCCHHHHHHHHHHHCCCC
RNFAIVDAAMNDMLRPALYQAYHSILPIAKRTGETKIYQIVGPVCETGDFLGHDRNLTLE
CCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHCCCCCCCCCCEEEC
SNDLLAVMSAGAYGMSMSSNYNTRPRAVEVMVDGSSVHLIRARETIEDLYALEKIPT
CCCEEEEEECCCCCEEECCCCCCCCCEEEEEECCCCEEEEEHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SHFSSFNYRNHQLFAEEIPLTAIAAEFGTPCYVYSSAAIRTAYQSFDRAFGQRNHLICY
CCCCCCCCCCCCHHHHHCCHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHCCCCCEEEE
AVKANSNLAVLNLLARLGSGFDIVSGGELQRVLKAGGDLQKTVFSGVGKTFEEIRIALAA
EEECCCCHHHHHHHHHHCCCCEECCCHHHHHHHHCCCCHHHHHHHHHCHHHHHHHHHHEE
NIFCFNVESEMELIALNEIAGQMGKIAPVSLRVNPDVDANTHPYISTGMKENKFGIPAAE
EEEEEECCCCCCEEEHHHHHHHCCCCEEEEEEECCCCCCCCCCCEECCCCCCCCCCCCHH
AERIYAIAQQLPYIRVSGLDCHIGSQLTEIAPFIEAAHKMLDLLARLQATGISIEHLDLG
HHHHHHHHHHCCEEEEECCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
GGLGVRYDLEIPPTIEEYVKALCAATENYPQQLLIEPGRSMVGNAGLLLTRVHYLKHAPH
CCCCEEEECCCCCCHHHHHHHHHHHHCCCCHHHEECCCCHHHCCCHHHHHHHHHHHCCCC
RNFAIVDAAMNDMLRPALYQAYHSILPIAKRTGETKIYQIVGPVCETGDFLGHDRNLTLE
CCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHCCCCCCCCCCEEEC
SNDLLAVMSAGAYGMSMSSNYNTRPRAVEVMVDGSSVHLIRARETIEDLYALEKIPT
CCCEEEEEECCCCCEEECCCCCCCCCEEEEEECCCCEEEEEHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]