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The map label for this gene is cyp18 [H]

Identifier: 114330222

GI number: 114330222

Start: 193567

End: 194058

Strand: Direct

Name: cyp18 [H]

Synonym: Neut_0193

Alternate gene names: 114330222

Gene position: 193567-194058 (Clockwise)

Preceding gene: 114330221

Following gene: 114330223

Centisome position: 7.27

GC content: 43.9

Gene sequence:

>492_bases
ATGGTTAAAATACATACAAATTACGGCGCCATTACTTTGGAACTTGACAGCGATAAAACGCCTGTCACTGTCGAAAATTT
CCTGCGTTATGTTGATAGCGGACATTACGACAACACTTTGTTTCATCGTGTTATCGATGGTTTTATGATTCAAGGTGGTG
GTTATGCACCAGGAATGAAAGAAAAATCAACTTTGGCACCTATTCAGAATGAAGCTGCTTTGGGTTCTGGTAACGAGACC
TATACAATTGCCATGGCTCGCACTTCCGATGTGCATTCTGCCACTGCACAGTTTTTCATTAACGTTGCCAATAACGGTTT
TTTGAATCACACTGGCATGACGCCACAAGGTTTTGGTTACTGTGTATTTGGCCGGGTTGTGGAAGGCAAGGAAGTGGTGG
ATGCAATCAAGAAAGTGAAAACAGGTCGTTCTGCCGGACACCAGGATGTACCGCTGGAAGATGTCATCATTGAAAAAGCT
GAGCGGGCTTGA

Upstream 100 bases:

>100_bases
TAACAGAGATGTACCACAAAACATGATCGTTATTGAAAGTGTCAAATTGCTCCCGGCTTCTGCCAATTCCGAAAATCCGT
AAACTCAGGACAAAATTAAA

Downstream 100 bases:

>100_bases
GCTAAAATTCTGATAAATAATTTGTCTGGCACCAAAAATAATTTGGCCTGTGTTTTACAAATGGAAATTCAGTAGAAATG
ATGGAGATCAATAAAATTCT

Product: peptidyl-prolyl cis-trans isomerase, cyclophilin type

Products: NA

Alternate protein names: PPIase cyp18; SanCyp18; Rotamase cyp18 [H]

Number of amino acids: Translated: 163; Mature: 163

Protein sequence:

>163_residues
MVKIHTNYGAITLELDSDKTPVTVENFLRYVDSGHYDNTLFHRVIDGFMIQGGGYAPGMKEKSTLAPIQNEAALGSGNET
YTIAMARTSDVHSATAQFFINVANNGFLNHTGMTPQGFGYCVFGRVVEGKEVVDAIKKVKTGRSAGHQDVPLEDVIIEKA
ERA

Sequences:

>Translated_163_residues
MVKIHTNYGAITLELDSDKTPVTVENFLRYVDSGHYDNTLFHRVIDGFMIQGGGYAPGMKEKSTLAPIQNEAALGSGNET
YTIAMARTSDVHSATAQFFINVANNGFLNHTGMTPQGFGYCVFGRVVEGKEVVDAIKKVKTGRSAGHQDVPLEDVIIEKA
ERA
>Mature_163_residues
MVKIHTNYGAITLELDSDKTPVTVENFLRYVDSGHYDNTLFHRVIDGFMIQGGGYAPGMKEKSTLAPIQNEAALGSGNET
YTIAMARTSDVHSATAQFFINVANNGFLNHTGMTPQGFGYCVFGRVVEGKEVVDAIKKVKTGRSAGHQDVPLEDVIIEKA
ERA

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI22547215, Length=159, Percent_Identity=32.7044025157233, Blast_Score=74, Evalue=6e-14,
Organism=Homo sapiens, GI22547212, Length=159, Percent_Identity=32.7044025157233, Blast_Score=74, Evalue=6e-14,
Organism=Homo sapiens, GI7657473, Length=159, Percent_Identity=32.7044025157233, Blast_Score=74, Evalue=6e-14,
Organism=Homo sapiens, GI24308049, Length=157, Percent_Identity=35.6687898089172, Blast_Score=71, Evalue=5e-13,
Organism=Homo sapiens, GI19557636, Length=169, Percent_Identity=30.1775147928994, Blast_Score=66, Evalue=1e-11,
Organism=Escherichia coli, GI1786736, Length=158, Percent_Identity=62.6582278481013, Blast_Score=201, Evalue=3e-53,
Organism=Escherichia coli, GI1789763, Length=160, Percent_Identity=53.125, Blast_Score=162, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17532641, Length=164, Percent_Identity=31.0975609756098, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17506311, Length=163, Percent_Identity=30.6748466257669, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19922376, Length=171, Percent_Identity=29.2397660818713, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI19922912, Length=159, Percent_Identity=31.4465408805031, Blast_Score=63, Evalue=9e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 17740; Mature: 17740

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKIHTNYGAITLELDSDKTPVTVENFLRYVDSGHYDNTLFHRVIDGFMIQGGGYAPGMK
CEEEECCCCEEEEEECCCCCCEEHHHHHHHHHCCCCCHHHHHHHHHCEEECCCCCCCCCC
EKSTLAPIQNEAALGSGNETYTIAMARTSDVHSATAQFFINVANNGFLNHTGMTPQGFGY
CCCCCCCCCCCCCCCCCCCEEEEEEEECCCCHHHEEEEEEECCCCCEEECCCCCCCCCCE
CVFGRVVEGKEVVDAIKKVKTGRSAGHQDVPLEDVIIEKAERA
EEEEEEECCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MVKIHTNYGAITLELDSDKTPVTVENFLRYVDSGHYDNTLFHRVIDGFMIQGGGYAPGMK
CEEEECCCCEEEEEECCCCCCEEHHHHHHHHHCCCCCHHHHHHHHHCEEECCCCCCCCCC
EKSTLAPIQNEAALGSGNETYTIAMARTSDVHSATAQFFINVANNGFLNHTGMTPQGFGY
CCCCCCCCCCCCCCCCCCCEEEEEEEECCCCHHHEEEEEEECCCCCEEECCCCCCCCCCE
CVFGRVVEGKEVVDAIKKVKTGRSAGHQDVPLEDVIIEKAERA
EEEEEEECCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10400660 [H]