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The map label for this gene is ppiB [H]

Identifier: 114330221

GI number: 114330221

Start: 192907

End: 193548

Strand: Direct

Name: ppiB [H]

Synonym: Neut_0192

Alternate gene names: 114330221

Gene position: 192907-193548 (Clockwise)

Preceding gene: 114330219

Following gene: 114330222

Centisome position: 7.25

GC content: 43.61

Gene sequence:

>642_bases
ATGATAATCTTCTCCTTTGAGCGGCATACTGCTCGTTCAATAAAAATAGTTACCTCCACTACGCTTTTCTTTACCTTATG
CCTGACGATGTTGGCAACATCCGTTTTTGCAGCTAATCCTAAGGTTGAAATTAAAACCAATCTTGGCGCGATACAGATAG
AGCTTTATGCCGATCAGGCGCCAAAGACTGTCAAGAATTTTCTGAACTATGTTAATGATGATTACTATACCGGCACGATT
TTTCATCGGGTTATTGCCAAGTTCATGATTCAAGGGGGTGGATTCGATCAGAATTACGTACAGAAGCCTACCCGGCAGCC
TGTCGAAAATGAAGCTGCCAACGGGCTTAAAAATACACTTGGTACGATTGCGATGGCGCGCACCAATGAACCACATTCTG
CCTCGTCACAGTTTTTTATTAATGTCGCAAACAATAATTTTCTTGACTACACCGCTCCTACCATGCAGGGGTATGGTTAC
GCAGTCTTTGGTAAAGTTACAGCCGGCATGGATGTTGTTAATGCTATTGCCGGGACGCCAACCGGAGCAAATGGGCCTTT
TAACAGAGATGTACCACAAAACATGATCGTTATTGAAAGTGTCAAATTGCTCCCGGCTTCTGCCAATTCCGAAAATCCGT
AA

Upstream 100 bases:

>100_bases
TAGTTGTGAGAAGTGCTTATTTTATTGATAAAATCAGGGACTTTTCTTTATAACCGTCCGCCCGGCAGAACCAGGGGCAA
AACCGTGTGAGTATAGCATA

Downstream 100 bases:

>100_bases
ACTCAGGACAAAATTAAAATGGTTAAAATACATACAAATTACGGCGCCATTACTTTGGAACTTGACAGCGATAAAACGCC
TGTCACTGTCGAAAATTTCC

Product: peptidyl-prolyl cis-trans isomerase, cyclophilin type

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MIIFSFERHTARSIKIVTSTTLFFTLCLTMLATSVFAANPKVEIKTNLGAIQIELYADQAPKTVKNFLNYVNDDYYTGTI
FHRVIAKFMIQGGGFDQNYVQKPTRQPVENEAANGLKNTLGTIAMARTNEPHSASSQFFINVANNNFLDYTAPTMQGYGY
AVFGKVTAGMDVVNAIAGTPTGANGPFNRDVPQNMIVIESVKLLPASANSENP

Sequences:

>Translated_213_residues
MIIFSFERHTARSIKIVTSTTLFFTLCLTMLATSVFAANPKVEIKTNLGAIQIELYADQAPKTVKNFLNYVNDDYYTGTI
FHRVIAKFMIQGGGFDQNYVQKPTRQPVENEAANGLKNTLGTIAMARTNEPHSASSQFFINVANNNFLDYTAPTMQGYGY
AVFGKVTAGMDVVNAIAGTPTGANGPFNRDVPQNMIVIESVKLLPASANSENP
>Mature_213_residues
MIIFSFERHTARSIKIVTSTTLFFTLCLTMLATSVFAANPKVEIKTNLGAIQIELYADQAPKTVKNFLNYVNDDYYTGTI
FHRVIAKFMIQGGGFDQNYVQKPTRQPVENEAANGLKNTLGTIAMARTNEPHSASSQFFINVANNNFLDYTAPTMQGYGY
AVFGKVTAGMDVVNAIAGTPTGANGPFNRDVPQNMIVIESVKLLPASANSENP

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=142, Percent_Identity=38.0281690140845, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI5454154, Length=148, Percent_Identity=34.4594594594595, Blast_Score=81, Evalue=6e-16,
Organism=Homo sapiens, GI19557636, Length=145, Percent_Identity=35.1724137931034, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI22547212, Length=162, Percent_Identity=32.7160493827161, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI7657473, Length=162, Percent_Identity=32.7160493827161, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI22547215, Length=162, Percent_Identity=32.7160493827161, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI310110104, Length=145, Percent_Identity=36.551724137931, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI64276486, Length=174, Percent_Identity=32.183908045977, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI310129267, Length=137, Percent_Identity=35.036496350365, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI310120620, Length=137, Percent_Identity=35.036496350365, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI10863927, Length=149, Percent_Identity=32.2147651006711, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI24308049, Length=145, Percent_Identity=34.4827586206897, Blast_Score=68, Evalue=6e-12,
Organism=Escherichia coli, GI1786736, Length=160, Percent_Identity=55.625, Blast_Score=189, Evalue=8e-50,
Organism=Escherichia coli, GI1789763, Length=182, Percent_Identity=50.5494505494505, Blast_Score=173, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI71980590, Length=140, Percent_Identity=40.7142857142857, Blast_Score=88, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71980594, Length=140, Percent_Identity=40.7142857142857, Blast_Score=88, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17552780, Length=212, Percent_Identity=34.4339622641509, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17539496, Length=178, Percent_Identity=35.3932584269663, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17506311, Length=169, Percent_Identity=34.3195266272189, Blast_Score=74, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17532643, Length=148, Percent_Identity=34.4594594594595, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17539498, Length=168, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17532641, Length=163, Percent_Identity=29.4478527607362, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI71997782, Length=136, Percent_Identity=33.0882352941176, Blast_Score=70, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6323562, Length=210, Percent_Identity=31.4285714285714, Blast_Score=72, Evalue=7e-14,
Organism=Drosophila melanogaster, GI17986117, Length=148, Percent_Identity=34.4594594594595, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19922376, Length=171, Percent_Identity=29.8245614035088, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24586038, Length=150, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI20130249, Length=165, Percent_Identity=33.3333333333333, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24652460, Length=144, Percent_Identity=33.3333333333333, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI19922912, Length=165, Percent_Identity=32.7272727272727, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 23275; Mature: 23275

Theoretical pI: Translated: 8.41; Mature: 8.41

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIFSFERHTARSIKIVTSTTLFFTLCLTMLATSVFAANPKVEIKTNLGAIQIELYADQA
CEEEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEEECCCC
PKTVKNFLNYVNDDYYTGTIFHRVIAKFMIQGGGFDQNYVQKPTRQPVENEAANGLKNTL
CHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCHHHHHHHHHHHH
GTIAMARTNEPHSASSQFFINVANNNFLDYTAPTMQGYGYAVFGKVTAGMDVVNAIAGTP
HHEEEEECCCCCCCCCEEEEEECCCCEEEECCCCCCCCCEEEEEEHHHHHHHHHHHHCCC
TGANGPFNRDVPQNMIVIESVKLLPASANSENP
CCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCC
>Mature Secondary Structure
MIIFSFERHTARSIKIVTSTTLFFTLCLTMLATSVFAANPKVEIKTNLGAIQIELYADQA
CEEEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEEECCCC
PKTVKNFLNYVNDDYYTGTIFHRVIAKFMIQGGGFDQNYVQKPTRQPVENEAANGLKNTL
CHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCHHHHHHHHHHHH
GTIAMARTNEPHSASSQFFINVANNNFLDYTAPTMQGYGYAVFGKVTAGMDVVNAIAGTP
HHEEEEECCCCCCCCCEEEEEECCCCEEEECCCCCCCCCEEEEEEHHHHHHHHHHHHCCC
TGANGPFNRDVPQNMIVIESVKLLPASANSENP
CCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2007139; 9278503; 1864365; 9298646; 9600841; 1606970; 8601841 [H]